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Keywords: liver X receptor (LXR)
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Articles

Identification of interferon-γ as a new molecular target of liver X receptor

Qixue Wang, Xingzhe Ma, Yuanli Chen, Ling Zhang, Meixiu Jiang, Xiaoju Li, Rong Xiang, Robert Miao, David P. Hajjar, Yajun Duan, Jihong Han
Journal: Biochemical Journal
Biochem J (2014) 459 (2): 345–354.
https://doi.org/10.1042/BJ20131442
Published: 28 March 2014
... Systems. interferon-γ (IFN-γ) liver X receptor (LXR) Lewis lung carcinoma (LLC1) IFN-γ (interferon γ) has been well documented to have multiple functions including the protection of organisms against infection from viruses, bacteria and parasites, and anti-tumorigenesis [ 1 ]. IFN-γ...
View articletitled, Identification of interferon-γ as a new molecular target of liver X receptor
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Articles

Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1

Aldo Grefhorst, Marijke Schreurs, Maaike H. Oosterveer, Victor A. Cortés, Rick Havinga, Andreas W. Herling, Dirk-Jan Reijngoud, Albert K. Groen, Folkert Kuipers
Journal: Biochemical Journal
Biochem J (2010) 432 (2): 249–254.
https://doi.org/10.1042/BJ20101225
Published: 12 November 2010
... in elevated hepatic glycogen and G6P (glucose 6-phosphate) contents [ 2 ], as well as induction of hepatic lipid synthesis [ 3 ]. carbohydrate-response-element-binding protein (ChREBP) glucose 6-phosphate glycogen storage disease type 1 (GSD-1) liver X receptor (LXR) pentose-5-phosphate pathway...
View articletitled, Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1
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Articles

How essential is cholesterol?

Julian Stevenson, Andrew J. Brown
Journal: Biochemical Journal
Biochem J (2009) 420 (2): e1–e4.
https://doi.org/10.1042/BJ20090445
Published: 13 May 2009
... 24 -reductase (DHCR24) liver X receptor (LXR) sterol regulatory element binding protein (SREBP) Seladin-1 Cholesterol may receive a bad press from the mass media and in food advertising, but it is a critical lipid for mammalian life. It maintains membrane fluidity and integrity, allowing...
View articletitled, How essential is cholesterol?
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Articles

RXR heterodimerization allosterically activates LXR binding to the second NR box of activating signal co-integrator-2

You Lee Son, Ok Gu Park, Gwang Sik Kim, Jae Woon Lee, Young Chul Lee
Journal: Biochemical Journal
Biochem J (2008) 410 (2): 319–330.
https://doi.org/10.1042/BJ20070837
Published: 12 February 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 activating signal co-integrator 2 (ASC-2) interaction-defective mutants liver X receptor (LXR) LXXLL motif one- plus two-hybrid system phantom-ligand effect The NR (nuclear receptor) superfamily of proteins regulates...
View articletitled, RXR heterodimerization allosterically activates LXR binding to the second NR box of activating signal co-integrator-2
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Articles

Molecular basis for repression of liver X receptor-mediated gene transcription by receptor-interacting protein 140

Tomas Jakobsson, Waffa Osman, Jan-Åke Gustafsson, Johanna Zilliacus, Anette Wärnmark
Journal: Biochemical Journal
Biochem J (2007) 405 (1): 31–39.
https://doi.org/10.1042/BJ20070004
Published: 13 June 2007
... To whom correspondence should be addressed (email [email protected] ). 2 1 2007 27 3 2007 28 3 2007 28 3 2007 © 2007 Biochemical Society 2007 co-regulatory protein ligand-binding domain (LBD) liver X receptor (LXR) nuclear receptor receptor-interacting...
View articletitled, Molecular basis for repression of liver X receptor-mediated gene transcription by receptor-interacting protein 140
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Includes: Supplementary data
Articles

SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR

Jenny Wong, Carmel M. Quinn, Andrew J. Brown
Journal: Biochemical Journal
Biochem J (2006) 400 (3): 485–491.
https://doi.org/10.1042/BJ20060914
Published: 28 November 2006
...( S ) 25-epoxycholesterol liver X receptor (LXR) statin sterol-regulatory-element-binding protein 2 (SREBP-2) There are three main levels of control in the regulation of cholesterol homoeostasis: cholesterol synthesis, uptake and efflux. The transcription factor SREBP-2 (sterol-regulatory...
View articletitled, SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR
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Includes: Supplementary data
Articles

Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs

Nicolas Dif, Vanessa Euthine, Estelle Gonnet, Martine Laville, Hubert Vidal, Etienne Lefai
Journal: Biochemical Journal
Biochem J (2006) 400 (1): 179–188.
https://doi.org/10.1042/BJ20060499
Published: 27 October 2006
... ]. 4 4 2006 5 7 2006 10 7 2006 10 7 2006 The Biochemical Society, London 2006 insulin liver X receptor (LXR) promoter sterolregulatory-element-binding protein-1c (SREBP-1c) sterol-response element transcription Regulation of gene expression is a major action...
View articletitled, Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs
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Articles

Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARγ ligands

Carmel M. QUINN, Wendy JESSUP, Jenny WONG, Leonard KRITHARIDES, Andrew J. BROWN
Journal: Biochemical Journal
Biochem J (2005) 385 (3): 823–830.
https://doi.org/10.1042/BJ20041776
Published: 24 January 2005
... The Biochemical Society, London 2005 atherosclerosis cholesterol liver X receptor (LXR) macrophage peroxisome-proliferator-activated receptor γ (PPARγ) sterol 27-hydroxylase (CYP27A1) Efflux of cholesterol from macrophages to apoA-1 is dependent on a membrane transporter, ABCA1 (ATP-binding...
View articletitled, Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARγ ligands
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Articles

Restoration of sterol-regulatory-element-binding protein-1c gene expression in HepG2 cells by peroxisome-proliferator-activated receptor-γ co-activator-1α

Hannes OBERKOFLER, Elisabeth SCHRAML, Franz KREMPLER, Wolfgang PATSCH
Journal: Biochemical Journal
Biochem J (2004) 381 (2): 357–363.
https://doi.org/10.1042/BJ20040173
Published: 06 July 2004
... performed. co-activator gene expression liver X receptor (LXR) peroxisome-proliferator-activated receptor-γ co-activator-1α (PGC-1α) sterol-regulatory-element-binding protein (SREBP) The three SREBPs (sterol-regulatory-element-binding proteins), 1a, 1c and 2, belong to the basic helix–loop...
View articletitled, Restoration of sterol-regulatory-element-binding protein-1c gene expression in HepG2 cells by peroxisome-proliferator-activated receptor-γ co-activator-1α
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Articles

Liver-X-receptor-mediated increase in ATP-binding cassette transporter A1 expression is attenuated by fatty acids in CaCo- cells: effect on cholesterol efflux to high-density lipoprotein

Shubha MURTHY, Ella BORN, Satya N. MATHUR, F. Jeffrey FIELD
Journal: Biochemical Journal
Biochem J (2004) 377 (3): 545–552.
https://doi.org/10.1042/bj20030903
Published: 01 February 2004
... (ABCA1) CaCo-2 cells cholesterol fatty acids liver X receptor (LXR) retinoid X receptor (RXR) Abbreviations used: ABCA1, ATP-binding cassette transporter A1; ACAT, acyl-CoA:cholesterol acyltransferase; apoA1, apolipoprotein A1; HDL, LDL and VLDL, high-density, low-density and very-low...
View articletitled, Liver-X-receptor-mediated increase in ATP-binding cassette transporter A1 expression is attenuated by fatty acids in CaCo- cells: effect on cholesterol efflux to high-density lipoprotein
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