...Michael G. Friedrich; Zhen Wang; Kevin L. Schey; Roger J. W. Truscott Long-lived proteins (LLPs) are susceptible to the accumulation of both enzymatic and spontaneous post-translational modifications (PTMs). A prominent PTM observed in LLPs is covalent protein–protein crosslinking. In this study...

...Michael G. Friedrich; Zhen Wang; Kevin L. Schey; Roger J. W. Truscott Long-lived proteins (LLPs) are present in numerous tissues within the human body. With age, they deteriorate, often leading to the formation of irreversible modifications such as peptide bond cleavage and covalent cross-linking...

...Michael G. Friedrich; Zhen Wang; Kevin L. Schey; Roger J. W. Truscott The breakdown of long-lived proteins (LLPs) is associated with aging, as well as disease; however, our understanding of the molecular processes involved is still limited. Of particular relevance, cross-linked proteins are often...