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Articles

Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds

MD Khurshidul Zahid, Hazera Binte Sufian, Mahua Choudhury, Masao Yamasaki, Ahmed Al-Harrasi, Naima Moustaid-Moussa, Shaikh Mizanoor Rahman

Biochem J (2021) 478 (7): 1359–1375.

https://doi.org/10.1042/BCJ20200894

Published: 16 April 2021

... various chronic diseases. Recently, examining the effects of bioactive compounds on autophagy activity in atherogenesis has drawn considerable attention. The current review discusses the role of macrophage autophagy in the development and progression of atherosclerosis. We also summarize our current...

View article titled, Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds

Articles

Silencing carboxylesterase 1 in human THP-1 macrophages perturbs genes regulated by PPARγ/RXR and RAR/RXR: down-regulation of CYP27A1–LXRα signaling

Lee C. Mangum, Xiang Hou, Abdolsamad Borazjani, Jung Hwa Lee, Matthew K. Ross, J. Allen Crow

Biochem J (2018) 475 (3): 621–642.

https://doi.org/10.1042/BCJ20180008

Published: 09 February 2018

...Lee C. Mangum; Xiang Hou; Abdolsamad Borazjani; Jung Hwa Lee; Matthew K. Ross; J. Allen Crow Macrophage foam cells store excess cholesterol as cholesteryl esters, which need to be hydrolyzed for cholesterol efflux. We recently reported that silencing expression of carboxylesterase 1 (CES1) in human...

View article titled, Silencing carboxylesterase 1 in human THP-1 macrophages perturbs genes regulated by PPARγ/RXR and RAR/RXR: down-regulation of CYP27A1–LXRα signaling

Includes: Supplementary data

Articles

Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages

Nicola J. Darling, Rachel Toth, J. Simon C. Arthur, Kristopher Clark

Biochem J (2017) 474 (4): 521–537.

https://doi.org/10.1042/BCJ20160646

Published: 03 February 2017

...Nicola J. Darling; Rachel Toth; J. Simon C. Arthur; Kristopher Clark The salt-inducible kinases (SIKs) control a novel molecular switch regulating macrophage polarization. Pharmacological inhibition of the SIKs induces a macrophage phenotype characterized by the secretion of high levels of anti...

View article titled, Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages

Includes: Supplementary data

Articles

Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling

Fang Guo, Hui He, Zhi-Chao Fu, Shengping Huang, Tingtao Chen, Christopher J. Papasian, Leslie R. Morse, Yan Xu, Ricardo A. Battaglino, Xiao-Feng Yang, Zhisheng Jiang, Hong-Bo Xin, Mingui Fu

Biochem J (2015) 472 (3): 309–318.

https://doi.org/10.1042/BJ20150019

Published: 27 November 2015

...Fang Guo; Hui He; Zhi-Chao Fu; Shengping Huang; Tingtao Chen; Christopher J. Papasian; Leslie R. Morse; Yan Xu; Ricardo A. Battaglino; Xiao-Feng Yang; Zhisheng Jiang; Hong-Bo Xin; Mingui Fu Macrophages within adipose tissue play a key role in mediating inflammatory responses in adipose tissue...

View article titled, Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling

Articles

cAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-products

So Motoyoshi, Yasuhiko Yamamoto, Seiichi Munesue, Hirobumi Igawa, Ai Harashima, Hidehito Saito, Dong Han, Takuo Watanabe, Hiroshi Sato, Hiroshi Yamamoto

Biochem J (2014) 463 (1): 75–82.

https://doi.org/10.1042/BJ20140084

Published: 08 September 2014

... study, we show that cAMP-induced modulation of the RAGE isoform in macrophages can control the inflammatory state in both in vitro and in vivo experimental conditions. The RAGE ligand S100B stimulated MCP-1 (monocyte chemoattractant protein-1) secretion from peritoneal macrophages, but cAMP elevation...

View article titled, cAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-products

Includes: Supplementary data

Articles

Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity

Sandra Galic, Nirupa Sachithanandan, Thomas W. Kay, Gregory R. Steinberg

Biochem J (2014) 461 (2): 177–188.

https://doi.org/10.1042/BJ20140143

Published: 26 June 2014

... such as macrophages and T-cells and the impact this can have on systemic inflammation and insulin resistance. We also dissect the mechanisms by which SOCS (1–7) regulate insulin signalling in different tissues including their impact on the insulin receptor and insulin receptor substrates. Lastly, we discuss...

View article titled, Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity

Articles

Involvement of monocytes/macrophages as key factors in the development and progression of cardiovascular diseases

María Fernández-Velasco, Silvia González-Ramos, Lisardo Boscá

Biochem J (2014) 458 (2): 187–193.

https://doi.org/10.1042/BJ20131501

Published: 14 February 2014

... mobilize from the bone marrow to wounded tissues where they differentiate into macrophages or dendritic cells and trigger an immune response. In the healthy heart a limited, but near-constant, number of resident macrophages have been detected; however, this number significantly increases during cardiac...

View article titled, Involvement of monocytes/macrophages as key factors in the development and progression of cardiovascular diseases

Includes: Multimedia, Supplementary data

Articles

Tamoxifen inhibits macrophage FABP4 expression through the combined effects of the GR and PPARγ pathways

Meixiu Jiang, Ling Zhang, Xingzhe Ma, Wenquan Hu, Yuanli Chen, Miao Yu, Qixue Wang, Xiaoju Li, Zhinan Yin, Yan Zhu, Xiumei Gao, David P. Hajjar, Yajun Duan, Jihong Han

Biochem J (2013) 454 (3): 467–477.

https://doi.org/10.1042/BJ20130580

Published: 29 August 2013

...Meixiu Jiang; Ling Zhang; Xingzhe Ma; Wenquan Hu; Yuanli Chen; Miao Yu; Qixue Wang; Xiaoju Li; Zhinan Yin; Yan Zhu; Xiumei Gao; David P. Hajjar; Yajun Duan; Jihong Han Macrophage adipocyte fatty acid-binding protein (FABP4) plays an important role in foam cell formation and development...

View article titled, Tamoxifen inhibits macrophage FABP4 expression through the combined effects of the GR and PPARγ pathways

Articles

An antioxidant role for catecholate siderophores in Salmonella

Maud E. S. Achard, Kaiwen W. Chen, Matthew J. Sweet, Rebecca E. Watts, Kate Schroder, Mark A. Schembri, Alastair G. McEwan

Biochem J (2013) 454 (3): 543–549.

https://doi.org/10.1042/BJ20121771

Published: 29 August 2013

... enterica sv. Typhimurium could act as antioxidants and protect from the oxidative stress encountered after macrophage invasion. Our results show that the ability to produce siderophores enhanced the survival of Salmonella in the macrophage mainly at the early stages of infection, coincident...

View article titled, An antioxidant role for catecholate siderophores in Salmonella

Includes: Supplementary data

Articles

Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes

Robert Stöhr, Massimo Federici

Biochem J (2013) 454 (1): 1–11.

https://doi.org/10.1042/BJ20130121

Published: 26 July 2013

... by the infiltration of immune cells into the adipose tissue and the vascular walls respectively. The monocyte/macrophage populations that are recruited in these seemingly different settings also display a high similarity by exhibiting similar phenotypes in both conditions. In the insulin resistant as well...

View article titled, Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes

Articles

Ferroportin expression in haem oxygenase 1-deficient mice

Rafał R. Starzyński, François Canonne-Hergaux, Małgorzata Lenartowicz, Wojciech Krzeptowski, Alexandra Willemetz, Agnieszka Styś, Joanna Bierła, Piotr Pietrzak, Tomasz Dziaman, Paweł Lipiński

Biochem J (2013) 449 (1): 69–78.

https://doi.org/10.1042/BJ20121139

Published: 07 December 2012

.... In the present study, we characterize the cellular and systemic factors influencing Fpn expression in Hmox1 −/− bone marrow-derived macrophages and in the liver and kidney of Hmox1 −/− mice. In Hmox1 −/− macrophages, Fpn protein was relatively highly expressed under high levels of hepcidin in culture medium...

View article titled, Ferroportin expression in haem oxygenase 1-deficient mice

Includes: Supplementary data

Articles

SP-1 regulation of MMP-9 expression requires Ser 586 in the PEST domain

Shubha Murthy, Alan J. Ryan, A. Brent Carter

Biochem J (2012) 445 (2): 229–236.

https://doi.org/10.1042/BJ20120053

Published: 27 June 2012

...Shubha Murthy; Alan J. Ryan; A. Brent Carter Rac1, a small GTPase, regulates macrophage MMP (matrix metalloproteinase)-9 in an ERK (extracellular-signal-regulated kinase)- and SP (specificity protein)-1-dependent manner. SP-1 contains a PEST (Pro-Glu-Ser-Thr) domain that may modulate protein...

View article titled, SP-1 regulation of MMP-9 expression requires Ser 586 in the PEST domain

Articles

Copper redistribution in murine macrophages in response to Salmonella infection

Maud E. S. Achard, Sian L. Stafford, Nilesh J. Bokil, Jy Chartres, Paul V. Bernhardt, Mark A. Schembri, Matthew J. Sweet, Alastair G. McEwan

Biochem J (2012) 444 (1): 51–57.

https://doi.org/10.1042/BJ20112180

Published: 26 April 2012

...Maud E. S. Achard; Sian L. Stafford; Nilesh J. Bokil; Jy Chartres; Paul V. Bernhardt; Mark A. Schembri; Matthew J. Sweet; Alastair G. McEwan The movement of key transition metal ions is recognized to be of critical importance in the interaction between macrophages and intracellular pathogens...

View article titled, Copper redistribution in murine macrophages in response to Salmonella infection

Includes: Multimedia, Supplementary data

Articles

Glucan particles for selective delivery of siRNA to phagocytic cells in mice

Gregory J. Tesz, Myriam Aouadi, Matthieu Prot, Sarah M. Nicoloro, Emilie Boutet, Shinya U. Amano, Anca Goller, Mengxi Wang, Chang-An Guo, William E. Salomon, Joseph V. Virbasius, Rebecca A. Baum, Mark J. O'Connor, Jr, Ernesto Soto, Gary R. Ostroff, Michael P. Czech

Biochem J (2011) 436 (2): 351–362.

https://doi.org/10.1042/BJ20110352

Published: 13 May 2011

...Gregory J. Tesz; Myriam Aouadi; Matthieu Prot; Sarah M. Nicoloro; Emilie Boutet; Shinya U. Amano; Anca Goller; Mengxi Wang; Chang-An Guo; William E. Salomon; Joseph V. Virbasius; Rebecca A. Baum; Mark J. O'Connor, Jr; Ernesto Soto; Gary R. Ostroff; Michael P. Czech Phagocytic macrophages...

View article titled, Glucan particles for selective delivery of siRNA to phagocytic cells in mice

Includes: Supplementary data

Articles

Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response

Noam Bourquard, Carey J. Ng, Srinivasa T. Reddy

Biochem J (2011) 436 (1): 91–100.

https://doi.org/10.1042/BJ20101891

Published: 27 April 2011

... hepatic oxidative stress coupled with an exacerbated inflammatory response from PON2-deficient macrophages. In the present paper, we demonstrate that PON2 deficiency is associated with inhibitory insulin-mediated phosphorylation of hepatic IRS-1 (insulin receptor substrate-1). Unexpectedly, we observed...

View article titled, Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response

Includes: Supplementary data

Articles

Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression

Catherine Aude-Garcia, Véronique Collin-Faure, Huguette Bausinger, Daniel Hanau, Thierry Rabilloud, Claudie Lemercier

Biochem J (2010) 430 (2): 237–244.

https://doi.org/10.1042/BJ20100131

Published: 13 August 2010

... in the present study that MEF2A and MEF2D, two other MEF2 family members, are expressed in human primary monocytes and in higher amounts in monocyte-derived macrophages. High levels of MEF2A–MEF2D heterodimers are found in macrophage-differentiated HL60 cells. Chromatin immunoprecipitations demonstrate...

View article titled, Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression

Includes: Supplementary data

Articles

Apolipoprotein E inhibits Toll-like receptor (TLR)-3- and TLR-4-mediated macrophage activation through distinct mechanisms

Yanjuan Zhu, Ahmer Kodvawala, David Y. Hui

Biochem J (2010) 428 (1): 47–54.

https://doi.org/10.1042/BJ20100016

Published: 28 April 2010

...Yanjuan Zhu; Ahmer Kodvawala; David Y. Hui Previous studies have shown that apoE (apolipoprotein E) expression in macrophages suppresses inflammatory responses; however, whether endogenously synthesized apoE acts intracellularly or after its secretion in suppressing macrophage inflammation remains...

View article titled, Apolipoprotein E inhibits Toll-like receptor (TLR)-3- and TLR-4-mediated macrophage activation through distinct mechanisms

Articles

MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

Joanne Darragh, Olga Ananieva, Alan Courtney, Suzanne Elcombe, J. Simon C. Arthur

Biochem J (2010) 425 (3): 595–602.

https://doi.org/10.1042/BJ20091062

Published: 15 January 2010

... that in macrophages the TLR (Toll-like receptor)-mediated induction of IL-1ra from both its proximal and distal promoters involves the p38 and ERK1/2 (extracellular-signal-regulated kinase 1/2) MAPK (mitogen-activated protein kinase) cascades. In addition, we show that MSK1 and 2 (mitogen- and stress-activated kinase...

View article titled, MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

Articles

G-protein-coupled-receptor kinases mediate TNFα-induced NF-κB signalling via direct interaction with and phosphorylation of IκBα

Sonika Patial, Jiansong Luo, Katie J. Porter, Jeffrey L. Benovic, Narayanan Parameswaran

Biochem J (2010) 425 (1): 169–180.

https://doi.org/10.1042/BJ20090908

Published: 14 December 2009

... particularly in macrophages has been implicated in many diseases. We demonstrate in the present study that GRK2 and GRK5 (G-protein-coupled-receptor kinases 2 and 5) regulate TNFα-induced NF-κB signalling in Raw 264.7 macrophages. RNAi (RNA interference) knockdown of GRK2 or GRK5 in macrophages significantly...

View article titled, G-protein-coupled-receptor kinases mediate TNFα-induced NF-κB signalling via direct interaction with and phosphorylation of IκBα

Includes: Supplementary data

Articles

Why do phosphatidylinositol kinases have so many isoforms?

Sang H. Min, Charles S. Abrams

Biochem J (2009) 423 (1): e5–e8.

https://doi.org/10.1042/BJ20091274

Published: 14 September 2009

... phagocytosis J. Cell Biol. 2009 184 281 296 8 Tamura N. Hazeki K. Okazaki N. Kametani Y. Murakami H. Takaba Y. Ishikawa Y. Nigorikawa K. Hazeki O. Specific role of phosphoinositide 3-kinase p110α in the regulation of phagocytosis and pinocytosis in macrophages...

View article titled, Why do phosphatidylinositol kinases have so many isoforms?

Articles

Specific role of phosphoinositide 3-kinase p110α in the regulation of phagocytosis and pinocytosis in macrophages

Namiko Tamura, Kaoru Hazeki, Natsumi Okazaki, Yukiko Kametani, Hiroki Murakami, Yuki Takaba, Yuki Ishikawa, Kiyomi Nigorikawa, Osamu Hazeki

Biochem J (2009) 423 (1): 99–108.

https://doi.org/10.1042/BJ20090687

Published: 14 September 2009

...Namiko Tamura; Kaoru Hazeki; Natsumi Okazaki; Yukiko Kametani; Hiroki Murakami; Yuki Takaba; Yuki Ishikawa; Kiyomi Nigorikawa; Osamu Hazeki PI3K (phosphoinositide 3-kinase) α has been implicated in phagocytosis and fluid-phase pinocytosis in macrophages. The subtype-specific role of PI3K...

View article titled, Specific role of phosphoinositide 3-kinase p110α in the regulation of phagocytosis and pinocytosis in macrophages

Articles

The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases

Kei Miyano, Hirofumi Koga, Reiko Minakami, Hideki Sumimoto

Biochem J (2009) 422 (2): 373–382.

https://doi.org/10.1042/BJ20082182

Published: 13 August 2009

... by macrophage-like RAW264.7 cells. The insert region of Rac2 is also dispensable for gp91 phox /Nox2 activation at the cellular level. Although Rac2, as well as Rac1, is capable of enhancing superoxide production by Nox1 and Nox3, the enhancements by the two GTPases are both independent of the insert region. We...

View article titled, The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases

Articles

Macrophage activation induces formation of the anti-inflammatory lipid cholesteryl-nitrolinoleate

Ana M. Ferreira, Mariana I. Ferrari, Andrés Trostchansky, Carlos Batthyany, José M. Souza, María N. Alvarez, Gloria V. López, Paul R. S. Baker, Francisco J. Schopfer, Valerie O'Donnell, Bruce A. Freeman, Homero Rubbo

Biochem J (2009) 417 (1): 223–238.

https://doi.org/10.1042/BJ20080701

Published: 12 December 2008

..., their generation by inflammatory stimuli has not been reported. In the present study, we show increased nitration of cholesteryl-linoleate by activated murine J774.1 macrophages, yielding the mononitrated nitroalkene CLNO 2 (cholesteryl-nitrolinoleate). CLNO 2 levels were found to increase ∼20-fold 24 h after...

View article titled, Macrophage activation induces formation of the anti-inflammatory lipid cholesteryl-nitrolinoleate

Includes: Supplementary data

Articles

A novel role for Oct-2 in the lipopolysaccharide-mediated induction of resistin gene expression in RAW264.7 cells

Shao-Chun Lu, Shwu-Fen Chang, Hui-Ling Chen, Yuan-Yi Chou, Ya-Hsin Lan, Chia-Ying Chuang, Wei-Hsuan Yu, Chia-Lin Chen

Biochem J (2007) 402 (2): 387–395.

https://doi.org/10.1042/BJ20061096

Published: 12 February 2007

... (lipopolysaccharide). In the present study, we showed that LPS increased levels of resistin mRNA and promoter activity in murine RAW264.7 macrophages. Investigation of cis -regulatory elements in the mouse resistin promoter required for LPS-mediated induction showed that an Octamer (ATTTGCAT) element, located at −914...

View article titled, A novel role for Oct-2 in the lipopolysaccharide-mediated induction of resistin gene expression in RAW264.7 cells

Articles

Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2

Carol A. Rouzer, Susanne Tranguch, Haibin Wang, Hao Zhang, Sudhansu K. Dey, Lawrence J. Marnett

Biochem J (2006) 399 (1): 91–99.

https://doi.org/10.1042/BJ20060615

Published: 13 September 2006

...) respectively. In vitro , 2-AG is a selective substrate for COX-2, but in zymosan-stimulated peritoneal macrophages, PG-G synthesis is not sensitive to selective COX-2 inhibition. This suggests that COX-1 oxygenates 2-AG, so studies were carried out to identify enzymes involved in zymosan-dependent PG-G and PG...

View article titled, Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2

Articles

Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-κB in A 2A adenosine receptor induction

Lauren J. Murphree, Gail W. Sullivan, Melissa A. Marshall, Joel Linden

Biochem J (2005) 391 (3): 575–580.

https://doi.org/10.1042/BJ20050888

Published: 25 October 2005

... in human monocytes and monocytic cell lines. We investigated the effects of LPS on the expression of adenosine receptor mRNAs in primary mouse IPMΦ (intraperitoneal macrophages), human macrophages and Wehi-3 cells. Treatment with 10 ng/ml LPS for 4 h produced a >100-fold increase in A 2A AR mRNA. LPS...

View article titled, Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-κB in A 2A adenosine receptor induction

Articles

Human ADA2 belongs to a new family of growth factors with adenosine deaminase activity

Andrey V. Zavialov, Åke Engström

Biochem J (2005) 391 (1): 51–57.

https://doi.org/10.1042/BJ20050683

Published: 26 September 2005

... that have revealed an important role for it in lymphocyte activation. In contrast, the physiological role of ADA2 is unknown. ADA2 is found in negligible quantities in serum and may be produced by monocytes/macrophages. ADA2 activity in the serum is increased in various diseases in which monocyte/macrophage...

View article titled, Human ADA2 belongs to a new family of growth factors with adenosine deaminase activity

Articles

Radiation-induced cell death: importance of lysosomal destabilization

H. Lennart Persson, Tino Kurz, John W. Eaton, Ulf T. Brunk

Biochem J (2005) 389 (3): 877–884.

https://doi.org/10.1042/BJ20050271

Published: 26 July 2005

... apoptosis ionizing radiation iron chelator lysosome macrophage oxidative stress In attempts to explain the cytotoxic effects of radiation damage, HO · has been repeatedly invoked as an important intermediate, because HO · forms by radiolysis of water. It is generally assumed that HO...

View article titled, Radiation-induced cell death: importance of lysosomal destabilization

Articles

Decreased lipid efflux and increased susceptibility to cholesterol-induced apoptosis in macrophages lacking phosphatidylcholine transfer protein

Juan M. BAEZ, Ira TABAS, David E. COHEN

Biochem J (2005) 388 (1): 57–63.

https://doi.org/10.1042/BJ20041899

Published: 10 May 2005

...Juan M. BAEZ; Ira TABAS; David E. COHEN Macrophages are the predominant cellular component of atherosclerotic lesions, where they scavenge oxidatively modified lipoproteins while defending themselves against cholesterol-induced cytotoxicity by adaptive mechanisms that depend in part...

View article titled, Decreased lipid efflux and increased susceptibility to cholesterol-induced apoptosis in macrophages lacking phosphatidylcholine transfer protein

Articles

Critical role for Ets, AP-1 and GATA-like transcription factors in regulating mouse Toll-like receptor 4 ( Tlr4 ) gene expression

Thierry ROGER, Isabelle MICONNET, Anne-Laure SCHIESSER, Hirofumi KAI, Kensuke MIYAKE, Thierry CALANDRA

Biochem J (2005) 387 (2): 355–365.

https://doi.org/10.1042/BJ20041243

Published: 05 April 2005

... predisposition to or outcome of Gram-negative sepsis. In the present work, we studied the expression and regulation of the Tlr4 gene of mouse. In vivo , TLR4 levels were higher in macrophages compared with B, T or natural killer cells. High basal TLR4 promoter activity was observed in RAW 264.7, J774 and P388D1...

View article titled, Critical role for Ets, AP-1 and GATA-like transcription factors in regulating mouse Toll-like receptor 4 ( Tlr4 ) gene expression

Articles

2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells

Maiko GOKOH, Seishi KISHIMOTO, Saori OKA, Masahiro MORI, Keizo WAKU, Yoshio ISHIMA, Takayuki SUGIURA

Biochem J (2005) 386 (3): 583–589.

https://doi.org/10.1042/BJ20041163

Published: 08 March 2005

...-arachidonoylglycerol cannabinoid macrophage morphological change Arachidonic acid, essentially fatty acid-free BSA, 1,25(OH) 2 D 3 (1α, 25-dihydroxyvitamin D 3 ) and Clostridium difficile toxin B were purchased from Sigma (St. Louis, MO, U.S.A.). Formaldehyde, lysophosphatidylcholine, wortmannin...

View article titled, 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells

Articles

Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARγ ligands

Carmel M. QUINN, Wendy JESSUP, Jenny WONG, Leonard KRITHARIDES, Andrew J. BROWN

Biochem J (2005) 385 (3): 823–830.

https://doi.org/10.1042/BJ20041776

Published: 24 January 2005

...Carmel M. QUINN; Wendy JESSUP; Jenny WONG; Leonard KRITHARIDES; Andrew J. BROWN CYP27A1 (sterol 27-hydroxylase) catalyses an important sterol elimination pathway in the human macrophage, and consequently may protect against atherosclerosis. We studied the expression and regulation of CYP27A1...

View article titled, Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARγ ligands

Articles

CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells

Weiping CAO, Szu Hee LEE, Jinhua LU

Biochem J (2005) 385 (1): 85–93.

https://doi.org/10.1042/BJ20040741

Published: 14 December 2004

... the lack of CD83 on immature DCs, it was detected in these cells by Western blotting and flow cytometry. Indirect immunofluorescence revealed CD83 inside immature DCs in perinuclear regions. CD83 was absent on monocytes and macrophages, but it was detected inside these cells and found to be rapidly surface...

View article titled, CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells

Articles

Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide

Philip BUFLER, Fabia GAMBONI-ROBERTSON, Tania AZAM, Soo-Hyun KIM, Charles A. DINARELLO

Biochem J (2004) 381 (2): 503–510.

https://doi.org/10.1042/BJ20040217

Published: 06 July 2004

...-regulated by LPS (lipopolysaccharide) in human monocytes. In stable transfectants of murine RAW264.7 macrophage cells, there was no IL-1F7b protein expression despite a highly active CMV promoter. We found that IL-1F7b-specific mRNA was rapidly degraded in transfected cells, via a 3′-UTR (untranslated...

View article titled, Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide

Articles

N-Cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase

Kazuhito TSUBOI, Christine HILLIGSMANN, Séverine VANDEVOORDE, Didier M. LAMBERT, Natsuo UEDA

Biochem J (2004) 379 (1): 99–106.

https://doi.org/10.1042/bj20031695

Published: 01 April 2004

... at concentrations up to 100 µM. The inhibition was reversible and non-competitive. This compound also inhibited the acid amidase in intact alveolar macrophages. With the aid of this inhibitor, it was revealed that rat basophilic leukaemia cells possess the acid amidase as well as FAAH. Thus the inhibitor may...

View article titled, N-Cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase

Articles

Hormone-sensitive lipase - new roles for an old enzyme

Stephen J. YEAMAN

Biochem J (2004) 379 (1): 11–22.

https://doi.org/10.1042/bj20031811

Published: 01 April 2004

.... It is also apparent from work with HSL null mice that more than one enzyme species may be classified as a hormone-sensitive lipase. The possible presence of HSL in macrophages remains controversial, and the role of the protein in pancreatic β-cells has yet to be fully elucidated. Altered expression of HSL...

View article titled, Hormone-sensitive lipase - new roles for an old enzyme

Articles

Emerging and diverse roles of protein kinase C in immune cell signalling

Seng-Lai TAN, Peter J. PARKER

Biochem J (2003) 376 (3): 545–552.

https://doi.org/10.1042/bj20031406

Published: 15 December 2003

... signalling pathways play a significant role in many aspects of immune responses, from development, differentiation, activation and survival of lymphocytes to macrophage activation. The importance of PKCs in cellular immune responses suggests that improved understanding of the molecular events that govern...

View article titled, Emerging and diverse roles of protein kinase C in immune cell signalling

Articles

Interferon-γ regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways

Concepció SOLER, Antonio FELIPE, José GARCÍA-MANTEIGA, Maria SERRA, Elena GUILLÉN-GÓMEZ, F. Javier CASADO, Carol MacLEOD, Manuel MODOLELL, Marçal PASTOR-ANGLADA, Antonio CELADA

Biochem J (2003) 375 (3): 777–783.

https://doi.org/10.1042/bj20030260

Published: 01 November 2003

...Concepció SOLER; Antonio FELIPE; José GARCÍA-MANTEIGA; Maria SERRA; Elena GUILLÉN-GÓMEZ; F. Javier CASADO; Carol MacLEOD; Manuel MODOLELL; Marçal PASTOR-ANGLADA; Antonio CELADA The expressions of CNT and ENT (concentrative and equilibrative nucleoside transporters) in macrophages are differentially...

View article titled, Interferon-γ regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways

Articles

Molecular characterization of the constitutive expression of the plasma platelet-activating factor acetylhydrolase gene in macrophages

Xiaoqing WU, Thomas M. McINTYRE, Guy A. ZIMMERMAN, Stephen M. PRESCOTT, Diana M. STAFFORINI

Biochem J (2003) 375 (2): 351–363.

https://doi.org/10.1042/bj20030636

Published: 15 October 2003

... -elements required for basal transcription are localized within the −316 to −68 bp region. In vitro band-shift and supershift assays showed that Sp1 and Sp3 transcription factors from RAW264.7 and J774A.1 macrophage nuclear extracts bound strongly to a distal GC-rich site within −278/−243 [specificity...

View article titled, Molecular characterization of the constitutive expression of the plasma platelet-activating factor acetylhydrolase gene in macrophages

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Induced expression of manganese superoxide dismutase by non-toxic concentrations of oxidized low-density lipoprotein (oxLDL) protects against oxLDL-mediated cytotoxicity

Vladimir A. SHATROV, Bernhard BRÜNE

Biochem J (2003) 374 (2): 505–511.

https://doi.org/10.1042/bj20030420

Published: 01 September 2003

...Vladimir A. SHATROV; Bernhard BRÜNE Oxidized low-density lipoprotein (oxLDL) affects macrophages and plays a critical role in the development of atherosclerosis. In the present paper, we demonstrate that high concentrations of oxLDL provoked apoptosis of human Mono-Mac-6 cells, which was blocked...

View article titled, Induced expression of manganese superoxide dismutase by non-toxic concentrations of oxidized low-density lipoprotein (oxLDL) protects against oxLDL-mediated cytotoxicity

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A novel serine protease predominately expressed in macrophages

Cailin CHEN, Andrew L. DARROW, Jian-shen QI, Michael R. D'ANDREA, Patricia ANDRADE-GORDON

Biochem J (2003) 374 (1): 97–107.

https://doi.org/10.1042/bj20030242

Published: 15 August 2003

... in situ hybridization. The results from both immunohistochemistry and in situ hybridization indicate that EOS is associated with macrophages. We corroborated this observation by double immunofluorescence using the anti-EOS antibody and an anti-CD68 antibody, a macrophage specific marker. Furthermore, we...

View article titled, A novel serine protease predominately expressed in macrophages

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Role of superoxide dismutase in survival of Leishmania within the macrophage

Sanjay GHOSH, Srikanta GOSWAMI, Samit ADHYA

Biochem J (2003) 369 (3): 447–452.

https://doi.org/10.1042/bj20021684

Published: 01 February 2003

...Sanjay GHOSH; Srikanta GOSWAMI; Samit ADHYA Intracellular parasitic protozoans of the genus Leishmania depend for their survival on the elaboration of enzymic and other mechanisms for evading toxic free-radical damage inflicted by their phagocytic macrophage host. One such mechanism may involve...

View article titled, Role of superoxide dismutase in survival of Leishmania within the macrophage

Articles

Phagosome maturation: aging gracefully

Otilia V. VIEIRA, Roberto J. BOTELHO, Sergio GRINSTEIN

Biochem J (2002) 366 (3): 689–704.

https://doi.org/10.1042/bj20020691

Published: 15 September 2002

... 2002 endocytosis macrophage neutrophil phagocytosis phosphoinositide Rab SNARE Abbreviations used: ARF, ADP-ribosylation factor; [Ca 2+ ] i , cytosolic free calcium concentration; CR3, complement receptor 3; EEA1, early endosome antigen 1; FcγR, Fcγ receptor; GAP, GTPase-activating...

View article titled, Phagosome maturation: aging gracefully

Articles

Mechanisms balancing skeletal matrix synthesis and degradation

Harry C. BLAIR, Mone ZAIDI, Paul H. SCHLESINGER

Biochem J (2002) 364 (2): 329–341.

https://doi.org/10.1042/bj20020165

Published: 01 June 2002

... and the relation of skeletal and non-skeletal structures. Removal of mineralized matrix involves apoptosis of matrix cells and differentiation of acid-secreting cells (osteoclasts) from macrophage precursors. Key regulators of matrix removal are signals in the tumour-necrosis-factor family. Osteoclasts dissolve...

View article titled, Mechanisms balancing skeletal matrix synthesis and degradation

Articles

Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake

Victoriano MULERO, Susan SEARLE, Jenefer M. BLACKWELL, Jeremy H. BROCK

Biochem J (2002) 363 (1): 89–94.

https://doi.org/10.1042/bj3630089

Published: 22 March 2002

...Victoriano MULERO; Susan SEARLE; Jenefer M. BLACKWELL; Jeremy H. BROCK Solute carrier 11a1 (Slc11a1; formerly Nramp1; where Nramp stands for natural-resistance-associated macrophage protein) is a proton/bivalent cation antiporter that localizes to late endosomes/lysosomes and controls resistance...

View article titled, Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake

Articles

Stabilin-1 and −2 constitute a novel family of fasciclin-like hyaluronan receptor homologues

Oliver POLITZ, Alexei GRATCHEV, Peter A. G. McCOURT, Kai SCHLEDZEWSKI, Pierre GUILLOT, Sophie JOHANSSON, Gunbjorg SVINENG, Peter FRANKE, Christoph KANNICHT, Julia KZHYSHKOWSKA, Paola LONGATI, Florian W. VELTEN, Staffan JOHANSSON, Sergij GOERDT

Biochem J (2002) 362 (1): 155–164.

https://doi.org/10.1042/bj3620155

Published: 08 February 2002

...-continuous and angiogenic endothelial cells and by alternatively activated macrophages (Mφ2), and the hepatic sinusoidal endothelial hyaluronan clearance receptor are similar with respect to tissue distribution and biochemical characteristics. In the present study we purified these proteins by immuno...

View article titled, Stabilin-1 and −2 constitute a novel family of fasciclin-like hyaluronan receptor homologues

Articles

Identification of a peroxisome-proliferator-activated-receptor response element in the apolipoprotein E gene control region

Román GALETTO, Marta ALBAJAR, José I. POLANCO, Mario M. ZAKIN, José C. RODRÍGUEZ-REY

Biochem J (2001) 357 (2): 521–527.

https://doi.org/10.1042/bj3570521

Published: 09 July 2001

...Román GALETTO; Marta ALBAJAR; José I. POLANCO; Mario M. ZAKIN; José C. RODRÍGUEZ-REY Apolipoprotein E (apoE) is a protein involved in reverse cholesterol transport. Among other tissues, apoE is expressed in macrophages where its expression increases when macrophages develop into foam cells. It has...

View article titled, Identification of a peroxisome-proliferator-activated-receptor response element in the apolipoprotein E gene control region

Articles

Cloning of a lymphatic peptide/histidine transporter

Kazuko SAKATA, Toshihide YAMASHITA, Mitsuyo MAEDA, Yoshinori MORIYAMA, Shoichi SHIMADA, Masaya TOHYAMA

Biochem J (2001) 356 (1): 53–60.

https://doi.org/10.1042/bj3560053

Published: 08 May 2001

... 2001 The Biochemical Society, London ©2001 2001 cellular localization lysosome macrophage molecular cloning subcellular localization Abbreviations used: PHT, peptide/histidine transporter; r, rat; PepT, peptide transporter; PEPT, oligopeptide transporter; LAMP1, lysosome...

View article titled, Cloning of a lymphatic peptide/histidine transporter

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A new phosphospecific cell-based ELISA for p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, protein kinase B and cAMP-response-element-binding protein

Henri H. VERSTEEG, Evert NIJHUIS, Gijs R. VAN DEN BRINK, Maaike EVERTZEN, Gwenda N. PYNAERT, Sander J. H. VAN DEVENTER, Paul J. COFFER, Maikel P. PEPPELENBOSCH

Biochem J (2000) 350 (3): 717–722.

https://doi.org/10.1042/bj3500717

Published: 08 September 2000

... correlated with those measured via classical methodology. Using PACE we have now characterized for the first time the concentration-dependent effects of various inflammatory prostaglandins on CREB phosphorylation in macrophages. PACE is a straightforward and novel technique enabling the large-scale analysis...

View article titled, A new phosphospecific cell-based ELISA for p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, protein kinase B and cAMP-response-element-binding protein

Articles

Salicylate-enhanced activation of transcription factors induced by interferon-γ

Li-Chun CHEN, Diane KEPKA-LENHART, Timothy M. WRIGHT, Sidney M. MORRIS, JR.

Biochem J (1999) 342 (3): 503–507.

https://doi.org/10.1042/bj3420503

Published: 05 September 1999

...Li-Chun CHEN; Diane KEPKA-LENHART; Timothy M. WRIGHT; Sidney M. MORRIS, JR. Salicylate enhanced the interferon-γ-dependent activation of two transcription factors in a murine macrophage cell line: signal transducer and activator of transcription (STAT)1 and interferon-γ-responsive factor 1...

View article titled, Salicylate-enhanced activation of transcription factors induced by interferon-γ

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