...Gilbert Salloum; Anne R. Bresnick; Jonathan M. Backer Macropinocytosis is defined as an actin-dependent but coat- and dynamin-independent endocytic uptake process, which generates large intracellular vesicles (macropinosomes) containing a non-selective sampling of extracellular fluid...

... + exchanger is an established inducer of macropinocytosis, an endocytic process for cellular uptake of bulk fluid and its components, we examined the impact of SLC38A5 on macropinocytosis in TNBC cells. We found that the transport function of SLC38A5 is coupled to the induction of macropinocytosis...

... that triggers macropinocytosis may therefore be amplified downstream in a way that depends on macropinocytosis. This argument provides a context for recent findings that signalling to Akt (an effector of PIP3) is sensitive to cytoskeletal and macropinocytic inhibitors. Drawing these studies together...

... expressing a mutant p110β that cannot bind Rac1. Instead of directly binding to PI3Kβ, CA-Rac1 acts by enhancing Gβγ coupling to PI3Kβ, as CA-Rac1-mediated Akt activation was blocked by inhibitors of Gβγ. Cells expressing CA-Rac1 exhibited a robust induction of macropinocytosis, and inhibitors...

... is important for HDGF internalization. We further demonstrate that both HATH and HATH (K96A) could be internalized through macropinocytosis after binding to the cell surface HS. Interestingly, HS-mediated HATH (K96A) internalization is found to exhibit an inhibitory effect on cell migration and proliferation...

... syntaxin 8 t-SNARE complex is associated with incoming endocytic material. Key words: endocytosis, macropinocytosis, membrane fusion. the internal pH concomitantly returns to 6.5. Egestion of undigested material occurs from these post-lysosomal compart- ments through exocytosis [9,10]. Eukaryotic membrane...