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A Plasmodium falciparum ubiquitin-specific protease ( Pf USP) is essential for parasite survival and its disruption enhances artemisinin efficacy

Priya Arora, Monika Narwal, Vandana Thakur, Osama Mukhtar, Pawan Malhotra, Asif Mohmmed

Biochem J (2023) 480 (1): 25–39.

https://doi.org/10.1042/BCJ20220429

Published: 06 January 2023

...Priya Arora; Monika Narwal; Vandana Thakur; Osama Mukhtar; Pawan Malhotra; Asif Mohmmed Proteins associated with ubiquitin–proteasome system (UPS) are potential drug targets in the malaria parasite. The ubiquitination and deubiquitination are key regulatory processes for the functioning of UPS...

View article titled, A Plasmodium falciparum ubiquitin-specific protease ( Pf USP) is essential for parasite survival and its disruption enhances artemisinin efficacy

Includes: Supplementary data

Articles

Nanobodies against Pfs230 block Plasmodium falciparum transmission

Melanie H. Dietrich, Mikha Gabriela, Kitsanapong Reaksudsan, Matthew W. A. Dixon, Li-Jin Chan, Amy Adair, Stephanie Trickey, Matthew T. O'Neill, Li Lynn Tan, Sash Lopaticki, Julie Healer, Sravya Keremane, Alan F. Cowman, Wai-Hong Tham

Biochem J (2022) 479 (24): 2529–2546.

https://doi.org/10.1042/BCJ20220554

Published: 22 December 2022

...Melanie H. Dietrich; Mikha Gabriela; Kitsanapong Reaksudsan; Matthew W. A. Dixon; Li-Jin Chan; Amy Adair; Stephanie Trickey; Matthew T. O'Neill; Li Lynn Tan; Sash Lopaticki; Julie Healer; Sravya Keremane; Alan F. Cowman; Wai-Hong Tham Transmission blocking interventions can stop malaria parasite...

View article titled, Nanobodies against Pfs230 block Plasmodium falciparum transmission

Includes: Supplementary data

Articles

N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum

Samuel Pazicky, Arne Alder, Haydyn Mertens, Dmitri Svergun, Tim Gilberger, Christian Löw

Biochem J (2022) 479 (3): 337–356.

https://doi.org/10.1042/BCJ20210829

Published: 04 February 2022

...Samuel Pazicky; Arne Alder; Haydyn Mertens; Dmitri Svergun; Tim Gilberger; Christian Löw As the decline of malaria cases stalled over the last five years, novel targets in Plasmodium falciparum are necessary for the development of new drugs. Glycogen Synthase Kinase (PfGSK3) has been identified...

View article titled, N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum

Includes: Supplementary data

Articles

Glm S mediated knock-down of a phospholipase expedite alternate pathway to generate phosphocholine required for phosphatidylcholine synthesis in Plasmodium falciparum

Pradeep Kumar Sheokand, Monika Narwal, Vandana Thakur, Asif Mohmmed

Biochem J (2021) 478 (18): 3429–3444.

https://doi.org/10.1042/BCJ20200549

Published: 23 September 2021

...Pradeep Kumar Sheokand; Monika Narwal; Vandana Thakur; Asif Mohmmed Phospholipid synthesis is crucial for membrane proliferation in malaria parasites during the entire cycle in the host cell. The major phospholipid of parasite membranes, phosphatidylcholine (PC), is mainly synthesized through...

View article titled, Glm S mediated knock-down of a phospholipase expedite alternate pathway to generate phosphocholine required for phosphatidylcholine synthesis in Plasmodium falciparum

Includes: Multimedia, Supplementary data

Articles

Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate

Renu Sudhakar, Divya Das, Subramanian Thanumalayan, Somesh Gorde, Puran Singh Sijwali

Biochem J (2021) 478 (9): 1705–1732.

https://doi.org/10.1042/BCJ20210001

Published: 10 May 2021

...Renu Sudhakar; Divya Das; Subramanian Thanumalayan; Somesh Gorde; Puran Singh Sijwali Autophagy, a lysosome-dependent degradative process, does not appear to be a major degradative process in malaria parasites and has a limited repertoire of genes. To better understand the autophagy process, we...

View article titled, Plasmodium falciparum Atg18 localizes to the food vacuole via interaction with the multi-drug resistance protein 1 and phosphatidylinositol 3-phosphate

Includes: Supplementary data

Articles

Nanobody generation and structural characterization of Plasmodium falciparum 6-cysteine protein Pf12p

In Collection

Awards

Melanie H. Dietrich, Li-Jin Chan, Amy Adair, Sravya Keremane, Phillip Pymm, Alvin W. Lo, Yi-Chun Cao, Wai-Hong Tham

Biochem J (2021) 478 (3): 579–595.

https://doi.org/10.1042/BCJ20200415

Published: 10 February 2021

... in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. 6-cysteine proteins malaria nanobody Plasmodium falciparum is the most lethal of human malaria species and responsible for the majority of malaria...

View article titled, Nanobody generation and structural characterization of Plasmodium falciparum 6-cysteine protein Pf12p

Includes: Supplementary data

Articles

Structural–functional diversity of malaria parasite's PfHSP70-1 and PfHSP40 chaperone pair gives an edge over human orthologs in chaperone-assisted protein folding

In Collection

Protein structure and function

Mohammad Anas, Ankita Shukla, Aradhya Tripathi, Varsha Kumari, Chetan Prakash, Priyabrata Nag, L. Sathish Kumar, Sandeep K. Sharma, Ravishankar Ramachandran, Niti Kumar

Biochem J (2020) 477 (18): 3625–3643.

https://doi.org/10.1042/BCJ20200434

Published: 28 September 2020

...Mohammad Anas; Ankita Shukla; Aradhya Tripathi; Varsha Kumari; Chetan Prakash; Priyabrata Nag; L. Sathish Kumar; Sandeep K. Sharma; Ravishankar Ramachandran; Niti Kumar Plasmodium falciparum , the human malaria parasite harbors a metastable proteome which is vulnerable to proteotoxic stress...

View article titled, Structural–functional diversity of malaria parasite's PfHSP70-1 and PfHSP40 chaperone pair gives an edge over human orthologs in chaperone-assisted protein folding

Includes: Supplementary data

Articles

A nonpeptidyl molecule modulates apoptosis-like cell death by inhibiting P. falciparum metacaspase-2

Vandana, Sudha Shankar, Kona Madhavinadha Prasad, Mohammad Kashif, Inderjeet Kalia, Rajkishor Rai, Agam P. Singh, Kailash C. Pandey

Biochem J (2020) 477 (7): 1323–1344.

https://doi.org/10.1042/BCJ20200050

Published: 17 April 2020

... Society 2020 Plasmodium falciparum metacaspase-2 apoptosis-like cell death malaria mitochondrial potential oxidative stress SS-5 Z-FA-FMK analog Apoptosis is a highly regulated phenomenon important for the maintenance of homeostasis in tissues and during embryonic development [ 1...

View article titled, A nonpeptidyl molecule modulates apoptosis-like cell death by inhibiting P. falciparum metacaspase-2

Includes: Supplementary data

Articles

Interaction with complement proteins and dendritic cells implicates LCCL domain-containing proteins (CCps) of malaria parasites in immunomodulation

Puran Singh Sijwali

Biochem J (2018) 475 (21): 3311–3314.

https://doi.org/10.1042/BCJ20180494

Published: 06 November 2018

... of the complement system through direct encounter with pathogens or some other agents leads to osmolysis of pathogens, clearance of soluble immune complexes and recruitment of lymphocytes at the site of activation. Although malaria parasites are not exposed to the complement system owing to their intracellular...

View article titled, Interaction with complement proteins and dendritic cells implicates LCCL domain-containing proteins (CCps) of malaria parasites in immunomodulation

Articles

Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism

Jose E. Pietri, Nazzy Pakpour, Eleonora Napoli, Gyu Song, Eduardo Pietri, Rashaun Potts, Kong W. Cheung, Gregory Walker, Michael A. Riehle, Hannah Starcevich, Cecilia Giulivi, Edwin E. Lewis, Shirley Luckhart

Biochem J (2016) 473 (20): 3487–3503.

https://doi.org/10.1042/BCJ20160271

Published: 11 October 2016

... with these studies, we previously showed that knockdown of either of two closely related, infection-induced ILPs, ILP3 and ILP4, in the mosquito Anopheles stephensi decreased infection with the human malaria parasite Plasmodium falciparum through kinetically distinct effects on parasite death. However, the precise...

View article titled, Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism

Includes: Supplementary data

Articles

Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum

Nyssa Drinkwater, Komagal Kannan Sivaraman, Rebecca S. Bamert, Wioletta Rut, Khadija Mohamed, Natalie B. Vinh, Peter J. Scammells, Marcin Drag, Sheena McGowan

Biochem J (2016) 473 (19): 3189–3204.

https://doi.org/10.1042/BCJ20160550

Published: 27 September 2016

...Nyssa Drinkwater; Komagal Kannan Sivaraman; Rebecca S. Bamert; Wioletta Rut; Khadija Mohamed; Natalie B. Vinh; Peter J. Scammells; Marcin Drag; Sheena McGowan Malaria is one of the world's most prevalent parasitic diseases, with over 200 million cases annually. Alarmingly, the spread of drug...

View article titled, Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum

Includes: Supplementary data

Articles

From crystal to compound: structure-based antimalarial drug discovery

Nyssa Drinkwater, Sheena McGowan

Biochem J (2014) 461 (3): 349–369.

https://doi.org/10.1042/BJ20140240

Published: 10 July 2014

...Nyssa Drinkwater; Sheena McGowan Despite a century of control and eradication campaigns, malaria remains one of the world's most devastating diseases. Our once-powerful therapeutic weapons are losing the war against the Plasmodium parasite, whose ability to rapidly develop and spread drug...

View article titled, From crystal to compound: structure-based antimalarial drug discovery

Articles

Genetic ablation of plasmoDJ1, a multi-activity enzyme, attenuates parasite virulence and reduces oocyst production

Neha Singhal, Atul, Babu S. Mastan, Kota Arun Kumar, Puran Singh Sijwali

Biochem J (2014) 461 (2): 189–203.

https://doi.org/10.1042/BJ20140051

Published: 26 June 2014

...Neha Singhal; Atul; Babu S. Mastan; Kota Arun Kumar; Puran Singh Sijwali Malaria parasites must respond to stresses and environmental signals to perpetuate efficiently during their multistage development in diverse environments. To gain insights into the parasite's stress response mechanisms, we...

View article titled, Genetic ablation of plasmoDJ1, a multi-activity enzyme, attenuates parasite virulence and reduces oocyst production

Includes: Supplementary data

Articles

Completing the folate biosynthesis pathway in Plasmodium falciparum : p -aminobenzoate is produced by a highly divergent promiscuous aminodeoxychorismate lyase

Giovanni Magnani, Michela Lomazzi, Alessio Peracchi

Biochem J (2013) 455 (2): 149–155.

https://doi.org/10.1042/BJ20130896

Published: 27 September 2013

... -aminobenzoate aminodeoxychorismate lyase antifolate catalytic promiscuity malaria pyridoxal phosphate Tetrahydrofolate and related cofactors, collectively termed folates, are used by enzymes that mediate the transfer of one-carbon units and are strictly required for a number of basic metabolic...

View article titled, Completing the folate biosynthesis pathway in Plasmodium falciparum : p -aminobenzoate is produced by a highly divergent promiscuous aminodeoxychorismate lyase

Includes: Supplementary data

Articles

Specific phosphorylation of the Pf Rh2b invasion ligand of Plasmodium falciparum

Klemens Engelberg, Aditya S. Paul, Boris Prinz, Maya Kono, Wilhelm Ching, Dorothee Heincke, Thomas Dobner, Tobias Spielmann, Manoj T. Duraisingh, Tim-Wolf Gilberger

Biochem J (2013) 452 (3): 457–466.

https://doi.org/10.1042/BJ20121694

Published: 31 May 2013

...Klemens Engelberg; Aditya S. Paul; Boris Prinz; Maya Kono; Wilhelm Ching; Dorothee Heincke; Thomas Dobner; Tobias Spielmann; Manoj T. Duraisingh; Tim-Wolf Gilberger Red blood cell invasion by the malaria parasite Plasmodium falciparum relies on a complex protein network that uses low and high...

View article titled, Specific phosphorylation of the Pf Rh2b invasion ligand of Plasmodium falciparum

Includes: Supplementary data

Articles

Inhibition of Plasmodium falciparum CDPK1 by conditional expression of its J-domain demonstrates a key role in schizont development

Mauro F. Azevedo, Paul R. Sanders, Efrosinia Krejany, Catherine Q. Nie, Ping Fu, Leon A. Bach, Gerhard Wunderlich, Brendan S. Crabb, Paul R. Gilson

Biochem J (2013) 452 (3): 433–441.

https://doi.org/10.1042/BJ20130124

Published: 31 May 2013

... or [email protected] ). 22 1 2013 26 3 2013 3 4 2013 3 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 calcium calcium-dependent protein kinase 1 (CDPK1) malaria phosphorylation Plasmodium signalling Intracellular signalling events...

View article titled, Inhibition of Plasmodium falciparum CDPK1 by conditional expression of its J-domain demonstrates a key role in schizont development

Includes: Supplementary data

Articles

Structure of Plasmodium falciparum TRAP (thrombospondin-related anonymous protein) A domain highlights distinct features in apicomplexan von Willebrand factor A homologues

Tero Pihlajamaa, Tommi Kajander, Juho Knuuti, Kaisa Horkka, Amit Sharma, Perttu Permi

Biochem J (2013) 450 (3): 469–476.

https://doi.org/10.1042/BJ20121058

Published: 28 February 2013

...Tero Pihlajamaa; Tommi Kajander; Juho Knuuti; Kaisa Horkka; Amit Sharma; Perttu Permi TRAP (thrombospondin-related anonymous protein), localized in the micronemes and on the surface of sporozoites of the notorious malaria parasite Plasmodium , is a key molecule upon infection of mammalian host...

View article titled, Structure of Plasmodium falciparum TRAP (thrombospondin-related anonymous protein) A domain highlights distinct features in apicomplexan von Willebrand factor A homologues

Includes: Supplementary data

Articles

Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active

Sweta Maheshwari, Marina Lavigne, Alicia Contet, Blandine Alberge, Emilie Pihan, Clemens Kocken, Kai Wengelnik, Dominique Douguet, Henri Vial, Rachel Cerdan

Biochem J (2013) 450 (1): 159–167.

https://doi.org/10.1042/BJ20121480

Published: 24 January 2013

...Sweta Maheshwari; Marina Lavigne; Alicia Contet; Blandine Alberge; Emilie Pihan; Clemens Kocken; Kai Wengelnik; Dominique Douguet; Henri Vial; Rachel Cerdan The intra-erythrocytic proliferation of the human malaria parasite Plasmodium falciparum requires massive synthesis of PE...

View article titled, Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active

Includes: Supplementary data

Articles

The antioxidative effect of de novo generated vitamin B 6 in Plasmodium falciparum validated by protein interference

Julia Knöckel, Ingrid B. Müller, Sabine Butzloff, Bärbel Bergmann, Rolf D. Walter, Carsten Wrenger

Biochem J (2012) 443 (2): 397–405.

https://doi.org/10.1042/BJ20111542

Published: 27 March 2012

...Julia Knöckel; Ingrid B. Müller; Sabine Butzloff; Bärbel Bergmann; Rolf D. Walter; Carsten Wrenger The malaria parasite Plasmodium falciparum is able to synthesize de novo PLP (pyridoxal 5′-phosphate), the active form of vitamin B 6 . In the present study, we have shown that the de novo synthesized...

View article titled, The antioxidative effect of de novo generated vitamin B 6 in Plasmodium falciparum validated by protein interference

Articles

A role for heparan sulfate proteoglycans in Plasmodium falciparum sporozoite invasion of anopheline mosquito salivary glands

Jennifer S. Armistead, Iain B.H. Wilson, Toin H. van Kuppevelt, Rhoel R. Dinglasan

Biochem J (2011) 438 (3): 475–483.

https://doi.org/10.1042/BJ20110694

Published: 26 August 2011

... can only interact with the basal face of the salivary gland HSPGs (since sporozoites invade from the haemocoel of the mosquito). To test this, we first had to demonstrate that (i) a salivary gland polypeptide-OXT from the malaria vector mosquito Anopheles gambiae can initiate both heparan...

View article titled, A role for heparan sulfate proteoglycans in Plasmodium falciparum sporozoite invasion of anopheline mosquito salivary glands

Articles

Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities

Lyn-Marie Birkholtz, Marni Williams, Jandeli Niemand, Abraham I. Louw, Lo Persson, Olle Heby

Biochem J (2011) 438 (2): 229–244.

https://doi.org/10.1042/BJ20110362

Published: 12 August 2011

...Lyn-Marie Birkholtz; Marni Williams; Jandeli Niemand; Abraham I. Louw; Lo Persson; Olle Heby New drugs are urgently needed for the treatment of tropical and subtropical parasitic diseases, such as African sleeping sickness, Chagas' disease, leishmaniasis and malaria. Enzymes in polyamine...

View article titled, Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities

Includes: Multimedia, Supplementary data

Articles

Glucose-6-phosphate dehydrogenase–6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum

Esther Jortzik, Boniface M. Mailu, Janina Preuss, Marina Fischer, Lars Bode, Stefan Rahlfs, Katja Becker

Biochem J (2011) 436 (3): 641–650.

https://doi.org/10.1042/BJ20110170

Published: 27 May 2011

...Esther Jortzik; Boniface M. Mailu; Janina Preuss; Marina Fischer; Lars Bode; Stefan Rahlfs; Katja Becker The survival of malaria parasites in human RBCs (red blood cells) depends on the pentose phosphate pathway, both in Plasmodium falciparum and its human host. G6PD (glucose-6-phosphate...

View article titled, Glucose-6-phosphate dehydrogenase–6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum

Includes: Supplementary data

Articles

Structural basis for the efficient phosphorylation of AZT-MP (3′-azido-3′-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

Jean L. Whittingham, Juana Carrero-Lerida, James A. Brannigan, Luis M. Ruiz-Perez, Ana P. G. Silva, Mark J. Fogg, Anthony J. Wilkinson, Ian H. Gilbert, Keith S. Wilson, Dolores González-Pacanowska

Biochem J (2010) 428 (3): 499–509.

https://doi.org/10.1042/BJ20091880

Published: 27 May 2010

...Jean L. Whittingham; Juana Carrero-Lerida; James A. Brannigan; Luis M. Ruiz-Perez; Ana P. G. Silva; Mark J. Fogg; Anthony J. Wilkinson; Ian H. Gilbert; Keith S. Wilson; Dolores González-Pacanowska Plasmodium falciparum is the causative agent of malaria, a disease where new drug targets are required...

View article titled, Structural basis for the efficient phosphorylation of AZT-MP (3′-azido-3′-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

Includes: Supplementary data

Articles

Metabolic pathways in Anopheles stephensi mitochondria

Cecilia Giulivi, Catherine Ross-Inta, Ashley A. Horton, Shirley Luckhart

Biochem J (2008) 415 (2): 309–316.

https://doi.org/10.1042/BJ20080973

Published: 25 September 2008

...Cecilia Giulivi; Catherine Ross-Inta; Ashley A. Horton; Shirley Luckhart No studies have been performed on the mitochondria of malaria vector mosquitoes. This information would be valuable in understanding mosquito aging and detoxification of insecticides, two parameters that have a significant...

View article titled, Metabolic pathways in Anopheles stephensi mitochondria

Articles

Selective permeabilization of the host cell membrane of Plasmodium falciparum -infected red blood cells with streptolysin O and equinatoxin II

Katherine E. Jackson, Tobias Spielmann, Eric Hanssen, Akinola Adisa, Frances Separovic, Matthew W. A. Dixon, Katharine R. Trenholme, Paula L. Hawthorne, Don L. Gardiner, Tim Gilberger, Leann Tilley

Biochem J (2007) 403 (1): 167–175.

https://doi.org/10.1042/BJ20061725

Published: 13 March 2007

... 12 12 2006 The Biochemical Society, London 2007 cholesterol equinatoxin II malaria Plasmodium falciparum pore-forming toxin streptolysin O The pore-forming toxin, SLO (streptolysin O), is a 69 kDa protein from group A streptococci [ 1 ]. Water-soluble toxin molecules bind...

View article titled, Selective permeabilization of the host cell membrane of Plasmodium falciparum -infected red blood cells with streptolysin O and equinatoxin II

Includes: Multimedia, Supplementary data

Articles

The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization

John M. Pisciotta, Isabelle Coppens, Abhai K. Tripathi, Peter F. Scholl, Joel Shuman, Sunil Bajad, Vladimir Shulaev, David J. Sullivan, Jr

Biochem J (2007) 402 (1): 197–204.

https://doi.org/10.1042/BJ20060986

Published: 25 January 2007

...John M. Pisciotta; Isabelle Coppens; Abhai K. Tripathi; Peter F. Scholl; Joel Shuman; Sunil Bajad; Vladimir Shulaev; David J. Sullivan, Jr The intraerythrocytic malaria parasite constructs an intracellular haem crystal, called haemozoin, within an acidic digestive vacuole where haemoglobin...

View article titled, The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization

Includes: Supplementary data

Articles

Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery

Manoj K. Ramjee, Nicholas S. Flinn, Tracy P. Pemberton, Martin Quibell, Yikang Wang, John P. Watts

Biochem J (2006) 399 (1): 47–57.

https://doi.org/10.1042/BJ20060422

Published: 13 September 2006

... of selected reversible compounds against FP-2, FP-3, BP-2 and selected human cathepsin peptidases Table 2 Second-order inactivation rate constants for selected irreversible compounds against FP-2, FP-3 and BP-2 Malaria parasites utilize a wealth of processes to complete...

View article titled, Substrate mapping and inhibitor profiling of falcipain-2, falcipain-3 and berghepain-2: implications for peptidase anti-malarial drug discovery

Includes: Supplementary data

Articles

Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum , a key enzyme in fatty acid biosynthesis

Sasala R. Wickramasinghe, Kirstine A. Inglis, Jonathan E. Urch, Sylke Müller, Daan M. F. van Aalten, Alan H. Fairlamb

Biochem J (2006) 393 (2): 447–457.

https://doi.org/10.1042/BJ20050832

Published: 23 December 2005

...-carrier-protein reductase have been deposited in the PDB under code 2C07. 20 5 2005 26 9 2005 14 10 2005 14 10 2005 The Biochemical Society, London 2006 acetoacetyl-CoA fatty acid biosynthesis hexachlorophene malaria NADPH Plasmodium falciparum...

View article titled, Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum , a key enzyme in fatty acid biosynthesis

Articles

Identification, molecular cloning and functional characterization of an octaprenyl pyrophosphate synthase in intra-erythrocytic stages of Plasmodium falciparum

Renata Tonhosolo, Fabio L. D'Alexandri, Fernando A. Genta, Gerhard Wunderlich, Fabio C. Gozzo, Marcos N. Eberlin, Valnice J. Peres, Emilia A. Kimura, Alejandro M. Katzin

Biochem J (2005) 392 (1): 117–126.

https://doi.org/10.1042/BJ20050441

Published: 08 November 2005

... antimalarial isoprenoid malaria Plasmodium falciparum prenyltransferase terpene Malaria, one of the most important infectious diseases in the world, kills over one million people each year, and its incidence is increasing in several regions of the world. Lethal forms of the disease are caused...

View article titled, Identification, molecular cloning and functional characterization of an octaprenyl pyrophosphate synthase in intra-erythrocytic stages of Plasmodium falciparum

Articles

Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase

Lionel KUNTZ, Denis TRITSCH, Catherine GROSDEMANGE-BILLIARD, Andréa HEMMERLIN, Audrey WILLEM, Thomas J. BACH, Michel ROHMER

Biochem J (2005) 386 (1): 127–135.

https://doi.org/10.1042/BJ20041378

Published: 08 February 2005

...Lionel KUNTZ; Denis TRITSCH; Catherine GROSDEMANGE-BILLIARD; Andréa HEMMERLIN; Audrey WILLEM; Thomas J. BACH; Michel ROHMER Isoprenoid biosynthesis via the methylerythritol phosphate pathway is a target against pathogenic bacteria and the malaria parasite Plasmodium falciparum . 4-(Hydroxyamino)-4...

View article titled, Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase

Articles

‘FAS’t inhibition of malaria

Avadhesha SUROLIA, T. N. C. RAMYA, V. RAMYA, Namita SUROLIA

Biochem J (2004) 383 (3): 401–412.

https://doi.org/10.1042/BJ20041051

Published: 26 October 2004

...Avadhesha SUROLIA; T. N. C. RAMYA; V. RAMYA; Namita SUROLIA Malaria, a tropical disease caused by Plasmodium sp., has been haunting mankind for ages. Unsuccessful attempts to develop a vaccine, the emergence of resistance against the existing drugs and the increasing mortality rate all call...

View article titled, ‘FAS’t inhibition of malaria

Articles

Analysis of Plasmodium vivax hexose transporters and effects of a parasitocidal inhibitor

Thierry JOËT, Kesinee CHOTIVANICH, Kamolrat SILAMUT, Asha P. PATEL, Christophe MORIN, Sanjeev KRISHNA

Biochem J (2004) 381 (3): 905–909.

https://doi.org/10.1042/BJ20040433

Published: 27 July 2004

...Thierry JOËT; Kesinee CHOTIVANICH; Kamolrat SILAMUT; Asha P. PATEL; Christophe MORIN; Sanjeev KRISHNA Plasmodium vivax is the second most common species of malaria parasite and causes up to 80 million episodes of infection each year. New drug targets are urgently needed because of emerging...

View article titled, Analysis of Plasmodium vivax hexose transporters and effects of a parasitocidal inhibitor

Articles

Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD +

Mili KAPOOR, P. L. Swarna MUKHI, Namita SUROLIA, K. SUGUNA, Avadhesha SUROLIA

Biochem J (2004) 381 (3): 725–733.

https://doi.org/10.1042/BJ20040228

Published: 27 July 2004

... 1UH5 and 1V35 respectively. 11 2 2004 15 4 2004 5 5 2004 5 5 2004 The Biochemical Society, London 2004 antimalarial drug enoyl-ACP (acyl-carrier protein) reductase fatty acid biosynthesis malaria surface plasmon resonance triclosan The first...

View article titled, Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD +

Includes: Supplementary data

Articles

Heparan sulphate identified on human erythrocytes: a Plasmodium falciparum receptor

Anna M. VOGT, Gerhard WINTER, Mats WAHLGREN, Dorothe SPILLMANN

Biochem J (2004) 381 (3): 593–597.

https://doi.org/10.1042/BJ20040762

Published: 27 July 2004

... demonstrate that human RBCs carry epitopes for an anti-HS antibody. Glycans isolated from RBC membranes reacted to HS-specific degradations and adhered to an HS-binding malaria antigen. Additionally, an HS core protein was identified. This suggests that HS is present on human RBCs. 1 To whom...

View article titled, Heparan sulphate identified on human erythrocytes: a Plasmodium falciparum receptor

Articles

Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions

Lyn-Marie BIRKHOLTZ, Carsten WRENGER, Fourie JOUBERT, Gordon A. WELLS, Rolf D. WALTER, Abraham I. LOUW

Biochem J (2004) 377 (2): 439–448.

https://doi.org/10.1042/bj20030614

Published: 15 January 2004

...Lyn-Marie BIRKHOLTZ; Carsten WRENGER; Fourie JOUBERT; Gordon A. WELLS; Rolf D. WALTER; Abraham I. LOUW Polyamine biosynthesis of the malaria parasite, Plasmodium falciparum , is regulated by a single, hinge-linked bifunctional PfAdoMetDC/ODC [ P. falciparum AdoMetDC (S-adenosylmethionine...

View article titled, Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions

Articles

Characterization of the lipid-binding domain of the Plasmodium falciparum CTP:phosphocholine cytidylyltransferase through synthetic-peptide studies

Marie-Pierre LARVOR, Rachel CERDAN, Catherine GUMILA, Luc MAURIN, Patrick SETA, Claude ROUSTAN, Henri VIAL

Biochem J (2003) 375 (3): 653–661.

https://doi.org/10.1042/bj20031011

Published: 01 November 2003

.... 1 To whom correspondence should be addressed (e-mail [email protected] ). 7 7 2003 5 8 2003 5 8 2003 The Biochemical Society, London ©2003 2003 CTP:phosphocholine cytidylyltransferase malaria membrane-binding domain phospholipid bilayer Plasmodium falciparum...

View article titled, Characterization of the lipid-binding domain of the Plasmodium falciparum CTP:phosphocholine cytidylyltransferase through synthetic-peptide studies

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Comparative characterization of hexose transporters of Plasmodium knowlesi, Plasmodium yoelii and Toxoplasma gondii highlights functional differences within the apicomplexan family

Thierry JOËT, Lennart HOLTERMAN, Timothy T. STEDMAN, Clemens H.M. KOCKEN, Annemarie van der WEL, Alan W. THOMAS, Sanjeev KRISHNA

Biochem J (2002) 368 (3): 923–929.

https://doi.org/10.1042/bj20021189

Published: 15 December 2002

..., London ©2002 2002 glucose malaria oocyte transport Xenopus Abbreviations used: DOG, deoxy-d-glucose; OMG, O -methyl-d-glucose; PfHT1, Plasmodium falciparum hexose transporter 1; PkHT1, Plasmodium knowlesi hexose transporter 1; PvHT1, Plasmodium vivax hexose transporter 1...

View article titled, Comparative characterization of hexose transporters of Plasmodium knowlesi, Plasmodium yoelii and Toxoplasma gondii highlights functional differences within the apicomplexan family

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Glutathione synthetase from Plasmodium falciparum

Svenja MEIERJOHANN, Rolf D. WALTER, Sylke MÜLLER

Biochem J (2002) 363 (3): 833–838.

https://doi.org/10.1042/bj3630833

Published: 24 April 2002

..., in which γ-glutamylcysteine synthetase (γ-GCS) catalyses the ligation of glutamate and cysteine and subsequently glutathione synthetase (GS) adds glycine to the dipeptide. Recently it was shown that the synthesis of γ-glutamylcysteine is crucial for the survival of the erythrocytic stages of the malaria...

View article titled, Glutathione synthetase from Plasmodium falciparum

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Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3

Puran S. SIJWALI, Bhaskar R. SHENAI, Jiri GUT, Ajay SINGH, Philip J. ROSENTHAL

Biochem J (2001) 360 (2): 481–489.

https://doi.org/10.1042/bj3600481

Published: 26 November 2001

...Puran S. SIJWALI; Bhaskar R. SHENAI; Jiri GUT; Ajay SINGH; Philip J. ROSENTHAL In the malaria parasite Plasmodium falciparum , erythrocytic trophozoites hydrolyse haemoglobin to provide amino acids for parasite protein synthesis. Cysteine protease inhibitors block parasite haemoglobin hydrolysis...

View article titled, Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3

Articles

Mechanism of malarial haem detoxification inhibition by chloroquine

Amit V. PANDEY, Himani BISHT, Vinod K. BABBARWAL, Jaya SRIVASTAVA, Kailash C. PANDEY, Virander S. CHAUHAN

Biochem J (2001) 355 (2): 333–338.

https://doi.org/10.1042/bj3550333

Published: 06 April 2001

...Amit V. PANDEY; Himani BISHT; Vinod K. BABBARWAL; Jaya SRIVASTAVA; Kailash C. PANDEY; Virander S. CHAUHAN The haem detoxification pathway of the malaria parasite Plasmodium falciparum is a potential biochemical target for drug development. Free haem, released after haemoglobin degradation...

View article titled, Mechanism of malarial haem detoxification inhibition by chloroquine

Articles

The ornithine decarboxylase domain of the bifunctional ornithine decarboxylase/S-adenosylmethionine decarboxylase of Plasmodium falciparum: recombinant expression and catalytic properties of two different constructs

Tanja KRAUSE, Kai LÜERSEN, Carsten WRENGER, Tim-Wolf GILBERGER, Sylke MÜLLER, Rolf D. WALTER

Biochem J (2000) 352 (2): 287–292.

https://doi.org/10.1042/bj3520287

Published: 24 November 2000

... decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), has been proposed as a therapeutic strategy against cancer and parasitic infections. In the case of Plasmodium falciparum , the causative agent of malaria tropica, this approach is especially interesting, because here both key enzymes, ODC...

View article titled, The ornithine decarboxylase domain of the bifunctional ornithine decarboxylase/S-adenosylmethionine decarboxylase of Plasmodium falciparum: recombinant expression and catalytic properties of two different constructs

Articles

Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy

Marie D. PARKER, Ralph J. HYDE, Sylvia Y. M. YAO, Louisa MCROBERT, Carol E. CASS, James D. YOUNG, Glenn A. MCCONKEY, Stephen A. BALDWIN

Biochem J (2000) 349 (1): 67–75.

https://doi.org/10.1042/bj3490067

Published: 26 June 2000

...Marie D. PARKER; Ralph J. HYDE; Sylvia Y. M. YAO; Louisa MCROBERT; Carol E. CASS; James D. YOUNG; Glenn A. MCCONKEY; Stephen A. BALDWIN Plasmodium , the aetiologic agent of malaria, cannot synthesize purines de novo , and hence depends upon salvage from the host. Here we describe the molecular...

View article titled, Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy

Articles

Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione

Kai LÜERSEN, Rolf D. WALTER, Sylke MÜLLER

Biochem J (2000) 346 (2): 545–552.

https://doi.org/10.1042/bj3460545

Published: 22 February 2000

... the depletion of GSH is proposed as a chemotherapeutic strategy for malaria, and γ-GCS is proposed as a potential drug target. 1 To whom correspondence should be addressed (e-mail [email protected]). 17 6 1999 15 11 1999 15 12 1999 The Biochemical Society, London © 2000...

View article titled, Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione

Articles

Active isoprenoid pathway in the intra-erythrocytic stages of Plasmodium falciparum : presence of dolichols of 11 and 12 isoprene units

Alicia S. COUTO, Emilia A. KIMURA, Valnice J. PERES, Maria L. UHRIG, Alejandro M. KATZIN

Biochem J (1999) 341 (3): 629–637.

https://doi.org/10.1042/bj3410629

Published: 26 July 1999

...-trophozoite stages after mevastatin treatment of parasite cultures. Therefore the isoprenoid pathway may represent a different approach to the development of new anti-malarial drugs. [1(n)- 3 H]farnesyl triammonium pyrophosphate [1(n)- 3 H]geranylgeranyl triammonium pyrophosphate malaria mevastatin...

View article titled, Active isoprenoid pathway in the intra-erythrocytic stages of Plasmodium falciparum : presence of dolichols of 11 and 12 isoprene units

Articles

Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials

Paul LORIA, Susanne MILLER, Michael FOLEY, Leann TILLEY

Biochem J (1999) 339 (2): 363–370.

https://doi.org/10.1042/bj3390363

Published: 08 April 1999

...Paul LORIA; Susanne MILLER; Michael FOLEY; Leann TILLEY The malaria parasite feeds by degrading haemoglobin in an acidic food vacuole, producing free haem moieties as a by-product. The haem in oxyhaemoglobin is oxidized from the Fe(II) state to the Fe(III) state with the consequent production...

View article titled, Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials

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