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Keywords: malaria
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Articles
Biochem J (2021) 478 (18): 3429–3444.
Published: 23 September 2021
...Pradeep Kumar Sheokand; Monika Narwal; Vandana Thakur; Asif Mohmmed Phospholipid synthesis is crucial for membrane proliferation in malaria parasites during the entire cycle in the host cell. The major phospholipid of parasite membranes, phosphatidylcholine (PC), is mainly synthesized through...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2021) 478 (9): 1705–1732.
Published: 10 May 2021
...Renu Sudhakar; Divya Das; Subramanian Thanumalayan; Somesh Gorde; Puran Singh Sijwali Autophagy, a lysosome-dependent degradative process, does not appear to be a major degradative process in malaria parasites and has a limited repertoire of genes. To better understand the autophagy process, we...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (3): 579–595.
Published: 10 February 2021
... in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. 6-cysteine proteins malaria nanobody Plasmodium falciparum is the most lethal of human malaria species and responsible for the majority of malaria...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (18): 3625–3643.
Published: 28 September 2020
...Mohammad Anas; Ankita Shukla; Aradhya Tripathi; Varsha Kumari; Chetan Prakash; Priyabrata Nag; L. Sathish Kumar; Sandeep K. Sharma; Ravishankar Ramachandran; Niti Kumar Plasmodium falciparum , the human malaria parasite harbors a metastable proteome which is vulnerable to proteotoxic stress...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (7): 1323–1344.
Published: 17 April 2020
... Society 2020 Plasmodium falciparum metacaspase-2 apoptosis-like cell death malaria mitochondrial potential oxidative stress SS-5 Z-FA-FMK analog Apoptosis is a highly regulated phenomenon important for the maintenance of homeostasis in tissues and during embryonic development [ 1...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (21): 3311–3314.
Published: 06 November 2018
... of the complement system through direct encounter with pathogens or some other agents leads to osmolysis of pathogens, clearance of soluble immune complexes and recruitment of lymphocytes at the site of activation. Although malaria parasites are not exposed to the complement system owing to their intracellular...
Articles
Biochem J (2016) 473 (20): 3487–3503.
Published: 11 October 2016
... with these studies, we previously showed that knockdown of either of two closely related, infection-induced ILPs, ILP3 and ILP4, in the mosquito Anopheles stephensi decreased infection with the human malaria parasite Plasmodium falciparum through kinetically distinct effects on parasite death. However, the precise...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (19): 3189–3204.
Published: 27 September 2016
...Nyssa Drinkwater; Komagal Kannan Sivaraman; Rebecca S. Bamert; Wioletta Rut; Khadija Mohamed; Natalie B. Vinh; Peter J. Scammells; Marcin Drag; Sheena McGowan Malaria is one of the world's most prevalent parasitic diseases, with over 200 million cases annually. Alarmingly, the spread of drug...
Includes: Supplementary data
Articles
Biochem J (2014) 461 (3): 349–369.
Published: 10 July 2014
...Nyssa Drinkwater; Sheena McGowan Despite a century of control and eradication campaigns, malaria remains one of the world's most devastating diseases. Our once-powerful therapeutic weapons are losing the war against the Plasmodium parasite, whose ability to rapidly develop and spread drug...
Articles
Biochem J (2014) 461 (2): 189–203.
Published: 26 June 2014
...Neha Singhal; Atul; Babu S. Mastan; Kota Arun Kumar; Puran Singh Sijwali Malaria parasites must respond to stresses and environmental signals to perpetuate efficiently during their multistage development in diverse environments. To gain insights into the parasite's stress response mechanisms, we...
Includes: Supplementary data
Articles
Biochem J (2013) 455 (2): 149–155.
Published: 27 September 2013
... aminodeoxychorismate lyase antifolate catalytic promiscuity malaria pyridoxal phosphate Tetrahydrofolate and related cofactors, collectively termed folates, are used by enzymes that mediate the transfer of one-carbon units and are strictly required for a number of basic metabolic processes, in particular...
Includes: Supplementary data
Articles
Biochem J (2013) 452 (3): 457–466.
Published: 31 May 2013
...Klemens Engelberg; Aditya S. Paul; Boris Prinz; Maya Kono; Wilhelm Ching; Dorothee Heincke; Thomas Dobner; Tobias Spielmann; Manoj T. Duraisingh; Tim-Wolf Gilberger Red blood cell invasion by the malaria parasite Plasmodium falciparum relies on a complex protein network that uses low and high...
Includes: Supplementary data
Articles
Biochem J (2013) 452 (3): 433–441.
Published: 31 May 2013
... 3 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 calcium calcium-dependent protein kinase 1 (CDPK1) malaria phosphorylation Plasmodium signalling P. falciparum -infected RBCs were lysed in 0.15% saponin to remove excess RBC protein...
Includes: Supplementary data
Articles
Biochem J (2013) 450 (3): 469–476.
Published: 28 February 2013
...Tero Pihlajamaa; Tommi Kajander; Juho Knuuti; Kaisa Horkka; Amit Sharma; Perttu Permi TRAP (thrombospondin-related anonymous protein), localized in the micronemes and on the surface of sporozoites of the notorious malaria parasite Plasmodium , is a key molecule upon infection of mammalian host...
Includes: Supplementary data
Articles
Biochem J (2013) 450 (1): 159–167.
Published: 24 January 2013
...Sweta Maheshwari; Marina Lavigne; Alicia Contet; Blandine Alberge; Emilie Pihan; Clemens Kocken; Kai Wengelnik; Dominique Douguet; Henri Vial; Rachel Cerdan The intra-erythrocytic proliferation of the human malaria parasite Plasmodium falciparum requires massive synthesis of PE...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (2): 397–405.
Published: 27 March 2012
...Julia Knöckel; Ingrid B. Müller; Sabine Butzloff; Bärbel Bergmann; Rolf D. Walter; Carsten Wrenger The malaria parasite Plasmodium falciparum is able to synthesize de novo PLP (pyridoxal 5′-phosphate), the active form of vitamin B 6 . In the present study, we have shown that the de novo synthesized...
Articles
Biochem J (2011) 438 (3): 475–483.
Published: 26 August 2011
... ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. Anopheles cell invasion glycobiology glycos-aminoglycan (GAG) heparan sulfate (HS) malaria...
Articles
Biochem J (2011) 438 (2): 229–244.
Published: 12 August 2011
...Lyn-Marie Birkholtz; Marni Williams; Jandeli Niemand; Abraham I. Louw; Lo Persson; Olle Heby New drugs are urgently needed for the treatment of tropical and subtropical parasitic diseases, such as African sleeping sickness, Chagas' disease, leishmaniasis and malaria. Enzymes in polyamine...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2011) 436 (3): 641–650.
Published: 27 May 2011
...Esther Jortzik; Boniface M. Mailu; Janina Preuss; Marina Fischer; Lars Bode; Stefan Rahlfs; Katja Becker The survival of malaria parasites in human RBCs (red blood cells) depends on the pentose phosphate pathway, both in Plasmodium falciparum and its human host. G6PD (glucose-6-phosphate...
Includes: Supplementary data
Articles
Biochem J (2010) 428 (3): 499–509.
Published: 27 May 2010
...Jean L. Whittingham; Juana Carrero-Lerida; James A. Brannigan; Luis M. Ruiz-Perez; Ana P. G. Silva; Mark J. Fogg; Anthony J. Wilkinson; Ian H. Gilbert; Keith S. Wilson; Dolores González-Pacanowska Plasmodium falciparum is the causative agent of malaria, a disease where new drug targets are required...
Includes: Supplementary data
Articles
Biochem J (2008) 415 (2): 309–316.
Published: 25 September 2008
...Cecilia Giulivi; Catherine Ross-Inta; Ashley A. Horton; Shirley Luckhart No studies have been performed on the mitochondria of malaria vector mosquitoes. This information would be valuable in understanding mosquito aging and detoxification of insecticides, two parameters that have a significant...
Articles
Biochem J (2007) 403 (1): 167–175.
Published: 13 March 2007
... equally to this work. 2 To whom correspondence may be addressed (email L.Tilley@latrobe.edu.au ). 20 11 2006 7 12 2006 12 12 2006 12 12 2006 The Biochemical Society, London 2007 cholesterol equinatoxin II malaria Plasmodium falciparum pore-forming toxin...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2007) 402 (1): 197–204.
Published: 25 January 2007
...John M. Pisciotta; Isabelle Coppens; Abhai K. Tripathi; Peter F. Scholl; Joel Shuman; Sunil Bajad; Vladimir Shulaev; David J. Sullivan, Jr The intraerythrocytic malaria parasite constructs an intracellular haem crystal, called haemozoin, within an acidic digestive vacuole where haemoglobin...
Includes: Supplementary data
Articles
Biochem J (2006) 399 (1): 47–57.
Published: 13 September 2006
... 2006 The Biochemical Society, London 2006 cysteine protease inhibitor malaria mapping substrate Malaria, a disease caused by several species of obligate protozoan parasites, remains one of the most prevalent and persistent diseases to affect the global population, with hundreds...
Includes: Supplementary data
Articles
Biochem J (2006) 393 (2): 447–457.
Published: 23 December 2005
...-carrier-protein reductase have been deposited in the PDB under code 2C07. 20 5 2005 26 9 2005 14 10 2005 14 10 2005 The Biochemical Society, London 2006 acetoacetyl-CoA fatty acid biosynthesis hexachlorophene malaria NADPH Plasmodium falciparum...
Articles
Biochem J (2005) 392 (1): 117–126.
Published: 08 November 2005
..., decaprenyl pyrophosphate synthase, we suggest that the identified enzyme and its recombinant version could be exploited in the screening of novel drugs. Malaria, one of the most important infectious diseases in the world, kills over one million people each year, and its incidence is increasing...
Articles
Biochem J (2005) 386 (1): 127–135.
Published: 08 February 2005
...Lionel KUNTZ; Denis TRITSCH; Catherine GROSDEMANGE-BILLIARD; Andréa HEMMERLIN; Audrey WILLEM; Thomas J. BACH; Michel ROHMER Isoprenoid biosynthesis via the methylerythritol phosphate pathway is a target against pathogenic bacteria and the malaria parasite Plasmodium falciparum . 4-(Hydroxyamino)-4...
Articles
Biochem J (2004) 383 (3): 401–412.
Published: 26 October 2004
...Avadhesha SUROLIA; T. N. C. RAMYA; V. RAMYA; Namita SUROLIA Malaria, a tropical disease caused by Plasmodium sp., has been haunting mankind for ages. Unsuccessful attempts to develop a vaccine, the emergence of resistance against the existing drugs and the increasing mortality rate all call...
Articles
Biochem J (2004) 381 (3): 905–909.
Published: 27 July 2004
...Thierry JOËT; Kesinee CHOTIVANICH; Kamolrat SILAMUT; Asha P. PATEL; Christophe MORIN; Sanjeev KRISHNA Plasmodium vivax is the second most common species of malaria parasite and causes up to 80 million episodes of infection each year. New drug targets are urgently needed because of emerging...
Articles
Biochem J (2004) 381 (3): 593–597.
Published: 27 July 2004
... demonstrate that human RBCs carry epitopes for an anti-HS antibody. Glycans isolated from RBC membranes reacted to HS-specific degradations and adhered to an HS-binding malaria antigen. Additionally, an HS core protein was identified. This suggests that HS is present on human RBCs. glycans heparan...
Articles
Biochem J (2004) 381 (3): 725–733.
Published: 27 July 2004
... 1UH5 and 1V35 respectively. 11 2 2004 15 4 2004 5 5 2004 5 5 2004 The Biochemical Society, London 2004 antimalarial drug enoyl-ACP (acyl-carrier protein) reductase fatty acid biosynthesis malaria surface plasmon resonance triclosan It is estimated...
Includes: Supplementary data
Articles
Biochem J (2004) 377 (2): 439–448.
Published: 15 January 2004
...Lyn-Marie BIRKHOLTZ; Carsten WRENGER; Fourie JOUBERT; Gordon A. WELLS; Rolf D. WALTER; Abraham I. LOUW Polyamine biosynthesis of the malaria parasite, Plasmodium falciparum , is regulated by a single, hinge-linked bifunctional PfAdoMetDC/ODC [ P. falciparum AdoMetDC (S-adenosylmethionine...
Articles
Biochem J (2003) 375 (3): 653–661.
Published: 01 November 2003
.... 1 To whom correspondence should be addressed (e-mail vial@univ-montp2.fr ). 7 7 2003 5 8 2003 5 8 2003 The Biochemical Society, London ©2003 2003 CTP:phosphocholine cytidylyltransferase malaria membrane-binding domain phospholipid bilayer Plasmodium falciparum...
Articles
Biochem J (2002) 368 (3): 923–929.
Published: 15 December 2002
..., London ©2002 2002 glucose malaria oocyte transport Xenopus Abbreviations used: DOG, deoxy-d-glucose; OMG, O -methyl-d-glucose; PfHT1, Plasmodium falciparum hexose transporter 1; PkHT1, Plasmodium knowlesi hexose transporter 1; PvHT1, Plasmodium vivax hexose transporter 1...
Articles
Biochem J (2002) 363 (3): 833–838.
Published: 24 April 2002
..., in which γ-glutamylcysteine synthetase (γ-GCS) catalyses the ligation of glutamate and cysteine and subsequently glutathione synthetase (GS) adds glycine to the dipeptide. Recently it was shown that the synthesis of γ-glutamylcysteine is crucial for the survival of the erythrocytic stages of the malaria...
Articles
Biochem J (2001) 360 (2): 481–489.
Published: 26 November 2001
...Puran S. SIJWALI; Bhaskar R. SHENAI; Jiri GUT; Ajay SINGH; Philip J. ROSENTHAL In the malaria parasite Plasmodium falciparum , erythrocytic trophozoites hydrolyse haemoglobin to provide amino acids for parasite protein synthesis. Cysteine protease inhibitors block parasite haemoglobin hydrolysis...
Articles
Biochem J (2001) 355 (2): 333–338.
Published: 06 April 2001
...Amit V. PANDEY; Himani BISHT; Vinod K. BABBARWAL; Jaya SRIVASTAVA; Kailash C. PANDEY; Virander S. CHAUHAN The haem detoxification pathway of the malaria parasite Plasmodium falciparum is a potential biochemical target for drug development. Free haem, released after haemoglobin degradation...
Articles
Biochem J (2000) 352 (2): 287–292.
Published: 24 November 2000
... decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC), has been proposed as a therapeutic strategy against cancer and parasitic infections. In the case of Plasmodium falciparum , the causative agent of malaria tropica, this approach is especially interesting, because here both key enzymes, ODC...
Articles
Biochem J (2000) 349 (1): 67–75.
Published: 26 June 2000
...Marie D. PARKER; Ralph J. HYDE; Sylvia Y. M. YAO; Louisa MCROBERT; Carol E. CASS; James D. YOUNG; Glenn A. MCCONKEY; Stephen A. BALDWIN Plasmodium , the aetiologic agent of malaria, cannot synthesize purines de novo , and hence depends upon salvage from the host. Here we describe the molecular...
Articles
Biochem J (2000) 346 (2): 545–552.
Published: 22 February 2000
... the depletion of GSH is proposed as a chemotherapeutic strategy for malaria, and γ-GCS is proposed as a potential drug target. 1 To whom correspondence should be addressed (e-mail smueller@bni.uni-hamburg.de). 17 6 1999 15 11 1999 15 12 1999 The Biochemical Society, London © 2000...
Articles
Biochem J (1999) 341 (3): 629–637.
Published: 26 July 1999
...-trophozoite stages after mevastatin treatment of parasite cultures. Therefore the isoprenoid pathway may represent a different approach to the development of new anti-malarial drugs. [1(n)- 3 H]farnesyl triammonium pyrophosphate [1(n)- 3 H]geranylgeranyl triammonium pyrophosphate malaria mevastatin...
Articles
Biochem J (1999) 339 (2): 363–370.
Published: 08 April 1999
...Paul LORIA; Susanne MILLER; Michael FOLEY; Leann TILLEY The malaria parasite feeds by degrading haemoglobin in an acidic food vacuole, producing free haem moieties as a by-product. The haem in oxyhaemoglobin is oxidized from the Fe(II) state to the Fe(III) state with the consequent production...