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1-9 of 9
Keywords: malonyl-CoA
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Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (22): 3783–3797.
Published: 06 November 2017
... of the lipoic acid cofactor indispensable for the function of several mitochondrial enzyme complexes and essential for embryonic development in mice. Mutations in human mtFAS have been reported to lead to neurodegenerative disease. The source of malonyl-CoA for mtFAS in mammals has remained unclear. We report...
Includes: Supplementary data
Articles
Dongju Jung, Lutfi Abu-Elheiga, Rie Ayuzawa, Ziwei Gu, Takashi Shirakawa, Yukio Fujiki, Norio Nakatsuji, Salih J. Wakil, Motonari Uesugi
Journal:
Biochemical Journal
Biochem J (2012) 448 (3): 409–416.
Published: 21 November 2012
... the binding of chromeceptin with MFP-2 blocks adipogenesis and activates STAT6. The results of the present study show that the chromeceptin–MFP-2 complex binds to and inhibits ACC1 (acetyl-CoA carboxylase 1), an enzyme important for the de novo synthesis of malonyl-CoA and fatty acids. The formation...
Includes: Supplementary data
Articles
Brennan K. Smith, Christopher G. R. Perry, Timothy R. Koves, David C. Wright, Jeffrey C. Smith, P. Darrell Neufer, Deborah M. Muoio, Graham P. Holloway
Journal:
Biochemical Journal
Biochem J (2012) 448 (1): 13–20.
Published: 18 October 2012
...Brennan K. Smith; Christopher G. R. Perry; Timothy R. Koves; David C. Wright; Jeffrey C. Smith; P. Darrell Neufer; Deborah M. Muoio; Graham P. Holloway Published values regarding the sensitivity (IC 50 ) of CPT-I (carnitine palmitoyltransferase I) to M-CoA (malonyl-CoA) inhibition in isolated...
Articles
Takhar Kasumov, Jillian E. Adams, Fang Bian, France David, Katherine R. Thomas, Kathryn A. Jobbins, Paul E. Minkler, Charles L. Hoppel, Henri Brunengraber
Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 397–401.
Published: 05 July 2005
...Takhar Kasumov; Jillian E. Adams; Fang Bian; France David; Katherine R. Thomas; Kathryn A. Jobbins; Paul E. Minkler; Charles L. Hoppel; Henri Brunengraber We reported previously that a substantial fraction of the acetyl groups used to synthesize malonyl-CoA in rat heart is derived from peroxisomal...
Articles
Audrey FAYE, Karen BORTHWICK, Catherine ESNOUS, Nigel T. PRICE, Stéphanie GOBIN, Vicky N. JACKSON, Victor A. ZAMMIT, Jean GIRARD, Carina PRIP-BUUS
Journal:
Biochemical Journal
Biochem J (2005) 387 (1): 67–76.
Published: 22 March 2005
...Audrey FAYE; Karen BORTHWICK; Catherine ESNOUS; Nigel T. PRICE; Stéphanie GOBIN; Vicky N. JACKSON; Victor A. ZAMMIT; Jean GIRARD; Carina PRIP-BUUS We have previously proposed that changes in malonyl-CoA sensitivity of rat L-CPT1 (liver carnitine palmitoyltransferase 1) might occur through...
Articles
Nigel T. PRICE, Vicky N. JACKSON, Feike R. van der LEIJ, Jacqueline M. CAMERON, Maureen T. TRAVERS, Beatrijs BARTELDS, Nicolette C. HUIJKMAN, Victor A. ZAMMIT
Journal:
Biochemical Journal
Biochem J (2003) 372 (3): 871–879.
Published: 15 June 2003
... malonyl-CoA Biochem. J. (2003) 372, 871 879 (Printed in Great Britain) 871 Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme Nigel T. PRICE*1, Vicky N...
Articles
Neil M. BROADWAY, Richard J. PEASE, Graeme BIRDSEY, Majid SHAYEGHI, Nigel A. TURNER, E. DAVID SAGGERSON
Journal:
Biochemical Journal
Biochem J (2003) 370 (1): 223–231.
Published: 15 February 2003
...Neil M. BROADWAY; Richard J. PEASE; Graeme BIRDSEY; Majid SHAYEGHI; Nigel A. TURNER; E. DAVID SAGGERSON Liver microsomal fractions contain a malonyl-CoA-inhibitable carnitine acyltransferase (CAT) activity. It has been proposed [Fraser, Corstorphine, Price and Zammit (1999) FEBS Lett. 446 , 69—74...
Articles
Montserrat MORILLAS, Josep CLOTET, Blanca RUBÍ, Dolors SERRA, Joaquín ARIÑO, Fausto G. HEGARDT, Guillermina ASINS
Journal:
Biochemical Journal
Biochem J (2000) 351 (2): 495–502.
Published: 10 October 2000
... and that the full inhibitory properties of the drug will be shown only if both histidines are intact at the same time. Our data demonstrate that both etomoxir and malonyl-CoA inhibit COT by interacting with the same sites. 1 To whom correspondence should be addressed (e-mail [email protected]...
Articles
Nicolas VOILLEY, Raphaël RODUIT, Raffaela VICARETTI, Christophe BONNY, Gérard WAEBER, Jason R. B. DYCK, Gary D. LOPASCHUK, Marc PRENTKI
Journal:
Biochemical Journal
Biochem J (1999) 340 (1): 213–217.
Published: 10 May 1999
...Nicolas VOILLEY; Raphaël RODUIT; Raffaela VICARETTI; Christophe BONNY; Gérard WAEBER; Jason R. B. DYCK; Gary D. LOPASCHUK; Marc PRENTKI To gain insight into the function and regulation of malonyl-CoA decarboxylase (MCD) we have cloned rat MCD cDNA from a differentiated insulin-secreting pancreatic...