... or combined stimulations are complex and less understood. Growth factor receptors on the cell surface of hepatocytes were shown to be regulated by receptor interactions, receptor trafficking and feedback regulation. Here, we exemplify how mechanistic mathematical modelling based on quantitative data can...

...-A) insulin receptor with exon 11 (IR-B) mathematical modelling In the present study, we have carefully re-examined the ligand-binding kinetics of the two IR isoforms expressed in CHO cells using a recently developed structure-based mathematical model [ 31 ] of the insulin-binding mechanism...

... 5 2011 10 8 2011 15 8 2011 15 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 kinetics mathematical modelling phototransduction precoupling systems biology Phototransduction in vertebrates represents a paradigm for GPCR (G-protein...

... proximal tubule) cells and its activity was determined by monitoring changes in the intracellular pH induced by variations of transmembrane anion gradients. Combining measurements of pendrin activity with mathematical modelling we found that its affinity for Cl − , HCO 3 − and OH − varies...

... of endosomal receptors we analysed a whole-cell mathematical model of epidermal growth factor receptor trafficking and binding. We discovered that the stability of growth factor–receptor complexes within endosomes is governed by three primary independent factors: the endosomal dissociation constant, total...

... Signaling Technology. Unless otherwise noted, all other reagents were from Sigma–Aldrich. 25 6 2005 12 8 2005 14 9 2005 14 9 2005 The Biochemical Society, London 2006 mathematical modelling phosphoinositide 3-kinase (PI3K) platelet-derived growth factor (PDGF) Ras...

... , phosphatidylcholine/phosphatidylserine vesicles are often used to mimic natural pro-coagulant membranes. In the present study, we developed a quantitative mathematical model of Factor X activation by intrinsic tenase. We considered two situations, when complex assembly occurs on either the membrane of phospholipid...