... for this article was enabled by the participation of University of Melbourne in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. mechanistic target of rapamycin necroptosis protein kinase pseudokinase signalling...

...-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. kinase inhibitors mechanistic target of rapamycin nutrients Rapamycin was isolated from the bacterium Streptomyces hygroscopicus in 1972, and was characterized to have antifungal and antibacterial...

... is the regulation of transcription factor FOXO1 (forkhead box protein O1), which is phosphorylated downstream of mTORC2 (mammalian/mechanistic target of rapamycin in complex with raptor) and is therefore not exhibiting impaired response to insulin. However, the abundance, and activity, of FOXO1 is reduced by half...

... ( [email protected] ) 11 2 2018 19 4 2018 23 4 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 mechanistic target of rapamycin post-translational modification translation Signalling through multiprotein...

... mechanistic target of rapamycin p53 tyrosine kinase inhibitor The oncogenic fusion protein BCR/ABL is a constitutively active tyrosine kinase that triggers both chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) [ 1 ]. Tyrosine kinase...

...-regulation of eIF4E and 4E-BP1. bioprocessing Chinese hamster ovary cells mechanistic target of rapamycin monoclonal antibodies mRNA translation recombinant proteins Cultured mammalian cell expression systems, particularly Chinese hamster ovary (CHO) cells, are used to manufacture high-value...