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Keywords: melanoma
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Biochem J (2019) 476 (17): 2463–2486.
Published: 10 September 2019
... of chemotherapy, and targeted therapies in melanoma and the senescence-associated secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing treatment outcomes. Metabolic interventions can modulate the SASP, and an enhanced mitochondrial energy metabolism supports resistance to therapy...
Includes: Supplementary data
Biochem J (2015) 471 (2): 267–279.
Published: 02 October 2015
..., we found in a previous study that protein levels of several peroxiredoxins, including PRDX6 (peroxiredoxin 6), are highly elevated in experimentally induced melanomas. In the present study, we investigated the functional role of PRDX6 in human melanoma cells. PRDX6 is a bifunctional enzyme, which...
Includes: Supplementary data
Biochem J (2015) 467 (3): 425–438.
Published: 17 April 2015
..., this class of compounds selectively induces apoptosis in melanoma cells containing mutated BRaf and constitutively active ERK1/2 signalling, including melanoma cells that are inherently resistant to clinically relevant kinase inhibitors. These findings represent the identification and initial...
Includes: Supplementary data
Biochem J (2011) 437 (1): 97–107.
Published: 14 June 2011
...Alice Barbarin; Raymond Frade The switch of human melanoma cell phenotype from non to highly tumorigenic and metastatic is triggered by the increase of procathepsin L secretion, which modifies the tumour microenvironment. The aim of the present study was to identify components involved...
Biochem J (2002) 361 (1): 173–184.
Published: 17 December 2001
...Didier JEAN; Nathalie GUILLAUME; Raymond FRADE Cathepsin L is a cysteine protease whose overexpression in human melanoma cells increases their tumorigenicity and switches their phenotype from non-metastatic to highly metastatic. Regulation of the transcription of the gene encoding human cathepsin L...