... membrane traffic membrane trafficking kinetics signal transduction In the 100th year of the discovery of insulin we reflect on a famous cartoon of the 1970s in which ‘Chuck’ describes the black box theory of insulin action and the following sequence: insulin binds to its receptor; something...

...Peter G. Billcliff; Martin Lowe The specific interaction of phosphoinositides with proteins is critical for a plethora of cellular processes, including cytoskeleton remodelling, mitogenic signalling, ion channel regulation and membrane traffic. The spatiotemporal restriction of different...

... 29 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 adaptor protein 1 (AP-1) amphiphysin clathrin coated vesicle liposome membrane traffic Membrane transport through the secretory and endocytic pathways is typically mediated by vesicles formed...

... The Authors Journal compilation © 2010 Biochemical Society 2010 endosome Ent3p epsin N-terminal homology (ENTH) membrane traffic soluble N -ethylmaleimide-sensitive fusion protein-attachment protein receptor (SNARE) trans -Golgi network (TGN) In eukaryotic cells, vesicles containing cargo...

...) membrane traffic palmitoyl-acyl transferase recycling endosome S-acylated peripheral proteins such as the small G-proteins Ras, Gα subunit, and also the neuronal proteins post-synaptic density protein-95 and GAP-43 (growth-associated protein-43) [ 1 ] are synthesized in the cytosol and then post...

... (EXPRE35S35S protein labelling mix) from PerkinElmer (Waltham, MA, U.S.A.), fixed Staphylococcus aureu s cells (Pansorbin) from Calbiochem (San Diego, CA, U.S.A.), zymolyase from Seikagaku (Tokyo, Japan) and FM4-64 from Invitrogen (Carlsbad, CA, U.S.A.). membrane traffic recycling Saccharomyces...

... A (BFA) Exo2 Golgi membrane traffic secretory pathway Shiga toxin (STx) Although much of our knowledge of the secretory pathway comes from genetic or biochemical experiments [ 1 , 2 ], small-molecule inhibitors have also proven to be extremely useful tools for studying this pathway. Perhaps...

..., London ©2002 2002 C2 domain C-type tandem C2 protein dense-core vesicle exocytosis membrane traffic Abbreviations used: CAP, adenylate cyclase-associated protein; C-type, C-terminal-type; GFP, green fluorescent protein; GST, glutathione S-transferase; HRP, horseradish peroxidase; LC—MS...

... be addressed (e-mail stenmark!ulrik.uio.no). identified which contain a FYVE domain, and in this review we discuss the functions of PtdIns3P and its FYVE-domain-con- taining effector proteins in membrane trafficking, cytoskeletal regulation and receptor signalling. Key words: membrane traffic, phosphoinositide...

... functions in signal transduction, membrane vesicle trafficking and cytoskeletal dynamics. 1 To whom correspondence should be sent (e-mail moti.liscovitch@;weizmann.ac.il). The Biochemical Society, London © 2000 2000 membrane traffic phosphatidic acid phospholipase D phospholipid...

... 1999 1 4 1999 27 4 1999 The Biochemical Society, London © 1999 1999 ARF1 ARF6 chimaeras HL60 cells membrane traffic Biochem. J. (1999) 341, 185 192 (Printed in Great Britain) 185 ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal...