...Cameron Day; Jason D. Shepherd Arc (activity-regulated cytoskeleton-associated protein) is a neuron-specific immediate early gene that is required for enduring forms of synaptic plasticity and memory in the mammalian brain. Arc expression is highly dynamic, and tightly regulated by neuronal...

... neurological function in a mouse model with Mtrr deficiency. Mtrr +/+ , Mtrr +/gt and Mtrr gt/gt mice (3 months old) were assessed for short-term memory, brain volumes and hippocampal morphology. We also measured DNA methylation, apoptosis, neurogenesis, choline metabolites and expression of ChAT (choline...

... not require cytosolic factors or the continued presence of NAADP and persisted upon solubilization. NAADP receptors, however, failed to stabilize at reduced temperature. We conclude that NAADP receptors possess a simple molecular memory endowing them with the remarkable ability to detect the duration...

...Thomas J. NELSON; Wei-Qin ZHAO; Shauna YUAN; Antonella FAVIT; Lucas POZZO-MILLER; Daniel L. ALKON Calexcitin (CE), a Ca 2+ - and GTP-binding protein, which is phosphorylated during memory consolidation, is shown here to co-purify with ryanodine receptors (RyRs) and bind to RyRs in a calcium...