1-50 of 56
Keywords: metabolism
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem J (2021) 478 (4): 749–764.
Published: 24 February 2021
...Claire Thornton; Etty Grad; Rami Yaka The incidence of cocaine abuse is increasing especially in the U.K. where the rates are among the highest in Europe. In addition to its role as a psychostimulant, cocaine has profound effect on brain metabolism, impacting glycolysis and impairing oxidative...
Articles
Biochem J (2020) 477 (14): 2735–2754.
Published: 31 July 2020
... been implicated in metabolic disease and shown to mediate diet-induced obesity. In particular, knockout of MNK2 in mice protects from the weight gain induced by a high-fat diet. These and other data suggest that MNK2 regulates the expansion of adipose tissue (AT), a stable, long-term energy reserve...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (11): 2027–2038.
Published: 04 June 2020
... spite of their toxicity, these compounds are utilized as primary carbon and energy sources or are generated as intermediate metabolites in the metabolism of other compounds by many diverse bacteria. The aerobic metabolism of some of the smallest and most volatile of these compounds (propylene, acetone...
Articles
Biochem J (2019) 476 (22): 3435–3453.
Published: 21 November 2019
...Asma U. Husna; Nancy Wang; Jonathan J. Wilksch; Hayley J. Newton; Dianna M. Hocking; Iain D. Hay; Simon A. Cobbold; Mark R. Davies; Malcolm J. McConville; Trevor Lithgow; Richard A. Strugnell Key physiological differences between bacterial and mammalian metabolism provide opportunities for the...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (18): 2579–2594.
Published: 20 September 2019
...., Reistertown, MD 21136, U.S.A. 5 8 2019 27 8 2019 29 8 2019 29 8 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 biosynthesis enzyme activity evolutionary biology genomics metabolism polyamines Cellular...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (16): 2577–2592.
Published: 29 August 2018
...Markus Ralser Until recently, prebiotic precursors to metabolic pathways were not known. In parallel, chemistry achieved the synthesis of amino acids and nucleotides only in reaction sequences that do not resemble metabolic pathways, and by using condition step changes, incompatible with enzyme...
Articles
Biochem J (2018) 475 (14): 2305–2328.
Published: 31 July 2018
.... Tunneling nanotubes (TNTs) are newly discovered long-range intercellular connections that allow the exchange between cells of various cargos, ranging from ions to whole organelles such as mitochondria. TNT-transferred mitochondria were shown to change the metabolism and functional properties of recipient...
Articles
Biochem J (2018) 475 (9): 1611–1634.
Published: 09 May 2018
... strategy to improve the effectiveness of classical anticancer therapies. Recently, metabolism has been considered as a relevant player in CSC biology, and indeed, oncogenic alterations trigger the metabolite-driven dissemination of CSCs. More interestingly, the action of metabolic pathways in CSC...
Articles
Biochem J (2018) 475 (7): 1371–1383.
Published: 16 April 2018
... metabolism and a three-carbon sulfonate that is expelled from the cell. Sulfoglycolytic operons encoding an Embden–Meyerhof–Parnas-like or Entner–Doudoroff (ED)-like pathway harbor an uncharacterized gene ( yihR in Escherichia coli ; PpSQ1_00415 in Pseudomonas putida ) that is up-regulated in the presence of...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (17): 2925–2935.
Published: 11 August 2017
... nuclear localization. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a large family of RNA-binding proteins that are important for multiple aspects of nucleic acid metabolism. hnRNPs are also predominantly expressed in the nucleus. This review discusses the interactions of lncRNAs and hnRNPs in...
Articles
Biochem J (2017) 474 (16): 2897–2899.
Published: 10 August 2017
...Steven C. Ley; Luiz Pedro S. de Carvalho Regulation of metabolic pathways by signal transduction and transcriptional cascades can alter cellular levels of metabolites. Metabolites themselves can also have regulatory activity as shown in a new study published in the Biochemical Journal . Tsuchiya et...
Articles
Biochem J (2017) 474 (14): 2277–2299.
Published: 27 June 2017
...: gene duplication (and gene loss), horizontal and endosymbiotic gene transfer, and gene fusion. It will also discuss mechanisms that lead to convergence as well as divergence. To illustrate these mechanisms, one of the original metabolisms present in the last universal common ancestor will be employed...
Articles
Biochem J (2016) 473 (24): 4527–4550.
Published: 09 December 2016
...Philip Newsholme; Vinicius Fernandes Cruzat; Kevin Noel Keane; Rodrigo Carlessi; Paulo Ivo Homem de Bittencourt, Jr Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative...
Articles
Biochem J (2016) 473 (11): 1503–1506.
Published: 27 May 2016
...Yangzom D. Bhutia; Ellappan Babu; Vadivel Ganapathy Tumour cell metabolism is very different from normal cell metabolism; cancer cells re-programme the metabolic pathways that occur in normal cells in such a manner that it optimizes their proliferation, growth and survival. Although this metabolic...
Articles
Biochem J (2016) 473 (7): 929–936.
Published: 29 March 2016
... monocarboxylate transporters (MCTs), accounting for many of its known effects on tumour cell metabolism and bioenergetics. bioenergetics cancer metabolism mitochondrial pyruvate carrier monocarboxylate transporter tumour acidification Lonidamine (LND), first introduced in 1979 as an anti...
Articles
Biochem J (2016) 473 (2): 107–121.
Published: 05 January 2016
... droplets in the adrenal glands, implying decreased lipid metabolism, whereas instead lipid stores were depleted in testes and ovaries, implying excessive substrate consumption [ 111 ]. These observations provide strong evidence that there is an important role for TSPO in hormone-mediated steroidogenesis...
Articles
Biochem J (2015) 466 (1): 37–44.
Published: 06 February 2015
...Laura M. Jones; Anthony J. Flemming; Peter E. Urwin Knowledge of how drugs are metabolized and excreted is an essential component of understanding their fate within and among target and non-target organisms. Thiabendazole (TBZ) was the first benzimidazole (BZ) to be commercially available and...
Includes: Supplementary data
Articles
Biochem J (2014) 464 (1): 1.
Published: 23 October 2014
...Peter R. Shepherd © The Authors Journal compilation © 2014 Biochemical Society 2014 Asia Asian Chemical Biology Initiative chemical biology metabolism Science in Asia has been developing rapidly in recent years in both quality and quality. The Biochemical Journal spotted this...
Includes: Supplementary data
Articles
Biochem J (2014) 463 (2): 249–256.
Published: 22 September 2014
... metabolism PIGF Trypanosoma brucei 1 To whom correspondence should be addressed at the present address: Department of Microbiology, University of Massachusetts, Amherst, MA 01003, U.S.A. (email ymorita@microbio.umass.edu ). 28 4 2014 25 7 2014 30 7 2014 30 7 2014...
Articles
Biochem J (2014) 459 (2): e1–e3.
Published: 28 March 2014
... © 2014 Biochemical Society 2014 cancer cholesterol inflammation liver X receptor metabolism oxysterol Cholesterol plays an essential role in the stability and architecture of the plasma membrane, and as a precursor for bile acid and steroid hormone synthesis in mammals [ 1 ]. Under...
Articles
Biochem J (2014) 458 (2): 343–353.
Published: 14 February 2014
... encoding de novo pathway enzymes cause varying degrees of lethality and pleiotropic phenotypes in many organisms, including humans. We have examined how the absence of rad-6 activity leads to both UV-C hypersensitivity and a decline in both metabolic rate and lifespan. We discuss how rad-6 mutants adapt to...
Includes: Supplementary data
Articles
Biochem J (2013) 456 (2): 219–229.
Published: 08 November 2013
... gene have a glucose transport function in an oocyte expression system. We have named this gene fgt-1 (facilitated glucose transporter, isoform 1). We show that knockdown of fgt-1 RNA leads to loss of glucose transport and reduced glucose metabolism in wild-type worms. The FGT-1 glucose transporters of...
Includes: Supplementary data
Articles
Biochem J (2013) 455 (1): 75–85.
Published: 13 September 2013
... control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance, allowing resistant insects to metabolize insecticides at a higher rate. Among them, members of the mosquito CYP6Z subfamily, like Aedes aegypti CYP6Z8 and its Anopheles gambiae...
Includes: Supplementary data
Articles
Biochem J (2013) 452 (3): 369–379.
Published: 31 May 2013
... found ubiquitously in eukaryotic cells. The enzymes that synthesize them are similarly well distributed and can be found encoded in any eukaryote genome. Rapid progress has been made in characterizing inositol pyrophosphate metabolism and they have been linked to a surprisingly diverse range of cellular...
Articles
Biochem J (2013) 452 (3): 531–543.
Published: 31 May 2013
...-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is involved in cell proliferation owing to its role in carbohydrate metabolism. In the present study we analysed the mechanism of regulation of PFKFB3 as an immediate early gene controlled by stress stimuli that activates the p38...
Includes: Supplementary data
Articles
Biochem J (2013) 449 (1): 11–23.
Published: 07 December 2012
... different cell types, even if only slightly overlapping, are all enriched for E2F-regulated genes [ 27 ]. © The Authors Journal compilation © 2013 Biochemical Society 2013 angiogenesis genomic instability inflammation invasion/metastasis metabolism proliferation YB-1 (Y-box-binding...
Articles
Biochem J (2012) 448 (1): 165–169.
Published: 18 October 2012
...Derek Blair; Fay J. Dufort; Thomas C. Chiles Signals derived from the BCR (B-cell antigen receptor) control survival, development and antigenic responses. One mechanism by which BCR signals may mediate these responses is by regulating cell metabolism. Indeed, the bioenergetic demands of naïve B...
Includes: Supplementary data
Articles
Biochem J (2012) 445 (1): 11–27.
Published: 15 June 2012
... and cancer. Reflecting its key role in energy metabolism, AMPK has emerged as a potential therapeutic target. In the present review we examine the recent progress aimed at understanding the regulation of AMPK and discuss some of the latest developments that have emerged in key areas of human...
Articles
Biochem J (2012) 443 (1): 165–171.
Published: 14 March 2012
... liver and its expression induces a metabolic state that mimics long-term fasting. Thus FGF21 is critical for the induction of hepatic fat oxidation, ketogenesis and gluconeogenesis, metabolic processes which are essential for the adaptive metabolic response to starvation. In the present study, we have...
Articles
Biochem J (2012) 442 (2): 345–356.
Published: 13 February 2012
...), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is extensively involved in cell proliferation owing to its key role in carbohydrate metabolism. In the present study we analyse its mechanism of regulation by progestins in breast cancer cells. We report that exposure of T47D cells...
Articles
Biochem J (2011) 438 (3): e5–e6.
Published: 26 August 2011
... TNF (tumour necrosis factor). Recently, a role for metabolic pathways in the regulation of LPS signalling has become a focus of research in inflammation. A notable example is LPS promoting the so-called Warburg effect – aerobic glycolysis. This allows for an up-regulation in ATP production, and also...
Articles
Biochem J (2011) 436 (3): 621–629.
Published: 27 May 2011
... metabolism of glucocorticoids, 11β-HSD1 mediated solely 7-oxo reduction of 7-oxoLCA and its taurine and glycine conjugates. Furthermore, we investigated the interference of bile acids with 11β-HSD1-dependent interconversion of glucocorticoids. 7-OxoLCA and its conjugates preferentially inhibited cortisone...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (1): 285–296.
Published: 15 March 2011
...Xiaoli Wang; Colins O. Eno; Brian J. Altman; Yanglong Zhu; Guoping Zhao; Kristen E. Olberding; Jeffrey C. Rathmell; Chi Li Changes in metabolic processes play a critical role in the survival or death of cells subjected to various stresses. In the present study, we have investigated the effects of...
Includes: Supplementary data
Articles
Biochem J (2010) 432 (3): 505–516.
Published: 25 November 2010
...Steven T. Laing; Al Ivens; Roz Laing; Sai Ravikumar; Victoria Butler; Debra J. Woods; John S. Gilleard Knowledge of how anthelmintics are metabolized and excreted in nematodes is an integral part of understanding the factors that determine their potency, spectrum of activity and for investigating...
Includes: Supplementary data
Articles
Biochem J (2010) 427 (1): 1–17.
Published: 15 March 2010
...Jaswinder K. Sethi; Antonio Vidal-Puig At the cellular level, the biological processes of cell proliferation, growth arrest, differentiation and apoptosis are all tightly coupled to appropriate alterations in metabolic status. In the case of cell proliferation, this requires redirecting metabolic...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2009) 423 (1): 109–118.
Published: 14 September 2009
... inositol pyrophosphate inositol hexakisphosphate kinase (IP6K) Kcs1 metabolism Rad53 reactive oxygen species (ROS) Inositol pyrophosphates in both lower eukaryotes such as yeast as well as mammalian cells are generated by the sequential phosphorylation of IP 3 (inositol trisphosphate) [ 1 , 2...
Articles
Biochem J (2008) 416 (2): e11–e13.
Published: 12 November 2008
... the entire organ. Yet what is clear is that when such mechanisms fail or become inappropriately active they can lead to dire consequences such as diabetes, metabolic syndromes, cardiovascular diseases and cancer. In this issue of the Biochemical Journal , Anagnostou and Shepherd report the...
Articles
Biochem J (2008) 413 (3): 369–387.
Published: 15 July 2008
... reaction, replenishing oxaloacetate withdrawn from the tricarboxylic acid cycle for various pivotal biochemical pathways. PC is therefore considered as an enzyme that is crucial for intermediary metabolism, controlling fuel partitioning toward gluconeogenesis or lipogenesis and in insulin secretion. The...
Articles
Biochem J (2007) 408 (1): 123–130.
Published: 29 October 2007
... metabolism within cells. PFK (6-phosphofructo-1-kinase) is the key regulatory glycolytic enzyme which is regulated by diverse molecules and signals. PFK activity is directly correlated with cellular glucose consumption. The present study shows the property of lactate to down-regulate PFK activity in a...
Articles
Biochem J (2007) 403 (1): 197–205.
Published: 13 March 2007
...Emma Heart; Gordon C. Yaney; Richard F. Corkey; Vera Schultz; Esthere Luc; Lihan Liu; Jude T. Deeney; Orian Shirihai; Keith Tornheim; Peter J. S. Smith; Barbara E. Corkey The present study was undertaken to determine the main metabolic secretory signals generated by the mitochondrial substrate MeS...
Articles
Biochem J (2006) 395 (3): 641–652.
Published: 11 April 2006
...@bbsrc.ac.uk ). 14 10 2005 26 1 2006 2 2 2006 2 2 2006 The Biochemical Society, London 2006 cytochrome P450 haem hydroperoxide metabolism micelle oxylipin Cytochrome P450 enzymes are widespread in Nature, but members of the CYP74 (cytochrome P450 subfamily 74...
Includes: Supplementary data
Articles
Biochem J (2003) 376 (2): 403–411.
Published: 01 December 2003
... premature senescence, reactive oxygen species are considered important intermediates contributing to the phenotype. Moreover, distinct alterations of the cellular carbohydrate metabolism are known to contribute to oncogenic transformation, as is best documented for the phenomenon of aerobic glycolysis...
Articles
Biochem J (2002) 365 (3): 561–575.
Published: 01 August 2002
... C/EBPs has recently been investigated by a number of approaches, including studies on mice that lack specific members, and has identified pivotal roles of the family in the control of cellular proliferation and differentiation, metabolism, inflammation and numerous other responses, particularly in...
Articles
Biochem J (2001) 359 (3): 631–637.
Published: 25 October 2001
... γ-GT physiology and GSH metabolism. 1 To whom correspondence should be addressed (e-mail upemulb@resulb.ulb.ac.be ). 22 3 2001 22 6 2001 20 8 2001 The Biochemical Society, London ©2001 2001 enzymes fungi metabolism peptide thiol tonoplast Abbreviations...
Articles
Biochem J (2001) 355 (2): 297–305.
Published: 06 April 2001
...-regulated member of the AMPK-related gene family that represents a new candidate mediator of the cellular response to metabolic stress. 1 To whom correspondence should be sent at the Division of Dermatology address (e-mail c.rosen@utoronto.ca ). 20 7 2000 18 12 2000 1 2 2001...
Articles
Biochem J (2000) 352 (2): 501–509.
Published: 24 November 2000
...Alexander N. GRECHKIN; Lucia S. MUKHTAROVA; Mats HAMBERG The in vitro metabolism of [1- 14 C]linoleate, [1- 14 C]linolenate and their 9( S )-hydroperoxides was studied in cell-free preparations from tulip ( Tulipa gesneriana ) bulbs, leaves and flowers. Linoleate and its 9-hydroperoxide were...
Articles
Biochem J (2000) 351 (1): 207–214.
Published: 26 September 2000
... metabolism triglyceride Biochem. J. (2000) 351, 207 214 (Printed in Great Britain) 207 Stimulation of hormone-sensitive lipase activity by contractions in rat skeletal muscle Jozef LANGFORT*, Thorkil PLOUG‹, Jacob IHLEMANN‹, Cecilia HOLMŒ and Henrik GALBO‹1 *Department of Applied Physiology, The Polish...
Articles
Biochem J (2000) 351 (1): 215–220.
Published: 26 September 2000
... correspondence should be addressed (e-mail gad.galili@weizmann.ac.il ). 3 5 2000 20 6 2000 19 7 2000 catabolism essential amino acids metabolism Biochem. J. (2000) 351, 215 220 (Printed in Great Britain) 215 The catabolic function of the a-aminoadipic acid pathway in plants is...
Articles
Biochem J (2000) 349 (3): 775–781.
Published: 25 July 2000
... © 2000 2000 exercise insulin action metabolism signal transduction transport Biochem. J. (2000) 349, 775 781 (Printed in Great Britain) 775 Contraction inhibits insulin-stimulated insulin receptor substrate-1/2- associated phosphoinositide 3-kinase activity, but not protein kinase B...
Articles
Biochem J (2000) 348 (3): 481–495.
Published: 07 June 2000
..., in addition to this general role, retinoid-binding proteins have diverse and specific functions in regulating the disposition, metabolism and activities of retinoids. Some retinoid-binding proteins appear to act by sequestering their ligands, thereby generating concentration gradients that allow...