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1-50 of 64
Keywords: metabolism
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Articles
Arginine promotes the activation of human lung fibroblasts independent of its metabolism
Open AccessRobert B Hamanaka, Kun Woo D Shin, M Volkan Atalay, Rengul Cetin-Atalay, Hardik Shah, Jennifer C Houpy Szafran, Parker S Woods, Angelo Y Meliton, Obada R Shamaa, Yufeng Tian, Takugo Cho, Gökhan M Mutlu
Journal:
Biochemical Journal
Biochem J (2025) 482 (12): 823–838.
Published: 17 June 2025
... on the metabolic and signaling roles of arginine in the process of fibroblast activation has not been conducted. Here, we examined the role and regulation of arginine metabolism in lung fibroblasts activated with TGF-β. We found that TGF-β increases the expression of arginine biosynthetic and catabolic enzymes...
Includes: Supplementary data
Articles
Daniel M. Collins, Vishnu Janardan, David Barneda, Karen E. Anderson, Izabella Niewczas, Diane Taylor, Danye Qiu, Henning J. Jessen, Andrea F. Lopez-Clavijo, Simon Walker, Padinjat Raghu, Jonathan Clark, Len R. Stephens, Phillip T. Hawkins
Journal:
Biochemical Journal
Biochem J (2024) 481 (20): 1449–1473.
Published: 11 October 2024
... pleiotropic effects of CDS2 deletion on lipid metabolism/signalling. © 2024 The Author(s) 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Correspondence...
Includes: Supplementary data
Articles
In Collection
Cell signaling in the 21st century
Journal:
Biochemical Journal
Biochem J (2024) 481 (2): 45–91.
Published: 25 January 2024
...Aparna Ragupathi; Christian Kim; Estela Jacinto The mechanistic target of rapamycin, mTOR, controls cell metabolism in response to growth signals and stress stimuli. The cellular functions of mTOR are mediated by two distinct protein complexes, mTOR complex 1 (mTORC1) and mTORC2. Rapamycin and its...
Articles
In Collection
Awards
Journal:
Biochemical Journal
Biochem J (2023) 480 (21): 1767–1789.
Published: 15 November 2023
... to give an overview of what is known to date about these interactions including metabolic remodelling, mitochondrial morphology, mitochondrial turnover, cellular processes and muscle cell structure and function. Each of these topics is at a different stage of understanding, with some being well researched...
Articles
The adaptive response to alternative carbon sources in the pathogen Candida albicans involves a remodeling of thiol- and glutathione-dependent redox status
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2023) 480 (3): 197–217.
Published: 07 February 2023
... to changes in micronutrient levels, and, in parallel, explored changes in the intracellular redox and metabolic status of the cells. We show here that each of the carbon sources considered — glucose, acetate and lactate — induces a unique pattern of response in C. albicans cells, and that some conditions...
Includes: Supplementary data
Articles
Jonas A. Wik, Azazul Chowdhury, Shrikant Kolan, Nasser E. Bastani, Gaoyang Li, Kazi Alam, Franco Grimolizzi, Bjørn S. Skålhegg
Journal:
Biochemical Journal
Biochem J (2022) 479 (11): 1221–1235.
Published: 13 June 2022
...Jonas A. Wik; Azazul Chowdhury; Shrikant Kolan; Nasser E. Bastani; Gaoyang Li; Kazi Alam; Franco Grimolizzi; Bjørn S. Skålhegg To meet the demand for energy and biomass, T lymphocytes (T cells) activated to proliferation and clonal expansion, require uptake and metabolism of glucose (Gluc...
Includes: Supplementary data
Articles
In Collection
Towards systems biochemistry
Journal:
Biochemical Journal
Biochem J (2022) 479 (6): 787–804.
Published: 31 March 2022
...Satoshi Ohno; Saori Uematsu; Shinya Kuroda Cells change their metabolism in response to internal and external conditions by regulating the trans-omic network, which is a global biochemical network with multiple omic layers. Metabolic flux is a direct measure of the activity of a metabolic reaction...
Articles
Revisiting the contribution of mitochondrial biology to the pathophysiology of skeletal muscle insulin resistance
Available to PurchaseIn Collection
Celebrating 100 years of insulin research
Journal:
Biochemical Journal
Biochem J (2021) 478 (21): 3809–3826.
Published: 09 November 2021
... and the pathological production of reactive oxygen species (ROS), appear to rely on this high lipid environment. Mitochondrial biology is a central component to these processes, as these organelles are almost exclusively responsible for the oxidation and metabolism of lipids within skeletal muscle and are a primary...
Articles
The role of mitochondria in cocaine addiction
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Journal:
Biochemical Journal
Biochem J (2021) 478 (4): 749–764.
Published: 24 February 2021
...Claire Thornton; Etty Grad; Rami Yaka The incidence of cocaine abuse is increasing especially in the U.K. where the rates are among the highest in Europe. In addition to its role as a psychostimulant, cocaine has profound effect on brain metabolism, impacting glycolysis and impairing oxidative...
Articles
MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity
Open Access
Journal:
Biochemical Journal
Biochem J (2020) 477 (14): 2735–2754.
Published: 31 July 2020
... been implicated in metabolic disease and shown to mediate diet-induced obesity. In particular, knockout of MNK2 in mice protects from the weight gain induced by a high-fat diet. These and other data suggest that MNK2 regulates the expansion of adipose tissue (AT), a stable, long-term energy reserve...
Includes: Supplementary data
Articles
Insights into the unique carboxylation reactions in the metabolism of propylene and acetone
Available to PurchaseFlorence Mus, Hsin-Hua Wu, Alexander B. Alleman, Krista A. Shisler, Oleg A. Zadvornyy, Brian Bothner, Jennifer L. Dubois, John W. Peters
Journal:
Biochemical Journal
Biochem J (2020) 477 (11): 2027–2038.
Published: 04 June 2020
.... In spite of their toxicity, these compounds are utilized as primary carbon and energy sources or are generated as intermediate metabolites in the metabolism of other compounds by many diverse bacteria. The aerobic metabolism of some of the smallest and most volatile of these compounds (propylene, acetone...
Articles
The multifunctional enzyme S-adenosylhomocysteine/methylthioadenosine nucleosidase is a key metabolic enzyme in the virulence of Salmonella enterica var Typhimurium
Available to PurchaseAsma U. Husna, Nancy Wang, Jonathan J. Wilksch, Hayley J. Newton, Dianna M. Hocking, Iain D. Hay, Simon A. Cobbold, Mark R. Davies, Malcolm J. McConville, Trevor Lithgow, Richard A. Strugnell
Journal:
Biochemical Journal
Biochem J (2019) 476 (22): 3435–3453.
Published: 21 November 2019
...Asma U. Husna; Nancy Wang; Jonathan J. Wilksch; Hayley J. Newton; Dianna M. Hocking; Iain D. Hay; Simon A. Cobbold; Mark R. Davies; Malcolm J. McConville; Trevor Lithgow; Richard A. Strugnell Key physiological differences between bacterial and mammalian metabolism provide opportunities...
Includes: Supplementary data
Articles
A polyamine-independent role for S -adenosylmethionine decarboxylase
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Journal:
Biochemical Journal
Biochem J (2019) 476 (18): 2579–2594.
Published: 20 September 2019
... genomics metabolism polyamines Cellular growth and proliferation in all eukaryotes, most archaea and many bacteria are likely contingent on the presence of the polyamine spermidine [ 1 ]. The pyruvoyl-dependent enzyme S -adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme...
Includes: Supplementary data
Articles
An appeal to magic? The discovery of a non-enzymatic metabolism and its role in the origins of life
Open AccessIn Collection
Awards
, Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019
Journal:
Biochemical Journal
Biochem J (2018) 475 (16): 2577–2592.
Published: 29 August 2018
...Markus Ralser Until recently, prebiotic precursors to metabolic pathways were not known. In parallel, chemistry achieved the synthesis of amino acids and nucleotides only in reaction sequences that do not resemble metabolic pathways, and by using condition step changes, incompatible with enzyme...
Articles
The role of metabolism and tunneling nanotube-mediated intercellular mitochondria exchange in cancer drug resistance
Available to PurchaseIn Collection
Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019
Journal:
Biochemical Journal
Biochem J (2018) 475 (14): 2305–2328.
Published: 31 July 2018
.... Tunneling nanotubes (TNTs) are newly discovered long-range intercellular connections that allow the exchange between cells of various cargos, ranging from ions to whole organelles such as mitochondria. TNT-transferred mitochondria were shown to change the metabolism and functional properties of recipient...
Articles
In Collection
Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019
Journal:
Biochemical Journal
Biochem J (2018) 475 (9): 1611–1634.
Published: 09 May 2018
... strategy to improve the effectiveness of classical anticancer therapies. Recently, metabolism has been considered as a relevant player in CSC biology, and indeed, oncogenic alterations trigger the metabolite-driven dissemination of CSCs. More interestingly, the action of metabolic pathways in CSC...
Articles
Palika Abayakoon, James P. Lingford, Yi Jin, Christopher Bengt, Gideon J. Davies, Shenggen Yao, Ethan D. Goddard-Borger, Spencer J. Williams
Journal:
Biochemical Journal
Biochem J (2018) 475 (7): 1371–1383.
Published: 16 April 2018
... metabolism and a three-carbon sulfonate that is expelled from the cell. Sulfoglycolytic operons encoding an Embden–Meyerhof–Parnas-like or Entner–Doudoroff (ED)-like pathway harbor an uncharacterized gene ( yihR in Escherichia coli ; PpSQ1_00415 in Pseudomonas putida ) that is up-regulated in the presence...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (17): 2925–2935.
Published: 11 August 2017
... nuclear localization. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a large family of RNA-binding proteins that are important for multiple aspects of nucleic acid metabolism. hnRNPs are also predominantly expressed in the nucleus. This review discusses the interactions of lncRNAs and hnRNPs...
Articles
Protein CoAlation: a redox-linked post-translational modification
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2017) 474 (16): 2897–2899.
Published: 10 August 2017
...Steven C. Ley; Luiz Pedro S. de Carvalho Regulation of metabolic pathways by signal transduction and transcriptional cascades can alter cellular levels of metabolites. Metabolites themselves can also have regulatory activity as shown in a new study published in the Biochemical Journal . Tsuchiya et...
Articles
Evolution of biosynthetic diversity
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Journal:
Biochemical Journal
Biochem J (2017) 474 (14): 2277–2299.
Published: 27 June 2017
... duplication (and gene loss), horizontal and endosymbiotic gene transfer, and gene fusion. It will also discuss mechanisms that lead to convergence as well as divergence. To illustrate these mechanisms, one of the original metabolisms present in the last universal common ancestor will be employed: polyamine...
Articles
Molecular mechanisms of ROS production and oxidative stress in diabetes
Available to PurchasePhilip Newsholme, Vinicius Fernandes Cruzat, Kevin Noel Keane, Rodrigo Carlessi, Paulo Ivo Homem de Bittencourt, Jr
Journal:
Biochemical Journal
Biochem J (2016) 473 (24): 4527–4550.
Published: 09 December 2016
...Philip Newsholme; Vinicius Fernandes Cruzat; Kevin Noel Keane; Rodrigo Carlessi; Paulo Ivo Homem de Bittencourt, Jr Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative...
Articles
Re-programming tumour cell metabolism to treat cancer: no lone target for lonidamine
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Journal:
Biochemical Journal
Biochem J (2016) 473 (11): 1503–1506.
Published: 27 May 2016
...Yangzom D. Bhutia; Ellappan Babu; Vadivel Ganapathy Tumour cell metabolism is very different from normal cell metabolism; cancer cells re-programme the metabolic pathways that occur in normal cells in such a manner that it optimizes their proliferation, growth and survival. Although this metabolic...
Articles
The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters
Available to PurchaseBethany Nancolas, Lili Guo, Rong Zhou, Kavindra Nath, David S. Nelson, Dennis B. Leeper, Ian A. Blair, Jerry D. Glickson, Andrew P. Halestrap
Journal:
Biochemical Journal
Biochem J (2016) 473 (7): 929–936.
Published: 29 March 2016
... that lonidamine potently inhibits the mitochondrial pyruvate carrier (MPC) and plasma membrane monocarboxylate transporters (MCTs), accounting for many of its known effects on tumour cell metabolism and bioenergetics. bioenergetics cancer metabolism mitochondrial pyruvate carrier monocarboxylate...
Articles
TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2016) 473 (2): 107–121.
Published: 05 January 2016
... 2016 Authors; published by Portland Press Limited 2016 autophagy biochemistry and mitochondrial pharmacology metabolism peripheral benzodiazepine receptor (PBR) steroids translocator protein (TSPO) The cross-disciplinary nature of translocator protein (TSPO) has been recently...
Articles
Journal:
Biochemical Journal
Biochem J (2015) 466 (1): 37–44.
Published: 06 February 2015
...Laura M. Jones; Anthony J. Flemming; Peter E. Urwin Knowledge of how drugs are metabolized and excreted is an essential component of understanding their fate within and among target and non-target organisms. Thiabendazole (TBZ) was the first benzimidazole (BZ) to be commercially available...
Includes: Supplementary data
Articles
Biochemical Journal strengthens links in Asia
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Journal:
Biochemical Journal
Biochem J (2014) 464 (1): 1.
Published: 23 October 2014
...Peter R. Shepherd Last year also saw the appointment of our first Asia-based Deputy Chair, Professor Aimin Xu (University of Hong Kong) in the Metabolism Knowledge Environment. We were recently also pleased to announce the appointment of Professor Motonari Uesugi from Kyoto University...
Includes: Supplementary data
Articles
New insights into the functions of PIGF, a protein involved in the ethanolamine phosphate transfer steps of glycosylphosphatidylinositol biosynthesis
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Journal:
Biochemical Journal
Biochem J (2014) 463 (2): 249–256.
Published: 22 September 2014
...-phosphatidylinositol membrane protein metabolism PIGF Trypanosoma brucei Phosphatidylinositol-anchored proteins and glycans are found in evolutionarily diverse organisms including bacteria, protozoa, fungi, plants and animals. The structure of eukaryotic glycosylphosphatidylinositol (GPI) was first...
Articles
Liver X receptor: from metabolism to cancer
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Journal:
Biochemical Journal
Biochem J (2014) 459 (2): e1–e3.
Published: 28 March 2014
... 2014 Biochemical Society 2014 cancer cholesterol inflammation liver X receptor metabolism oxysterol Cholesterol plays an essential role in the stability and architecture of the plasma membrane, and as a precursor for bile acid and steroid hormone synthesis in mammals [ 1 ]. Under...
Articles
RAD-6: pyrimidine synthesis and radiation sensitivity in Caenorhabditis elegans
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Journal:
Biochemical Journal
Biochem J (2014) 458 (2): 343–353.
Published: 14 February 2014
... encoding de novo pathway enzymes cause varying degrees of lethality and pleiotropic phenotypes in many organisms, including humans. We have examined how the absence of rad-6 activity leads to both UV-C hypersensitivity and a decline in both metabolic rate and lifespan. We discuss how rad-6 mutants adapt...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 456 (2): 219–229.
Published: 08 November 2013
... gene have a glucose transport function in an oocyte expression system. We have named this gene fgt-1 (facilitated glucose transporter, isoform 1). We show that knockdown of fgt-1 RNA leads to loss of glucose transport and reduced glucose metabolism in wild-type worms. The FGT-1 glucose transporters...
Includes: Supplementary data
Articles
Alexia Chandor-Proust, Jaclyn Bibby, Myriam Régent-Kloeckner, Jessica Roux, Emilie Guittard-Crilat, Rodolphe Poupardin, Muhammad Asam Riaz, Mark Paine, Chantal Dauphin-Villemant, Stéphane Reynaud, Jean-Philippe David
Journal:
Biochemical Journal
Biochem J (2013) 455 (1): 75–85.
Published: 13 September 2013
... control programmes worldwide. Cytochrome P450 monooxygenases (CYPs) are known to play a major role in insecticide resistance, allowing resistant insects to metabolize insecticides at a higher rate. Among them, members of the mosquito CYP6Z subfamily, like Aedes aegypti CYP6Z8 and its Anopheles gambiae...
Includes: Supplementary data
Articles
PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli
Available to PurchaseLaura Novellasdemunt, Laurent Bultot, Anna Manzano, Francesc Ventura, Jose Luis Rosa, Didier Vertommen, Mark H. Rider, Àurea Navarro-Sabate, Ramon Bartrons
Journal:
Biochemical Journal
Biochem J (2013) 452 (3): 531–543.
Published: 31 May 2013
...-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is involved in cell proliferation owing to its role in carbohydrate metabolism. In the present study we analysed the mechanism of regulation of PFKFB3 as an immediate early gene controlled by stress stimuli that activates the p38...
Includes: Supplementary data
Articles
Inositol pyrophosphates: between signalling and metabolism
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Journal:
Biochemical Journal
Biochem J (2013) 452 (3): 369–379.
Published: 31 May 2013
... be found ubiquitously in eukaryotic cells. The enzymes that synthesize them are similarly well distributed and can be found encoded in any eukaryote genome. Rapid progress has been made in characterizing inositol pyrophosphate metabolism and they have been linked to a surprisingly diverse range of cellular...
Articles
YB-1: oncoprotein, prognostic marker and therapeutic target?
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Journal:
Biochemical Journal
Biochem J (2013) 449 (1): 11–23.
Published: 07 December 2012
... proliferation, survival, metabolism and metastasis (reviewed in [ 37 ]). The PI3K pathway also cross-talks with the E2F pathway discussed above, by modulating the pro-apoptotic functions of E2F1 [ 38 ]. YB-1 appears to be linked to, and plays an integral role within, the PI3K/Akt/mTOR pathway ( Figure 2...
Articles
Protein kinase Cβ is critical for the metabolic switch to glycolysis following B-cell antigen receptor engagement
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Journal:
Biochemical Journal
Biochem J (2012) 448 (1): 165–169.
Published: 18 October 2012
...Derek Blair; Fay J. Dufort; Thomas C. Chiles Signals derived from the BCR (B-cell antigen receptor) control survival, development and antigenic responses. One mechanism by which BCR signals may mediate these responses is by regulating cell metabolism. Indeed, the bioenergetic demands of naïve B...
Includes: Supplementary data
Articles
AMP-activated protein kinase: new regulation, new roles?
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Journal:
Biochemical Journal
Biochem J (2012) 445 (1): 11–27.
Published: 15 June 2012
... and cancer. Reflecting its key role in energy metabolism, AMPK has emerged as a potential therapeutic target. In the present review we examine the recent progress aimed at understanding the regulation of AMPK and discuss some of the latest developments that have emerged in key areas of human physiology where...
Articles
Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
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Journal:
Biochemical Journal
Biochem J (2012) 443 (1): 165–171.
Published: 14 March 2012
... in liver and its expression induces a metabolic state that mimics long-term fasting. Thus FGF21 is critical for the induction of hepatic fat oxidation, ketogenesis and gluconeogenesis, metabolic processes which are essential for the adaptive metabolic response to starvation. In the present study, we have...
Articles
Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells
Available to PurchaseLaura Novellasdemunt, Mercè Obach, Lluís Millán-Ariño, Anna Manzano, Francesc Ventura, Jose Luis Rosa, Albert Jordan, Àurea Navarro-Sabate, Ramon Bartrons
Journal:
Biochemical Journal
Biochem J (2012) 442 (2): 345–356.
Published: 13 February 2012
...), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is extensively involved in cell proliferation owing to its key role in carbohydrate metabolism. In the present study we analyse its mechanism of regulation by progestins in breast cancer cells. We report that exposure of T47D cells...
Articles
A critical role for citrate metabolism in LPS signalling
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Journal:
Biochemical Journal
Biochem J (2011) 438 (3): e5–e6.
Published: 26 August 2011
... such as TNF (tumour necrosis factor). Recently, a role for metabolic pathways in the regulation of LPS signalling has become a focus of research in inflammation. A notable example is LPS promoting the so-called Warburg effect – aerobic glycolysis. This allows for an up-regulation in ATP production, and also...
Articles
Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11β-hydroxysteroid dehydrogenase 1
Available to PurchaseAlex Odermatt, Thierry Da Cunha, Carlos A. Penno, Charlie Chandsawangbhuwana, Christian Reichert, Armin Wolf, Min Dong, Michael E. Baker
Journal:
Biochemical Journal
Biochem J (2011) 436 (3): 621–629.
Published: 27 May 2011
... in the ER (endoplasmic reticulum) and dependence on NADPH-generating H6PDH (hexose-6-phosphate dehydrogenase). Using recombinant human 11β-HSD1 (11β-hydroxysteroid dehydrogenase 1), we demonstrate efficient conversion of 7-oxoLCA into CDCA and, to a lesser extent, UDCA. Unlike the reversible metabolism...
Includes: Supplementary data
Articles
ER stress modulates cellular metabolism
Available to PurchaseXiaoli Wang, Colins O. Eno, Brian J. Altman, Yanglong Zhu, Guoping Zhao, Kristen E. Olberding, Jeffrey C. Rathmell, Chi Li
Journal:
Biochemical Journal
Biochem J (2011) 435 (1): 285–296.
Published: 15 March 2011
...Xiaoli Wang; Colins O. Eno; Brian J. Altman; Yanglong Zhu; Guoping Zhao; Kristen E. Olberding; Jeffrey C. Rathmell; Chi Li Changes in metabolic processes play a critical role in the survival or death of cells subjected to various stresses. In the present study, we have investigated the effects...
Includes: Supplementary data
Articles
Characterization of the xenobiotic response of Caenorhabditis elegans to the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites
Available to PurchaseSteven T. Laing, Al Ivens, Roz Laing, Sai Ravikumar, Victoria Butler, Debra J. Woods, John S. Gilleard
Journal:
Biochemical Journal
Biochem J (2010) 432 (3): 505–516.
Published: 25 November 2010
...Steven T. Laing; Al Ivens; Roz Laing; Sai Ravikumar; Victoria Butler; Debra J. Woods; John S. Gilleard Knowledge of how anthelmintics are metabolized and excreted in nematodes is an integral part of understanding the factors that determine their potency, spectrum of activity and for investigating...
Includes: Supplementary data
Articles
Wnt signalling and the control of cellular metabolism
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Journal:
Biochemical Journal
Biochem J (2010) 427 (1): 1–17.
Published: 15 March 2010
...Jaswinder K. Sethi; Antonio Vidal-Puig At the cellular level, the biological processes of cell proliferation, growth arrest, differentiation and apoptosis are all tightly coupled to appropriate alterations in metabolic status. In the case of cell proliferation, this requires redirecting metabolic...
Includes: Multimedia, Supplementary data
Articles
Inositol pyrophosphates modulate hydrogen peroxide signalling
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Journal:
Biochemical Journal
Biochem J (2009) 423 (1): 109–118.
Published: 14 September 2009
... modification of this evolutionarily conserved class of enzymes. inositol pyrophosphate inositol hexakisphosphate kinase (IP6K) Kcs1 metabolism Rad53 reactive oxygen species (ROS) 1 To whom correspondence should be addressed (email [email protected] ). 9 2 2009 14 7 2009 17...
Articles
Wnt signalling at the crossroads of nutritional regulation
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Journal:
Biochemical Journal
Biochem J (2008) 416 (2): e11–e13.
Published: 12 November 2008
... of the entire organ. Yet what is clear is that when such mechanisms fail or become inappropriately active they can lead to dire consequences such as diabetes, metabolic syndromes, cardiovascular diseases and cancer. In this issue of the Biochemical Journal , Anagnostou and Shepherd report the identification...
Articles
Structure, mechanism and regulation of pyruvate carboxylase
Available to PurchaseSarawut Jitrapakdee, Martin St Maurice, Ivan Rayment, W. Wallace Cleland, John C. Wallace, Paul V. Attwood
Journal:
Biochemical Journal
Biochem J (2008) 413 (3): 369–387.
Published: 15 July 2008
... reaction, replenishing oxaloacetate withdrawn from the tricarboxylic acid cycle for various pivotal biochemical pathways. PC is therefore considered as an enzyme that is crucial for intermediary metabolism, controlling fuel partitioning toward gluconeogenesis or lipogenesis and in insulin secretion...
Articles
Lactate favours the dissociation of skeletal muscle 6-phosphofructo-1-kinase tetramers down-regulating the enzyme and muscle glycolysis
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2007) 408 (1): 123–130.
Published: 29 October 2007
... metabolism within cells. PFK (6-phosphofructo-1-kinase) is the key regulatory glycolytic enzyme which is regulated by diverse molecules and signals. PFK activity is directly correlated with cellular glucose consumption. The present study shows the property of lactate to down-regulate PFK activity...
Articles
Ca 2+ , NAD(P)H and membrane potential changes in pancreatic β-cells by methyl succinate: comparison with glucose
Available to PurchaseEmma Heart, Gordon C. Yaney, Richard F. Corkey, Vera Schultz, Esthere Luc, Lihan Liu, Jude T. Deeney, Orian Shirihai, Keith Tornheim, Peter J. S. Smith, Barbara E. Corkey
Journal:
Biochemical Journal
Biochem J (2007) 403 (1): 197–205.
Published: 13 March 2007
...Emma Heart; Gordon C. Yaney; Richard F. Corkey; Vera Schultz; Esthere Luc; Lihan Liu; Jude T. Deeney; Orian Shirihai; Keith Tornheim; Peter J. S. Smith; Barbara E. Corkey The present study was undertaken to determine the main metabolic secretory signals generated by the mitochondrial substrate MeS...
Articles
Richard K. Hughes, Eric J. Belfield, Mylrajan Muthusamay, Anuja Khan, Arthur Rowe, Stephen E. Harding, Shirley A. Fairhurst, Stephen Bornemann, Ruth Ashton, Roger N. F. Thorneley, Rod Casey
Journal:
Biochemical Journal
Biochem J (2006) 395 (3): 641–652.
Published: 11 April 2006
... Society, London 2006 cytochrome P450 haem hydroperoxide metabolism micelle oxylipin Cytochrome P450 enzymes are widespread in Nature, but members of the CYP74 (cytochrome P450 subfamily 74) subfamily of these enzymes, which are common in plants, have not been studied extensively. CYP74...
Includes: Supplementary data
Articles
Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence
Available to PurchaseWerner ZWERSCHKE, Sybille MAZUREK, Petra STÖCKL, Eveline HÜTTER, Erich EIGENBRODT, Pidder JANSEN-DÜRR
Journal:
Biochemical Journal
Biochem J (2003) 376 (2): 403–411.
Published: 01 December 2003
... premature senescence, reactive oxygen species are considered important intermediates contributing to the phenotype. Moreover, distinct alterations of the cellular carbohydrate metabolism are known to contribute to oncogenic transformation, as is best documented for the phenomenon of aerobic glycolysis...
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