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1-14 of 14
Keywords: metabolomics
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Articles
In Collection
Towards systems biochemistry
Journal:
Biochemical Journal
Biochem J (2023) 480 (12): 891–908.
Published: 28 June 2023
...Howbeer Muhamadali; Catherine L. Winder; Warwick B. Dunn; Royston Goodacre Metabolomics is a powerful research discovery tool with the potential to measure hundreds to low thousands of metabolites. In this review, we discuss the application of GC–MS and LC–MS in discovery-based metabolomics...
Articles
Hiroko Otsuka, Hisashi Yokomizo, Shintaro Nakamura, Yoshihiro Izumi, Masatomo Takahashi, Sachiko Obara, Motonao Nakao, Yosuke Ikeda, Naoichi Sato, Ryuichi Sakamoto, Yasutaka Miyachi, Takashi Miyazawa, Takeshi Bamba, Yoshihiro Ogawa
Journal:
Biochemical Journal
Biochem J (2022) 479 (3): 425–444.
Published: 11 February 2022
... slow and fast muscle mass is maintained. When the amount of food in CANA-treated mice is adjusted to that in vehicle-treated mice, fast muscle mass and function are reduced, but slow muscle was unaffected during SGLT2 inhibition. In metabolome analysis, glycolytic metabolites and ATP are increased...
Includes: Supplementary data
Articles
In Collection
Towards systems biochemistry
Journal:
Biochemical Journal
Biochem J (2021) 478 (20): 3685–3721.
Published: 21 October 2021
... by the participation of University of Liverpool in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. flux host metabolomics optimisation proteomics transcriptomics Much of microbial biotechnology consists...
Articles
Chen Li, Yan Niu, Hong Zheng, Congjia Shan, Qinbo Chen, Zhongzhou Yang, Liangcai Zhao, Changwei Yang, Hongchang Gao
Journal:
Biochemical Journal
Biochem J (2019) 476 (13): 1943–1954.
Published: 09 July 2019
... (PDK1) caused severe and lethal HF; however, the metabolic pattern of PDK1 deletion remains ambiguous. 1 H nuclear magnetic resonance-based metabolomics was applied to explore the altered metabolic pattern in Pdk1- deficient mice. Principle component analysis showed significant separation as early as 4...
Articles
Journal:
Biochemical Journal
Biochem J (2018) 475 (10): 1789–1791.
Published: 31 May 2018
... of conditions underlying metabolic syndrome is still inadequate. In a recent paper published in the Biochemical Journal [ Biochem. J. (2018) 475, 1019–1035], Candi et al. address this lack of knowledge, performing high-throughput metabolomics analysis of visceral fat isolated from obese individuals...
Articles
In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Eleonora Candi, Manfredi Tesauro, Carmine Cardillo, Anna Maria Lena, Francesca Schinzari, Giuseppe Rodia, Giuseppe Sica, Paolo Gentileschi, Valentina Rovella, Margherita Annicchiarico-Petruzzelli, Nicola Di Daniele, Gerry Melino
Journal:
Biochemical Journal
Biochem J (2018) 475 (5): 1019–1035.
Published: 15 March 2018
... spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS/MS) analyses were used to obtain the untargeted VAT metabolomic profiles of 481 metabolites belonging to all biochemical pathways. Our results indicated consistent increases in oxidative stress markers from the pathologically obese samples...
Includes: Supplementary data
Articles
Andrew A. Gibb, Pawel K. Lorkiewicz, Yu-Ting Zheng, Xiang Zhang, Aruni Bhatnagar, Steven P. Jones, Bradford G. Hill
Journal:
Biochemical Journal
Biochem J (2017) 474 (16): 2785–2801.
Published: 07 August 2017
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . cardiac hypertrophy glycolysis heart failure metabolomics mitochondria stable isotope All values are mean ± SEM. All comparisons were made to the relevant control group and performed...
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (21): 3871–3888.
Published: 27 October 2016
...). † Mean CGG expansion ± SD = 31 ± 5 and 103 ± 40, respectively, for controls and carriers ( P ≤ 0.0001). ‡ Female-to-male ratio = 1.3 and 1.1, respectively, for the control and premutation groups ( χ 2 P = 0.802). The protocol for plasma metabolomics was reported in detail recently [ 30...
Includes: Supplementary data
Articles
Annalaura Mastrangelo, María I. Panadero, Laura M. Pérez, Beatriz G. Gálvez, Antonia García, Coral Barbas, Francisco J. Rupérez
Journal:
Biochemical Journal
Biochem J (2016) 473 (14): 2187–2203.
Published: 12 July 2016
... understood. In the present study we used a multiplatform [LC/MS, GC/MS and capillary electrophoresis/MS (CE/MS)], metabolomics, untargeted approach to investigate the metabolic alteration underlying the inequalities observed in obesity-derived ASCs. The metabolic fingerprint (metabolites within the cells...
Includes: Supplementary data
Articles
Guo-Fang Zhang, Sushabhan Sadhukhan, Rafael A. Ibarra, Stephanie M. Lauden, Chia-Ying Chuang, Sophia Sushailo, Priya Chatterjee, Vernon E. Anderson, Gregory P. Tochtrop, Henri Brunengraber
Journal:
Biochemical Journal
Biochem J (2012) 444 (2): 333–341.
Published: 11 May 2012
... the catabolism of this compound in perfused rat livers. Using a combination of metabolomics and mass isotopomer analysis, we showed that GHB is metabolized by multiple processes, in addition to its previously reported metabolism in the citric acid cycle via oxidation to succinate. A substrate cycle operates...
Articles
Anne Roobol, Jo Roobol, Martin J. Carden, Amandine Bastide, Anne E. Willis, Warwick B. Dunn, Royston Goodacre, C. Mark Smales
Journal:
Biochemical Journal
Biochem J (2011) 435 (2): 499–508.
Published: 29 March 2011
... kinase (ATR) Chinese-hamster ovary cell (CHO cell) cold shock hypothermia lipidomics metabolomics p53 Under mildly hypothermic conditions (31–33 °C), mammalian cells proliferate slowly [ 1 ] and generally attenuate the processes of transcription and mRNA translation [ 2 ] (although protein...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 409 (1): 27–41.
Published: 11 December 2007
... to further our understanding of network regulation. Arabidopsis metabolic control metabolic flux metabolomics plant metabolic network subcellular compartmentation 1 To whom correspondence should be addressed (email [email protected] ). 14 8 2007 11 9 2007 14...
Articles
Peter S. Solomon, Ormonde D. C. Waters, Cordula I. Jörgens, Rohan G. T. Lowe, Judith Rechberger, Robert D. Trengove, Richard P. Oliver
Journal:
Biochemical Journal
Biochem J (2006) 399 (2): 231–239.
Published: 27 September 2006
... demonstrated in a large number of fungal species, and it was proposed that they formed an enzymic cycle [ 15 ]. While this theory has been disputed [ 16 ], there is growing evidence that this cycle does exist, but is awaiting positive proof [ 8 ]. mannitol metabolomics primary fungal metabolism...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2005) 388 (2): 669–677.
Published: 24 May 2005
... derivatization method for metabolome analysis of yeast, coupled to data-mining software that achieve comparable throughput, effort and cost compared with DNA arrays. Our sample workup method enables simultaneous metabolite measurements throughout central carbon metabolism and amino acid biosynthesis, using...