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Keywords: metastasis
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Articles
Biochem J (2024) 481 (24): 1877–1900.
Published: 09 December 2024
... cancer stemness and achieve a definitive cure remains elusive. CD44, a well-defined cancer stem cell (CSC) marker is reported to promote breast cancer tumorigenesis, metastasis, and chemoresistance. However, mechanisms leading to its enhanced expression and function is poorly understood. Here, we...
Includes: Supplementary data
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Biochem J (2022) 479 (11): 1149–1164.
Published: 08 June 2022
..., providing protection against natural killer (NK) cell killing activity. We utilized small interfering RNA (siRNA) to down-regulate UCKL-1 in vitro and in vivo to determine the effect of UCKL-1 on tumor growth and metastasis. The down-regulation of UCKL-1 in YAC-1 lymphoma cells in vitro resulted...
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Biochem J (2021) 478 (12): 2265–2283.
Published: 18 June 2021
... supernatants from tumor cells have significantly higher amounts of secreted calnuc compared to non-tumor cells, selectively packaged into exosomes. Exosomal calnuc is causal for epithelial–mesenchymal transition and atypical migration in non-tumor cells, which are key events in tumorigenesis and metastasis...
Includes: Supplementary data
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Biochem J (2021) 478 (9): 1809–1825.
Published: 14 May 2021
... that have been co-opted by cancer cells to undergo tumor metastasis. These processes are regulated at multiple instances, whereas the post-transcriptional regulation of key genes mediated by microRNAs is gaining major attention as a common and conserved pathway. In this review, we focus on discussing...
Articles
Biochem J (2021) 478 (3): 597–617.
Published: 12 February 2021
... and systemically. Recently, a new concept has emerged to better describe this process by defining four attributes that metastatic cells should undergo. Every individual hallmark represents a unique trait of a metastatic cell that impacts directly in the outcome of the metastasis process. These critical features...
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Biochem J (2020) 477 (6): 1159–1178.
Published: 27 March 2020
...Min Du; Guozheng Wang; Igor L. Barsukov; Stephane R. Gross; Richard Smith; Philip S. Rudland Overexpression of S100P promotes breast cancer metastasis in animals and elevated levels in primary breast cancers are associated with poor patient outcomes. S100P can differentially interact with nonmuscle...
Includes: Supplementary data
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Biochem J (2019) 476 (16): 2321–2346.
Published: 28 August 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 4-kinase Golgi apparatus lipid metabolism metastasis phosphatidylinositol PI4P Phosphoinositides, also known as inositol phospholipids or PIPs, regulate a vast array of cellular functions including receptor-mediated...
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Biochem J (2017) 474 (19): 3227–3240.
Published: 12 September 2017
...Christopher J. Clarke; Stephane R. Gross; Thamir M. Ismail; Philip S. Rudland; Morteta Al-Medhtiy; Michael Santangeli; Roger Barraclough S100P protein in human breast cancer cells is associated with reduced patient survival and, in a model system of metastasis, it confers a metastatic phenotype...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (1): 21–45.
Published: 22 December 2016
... of signals between cancer and resident stromal cells to facilitate tumorigenesis and metastasis. An important step of the metastatic cascade is the reprogramming of cancer cells from an epithelial to mesenchymal phenotype (epithelial–mesenchymal transition, EMT), which is associated with increased...
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Biochem J (2016) 473 (11): 1629–1640.
Published: 27 May 2016
...) is an E3 ubiquitin ligase which has been implicated in various cancers but its role in H. pylori -mediated gastric carcinogenesis has not been established. We investigated the involvement of Siah2 in gastric cancer metastasis which was assessed by invasiveness and migration of H. pylori -infected gastric...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (6): 703–715.
Published: 10 March 2016
... environments, particularly with regard to oxygen and nutrient availability. Our results indicate that progression to metastasis requires mitochondrial function. Our research, centered on cell lines that display increasing degrees of malignancy, focused on metabolic events, especially those involving...
Includes: Supplementary data
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Biochem J (2016) 473 (4): 449–461.
Published: 09 February 2016
... regulation of FABP5 gene expression plays an important role during human prostate carcinogenesis, along with up-regulation of c-Myc and Sp1. DNA methylation epigenetics fatty-acid-binding proteins (FABPs) FABP5 metastasis prostate cancer To quantitate the DNA methylation level...
Includes: Supplementary data
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Biochem J (2016) 473 (1): 31–42.
Published: 09 December 2015
... and include matrix remodelling, adhesion and migration. S100A4 belongs to the Ca 2+ -binding EF-hand S100 protein family and acts both intra- and extra-cellularly through binding to various partners. It regulates cell migration and its overexpression is strongly associated with metastasis and poor survival...
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Biochem J (2015) 465 (1): 89–101.
Published: 12 December 2014
...Fauzia Chaudhary; Robert Lucito; Nicholas K. Tonks MIM (Missing-in-Metastasis), also known as MTSS1 (metastasis suppressor 1), is a scaffold protein that is down-regulated in multiple metastatic cancer cell lines compared with non-metastatic counterparts. MIM regulates cytoskeletal dynamics...
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Biochem J (2014) 463 (1): 157–165.
Published: 08 September 2014
... signalling axis to be capable of influencing growth, invasion, metastasis and even the therapeutic response of breast cancer. autotaxin breast cancer lysophosphatidic acid metastasis therapy Breast cancer is the most common malignancy among women worldwide, with an estimated 1.7 million...
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Biochem J (2010) 426 (3): 327–335.
Published: 24 February 2010
...Isao Matsuura; Chen-Yu Lai; Keng-Nan Chiang TGF-β (transforming growth factor-β) induces a cytostatic response in most normal cell types. In cancer cells, however, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we show that S100A4...
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Biochem J (2010) 425 (2): 361–371.
Published: 23 December 2009
... vascular endothelial growth factor, and the activity of matrix metalloproteinase-2. Lung metastasis of intravenously injected LLC cells was also significantly less obvious in mPGES-1-null mice than in wild-type mice. Thus our present approaches provide unequivocal evidence for critical roles of the mPGES-1...
Includes: Supplementary data
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Biochem J (2008) 409 (3): 635–649.
Published: 15 January 2008
.... There is now overwhelming evidence that chemokines are also involved in the progression of cancer, where they function in several capacities. First, specific chemokine–receptor pairs are involved in tumour metastasis. This is not surprising, in view of their role as chemoattractants in cell migration. Secondly...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2007) 407 (2): 199–205.
Published: 25 September 2007
...Sabine Middelhaufe; Livia Garzia; Uta-Maria Ohndorf; Barbara Kachholz; Massimo Zollo; Clemens Steegborn The human orthologue of the Drosophila prune protein (h-Prune) is an interaction partner and regulator of the metastasis suppressor protein NM23-H1 (non-metastatic protein 23). Studies...
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Biochem J (2005) 388 (3): 967–972.
Published: 07 June 2005
... and malignant cell types. Previous in vitro studies on prostate cancer cells suggest a role for PAR-2 in prostate cancer metastasis. A polyclonal anti-human TMPRSS2 antibody was generated against the TMPRSS2 serine protease domain. The antibody showed specific reactivity with recombinant expressed TMPRSS2...
Articles
Biochem J (2003) 374 (3): 715–722.
Published: 15 September 2003
... to stimulation of cell migration, particularly at the lower S1P concentrations. Treatment of B16F10 cells with S1P inhibited lung metastasis 3 weeks after injection into mouse tail veins. Intriguingly, overexpression of S1P 2 greatly potentiated the inhibition of metastasis by S1P, whereas that of S1P 1 resulted...
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Biochem J (2003) 371 (2): 463–471.
Published: 15 April 2003
...Jacquelyn A. WOODINGS; Stewart J. SHARP; Laura M. MACHESKY We have found that MIM-B, a putative metastasis suppressor protein, is implicated in actin cytoskeletal control and interaction with a protein tyrosine phosphatase (PTP). MIM was originally described as a protein whose mRNA was M issing i n...
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Biochem J (2002) 363 (1): 137–145.
Published: 22 March 2002
..., London ©2002 2002 leucine-rich repeat protein metastasis oncotrophoblast antigen oligosaccharide tumour-associated antigen Abbreviations used: 2-AB, 2-aminobenzamide; ECL ® (Amersham Biosciences), enhanced chemiluminescence; GU, glucose units; HPAEC—PAD, high-pH anion-exchange...
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Biochem J (2000) 346 (3): 623–630.
Published: 07 March 2000
...Paul D. WAGNER; Ngoc-Diep VU nm23 genes have been implicated in the suppression of tumour metastasis and cell motility; however, the biochemical mechanisms for these suppressions are not known. We have previously described the transfer of phosphate from the catalytic histidine residues of nm23...
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Biochem J (1999) 342 (2): 361–368.
Published: 24 August 1999
... specificities, peptide sequences and immunoreactivities, we propose that heparanase activities present in human platelets, rat liver and in rat and human tumour cells are, in fact, mediated by a similar enzyme. Key words: cancer, ECM degradation, heparan sulphate, hep- arin, metastasis. both heparin and HS...