Page 1 | Search Results | Biochemical Journal

1-30 of 30

Sort by

Sort Order Select

Articles

USP10 deubiquitinates and stabilizes CD44 leading to enhanced breast cancer cell proliferation, stemness and metastasis

Arppita Sethi, Shivkant Mishra, Vishal Upadhyay, Parul Dubey, Shumaila Siddiqui, Anil Kumar Singh, Sangita Chowdhury, Swati Srivastava, Pragya Srivastava, Prasannajit Sahoo, Madan L. B. Bhatt, Anand Mishra, Arun Kumar Trivedi

Biochem J (2024) 481 (24): 1877–1900.

https://doi.org/10.1042/BCJ20240611

Published: 09 December 2024

... cancer stemness and achieve a definitive cure remains elusive. CD44, a well-defined cancer stem cell (CSC) marker is reported to promote breast cancer tumorigenesis, metastasis, and chemoresistance. However, mechanisms leading to its enhanced expression and function is poorly understood. Here, we...

View article titled, USP10 deubiquitinates and stabilizes CD44 leading to enhanced breast cancer cell proliferation, stemness and metastasis

Includes: Supplementary data

Articles

Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth

Emily C. Matchett, Elise C. Ambrose, Jacki Kornbluth

Biochem J (2022) 479 (11): 1149–1164.

https://doi.org/10.1042/BCJ20210770

Published: 08 June 2022

..., providing protection against natural killer (NK) cell killing activity. We utilized small interfering RNA (siRNA) to down-regulate UCKL-1 in vitro and in vivo to determine the effect of UCKL-1 on tumor growth and metastasis. The down-regulation of UCKL-1 in YAC-1 lymphoma cells in vitro resulted...

View article titled, Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth

Articles

Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer

Bradley K. Schniers, Mitchell S. Wachtel, Meenu Sharma, Ksenija Korac, Devaraja Rajasekaran, Shengping Yang, Tyler Sniegowski, Vadivel Ganapathy, Yangzom D. Bhutia

Biochem J (2022) 479 (5): 719–730.

https://doi.org/10.1042/BCJ20210855

Published: 16 March 2022

.... In fact, some of the AATs are actually down-regulated in response to Slc6a14 deletion, most likely related to altered mTORC1 signaling. Taken together, these results underscore the positive role SLC6A14 plays in PDAC growth and metastasis. Therefore, SLC6A14 is a viable drug target for the treatment...

View article titled, Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer

Articles

Aberrant environment and PS-binding to calnuc C-terminal tail drives exosomal packaging and its metastatic ability

Ravichandran Vignesh, Anita Sjölander, Ganesh Venkatraman, Suresh Kumar Rayala, Gopala Krishna Aradhyam

Biochem J (2021) 478 (12): 2265–2283.

https://doi.org/10.1042/BCJ20210016

Published: 18 June 2021

... supernatants from tumor cells have significantly higher amounts of secreted calnuc compared to non-tumor cells, selectively packaged into exosomes. Exosomal calnuc is causal for epithelial–mesenchymal transition and atypical migration in non-tumor cells, which are key events in tumorigenesis and metastasis...

View article titled, Aberrant environment and PS-binding to calnuc C-terminal tail drives exosomal packaging and its metastatic ability

Includes: Supplementary data

Articles

What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression

Yanel Bernardi, Pablo Hernán Strobl-Mazzulla

Biochem J (2021) 478 (9): 1809–1825.

https://doi.org/10.1042/BCJ20210083

Published: 14 May 2021

... that have been co-opted by cancer cells to undergo tumor metastasis. These processes are regulated at multiple instances, whereas the post-transcriptional regulation of key genes mediated by microRNAs is gaining major attention as a common and conserved pathway. In this review, we focus on discussing...

View article titled, What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression

Articles

Reprogramming the tumor metastasis cascade by targeting galectin-driven networks

Ramiro M. Perrotta, Camila A. Bach, Mariana Salatino, Gabriel A. Rabinovich

Biochem J (2021) 478 (3): 597–617.

https://doi.org/10.1042/BCJ20200167

Published: 12 February 2021

... and systemically. Recently, a new concept has emerged to better describe this process by defining four attributes that metastatic cells should undergo. Every individual hallmark represents a unique trait of a metastatic cell that impacts directly in the outcome of the metastasis process. These critical features...

View article titled, Reprogramming the tumor metastasis cascade by targeting galectin-driven networks

Articles

Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion

Min Du, Guozheng Wang, Igor L. Barsukov, Stephane R. Gross, Richard Smith, Philip S. Rudland

Biochem J (2020) 477 (6): 1159–1178.

https://doi.org/10.1042/BCJ20190644

Published: 27 March 2020

...Min Du; Guozheng Wang; Igor L. Barsukov; Stephane R. Gross; Richard Smith; Philip S. Rudland Overexpression of S100P promotes breast cancer metastasis in animals and elevated levels in primary breast cancers are associated with poor patient outcomes. S100P can differentially interact with nonmuscle...

View article titled, Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion

Includes: Supplementary data

Articles

The Great Escape: how phosphatidylinositol 4-kinases and PI4P promote vesicle exit from the Golgi (and drive cancer)

Mark G. Waugh

Biochem J (2019) 476 (16): 2321–2346.

https://doi.org/10.1042/BCJ20180622

Published: 28 August 2019

... by Portland Press Limited on behalf of the Biochemical Society 2019 4-kinase Golgi apparatus lipid metabolism metastasis phosphatidylinositol PI4P Phosphoinositides, also known as inositol phospholipids or PIPs, regulate a vast array of cellular functions including receptor-mediated...

View article titled, The Great Escape: how phosphatidylinositol 4-kinases and PI4P promote vesicle exit from the Golgi (and drive cancer)

Articles

Activation of tissue plasminogen activator by metastasis-inducing S100P protein

Christopher J. Clarke, Stephane R. Gross, Thamir M. Ismail, Philip S. Rudland, Morteta Al-Medhtiy, Michael Santangeli, Roger Barraclough

Biochem J (2017) 474 (19): 3227–3240.

https://doi.org/10.1042/BCJ20170578

Published: 12 September 2017

...Christopher J. Clarke; Stephane R. Gross; Thamir M. Ismail; Philip S. Rudland; Morteta Al-Medhtiy; Michael Santangeli; Roger Barraclough S100P protein in human breast cancer cells is associated with reduced patient survival and, in a model system of metastasis, it confers a metastatic phenotype...

View article titled, Activation of tissue plasminogen activator by metastasis-inducing S100P protein

Includes: Supplementary data

Articles

Extracellular vesicles: their role in cancer biology and epithelial–mesenchymal transition

Shashi K. Gopal, David W. Greening, Alin Rai, Maoshan Chen, Rong Xu, Adnan Shafiq, Rommel A. Mathias, Hong-Jian Zhu, Richard J. Simpson

Biochem J (2017) 474 (1): 21–45.

https://doi.org/10.1042/BCJ20160006

Published: 22 December 2016

... of signals between cancer and resident stromal cells to facilitate tumorigenesis and metastasis. An important step of the metastatic cascade is the reprogramming of cancer cells from an epithelial to mesenchymal phenotype (epithelial–mesenchymal transition, EMT), which is associated with increased...

View article titled, Extracellular vesicles: their role in cancer biology and epithelial–mesenchymal transition

Articles

ETS2 and Twist1 promote invasiveness of Helicobacter pylori -infected gastric cancer cells by inducing Siah2

Lopamudra Das, Shrikant Babanrao Kokate, Suvasmita Rath, Niranjan Rout, Shivaram Prasad Singh, Sheila Eileen Crowe, Asish K. Mukhopadhyay, Asima Bhattacharyya

Biochem J (2016) 473 (11): 1629–1640.

https://doi.org/10.1042/BCJ20160187

Published: 27 May 2016

...) is an E3 ubiquitin ligase which has been implicated in various cancers but its role in H. pylori -mediated gastric carcinogenesis has not been established. We investigated the involvement of Siah2 in gastric cancer metastasis which was assessed by invasiveness and migration of H. pylori -infected gastric...

View article titled, ETS2 and Twist1 promote invasiveness of Helicobacter pylori -infected gastric cancer cells by inducing Siah2

Includes: Supplementary data

Articles

Enhanced OXPHOS, glutaminolysis and β-oxidation constitute the metastatic phenotype of melanoma cells

Mariana F. Rodrigues, Emilie Obre, Fabiana H.M. de Melo, Gilson C. Santos, Jr, Antonio Galina, Miriam G. Jasiulionis, Rodrigue Rossignol, Franklin D. Rumjanek, Nivea D. Amoêdo

Biochem J (2016) 473 (6): 703–715.

https://doi.org/10.1042/BJ20150645

Published: 10 March 2016

... environments, particularly with regard to oxygen and nutrient availability. Our results indicate that progression to metastasis requires mitochondrial function. Our research, centered on cell lines that display increasing degrees of malignancy, focused on metabolic events, especially those involving...

View article titled, Enhanced OXPHOS, glutaminolysis and β-oxidation constitute the metastatic phenotype of melanoma cells

Includes: Supplementary data

Articles

The cancer-promoting gene fatty acid-binding protein 5 ( FABP5 ) is epigenetically regulated during human prostate carcinogenesis

Koichiro Kawaguchi, Ayumi Kinameri, Shunsuke Suzuki, Shogo Senga, Youqiang Ke, Hiroshi Fujii

Biochem J (2016) 473 (4): 449–461.

https://doi.org/10.1042/BJ20150926

Published: 09 February 2016

... regulation of FABP5 gene expression plays an important role during human prostate carcinogenesis, along with up-regulation of c-Myc and Sp1. DNA methylation epigenetics fatty-acid-binding proteins (FABPs) FABP5 metastasis prostate cancer To quantitate the DNA methylation level...

View article titled, The cancer-promoting gene fatty acid-binding protein 5 ( FABP5 ) is epigenetically regulated during human prostate carcinogenesis

Includes: Supplementary data

Articles

Metastasis-associated S100A4 is a specific amine donor and an activity-independent binding partner of transglutaminase-2

Beáta Biri, Bence Kiss, Róbert Király, Gitta Schlosser, Orsolya Láng, László Kőhidai, László Fésüs, László Nyitray

Biochem J (2016) 473 (1): 31–42.

https://doi.org/10.1042/BJ20150843

Published: 09 December 2015

... and include matrix remodelling, adhesion and migration. S100A4 belongs to the Ca 2+ -binding EF-hand S100 protein family and acts both intra- and extra-cellularly through binding to various partners. It regulates cell migration and its overexpression is strongly associated with metastasis and poor survival...

View article titled, Metastasis-associated S100A4 is a specific amine donor and an activity-independent binding partner of transglutaminase-2

Articles

Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity

Fauzia Chaudhary, Robert Lucito, Nicholas K. Tonks

Biochem J (2015) 465 (1): 89–101.

https://doi.org/10.1042/BJ20140573

Published: 12 December 2014

...Fauzia Chaudhary; Robert Lucito; Nicholas K. Tonks MIM (Missing-in-Metastasis), also known as MTSS1 (metastasis suppressor 1), is a scaffold protein that is down-regulated in multiple metastatic cancer cell lines compared with non-metastatic counterparts. MIM regulates cytoskeletal dynamics...

View article titled, Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity

Articles

The role and therapeutic potential of the autotaxin–lysophosphatidate signalling axis in breast cancer

Katy Teo, Valerie G. Brunton

Biochem J (2014) 463 (1): 157–165.

https://doi.org/10.1042/BJ20140680

Published: 08 September 2014

... signalling axis to be capable of influencing growth, invasion, metastasis and even the therapeutic response of breast cancer. autotaxin breast cancer lysophosphatidic acid metastasis therapy Breast cancer is the most common malignancy among women worldwide, with an estimated 1.7 million...

View article titled, The role and therapeutic potential of the autotaxin–lysophosphatidate signalling axis in breast cancer

Articles

Functional interaction between Smad3 and S100A4 (metastatin-1) for TGF-β-mediated cancer cell invasiveness

Isao Matsuura, Chen-Yu Lai, Keng-Nan Chiang

Biochem J (2010) 426 (3): 327–335.

https://doi.org/10.1042/BJ20090990

Published: 24 February 2010

...Isao Matsuura; Chen-Yu Lai; Keng-Nan Chiang TGF-β (transforming growth factor-β) induces a cytostatic response in most normal cell types. In cancer cells, however, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we show that S100A4...

View article titled, Functional interaction between Smad3 and S100A4 (metastatin-1) for TGF-β-mediated cancer cell invasiveness

Articles

Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis

Daisuke Kamei, Makoto Murakami, Yuka Sasaki, Yoshihito Nakatani, Masataka Majima, Yukio Ishikawa, Toshiharu Ishii, Satoshi Uematsu, Shizuo Akira, Shuntaro Hara, Ichiro Kudo

Biochem J (2010) 425 (2): 361–371.

https://doi.org/10.1042/BJ20090045

Published: 23 December 2009

... vascular endothelial growth factor, and the activity of matrix metalloproteinase-2. Lung metastasis of intravenously injected LLC cells was also significantly less obvious in mPGES-1-null mice than in wild-type mice. Thus our present approaches provide unequivocal evidence for critical roles of the mPGES-1...

View article titled, Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis

Includes: Supplementary data

Articles

A cyclic peptidylic inhibitor of murine urokinase-type plasminogen activator: changing species specificity by substitution of a single residue

Lisbeth M. Andersen, Troels Wind, Hanne D. Hansen, Peter A. Andreasen

Biochem J (2008) 412 (3): 447–457.

https://doi.org/10.1042/BJ20071646

Published: 28 May 2008

... validation in murine model systems. cancer metastasis peptide phage display serine protease urokinase-type plasminogen activator (uPA) Serine proteases of the trypsin family (clan SA) have many physiological and pathophysiological functions. There is therefore extensive interest in generating...

View article titled, A cyclic peptidylic inhibitor of murine urokinase-type plasminogen activator: changing species specificity by substitution of a single residue

Articles

Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment

Morgan O'Hayre, Catherina L. Salanga, Tracy M. Handel, Samantha J. Allen

Biochem J (2008) 409 (3): 635–649.

https://doi.org/10.1042/BJ20071493

Published: 15 January 2008

.... There is now overwhelming evidence that chemokines are also involved in the progression of cancer, where they function in several capacities. First, specific chemokine–receptor pairs are involved in tumour metastasis. This is not surprising, in view of their role as chemoattractants in cell migration. Secondly...

View article titled, Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment

Includes: Multimedia, Supplementary data

Articles

Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain

Sabine Middelhaufe, Livia Garzia, Uta-Maria Ohndorf, Barbara Kachholz, Massimo Zollo, Clemens Steegborn

Biochem J (2007) 407 (2): 199–205.

https://doi.org/10.1042/BJ20070408

Published: 25 September 2007

...Sabine Middelhaufe; Livia Garzia; Uta-Maria Ohndorf; Barbara Kachholz; Massimo Zollo; Clemens Steegborn The human orthologue of the Drosophila prune protein (h-Prune) is an interaction partner and regulator of the metastasis suppressor protein NM23-H1 (non-metastatic protein 23). Studies...

View article titled, Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain

Articles

The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells

Susan WILSON, Brett GREER, John HOOPER, Andries ZIJLSTRA, Brian WALKER, James QUIGLEY, Susan HAWTHORNE

Biochem J (2005) 388 (3): 967–972.

https://doi.org/10.1042/BJ20041066

Published: 07 June 2005

... and malignant cell types. Previous in vitro studies on prostate cancer cells suggest a role for PAR-2 in prostate cancer metastasis. A polyclonal anti-human TMPRSS2 antibody was generated against the TMPRSS2 serine protease domain. The antibody showed specific reactivity with recombinant expressed TMPRSS2...

View article titled, The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells

Articles

Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells

Hironori YAMAGUCHI, Joji KITAYAMA, Noriko TAKUWA, Kayo ARIKAWA, Isao INOKI, Kazuhiko TAKEHARA, Hirokazu NAGAWA, Yoh TAKUWA

Biochem J (2003) 374 (3): 715–722.

https://doi.org/10.1042/bj20030381

Published: 15 September 2003

... to stimulation of cell migration, particularly at the lower S1P concentrations. Treatment of B16F10 cells with S1P inhibited lung metastasis 3 weeks after injection into mouse tail veins. Intriguingly, overexpression of S1P 2 greatly potentiated the inhibition of metastasis by S1P, whereas that of S1P 1 resulted...

View article titled, Sphingosine-1-phosphate receptor subtype-specific positive and negative regulation of Rac and haematogenous metastasis of melanoma cells

Articles

MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta

Jacquelyn A. WOODINGS, Stewart J. SHARP, Laura M. MACHESKY

Biochem J (2003) 371 (2): 463–471.

https://doi.org/10.1042/bj20021962

Published: 15 April 2003

...Jacquelyn A. WOODINGS; Stewart J. SHARP; Laura M. MACHESKY We have found that MIM-B, a putative metastasis suppressor protein, is implicated in actin cytoskeletal control and interaction with a protein tyrosine phosphatase (PTP). MIM was originally described as a protein whose mRNA was M issing i n...

View article titled, MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta

Articles

Fine specificity of domain-I of recombinant tandem-repeat-type galectin-4 from rat gastrointestinal tract (G4-N)

Albert M. WU, June H. WU, Ming-Sung TSAI, Jia-Hau LIU, Sabine ANDRÉ, Kojiro WASANO, Herbert KALTNER, Hans-Joachim GABIUS

Biochem J (2002) 367 (3): 653–664.

https://doi.org/10.1042/bj20020600

Published: 01 November 2002

... correspondence should be addressed (e-mail [email protected] ). 16 4 2002 9 7 2002 22 7 2002 22 7 2002 The Biochemical Society, London ©2002 2002 enterocyte lacto- N -tetraose lectin-combining sites metastasis raft Abbreviations used: CRD, carbohydrate...

View article titled, Fine specificity of domain-I of recombinant tandem-repeat-type galectin-4 from rat gastrointestinal tract (G4-N)

Articles

Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen

David M. SHAW, Andrew M. WOODS, Kevin A. MYERS, Caroline WESTWATER, Veena RAHI-SAUND, Michael J. DAVIES, David V. RENOUF, Elizabeth F. HOUNSELL, Peter L. STERN

Biochem J (2002) 363 (1): 137–145.

https://doi.org/10.1042/bj3630137

Published: 22 March 2002

..., London ©2002 2002 leucine-rich repeat protein metastasis oncotrophoblast antigen oligosaccharide tumour-associated antigen Abbreviations used: 2-AB, 2-aminobenzamide; ECL ® (Amersham Biosciences), enhanced chemiluminescence; GU, glucose units; HPAEC—PAD, high-pH anion-exchange...

View article titled, Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen

Articles

Lithocholic acid and sulphated lithocholic acid differ in the ability to promote matrix metalloproteinase secretion in the human colon cancer cell line CaCo-2

Bente HALVORSEN, Anne Cathrine STAFF, Solveig LIGAARDEN, Kristian PRYDZ, Svein Olav KOLSET

Biochem J (2000) 349 (1): 189–193.

https://doi.org/10.1042/bj3490189

Published: 26 June 2000

... not affect the level of MMP-2 secretion, and after zymography the level of enzyme activity was 78% of control values after 18 h incubation. The secretion of MMPs is linked to increased cellular invasion and, in tumours, to increased capacity for metastasis. The ability of CaCo-2 cells to invade in a chamber...

View article titled, Lithocholic acid and sulphated lithocholic acid differ in the ability to promote matrix metalloproteinase secretion in the human colon cancer cell line CaCo-2

Articles

Histidine to aspartate phosphotransferase activity of nm23 proteins: phosphorylation of aldolase C on Asp-319

Paul D. WAGNER, Ngoc-Diep VU

Biochem J (2000) 346 (3): 623–630.

https://doi.org/10.1042/bj3460623

Published: 07 March 2000

...Paul D. WAGNER; Ngoc-Diep VU nm23 genes have been implicated in the suppression of tumour metastasis and cell motility; however, the biochemical mechanisms for these suppressions are not known. We have previously described the transfer of phosphate from the catalytic histidine residues of nm23...

View article titled, Histidine to aspartate phosphotransferase activity of nm23 proteins: phosphorylation of aldolase C on Asp-319

Articles

Synthesis and shedding of hyaluronan from plasma membranes of human fibroblasts and metastatic and non-metastatic melanoma cells

Hans-Joachim LüKE, Peter PREHM

Biochem J (1999) 343 (1): 71–75.

https://doi.org/10.1042/bj3430071

Published: 24 September 1999

... cell lines, which has been observed by others. 1 To whom correspondence should be addressed (e-mail [email protected] ). 7 4 1999 1 6 1999 16 7 1999 The Biochemical Society, London © 1999 1999 CD44 cell-surface receptors metastasis Biochem. J. (1999) 343...

View article titled, Synthesis and shedding of hyaluronan from plasma membranes of human fibroblasts and metastatic and non-metastatic melanoma cells

Articles

Evidence that platelet and tumour heparanases are similar enzymes

Craig FREEMAN, Anna M. BROWNE, Christopher R. PARISH

Biochem J (1999) 342 (2): 361–368.

https://doi.org/10.1042/bj3420361

Published: 24 August 1999

... specificities, peptide sequences and immunoreactivities, we propose that heparanase activities present in human platelets, rat liver and in rat and human tumour cells are, in fact, mediated by a similar enzyme. Key words: cancer, ECM degradation, heparan sulphate, hep- arin, metastasis. both heparin and HS...

View article titled, Evidence that platelet and tumour heparanases are similar enzymes

Update search

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only