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Keywords: metastasis
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Biochem J (2021) 478 (3): 597–617.
Published: 12 February 2021
... systemically. Recently, a new concept has emerged to better describe this process by defining four attributes that metastatic cells should undergo. Every individual hallmark represents a unique trait of a metastatic cell that impacts directly in the outcome of the metastasis process. These critical features...
Biochem J (2020) 477 (6): 1159–1178.
Published: 27 March 2020
...Min Du; Guozheng Wang; Igor L. Barsukov; Stephane R. Gross; Richard Smith; Philip S. Rudland Overexpression of S100P promotes breast cancer metastasis in animals and elevated levels in primary breast cancers are associated with poor patient outcomes. S100P can differentially interact with nonmuscle...
Includes: Supplementary data
Biochem J (2019) 476 (16): 2321–2346.
Published: 28 August 2019
... Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 4-kinase Golgi apparatus lipid metabolism metastasis phosphatidylinositol PI4P Phosphoinositides, also known as inositol phospholipids or PIPs, regulate a vast array of cellular functions including...
Biochem J (2017) 474 (19): 3227–3240.
Published: 12 September 2017
...Christopher J. Clarke; Stephane R. Gross; Thamir M. Ismail; Philip S. Rudland; Morteta Al-Medhtiy; Michael Santangeli; Roger Barraclough S100P protein in human breast cancer cells is associated with reduced patient survival and, in a model system of metastasis, it confers a metastatic phenotype...
Includes: Supplementary data
Biochem J (2017) 474 (1): 21–45.
Published: 22 December 2016
... of signals between cancer and resident stromal cells to facilitate tumorigenesis and metastasis. An important step of the metastatic cascade is the reprogramming of cancer cells from an epithelial to mesenchymal phenotype (epithelial–mesenchymal transition, EMT), which is associated with increased...
Biochem J (2016) 473 (11): 1629–1640.
Published: 27 May 2016
...) is an E3 ubiquitin ligase which has been implicated in various cancers but its role in H. pylori -mediated gastric carcinogenesis has not been established. We investigated the involvement of Siah2 in gastric cancer metastasis which was assessed by invasiveness and migration of H. pylori -infected...
Includes: Supplementary data
Biochem J (2016) 473 (6): 703–715.
Published: 10 March 2016
... environments, particularly with regard to oxygen and nutrient availability. Our results indicate that progression to metastasis requires mitochondrial function. Our research, centered on cell lines that display increasing degrees of malignancy, focused on metabolic events, especially those involving...
Includes: Supplementary data
Biochem J (2016) 473 (4): 449–461.
Published: 09 February 2016
... fatty acid-binding protein induces metastasis by up-regulating the expression of vascular endothelial growth factor gene in rat Rama 37 model cells Cancer Res. 2001 61 4357 4364 11389060 8 Jing C. Beesley C. Foster C.S. Rudland P.S. Fujii H. Ono T. Chen H...
Includes: Supplementary data
Biochem J (2016) 473 (1): 31–42.
Published: 09 December 2015
... and include matrix remodelling, adhesion and migration. S100A4 belongs to the Ca 2+ -binding EF-hand S100 protein family and acts both intra- and extra-cellularly through binding to various partners. It regulates cell migration and its overexpression is strongly associated with metastasis and poor...
Biochem J (2015) 465 (1): 89–101.
Published: 12 December 2014
...Fauzia Chaudhary; Robert Lucito; Nicholas K. Tonks MIM (Missing-in-Metastasis), also known as MTSS1 (metastasis suppressor 1), is a scaffold protein that is down-regulated in multiple metastatic cancer cell lines compared with non-metastatic counterparts. MIM regulates cytoskeletal dynamics and...
Biochem J (2014) 463 (1): 157–165.
Published: 08 September 2014
... ATX inhibitors in vivo have reported an almost 100% reduction in plasma LPA levels [ 19 ], suggesting that ATX is the major enzyme responsible for LPA production. autotaxin breast cancer lysophosphatidic acid metastasis therapy Breast cancer is the most common malignancy among women...
Biochem J (2010) 426 (3): 327–335.
Published: 24 February 2010
...Isao Matsuura; Chen-Yu Lai; Keng-Nan Chiang TGF-β (transforming growth factor-β) induces a cytostatic response in most normal cell types. In cancer cells, however, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we show that S100A4, a...
Biochem J (2010) 425 (2): 361–371.
Published: 23 December 2009
... vascular endothelial growth factor, and the activity of matrix metalloproteinase-2. Lung metastasis of intravenously injected LLC cells was also significantly less obvious in mPGES-1-null mice than in wild-type mice. Thus our present approaches provide unequivocal evidence for critical roles of the mPGES-1...
Includes: Supplementary data
Biochem J (2008) 412 (3): 447–457.
Published: 28 May 2008
... Biochemical Society 2008 cancer metastasis peptide phage display serine protease urokinase-type plasminogen activator (uPA) Serine proteases of the trypsin family (clan SA) have many physiological and pathophysiological functions. There is therefore extensive interest in generating specific...
Biochem J (2008) 409 (3): 635–649.
Published: 15 January 2008
... now overwhelming evidence that chemokines are also involved in the progression of cancer, where they function in several capacities. First, specific chemokine–receptor pairs are involved in tumour metastasis. This is not surprising, in view of their role as chemoattractants in cell migration. Secondly...
Includes: Multimedia, Supplementary data
Biochem J (2007) 407 (2): 199–205.
Published: 25 September 2007
...Sabine Middelhaufe; Livia Garzia; Uta-Maria Ohndorf; Barbara Kachholz; Massimo Zollo; Clemens Steegborn The human orthologue of the Drosophila prune protein (h-Prune) is an interaction partner and regulator of the metastasis suppressor protein NM23-H1 (non-metastatic protein 23). Studies on a...
Biochem J (2005) 388 (3): 967–972.
Published: 07 June 2005
... malignant cell types. Previous in vitro studies on prostate cancer cells suggest a role for PAR-2 in prostate cancer metastasis. A polyclonal anti-human TMPRSS2 antibody was generated against the TMPRSS2 serine protease domain. The antibody showed specific reactivity with recombinant expressed TMPRSS2, and...
Biochem J (2003) 374 (3): 715–722.
Published: 15 September 2003
... led to stimulation of cell migration, particularly at the lower S1P concentrations. Treatment of B16F10 cells with S1P inhibited lung metastasis 3 weeks after injection into mouse tail veins. Intriguingly, overexpression of S1P 2 greatly potentiated the inhibition of metastasis by S1P, whereas that of...
Biochem J (2003) 371 (2): 463–471.
Published: 15 April 2003
...Jacquelyn A. WOODINGS; Stewart J. SHARP; Laura M. MACHESKY We have found that MIM-B, a putative metastasis suppressor protein, is implicated in actin cytoskeletal control and interaction with a protein tyrosine phosphatase (PTP). MIM was originally described as a protein whose mRNA was M issing i n...
Biochem J (2002) 367 (3): 653–664.
Published: 01 November 2002
... analysis. enterocyte lacto- N -tetraose lectin-combining sites metastasis raft 1 To whom correspondence should be addressed (e-mail amwu@mail.cgu.edu.tw ). 16 4 2002 9 7 2002 22 7 2002 22 7 2002 The Biochemical Society, London ©2002 2002 Abbreviations...
Biochem J (2002) 363 (1): 137–145.
Published: 22 March 2002
... Society, London ©2002 2002 leucine-rich repeat protein metastasis oncotrophoblast antigen oligosaccharide tumour-associated antigen Abbreviations used: 2-AB, 2-aminobenzamide; ECL ® (Amersham Biosciences), enhanced chemiluminescence; GU, glucose units; HPAEC—PAD, high-pH anion-exchange...
Biochem J (2000) 349 (1): 189–193.
Published: 26 June 2000
... affect the level of MMP-2 secretion, and after zymography the level of enzyme activity was 78% of control values after 18 h incubation. The secretion of MMPs is linked to increased cellular invasion and, in tumours, to increased capacity for metastasis. The ability of CaCo-2 cells to invade in a chamber...
Biochem J (2000) 346 (3): 623–630.
Published: 07 March 2000
...Paul D. WAGNER; Ngoc-Diep VU nm23 genes have been implicated in the suppression of tumour metastasis and cell motility; however, the biochemical mechanisms for these suppressions are not known. We have previously described the transfer of phosphate from the catalytic histidine residues of nm23...
Biochem J (1999) 343 (1): 71–75.
Published: 24 September 1999
... melanoma cell lines, which has been observed by others. 1 To whom correspondence should be addressed (e-mail prehm@uni-muenster.de ). 7 4 1999 1 6 1999 16 7 1999 The Biochemical Society, London © 1999 1999 CD44 cell-surface receptors metastasis Biochem. J. (1999...
Biochem J (1999) 342 (2): 361–368.
Published: 24 August 1999
... 10 5 1999 21 6 1999 The Biochemical Society, London © 1999 1999 cancer ECM degradation heparan sulphate heparin metastasis Biochem. J. (1999) 342, 361 368 (Printed in Great Britain) 361 Evidence that platelet and tumour heparanases are similar enzymes Craig FREEMAN1, Anna M...