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Keywords: metformin
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Biochem J (2016) 473 (11): 1483–1501.
Published: 27 May 2016
... signalling with FSH or LH signalling at critical nodes are identified and the available evidence for such interactions in ovarian cells is discussed. Finally the action of the insulin-sensitizing drugs metformin and the thiazolidinedione rosiglitazone on follicular cells is reviewed. 1 To whom...
Biochem J (2015) 471 (3): 307–322.
Published: 16 October 2015
... these drugs are already established, effectively enabling preclinical studies to be bypassed. Metformin is one such drug currently being investigated for novel applications. The present review provides a thorough and detailed account of our current understanding of the molecular pharmacology and...
Biochem J (2014) 463 (3): e3–e5.
Published: 10 October 2014
...Eric Fontaine Metformin is the most widely prescribed drug used to treat patients affected by Type 2 diabetes. Metformin has also been shown to prevent some forms of cell death; however, evidence suggests that it may have anti-neoplastic properties. All of these effects have been attributed to...
Biochem J (2014) 462 (3): 475–487.
Published: 22 August 2014
...Hannah R. Bridges; Andrew J. Y. Jones; Michael N. Pollak; Judy Hirst The biguanide metformin is widely prescribed for Type II diabetes and has anti-neoplastic activity in laboratory models. Despite evidence that inhibition of mitochondrial respiratory complex I by metformin is the primary cause of...
Biochem J (2008) 412 (2): 211–221.
Published: 14 May 2008
... AMPK pathway by administration of metformin, phenformin or A-769662 to PTEN +/− mice significantly delayed tumour onset. We demonstrate that LKB1 is required for activators of AMPK to inhibit mTORC1 signalling as well as cell growth in PTEN-deficient cells. Our findings highlight, using an animal model...
Includes: Supplementary data
Biochem J (2008) 409 (2): 449–459.
Published: 21 December 2007
... findings suggest that TBC1D1 and AS160 may have complementary roles in regulating vesicle trafficking in response to insulin and AMPK-activating stimuli in skeletal muscle. 14-3-3 Akt substrate of 160 kDa (AS160) AMP-activated protein kinase (AMPK) metformin obesity protein kinase B (PKB) TBC1D1...
Includes: Supplementary data
Biochem J (2004) 382 (3): 877–884.
Published: 07 September 2004
...Bruno GUIGAS; Dominique DETAILLE; Christiane CHAUVIN; Cécile BATANDIER; Frédéric De OLIVEIRA; Eric FONTAINE; Xavier LEVERVE Metformin, a drug widely used in the treatment of Type II diabetes, has recently received attention owing to new findings regarding its mitochondrial and cellular effects. In...