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Keywords: methylation
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Articles
Biochem J (2021) 478 (19): 3613–3619.
Published: 08 October 2021
...Kendra R. Vann; Yashavantha L. Vishweshwaraiah; Nikolay V. Dokholyan; Tatiana G. Kutateladze Methylation of lysine residues plays crucial roles in a wide variety of cell signaling processes. While the biological importance of recognition of methylated histones by reader domains in the cell nucleus...
Includes: Supplementary data
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Biochem J (2020) 477 (5): 1033–1047.
Published: 13 March 2020
... Protein (HP1) 1 family are key players in chromatin organisation, acting as docking sites for chromatin modifiers. Here, we inactivated HP1α in HepG2 human liver carcinoma cells and showed that HP1α participated in cell proliferation. HP1α-depleted cells have a global decrease in DNA methylation...
Includes: Supplementary data
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Biochem J (2018) 475 (20): 3201–3219.
Published: 23 October 2018
...Chris Nevitt; John G. Tooley; Christine E. Schaner Tooley Deciphering the histone code has illustrated that acetylation or methylation on the same residue can have analogous or opposing roles. However, little is known about the interplay between these post-translational modifications (PTMs...
Includes: Supplementary data
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Biochem J (2017) 474 (6): 885–896.
Published: 07 March 2017
... of the Biochemical Society 2017 Epigenetic marks, such as DNA methylation, histone post-translational modifications, and nucleosome occupancy, are involved in determining the chromatin structure, while some transcription factors can bind to specific regulatory regions to recruit the epigenetic modifiers...
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Biochem J (2014) 459 (3): 505–512.
Published: 11 April 2014
... of methyl-lysine caging by calixarenes and suggests a high potential for these compounds in biochemical applications. Immunofluorescence analysis reveals that the supramolecular agents induce changes in chromatin organization that are consistent with their binding to and disruption of H3K9me3 sites...
Includes: Supplementary data
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Biochem J (2013) 456 (3): 453–462.
Published: 22 November 2013
...Janusz J. Petkowski; Lindsay A. Bonsignore; John G. Tooley; Daniel W. Wilkey; Michael L. Merchant; Ian G. Macara; Christine E. Schaner Tooley NRMT (N-terminal regulator of chromatin condensation 1 methyltransferase) was the first eukaryotic methyltransferase identified to specifically methylate...
Includes: Supplementary data
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Biochem J (2011) 440 (1): 73–84.
Published: 27 October 2011
... was induced in cell culture treated with the demethylating agent decitabine. The specific methylation of this CpG site impaired both the binding of USF and the formation of the functional NF-Y–USF complex as well as promoter activity, suggesting its importance for cell-specific transcription. Thus CpG...
Includes: Supplementary data
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Biochem J (2011) 435 (1): 175–185.
Published: 15 March 2011
... cell cycle methylation phosphorylation ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) Following genotoxic injury, the regulated process of mammalian cell cycle progression is often halted. This arrest occurs through the activation of checkpoints that result in cell...
Includes: Supplementary data
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Biochem J (2010) 432 (2): 323–332.
Published: 12 November 2010
...) and the other implying that short RNA forms a heteroduplex with DNA from the unwound double helix, an R-loop structure (RNA–DNA model). Likewise, the requirement for DNA methylation to enact TGS is still controversial. In vitro assays using purified recombinant murine Dnmt (DNA methyltransferase) 1-dN (where dN...
Includes: Supplementary data
Articles
Biochem J (2009) 423 (2): 179–187.
Published: 25 September 2009
... by acetylation or methylation of Lys 9 (H3K9ac and H3K9me respectively) but is inhibited by methylation of Lys 4 (H3K4me) or acetylation of Ala 1 (H3A1ac). An 18 μM binding affinity toward unmodified H3 rises to 0.6 μM for H3K9ac and to 0.9 μM for H3K9me3, whereas it drops to 2.0 mM for H3K4me3, as measured...
Includes: Supplementary data
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Biochem J (2006) 400 (1): 189–197.
Published: 27 October 2006
... residues were detected to be methylated in PIP2 aquaporins. Lys 3 and Glu 6 of PIP2;1, one of the most abundant aquaporins in the PM, occurred as di- and mono-methylated residues respectively. Ectopic expression in Arabidopsis suspension cells of PIP2;1, either wild-type or with altered methylation sites...
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Biochem J (2006) 399 (2): 177–190.
Published: 27 September 2006
...Shivakumara Bheemanaik; Yeturu V. R. Reddy; Desirazu N. Rao DNA MTases (methyltransferases) catalyse the transfer of methyl groups to DNA from AdoMet ( S -adenosyl- L -methionine) producing AdoHcy ( S -adenosyl- L -homocysteine) and methylated DNA. The C 5 and N 4 positions of cytosine and N 6...
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Biochem J (2004) 382 (3): 1009–1013.
Published: 07 September 2004
...Mark SHEPHERD; C. Neil HUNTER Magnesium protoporphyrin IX methyltransferase (ChlM), an enzyme in the chlorophyll biosynthetic pathway, catalyses the transfer of a methyl group to magnesium protoporphyrin IX (MgP) to form magnesium protoporphyrin IX monomethyl ester (MgPME). S -Adenosyl- L...
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Biochem J (2003) 371 (2): 351–360.
Published: 15 April 2003
...Mark SHEPHERD; James D. REID; C. Neil HUNTER Magnesium protoporphyrin IX methyltransferase (ChlM), catalyses the methylation of magnesium protoporphyrin IX (MgP) at the C 6 propionate side chain to form magnesium protoporphyrin IX monomethylester (MgPME). Threading methods biased by sequence...
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Biochem J (2003) 370 (3): 867–871.
Published: 15 March 2003
... to a deficiency of DnaA204 protein in slowly growing cells, which in turn leads to an increased initiation mass [3]. The degradation is in part prevented by the absence of the SeqA protein [3]. The SeqA protein binds to Dam-methylated DNA, especially hemi- methylated, and also to fully methylated DNA [4 8...
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Biochem J (2001) 356 (1): 1–10.
Published: 08 May 2001
... cytosine methylation and chromatin remodelling, result in alterations in gene expression which, in turn, affects the phenotype of the organism. Recent evidence, from our work and that of others in mice, suggests that these epigenetic modifications, which in the past were thought to be cleared and reset...
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Biochem J (2001) 353 (3): 417–439.
Published: 25 January 2001
... determine the substrate specificity, (sub)cellular localization and catalytic activity of the PP2A holoenzymes. Moreover, the catalytic subunit is subject to two types of post-translational modification, phosphorylation and methylation, which are also thought to be important regulatory devices...