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Keywords: microRNA
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Articles
Biochem J (2021) 478 (9): 1809–1825.
Published: 14 May 2021
... have been co-opted by cancer cells to undergo tumor metastasis. These processes are regulated at multiple instances, whereas the post-transcriptional regulation of key genes mediated by microRNAs is gaining major attention as a common and conserved pathway. In this review, we focus on discussing the...
Articles
Biochem J (2018) 475 (9): 1643–1667.
Published: 15 May 2018
... expression. Further aspects related to alternative splicing events and to ncRNAs (microRNAs and lncRNAs) are involved in the modulation of its expression. Notably, this important gene displays transcriptional variants relevant for the protein's function with the occurrence of at least seven transcripts which...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (24): 4219–4251.
Published: 14 December 2017
... development in cancer. Although microRNAs (miRNAs) are the most studied regulatory ncRNAs to date, and miRNA-targeted therapeutics have already reached clinical development, including the mimics of the tumour suppressive miRNAs miR-34 and miR-16, which reached phase I clinical trials for the treatment of...
Articles
Biochem J (2017) 474 (10): 1603–1618.
Published: 04 May 2017
...Min-Sun Song; John J. Rossi The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA and small interfering RNA, as well as a growing number of additional small RNAs derived from...
Articles
Biochem J (2016) 473 (21): 4027–4044.
Published: 27 October 2016
... method [ 43 ]. © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 HER2 HuR microRNA pH regulation posttranscriptional regulation sodium bicarbonate transport The NBCn1 3′UTR was amplified by polymerase chain reaction (PCR) from...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (3): 245–256.
Published: 25 January 2016
... fibroblasts and corresponding reductions in experimental markers of fibrosis. fibrosis lung microRNA transforming growth factor β The lung epithelium serves as a critical regulator of respiratory health. Not only does the epithelium perform a barrier function, protecting the pulmonary...
Includes: Supplementary data
Articles
Biochem J (2015) 465 (2): 315–323.
Published: 06 January 2015
... reducing miR-29b levels. This miR-29b -regulated menin translation alters the susceptibility of IECs to apoptosis, thus contributing to the maintenance of intestinal epithelial homoeostasis. intestinal epithelial cell intestinal epithelium homoeostasis menin microRNA post-transcriptional...
Includes: Supplementary data
Articles
Biochem J (2013) 452 (2): 281–291.
Published: 10 May 2013
...Shanshan Li; Yajuan Ran; Dandan Zhang; Jianguo Chen; Shuzhen Li; Daling Zhu Unbalanced apoptosis is a major cause of structural remodelling of vasculatures associated with PAH (pulmonary arterial hypertension), whereas the underlying mechanisms are still elusive. miRNAs (microRNAs) regulate the...
Includes: Supplementary data
Articles
Biochem J (2012) 448 (1): 103–113.
Published: 18 October 2012
...Dana Goldoni; Janet M. Yarham; Mary K. McGahon; Anna O’Connor; Jasenka Guduric-Fuchs; Kevin Edgar; Denise M. McDonald; David A. Simpson; Anthony Collins Gene targeting by microRNAs is important in health and disease. We developed a functional assay for identifying microRNA targets and applied it to...
Articles
Biochem J (2012) 443 (2): 407–416.
Published: 27 March 2012
...Robert H. Jenkins; John Martin; Aled O. Phillips; Timothy Bowen; Donald J. Fraser miR (microRNA)-192 plays key roles in renal pathological and physiological responses, by repressing targets including Zeb1, Zeb2 and Wnk1. In the present study, we have assessed the regulation of miR-192 expression...
Includes: Supplementary data
Articles
Biochem J (2012) 442 (2): 311–321.
Published: 13 February 2012
... profiled CRC tissue samples by miRNA (microRNA) microarray and found that four members of the miR-17 family had higher expression in CRC tissues than in normal tissues. This finding was further validated by qRT-PCR (quantitative reverse transcription PCR). Transfecting CRC cells with an inhibitor of miR-17...
Includes: Supplementary data
Articles
Biochem J (2012) 441 (2): 541–552.
Published: 21 December 2011
... examine the way in which signalling events through these pathways mediates invasion, regulates microRNAs and contributes to chemoresistance. 1 Correspondence may be addressed to either of these authors (email s-dangi-garimella@northwestern.edu or h-munshi@northwestern.edu ). 11 7 2011...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2011) 437 (2): 185–197.
Published: 28 June 2011
... review, we provide an overview of the biosynthesis and actions of resolvin E1, underscoring its protective role in vascular systems and regulating platelet responses. We also give an overview of newly described resolution circuitry whereby resolvins govern miRNAs (microRNAs), and transcription factors...
Articles
Biochem J (2009) 422 (2): 329–341.
Published: 13 August 2009
... microRNA are indeed critical, since circular let-7a does not support mRNA cleavage. However, the 5′ end is the key determinant, since its deletion abrogates activity. Surprisingly, we have found that alteration of the 5′ terminal uracil compromises mRNA cleavage. Importantly, we have found that...
Articles
Biochem J (2008) 414 (3): 327–341.
Published: 27 August 2008
...-translational histone modifications) have long been associated with neuronal disorders in humans such as Rett syndrome, Huntington's disease and some forms of mental retardation, and recent work has focused on unravelling their mechanisms of action. Finally, the discovery of microRNAs has produced a paradigm...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2008) 412 (3): 527–534.
Published: 28 May 2008
...Alexey A. Matskevich; Karin Moelling miRNAs (microRNAs) play important roles in diverse physiological processes, including stress response, apoptosis and carcinogenesis. Even though the role of individual miRNAs has been demonstrated, expression of proteins involved in miRNA production in response...