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Keywords: microtubule
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Biochem J (2024) 481 (5): 387–403.
Published: 29 February 2024
...Anthony M. Mozzicato; Joakim A. Bastrup; Jose L. Sanchez-Alonso; Jennifer van der Horst; Julia Gorelik; Per Hägglund; Thomas A. Jepps The dynamic nature of the microtubule network is dependent in part by post-translational modifications (PTMs) — particularly through acetylation, which stabilizes...
Includes: Supplementary data
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Biochem J (2020) 477 (6): 1159–1178.
Published: 27 March 2020
.... The overexpressed S100P is located mainly in nuclei and microtubule organising centres (MTOC) and it significantly reduces their number, slows down tubulin polymerisation and enhances cell migration in S100P-induced COS-7 or HeLa cells. It fails, however, to significantly reduce cell adhesion, in contrast...
Includes: Supplementary data
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Biochem J (2018) 475 (14): 2329–2353.
Published: 31 July 2018
...Mary Mirvis; Tim Stearns; W. James Nelson The cilium, once considered a vestigial structure, is a conserved, microtubule-based organelle critical for transducing extracellular chemical and mechanical signals that control cell polarity, differentiation, and proliferation. The cilium undergoes cycles...
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Biochem J (2014) 462 (2): 231–245.
Published: 07 August 2014
... of action of DMF. Taken together, our results demonstrate that succination is a novel post-translational modification of tubulin and suggest that extensive modification by fumarate, either physiologically or pharmacologically, may alter microtubule dynamics. 1 To whom correspondence should...
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Biochem J (2014) 462 (1): 185–197.
Published: 24 July 2014
... with galactose, whereas the other V 1 subunits remained at or near the membrane. FRET analysis demonstrated close proximity between V 1 and V o even under glucose-starvation conditions. Disassembly, but not reassembly, depended on functional microtubules. Results from overlay blots, pull-down assays...
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Biochem J (2011) 439 (1): 79–83.
Published: 14 September 2011
... immune responses to establish a beneficial niche for pathogenesis. TcpB inhibits NF-κB (nuclear factor κB) activation and pro-inflammatory cytokine secretions mediated by TLR (Toll-like receptor) 2 and TLR4. In the present study, we have demonstrated that TcpB modulates microtubule dynamics by acting...
Includes: Supplementary data
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Biochem J (2010) 430 (1): 151–159.
Published: 28 July 2010
... polyamines and especially quadrivalent spermine can be considered as potential regulators of the complex dynamical properties of anionic MTs (microtubules). Indeed, the C-terminal tails of tubulin display many negative residues in a row which should enable the formation of a correlated liquid-like phase...
Includes: Supplementary data
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Biochem J (2010) 425 (1): 95–108.
Published: 14 December 2009
... 1 10 2009 14 10 2009 14 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 breast cancer epithelial cadherin (E-cadherin) microtubule oncostatin M signal transducer and activator of transcription 3 (STAT3) superior cervical ganglia protein 10-like...
Includes: Multimedia, Supplementary data
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Biochem J (2009) 423 (1): e1–e3.
Published: 14 September 2009
... compilation © 2009 Biochemical Society 2009 cytokinesis GTP hydrolysis microtubule OTBA (3-{5-[4-oxo-2-thioxo-3-(3-trifluoromethyl-phenyl)-thiazolidin-5-ylidenemethyl]-furan-2-yl}-benzoic acid) protofilament Z-ring A conventional method of drug discovery has been to search for antibiotics from...
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Biochem J (2009) 421 (2): 171–180.
Published: 26 June 2009
...Tao Xu; Zhe Qu; Xueyong Yang; Xinghua Qin; Jiyuan Xiong; Youqun Wang; Dongtao Ren; Guoqin Liu Many biological processes require the co-operative involvement of both microtubules and microfilaments; however, only a few proteins mediating the interaction between microtubules and microfilaments have...
Includes: Supplementary data
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Biochem J (2008) 410 (1): 141–146.
Published: 29 January 2008
... that the vimentin cytoskeleton co-localized and interacted with mitochondria to a greater extent than other cytoskeletal components known to support mitochondria. Our results also suggest that vimentin could participate in the mitochondrial association of microtubules. As mitochondrial morphologies determine...
Includes: Supplementary data
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Biochem J (2006) 397 (1): 53–59.
Published: 14 June 2006
...Eva-María Jiménez-Mateos; Christian González-Billault; Hana N. Dawson; Michael P. Vitek; Jesús Avila The MAPs (microtubule-associated proteins) MAP1B and tau are well known for binding to microtubules and stabilizing these structures. An additional role for MAPs has emerged recently where...
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Biochem J (2006) 396 (2): 235–242.
Published: 15 May 2006
...Gurmeet Kaur; Melinda Hollingshead; Susan Holbeck; Vesna Schauer-Vukašinović; Richard F. Camalier; Alexander Dömling; Seema Agarwal Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest...
Includes: Supplementary data
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Biochem J (2005) 391 (2): e5.
Published: 10 October 2005
...Duane A. Compton The spindle is a dynamic, microtubule-based structure responsible for chromosome segregation during cell division. Spindles in mammalian cells contain several thousand microtubules that are arranged into highly symmetric bipolar arrays by the actions of numerous microtubule...
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Biochem J (2005) 391 (2): 433–440.
Published: 10 October 2005
...-activated protein kinase)-activated protein kinase-K2 (MAPKAP-K2) microtubule Nogo (neurite outgrowth inhibitor protein) p38 (p38 MAPK) The cells were washed twice in ice-cold PBS and lysed in buffer A [50 mM Tris/HCl (pH 7.4)/150 mM KCl/0.1 mM EDTA/1% (w/v) Nonidet P40/4 mM dithiothreitol/20 mM...
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Biochem J (2005) 389 (3): 611–617.
Published: 26 July 2005
... of aster formation, γ-Tu-GFP aggregated as dots on microtubules, and then the dots were translocated to the centre of the aster along microtubules in a manner dependent on cytoplasmic dynein activity. Inhibition of the function of γ-tubulin by an anti-γ-tubulin antibody resulted in failure of microtubule...
Includes: Supplementary data
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Biochem J (2005) 389 (2): 343–354.
Published: 05 July 2005
... in a wide range of both normal and transformed cell lines. The catalytic domain of hPTPN20 exhibited catalytic activity towards tyrosyl phosphorylated substrates, confirming that it is a bona fide PTP. In serum-starved COS1 cells, hPTPN20a was targeted to the nucleus and the microtubule network...
Includes: Supplementary data
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Biochem J (2004) 384 (2): 327–336.
Published: 23 November 2004
...Josefa ANDRADE; Sandy Timm PEARCE; Hu ZHAO; Margarida BARROSO Previously, we have shown that p22, an EF-hand Ca 2+ -binding protein, interacts indirectly with microtubules in an N-myristoylation-dependent and Ca 2+ -independent manner. In the present study, we report that N-myristoylated p22...
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Biochem J (2003) 375 (1): 121–129.
Published: 01 October 2003
...Silvia A. PURRO; C. Gastón BISIG; María A. CONTIN; Héctor S. BARRA; Carlos A. ARCE Detyrosination/tyrosination of tubulin is a post-translational modification that occurs at the C-terminus of the α-subunit, giving rise to microtubules rich in either tyrosinated or detyrosinated tubulin which...
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Biochem J (2000) 346 (3): 785–791.
Published: 07 March 2000
... could be linked to an increased β-sheet content. An assay of microtubule formation in the presence of tau indicated that PrP106-126 decreased the rate of microtubule formation that could be related to the displacement of tau. PrP106-126 carrying the 117 mutation was more efficient at inhibiting...