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Keywords: microtubule
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Articles
Anthony M. Mozzicato, Joakim A. Bastrup, Jose L. Sanchez-Alonso, Jennifer van der Horst, Julia Gorelik, Per Hägglund, Thomas A. Jepps
Journal:
Biochemical Journal
Biochem J (2024) 481 (5): 387–403.
Published: 29 February 2024
...Anthony M. Mozzicato; Joakim A. Bastrup; Jose L. Sanchez-Alonso; Jennifer van der Horst; Julia Gorelik; Per Hägglund; Thomas A. Jepps The dynamic nature of the microtubule network is dependent in part by post-translational modifications (PTMs) — particularly through acetylation, which stabilizes...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (6): 1159–1178.
Published: 27 March 2020
.... The overexpressed S100P is located mainly in nuclei and microtubule organising centres (MTOC) and it significantly reduces their number, slows down tubulin polymerisation and enhances cell migration in S100P-induced COS-7 or HeLa cells. It fails, however, to significantly reduce cell adhesion, in contrast...
Includes: Supplementary data
Articles
In Collection
Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019
Journal:
Biochemical Journal
Biochem J (2018) 475 (14): 2329–2353.
Published: 31 July 2018
...Mary Mirvis; Tim Stearns; W. James Nelson The cilium, once considered a vestigial structure, is a conserved, microtubule-based organelle critical for transducing extracellular chemical and mechanical signals that control cell polarity, differentiation, and proliferation. The cilium undergoes cycles...
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (21): 3559–3577.
Published: 18 October 2017
...Geethu Emily Thomas; Marira R. Renjith; Tapas K. Manna Chromosome congression and segregation require robust yet dynamic attachment of the kinetochore with the spindle microtubules. Force generated at the kinetochore–microtubule interface plays a vital role to drive the attachment...
Articles
Mark W. Richards, Laura O'Regan, Daniel Roth, Jessica M. Montgomery, Anne Straube, Andrew M. Fry, Richard Bayliss
Journal:
Biochemical Journal
Biochem J (2015) 467 (3): 529–536.
Published: 17 April 2015
...Mark W. Richards; Laura O'Regan; Daniel Roth; Jessica M. Montgomery; Anne Straube; Andrew M. Fry; Richard Bayliss We present crystal structures of a trimeric coiled-coil domain found in echinoderm microtubule (MT)-associated protein (EMAP)-like (EML) proteins. This trimerization domain (TD...
Includes: Supplementary data
Articles
Gerardo G. Piroli, Allison M. Manuel, Michael D. Walla, Matthew J. Jepson, Jonathan W. C. Brock, Mathur P. Rajesh, Ross M. Tanis, William E. Cotham, Norma Frizzell
Journal:
Biochemical Journal
Biochem J (2014) 462 (2): 231–245.
Published: 07 August 2014
... of action of DMF. Taken together, our results demonstrate that succination is a novel post-translational modification of tubulin and suggest that extensive modification by fumarate, either physiologically or pharmacologically, may alter microtubule dynamics. 1 To whom correspondence should...
Articles
Kristen E. Funk, Stefani N. Thomas, Kelsey N. Schafer, Grace L. Cooper, Zhongping Liao, David J. Clark, Austin J. Yang, Jeff Kuret
Journal:
Biochemical Journal
Biochem J (2014) 462 (1): 77–88.
Published: 24 July 2014
...Kristen E. Funk; Stefani N. Thomas; Kelsey N. Schafer; Grace L. Cooper; Zhongping Liao; David J. Clark; Austin J. Yang; Jeff Kuret In Alzheimer's disease, the microtubule-associated protein tau dissociates from the neuronal cytoskeleton and aggregates to form cytoplasmic inclusions. Although...
Articles
Katharina Tabke, Andrea Albertmelcher, Olga Vitavska, Markus Huss, Hans-Peter Schmitz, Helmut Wieczorek
Journal:
Biochemical Journal
Biochem J (2014) 462 (1): 185–197.
Published: 24 July 2014
... with galactose, whereas the other V 1 subunits remained at or near the membrane. FRET analysis demonstrated close proximity between V 1 and V o even under glucose-starvation conditions. Disassembly, but not reassembly, depended on functional microtubules. Results from overlay blots, pull-down assays...
Articles
Xi Lin Chen, Daniel Serrano, Marian Mayhue, Hans-Joachim Wieden, Jana Stankova, Guylain Boulay, Subburaj Ilangumaran, Sheela Ramanathan
Journal:
Biochemical Journal
Biochem J (2013) 449 (2): 353–364.
Published: 14 December 2012
... channels. Consistent with a role for GIMAP5 in regulating mitochondrial Ca 2+ , overexpression of GIMAP5 in HEK (human embryonic kidney)-293 cells resulted in increased Ca 2+ accumulation within the mitochondria. Disruption of microtubules, but not the actin cytoskeleton, abrogated mitochondrial Ca 2...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2011) 439 (1): 79–83.
Published: 14 September 2011
... immune responses to establish a beneficial niche for pathogenesis. TcpB inhibits NF-κB (nuclear factor κB) activation and pro-inflammatory cytokine secretions mediated by TLR (Toll-like receptor) 2 and TLR4. In the present study, we have demonstrated that TcpB modulates microtubule dynamics by acting...
Includes: Supplementary data
Articles
Asha Recino, Victoria Sherwood, Amy Flaxman, Wendy N. Cooper, Farida Latif, Andrew Ward, Andrew D. Chalmers
Journal:
Biochemical Journal
Biochem J (2010) 430 (2): 207–213.
Published: 13 August 2010
... not occur in cells in which RASSF7 was knocked down. We also show that endogenous RASSF7 protein localizes to the centrosome and demonstrate using microtubule-regrowth assays that RASSF7 is an important regulator of microtubule dynamics. On the basis of these observations, we propose that, owing to its key...
Includes: Supplementary data
Articles
Philippe Savarin, Aurélie Barbet, Stéphanie Delga, Vandana Joshi, Loïc Hamon, Julien Lefevre, Samir Nakib, Jean-Pascal De Bandt, Christophe Moinard, Patrick A. Curmi, David Pastré
Journal:
Biochemical Journal
Biochem J (2010) 430 (1): 151–159.
Published: 28 July 2010
... polyamines and especially quadrivalent spermine can be considered as potential regulators of the complex dynamical properties of anionic MTs (microtubules). Indeed, the C-terminal tails of tubulin display many negative residues in a row which should enable the formation of a correlated liquid-like phase...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 425 (1): 95–108.
Published: 14 December 2009
... 1 10 2009 14 10 2009 14 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 breast cancer epithelial cadherin (E-cadherin) microtubule oncostatin M signal transducer and activator of transcription 3 (STAT3) superior cervical ganglia protein 10-like...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2009) 423 (1): e1–e3.
Published: 14 September 2009
... compilation © 2009 Biochemical Society 2009 cytokinesis GTP hydrolysis microtubule OTBA (3-{5-[4-oxo-2-thioxo-3-(3-trifluoromethyl-phenyl)-thiazolidin-5-ylidenemethyl]-furan-2-yl}-benzoic acid) protofilament Z-ring A conventional method of drug discovery has been to search for antibiotics from...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 421 (2): 171–180.
Published: 26 June 2009
...Tao Xu; Zhe Qu; Xueyong Yang; Xinghua Qin; Jiyuan Xiong; Youqun Wang; Dongtao Ren; Guoqin Liu Many biological processes require the co-operative involvement of both microtubules and microfilaments; however, only a few proteins mediating the interaction between microtubules and microfilaments have...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2009) 418 (3): 651–664.
Published: 25 February 2009
... to microtubules and reduced the motility of microtubules along kinesin-coated slides. These results indicate that the pollen TGase can control different properties of the pollen tube cytoskeleton (including the ability of actin and tubulin to assemble and their interaction with motor proteins) and consequently...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 410 (1): 141–146.
Published: 29 January 2008
... that the vimentin cytoskeleton co-localized and interacted with mitochondria to a greater extent than other cytoskeletal components known to support mitochondria. Our results also suggest that vimentin could participate in the mitochondrial association of microtubules. As mitochondrial morphologies determine...
Includes: Supplementary data
Articles
Eva-María Jiménez-Mateos, Christian González-Billault, Hana N. Dawson, Michael P. Vitek, Jesús Avila
Journal:
Biochemical Journal
Biochem J (2006) 397 (1): 53–59.
Published: 14 June 2006
...Eva-María Jiménez-Mateos; Christian González-Billault; Hana N. Dawson; Michael P. Vitek; Jesús Avila The MAPs (microtubule-associated proteins) MAP1B and tau are well known for binding to microtubules and stabilizing these structures. An additional role for MAPs has emerged recently where...
Articles
Gurmeet Kaur, Melinda Hollingshead, Susan Holbeck, Vesna Schauer-Vukašinović, Richard F. Camalier, Alexander Dömling, Seema Agarwal
Journal:
Biochemical Journal
Biochem J (2006) 396 (2): 235–242.
Published: 15 May 2006
...Gurmeet Kaur; Melinda Hollingshead; Susan Holbeck; Vesna Schauer-Vukašinović; Richard F. Camalier; Alexander Dömling; Seema Agarwal Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2005) 391 (2): e5.
Published: 10 October 2005
...Duane A. Compton The spindle is a dynamic, microtubule-based structure responsible for chromosome segregation during cell division. Spindles in mammalian cells contain several thousand microtubules that are arranged into highly symmetric bipolar arrays by the actions of numerous microtubule...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 391 (2): 433–440.
Published: 10 October 2005
...-activated protein kinase)-activated protein kinase-K2 (MAPKAP-K2) microtubule Nogo (neurite outgrowth inhibitor protein) p38 (p38 MAPK) The cells were washed twice in ice-cold PBS and lysed in buffer A [50 mM Tris/HCl (pH 7.4)/150 mM KCl/0.1 mM EDTA/1% (w/v) Nonidet P40/4 mM dithiothreitol/20 mM...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 389 (3): 611–617.
Published: 26 July 2005
... of aster formation, γ-Tu-GFP aggregated as dots on microtubules, and then the dots were translocated to the centre of the aster along microtubules in a manner dependent on cytoplasmic dynein activity. Inhibition of the function of γ-tubulin by an anti-γ-tubulin antibody resulted in failure of microtubule...
Includes: Supplementary data
Articles
Michelle T. Fodero-Tavoletti, Matthew P. Hardy, Brent Cornell, Frosa Katsis, Christine M. Sadek, Christina A. Mitchell, Bruce E. Kemp, Tony Tiganis
Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 343–354.
Published: 05 July 2005
... in a wide range of both normal and transformed cell lines. The catalytic domain of hPTPN20 exhibited catalytic activity towards tyrosyl phosphorylated substrates, confirming that it is a bona fide PTP. In serum-starved COS1 cells, hPTPN20a was targeted to the nucleus and the microtubule network...
Includes: Supplementary data
Articles
Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1
Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 333–341.
Published: 05 July 2005
...Eva M. JiméNez-Mateos; Francisco Wandosell; Orly Reiner; Jesús Avila; Christian González-Billault For neuronal migration to occur, the cell must undergo morphological changes that require modifications of the cytoskeleton. Several different MAPs (microtubule-associated proteins) or actin-binding...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 384 (2): 327–336.
Published: 23 November 2004
...Josefa ANDRADE; Sandy Timm PEARCE; Hu ZHAO; Margarida BARROSO Previously, we have shown that p22, an EF-hand Ca 2+ -binding protein, interacts indirectly with microtubules in an N-myristoylation-dependent and Ca 2+ -independent manner. In the present study, we report that N-myristoylated p22...
Articles
Isabelle JOURDAIN, Sylvie LACHKAR, Elodie CHARBAUT, Benoit GIGANT, Marcel KNOSSOW, André SOBEL, Patrick A. CURMI
Journal:
Biochemical Journal
Biochem J (2004) 378 (3): 877–888.
Published: 15 March 2004
... microtubule dynamics by sequestering tubulin in a complex made of two tubulin heterodimers per stathmin molecule (T 2 S complex). The other proteins of the stathmin family can also bind two tubulin heterodimers through their SLD (stathmin-like domain), but the different tubulin:SLD complexes display varying...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 375 (1): 121–129.
Published: 01 October 2003
...Silvia A. PURRO; C. Gastón BISIG; María A. CONTIN; Héctor S. BARRA; Carlos A. ARCE Detyrosination/tyrosination of tubulin is a post-translational modification that occurs at the C-terminus of the α-subunit, giving rise to microtubules rich in either tyrosinated or detyrosinated tubulin which...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 367 (1): 137–143.
Published: 01 October 2002
... (FRAP) of a fluorescent marker (Mag-fluo 4) loaded into the ER lumen in order to determine directly the functional integrity of the ER in lacrimal cells. The half-time for FRAP was increased (indicating a reduction in the functional integrity of the ER) following exposure to anti-microtubule agents...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 357 (3): 759–767.
Published: 25 July 2001
...Jochen EIDENMÜLLER; Thomas FATH; Thorsten MAAS; Madeline POOL; Estelle SONTAG; Roland BRANDT The microtubule-associated tau proteins represent a family of closely related phosphoproteins that become enriched in the axons during brain development. In Alzheimer's disease (AD), tau aggregates...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 346 (3): 785–791.
Published: 07 March 2000
... could be linked to an increased β-sheet content. An assay of microtubule formation in the presence of tau indicated that PrP106-126 decreased the rate of microtubule formation that could be related to the displacement of tau. PrP106-126 carrying the 117 mutation was more efficient at inhibiting...