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Keywords: mitochondrial fission
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Melissa E. Smith, Trevor S. Tippetts, Eric S. Brassfield, Braden J. Tucker, Adelaide Ockey, Adam C. Swensen, Tamil S. Anthonymuthu, Trevor D. Washburn, Daniel A. Kane, John T. Prince, Benjamin T. Bikman
Journal:
Biochemical Journal
Biochem J (2013) 456 (3): 427–439.
Published: 22 November 2013
... in ceramide-treated cells. This effect is likely to be a result of increased Drp1 (dynamin-related protein 1) action, as ceramide increased Drp1 expression and Drp1 inhibition prevented ceramide-induced mitochondrial fission. Further, we found that ceramide treatment reduced mitochondrial O 2 consumption (i.e...
Includes: Supplementary data