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Keywords: mitochondrial targeting
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Articles

A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes

Henry Dube, David Selwood, Sylvanie Malouitre, Michela Capano, Michela I. Simone, Martin Crompton
Journal: Biochemical Journal
Biochem J (2012) 441 (3): 901–907.
https://doi.org/10.1042/BJ20111301
Published: 16 January 2012
..., Dube, Selwood and Crompton (2010) Biochem. J. 425 , 137–148] that cytoprotection by the CyP inhibitor CsA (cyclosporin A) is improved by selective targeting to mitochondria. To investigate this further, we have developed an improved mtCsA (mitochondrial-targeted CsA) by modifying the spacer linking...
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Articles

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

Meredith F. Ross, Tracy A. Prime, Irina Abakumova, Andrew M. James, Carolyn M. Porteous, Robin A. J. Smith, Michael P. Murphy
Journal: Biochemical Journal
Biochem J (2008) 411 (3): 633–645.
https://doi.org/10.1042/BJ20080063
Published: 14 April 2008
...) p.p.m. 31 P NMR: δ 25.57 p.p.m. (+)ESI-MS (positive ion electrospray ionization MS) found m/z =529.153 (C 28 H 35 PI + requires m/z =529.152). lipophilic cation membrane potential mitochondria mitochondrial targeting mitoquinone (MitoQ) Mitochondria are central to many aspects...
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Articles

Accumulation of lipophilic dications by mitochondria and cells

Meredith F. Ross, Tatiana Da Ros, Frances H. Blaikie, Tracy A. Prime, Carolyn M. Porteous, Inna I. Severina, Vladimir P. Skulachev, Henrik G. Kjaergaard, Robin A. J. Smith, Michael P. Murphy
Journal: Biochemical Journal
Biochem J (2006) 400 (1): 199–208.
https://doi.org/10.1042/BJ20060919
Published: 27 October 2006
... 2006 1 9 2006 1 9 2006 The Biochemical Society, London 2006 dications lipophilic cations membrane transport membrane potential mitochondria mitochondrial targeting Lipophilic cations, such as TPMP (methyltriphenylphosphonium), easily cross phospholipid bilayers...
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Includes: Supplementary data
Articles

Localization of GRP78 to mitochondria under the unfolded protein response

Fang-Chun Sun, Shou Wei, Chia-Wei Li, Yuo-Sheng Chang, Chih-Chung Chao, Yiu-Kay Lai
Journal: Biochemical Journal
Biochem J (2006) 396 (1): 31–39.
https://doi.org/10.1042/BJ20051916
Published: 26 April 2006
...) mitochondrial targeting unfolded protein response (UPR) The ER (endoplasmic reticulum) is a multifunctional organelle that controls important cellular processes, including Ca 2+ homoeostasis, protein synthesis, protein trafficking and apoptosis [ 1 , 2 ]. [Ca 2+ ] ER (ER Ca 2+ concentration...
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