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Articles

The RED light is on! New tools for monitoring Ca 2+ dynamics in the endoplasmic reticulum and mitochondria

Saverio Marchi, Paolo Pinton

Biochem J (2014) 464 (1): e5–e6.

https://doi.org/10.1042/BJ20141183

Published: 23 October 2014

... reticulum fluorescent Ca 2+ indicator GCaMP mitochondrion Since the identification of the intense Ca 2+ connection that occurs between the ER (endoplasmic reticulum) and mitochondria, several researchers began to focus their efforts on developing accurate approaches to measure Ca 2+ in the two...

View articletitled, The RED light is on! New tools for monitoring Ca 2+ dynamics in the endoplasmic reticulum and mitochondria

Articles

Red fluorescent genetically encoded Ca 2+ indicators for use in mitochondria and endoplasmic reticulum

Jiahui Wu, David L. Prole, Yi Shen, Zhihong Lin, Aswini Gnanasekaran, Yingjie Liu, Lidong Chen, Hang Zhou, S. R. Wayne Chen, Yuriy M. Usachev, Colin W. Taylor, Robert E. Campbell

Biochem J (2014) 464 (1): 13–22.

https://doi.org/10.1042/BJ20140931

Published: 23 October 2014

... Ca 2+ indicators with low affinities. These indicators enable monitoring of mitochondrial and ER Ca 2+ dynamics in combination with a green fluorescent indicator. endoplasmic reticulum (ER) fluorescence Ca 2+ imaging GCaMP mitochondrion multicolour imaging red fluorescent genetically...

View articletitled, Red fluorescent genetically encoded Ca 2+ indicators for use in mitochondria and endoplasmic reticulum

Includes: Supplementary data

Articles

Metformin and respiratory chain complex I: the last piece of the puzzle?

Eric Fontaine

Biochem J (2014) 463 (3): e3–e5.

https://doi.org/10.1042/BJ20141020

Published: 10 October 2014

.... [ 10 ] did not observe radioactivity inside mitochondria when Xenopus laevis oocytes were exposed to concentrations of metformin that led to complex I inhibition. ATP synthase cell death complex I metformin mitochondrion phenformin In 2000, two laboratories published independently...

View articletitled, Metformin and respiratory chain complex I: the last piece of the puzzle?

Articles

Selective induction and subcellular distribution of ACONITASE 3 reveal the importance of cytosolic citrate metabolism during lipid mobilization in Arabidopsis

Mark A. Hooks, J. William Allwood, Joanna K. D. Harrison, Joachim Kopka, Alexander Erban, Royston Goodacre, Janneke Balk

Biochem J (2014) 463 (2): 309–317.

https://doi.org/10.1042/BJ20140430

Published: 22 September 2014

... glyoxysome mitochondrion seedling All feeding experiments were conducted on seedlings harvested at an average weight of 12 μg per seedling. Feeding with [2- 14 C]acetate was conducted as described previously [ 30 ]. For germination and growth analyses, all seeds were surface-sterilized...

View articletitled, Selective induction and subcellular distribution of ACONITASE 3 reveal the importance of cytosolic citrate metabolism during lipid mobilization in Arabidopsis

Includes: Supplementary data

Articles

Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo

Xing Guo, Hiromi Sesaki, Xin Qi

Biochem J (2014) 461 (1): 137–146.

https://doi.org/10.1042/BJ20131438

Published: 13 June 2014

...) mitochondrion necrosis oxidative stress p53 ubiquitination Drp1 (dynamin-related protein 1) is a large GTPase that controls the process of mitochondrial division [ 3 , 5 ]. Drp1 localizes mainly to the cytoplasm. Upon activation, Drp1 translocates to the mitochondria where it binds to its...

View articletitled, Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo

Includes: Supplementary data

Articles

Glutamyl-tRNA Gln amidotransferase is essential for mammalian mitochondrial translation in vivo

Lucía Echevarría, Paula Clemente, Rosana Hernández-Sierra, María Esther Gallardo, Miguel A. Fernández-Moreno, Rafael Garesse

Biochem J (2014) 460 (1): 91–101.

https://doi.org/10.1042/BJ20131107

Published: 25 April 2014

... mitochondrion oxidative phosphorylation (OXPHOS) tRNA Gln Cytoplasmic and mitochondrial ROS were determined using DCFH-DA [5(6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate; Invitrogen] and DHR123 (dihydrorhodamine 123) respectively. Mitochondrial superoxide anion was measured using MitoSOX™...

View articletitled, Glutamyl-tRNA Gln amidotransferase is essential for mammalian mitochondrial translation in vivo

Articles

Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site

Craig T. Armstrong, J. L. Ross Anderson, Richard M. Denton

Biochem J (2014) 459 (2): 369–381.

https://doi.org/10.1042/BJ20131664

Published: 28 March 2014

... mitochondrion α-oxoglutarate dehydrogenase (OGDH) The OGDH (2-oxoglutarate dehydrogenase) complex plays a central role in the regulation of eukaryotic intramitochondrial metabolism, particularly the citrate cycle. It is well established that its overall activity in vertebrates is sensitive...

View articletitled, Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site

Includes: Supplementary data

Articles

Frataxin-bypassing Isu1: characterization of the bypass activity in cells and mitochondria

Heeyong Yoon, Simon A. B. Knight, Alok Pandey, Jayashree Pain, Yan Zhang, Debkumar Pain, Andrew Dancis

Biochem J (2014) 459 (1): 71–81.

https://doi.org/10.1042/BJ20131273

Published: 14 March 2014

... frataxin iron–sulfur Isu1 scaffold mitochondrion Frataxin is a conserved mitochondrial protein implicated in causation of Friedreich's ataxia, an inherited neurodegenerative disease [ 1 ]. It is the deficiency of frataxin in certain tissues, such as the dorsal root ganglia and heart...

View articletitled, Frataxin-bypassing Isu1: characterization of the bypass activity in cells and mitochondria

Includes: Supplementary data

Articles

Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan

Vladimir Klichko, Barbara H. Sohal, Svetlana N. Radyuk, William C. Orr, Rajindar S. Sohal

Biochem J (2014) 459 (1): 127–135.

https://doi.org/10.1042/BJ20131370

Published: 14 March 2014

... lifespan mitochondrion Decline in mitochondrial respiratory capacity, as manifested by attenuations of ADP-stimulated or state 3 respiration and the activities of ETC (electron-transport chain) oxidoreductases, is among the most consistent features of the aging process in widely divergent species...

View articletitled, Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan

Includes: Supplementary data

Articles

Effects of carbonic anhydrase-related protein VIII on human cells harbouring an A8344G mitochondrial DNA mutation

Tze-Kai Wang, Che-Kun Cheng, Tang-Hao Chi, Yi-Shing Ma, Shi-Bei Wu, Yau-Huei Wei, Mingli Hsieh

Biochem J (2014) 459 (1): 149–160.

https://doi.org/10.1042/BJ20131235

Published: 14 March 2014

... correspondence should be addressed (email [email protected] ). 17 9 2013 28 1 2014 30 1 2014 30 1 2014 apoptosis autophagy carbonic anhydrase-related protein VIII (CA8) mitochondrion mtDNA point mutation myoclonus epilepsy associated with ragged-red fibres (MERRF...

View articletitled, Effects of carbonic anhydrase-related protein VIII on human cells harbouring an A8344G mitochondrial DNA mutation

Articles

TIGAR's promiscuity

Juan P. Bolaños

Biochem J (2014) 458 (3): e5–e7.

https://doi.org/10.1042/BJ20140087

Published: 28 February 2014

...-bisphosphoglycerate phosphatase cancer glycolysis haemoglobin hypoxia mitochondrion oxygen sensing TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] is an important survival factor for cancer cells [ 1 ]. The enzymatic activity supported by sequence analysis led Bensaad et al...

View articletitled, TIGAR's promiscuity

Articles

Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: implications for the peroxidase mechanism and cytochrome c release

Tracy M. Josephs, Ian M. Morison, Catherine L. Day, Sigurd M. Wilbanks, Elizabeth C. Ledgerwood

Biochem J (2014) 458 (2): 259–265.

https://doi.org/10.1042/BJ20131386

Published: 14 February 2014

... of the 40–57 Ω loop in induction of peroxidase activity, but show that loss of axial Fe co-ordination is not essential. apoptosis cardiolipin cytochrome c mitochondrion omega loop peroxidase Cytochrome c plays an essential role in the intrinsic apoptosis pathway, with apoptosome...

View articletitled, Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: implications for the peroxidase mechanism and cytochrome c release

Includes: Supplementary data

Articles

Dynamics of mitochondrial Ca 2+ uptake in MICU1-knockdown cells

Sergio de la Fuente, Jessica Matesanz-Isabel, Rosalba I. Fonteriz, Mayte Montero, Javier Alvarez

Biochem J (2014) 458 (1): 33–40.

https://doi.org/10.1042/BJ20131025

Published: 20 January 2014

... compared with the scRNA cells for [Ca 2+ ] values below 2.5 μM. 1 To whom correspondence should be addressed (email [email protected] ). aequorin Ca 2+ uniporter Ca 2+ uniporter protein mitochondrial (MCU) Ca 2+ uptake protein 1 mitochondrial (MICU1) knockdown mitochondrion...

View articletitled, Dynamics of mitochondrial Ca 2+ uptake in MICU1-knockdown cells

Includes: Supplementary data

Articles

Loss of TRPML1 promotes production of reactive oxygen species: is oxidative damage a factor in mucolipidosis type IV?

Jessica Coblentz, Claudette St. Croix, Kirill Kiselyov

Biochem J (2014) 457 (2): 361–368.

https://doi.org/10.1042/BJ20130647

Published: 20 December 2013

... that TRPML1's role in the cell extends outside lysosomes. 1 To whom correspondence should be addressed (email [email protected] ). 9 5 2013 31 10 2013 6 11 2013 6 11 2013 iron lysosomal storage disease mitochondrion reactive oxygen species transient receptor potential...

View articletitled, Loss of TRPML1 promotes production of reactive oxygen species: is oxidative damage a factor in mucolipidosis type IV?

Includes: Supplementary data

Articles

Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle

Melissa E. Smith, Trevor S. Tippetts, Eric S. Brassfield, Braden J. Tucker, Adelaide Ockey, Adam C. Swensen, Tamil S. Anthonymuthu, Trevor D. Washburn, Daniel A. Kane, John T. Prince, Benjamin T. Bikman

Biochem J (2013) 456 (3): 427–439.

https://doi.org/10.1042/BJ20130807

Published: 22 November 2013

... disruption in skeletal muscle. ceramide dynamin-related protein 1 (Drp1) mitochondrion mitochondrial fission metabolic disruption The current worldwide trends of increasing prevalence of obesity and Type 2 diabetes suggest the complexity of the problem and the need for intensive research...

View articletitled, Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle

Includes: Supplementary data

Articles

Investigating the function of [2Fe–2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

James A. Birrell, Klaudia Morina, Hannah R. Bridges, Thorsten Friedrich, Judy Hirst

Biochem J (2013) 456 (1): 139–146.

https://doi.org/10.1042/BJ20130606

Published: 24 October 2013

...–sulfur cluster mitochondrion NADH:quinone oxidoreductase (complex I) oxidative stress superoxide 1 To whom correspondence should be addressed (email [email protected] ). Complex I (NADH:quinone oxidoreductase) is an essential respiratory enzyme in many organisms. It forms an entry...

View articletitled, Investigating the function of [2Fe–2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

Includes: Supplementary data

Articles

Identification and characterization of mitochondrial Mia40 as an iron–sulfur protein

Michael P. Spiller, Swee Kim Ang, Efrain Ceh-Pavia, Karl Fisher, Qi Wang, Stephen E. J. Rigby, Hui Lu

Biochem J (2013) 455 (1): 27–35.

https://doi.org/10.1042/BJ20130442

Published: 13 September 2013

... The mitochondrion is a vitally important organelle that performs essential functions in many biological processes from ATP generation and Fe–S (iron–sulfur) cluster biogenesis to signalling and cell death (apoptosis) [ 1 – 3 ]. Mia40 is an evolutionarily conserved protein located in the mitochondrial IMS...

View articletitled, Identification and characterization of mitochondrial Mia40 as an iron–sulfur protein

Articles

Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability

Jing Zou, Fei Yue, Xianhan Jiang, Wenjiao Li, Jinglin Yi, Leyuan Liu

Biochem J (2013) 454 (3): 447–457.

https://doi.org/10.1042/BJ20130306

Published: 29 August 2013

...Jing Zou; Fei Yue; Xianhan Jiang; Wenjiao Li; Jinglin Yi; Leyuan Liu The mitochondrion-associated protein LRPPRC (leucine-rich pentatricopeptide repeat-containing) interacts with one of the microtubule-associated protein family members MAP1S (microtubule-associated protein 1 small form), originally...

View articletitled, Mitochondrion-associated protein LRPPRC suppresses the initiation of basal levels of autophagy via enhancing Bcl-2 stability

Articles

Physiological and pathological roles of mitochondrial SLC25 carriers

Manuel Gutiérrez-Aguilar, Christopher P. Baines

Biochem J (2013) 454 (3): 371–386.

https://doi.org/10.1042/BJ20121753

Published: 29 August 2013

...Manuel Gutiérrez-Aguilar; Christopher P. Baines The mitochondrion relies on compartmentalization of certain enzymes, ions and metabolites for the sake of efficient metabolism. In order to fulfil its activities, a myriad of carriers are properly expressed, targeted and folded in the inner...

View articletitled, Physiological and pathological roles of mitochondrial SLC25 carriers

Articles

Evidence for novel aspects of Nox4 oxidase regulation of mitochondrial function and peroxide generation in an endothelial cell model of senescence

Michael S. Wolin

Biochem J (2013) 452 (2): e1–e2.

https://doi.org/10.1042/BJ20130484

Published: 10 May 2013

... of novel interactions between Nox4 and mitochondria that appear to promote increased mitochondrial peroxide generation and senescence in a manner which supports both free radical and mitochondrial dysfunction theories on aging [ 1 ]. electron transport chain endothelium mitochondrion Nox4...

View articletitled, Evidence for novel aspects of Nox4 oxidase regulation of mitochondrial function and peroxide generation in an endothelial cell model of senescence

Articles

Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4

Rafał Kozieł, Haymo Pircher, Manuela Kratochwil, Barbara Lener, Martin Hermann, Norbert A. Dencher, Pidder Jansen-Dürr

Biochem J (2013) 452 (2): 231–239.

https://doi.org/10.1042/BJ20121778

Published: 10 May 2013

... (FACS Canto II). The level of ROS was estimated as a mean value of DHE or H 2 -DCFDA fluorescence in 10 4 cells. Mitochondrial complex I inhibitor rotenone (1 μM) was added along with DHE as a positive control. complex I electron transport chain mitochondrion Nox4 oxidative stress senescence...

View articletitled, Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4

Includes: Supplementary data

Articles

The paradox of elongation factor 4: highly conserved, yet of no physiological significance?

Dejiu Zhang, Yan Qin

Biochem J (2013) 452 (2): 173–181.

https://doi.org/10.1042/BJ20121792

Published: 10 May 2013

...) (LepA) GTPase of unknown function 1 (Guf1) mitochondrion The ribosome is a universally conserved ribonucleoprotein machine present in all living cells which uses aa-tRNA (aminoacyl-tRNA) substrates to translate genomic information encoded in an mRNA [ 1 – 5 ]. Translation can be roughly...

View articletitled, The paradox of elongation factor 4: highly conserved, yet of no physiological significance?

Articles

Pathogenic mutations causing LBSL affect mitochondrial aspartyl-tRNA synthetase in diverse ways

Laura van Berge, Josta Kevenaar, Emiel Polder, Agnès Gaudry, Catherine Florentz, Marie Sissler, Marjo S. van der Knaap, Gert C. Scheper

Biochem J (2013) 450 (2): 345–350.

https://doi.org/10.1042/BJ20121564

Published: 15 February 2013

... aminoacyl-tRNA synthetase aspartylation leukoencephalopathy missense mutation mitochondrion LBSL (leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation) is an autosomal recessive white matter disorder [ 1 ]. Patients with LBSL suffer from slowly progressive...

View articletitled, Pathogenic mutations causing LBSL affect mitochondrial aspartyl-tRNA synthetase in diverse ways

Includes: Supplementary data

Articles

GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation

Xi Lin Chen, Daniel Serrano, Marian Mayhue, Hans-Joachim Wieden, Jana Stankova, Guylain Boulay, Subburaj Ilangumaran, Sheela Ramanathan

Biochem J (2013) 449 (2): 353–364.

https://doi.org/10.1042/BJ20120516

Published: 14 December 2012

... haematopoietic cell types, including stem cells [ 15 , 16 , 21 ]. calcium flux GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) mitochondrion microtubule T-lymphocyte Figure 2 Overexpression of Myc–GIMAP5 promotes mitochondrial Ca 2+ accumulation ( A and B ) Stable...

View articletitled, GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation

Includes: Multimedia, Supplementary data

Articles

Nitric oxide inhibits succinate dehydrogenase-driven oxygen consumption in potato tuber mitochondria in an oxygen tension-independent manner

Vagner Simonin, Antonio Galina

Biochem J (2013) 449 (1): 263–273.

https://doi.org/10.1042/BJ20120396

Published: 07 December 2012

... , [email protected] or [email protected] ). 6 3 2012 5 10 2012 8 10 2012 8 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 heterotrophic plant tissue mitochondrion nitric oxide succinate dehydrogenase ADP, ATP, faf-BSA...

View articletitled, Nitric oxide inhibits succinate dehydrogenase-driven oxygen consumption in potato tuber mitochondria in an oxygen tension-independent manner

Articles

Defective valyl-tRNA synthetase hampers the mitochondrial respiratory chain in Neurospora crassa

Margarida Duarte, Arnaldo Videira

Biochem J (2012) 448 (3): 297–306.

https://doi.org/10.1042/BJ20120963

Published: 21 November 2012

... described for a variety of pathways [ 19 ] involving mitochondrial ribosome assembly [ 20 ] and mitochondrial import proteins [ 21 ], as well as mitochondrial ARSs [ 17 , 22 ], among others. © The Authors Journal compilation © 2012 Biochemical Society 2012 aminoacyl-tRNA synthetase mitochondrion...

View articletitled, Defective valyl-tRNA synthetase hampers the mitochondrial respiratory chain in Neurospora crassa

Includes: Supplementary data

Articles

Persulfide formation on mitochondrial cysteine desulfurase: enzyme activation by a eukaryote-specific interacting protein and Fe–S cluster synthesis

Alok Pandey, Ramesh Golla, Heeyong Yoon, Andrew Dancis, Debkumar Pain

Biochem J (2012) 448 (2): 171–187.

https://doi.org/10.1042/BJ20120951

Published: 07 November 2012

... 24 8 2012 28 8 2012 28 8 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cysteine desulfurase Fe–S cluster mitochondrion Nfs1p·Isd11p complex persulfide yeast Spectrophotometric assays for aconitase [ 31 ], succinate dehydrogenase [ 32...

View articletitled, Persulfide formation on mitochondrial cysteine desulfurase: enzyme activation by a eukaryote-specific interacting protein and Fe–S cluster synthesis

Includes: Supplementary data

Articles

Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

Masato Ogura, Junko Yamaki, Miwako K. Homma, Yoshimi Homma

Biochem J (2012) 447 (2): 281–289.

https://doi.org/10.1042/BJ20120509

Published: 26 September 2012

... in any medium, provided the original work is properly cited. cell death energy metabolism mitochondrion Src tyrosine kinase reactive oxygen species (ROS) Mitochondrial oxygen consumption was determined using a Clark-type oxygen electrode (Strathkelvin Instruments) as described...

View articletitled, Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

Includes: Supplementary data

Articles

Mysterious Ca 2+ -independent muscular contraction: déjà vu

Andrey V. Kuznetsov, Rita Guzun, François Boucher, Rafaela Bagur, Tuuli Kaambre, Valdur Saks

Biochem J (2012) 445 (3): 333–336.

https://doi.org/10.1042/BJ20120439

Published: 13 July 2012

... To whom correspondence should be addressed (email [email protected] ). 12 3 2012 2 5 2012 3 5 2012 3 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 calcium-independent muscle contraction heart mitochondrion permeabilized myocyte...

View articletitled, Mysterious Ca 2+ -independent muscular contraction: déjà vu

Includes: Multimedia, Supplementary data

Articles

Effects of the novel mitochondrial protein mimitin in insulin-secreting cells

Katarzyna Hanzelka, Lukasz Skalniak, Jolanta Jura, Sigurd Lenzen, Ewa Gurgul-Convey

Biochem J (2012) 445 (3): 349–359.

https://doi.org/10.1042/BJ20111920

Published: 13 July 2012

... [email protected] ). 28 10 2011 8 5 2012 16 5 2012 16 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 ATP cytokine diabetes insulin-secreting cell mimitin mitochondrion Mimitin is a small 20 kDa mitochondrial protein...

View articletitled, Effects of the novel mitochondrial protein mimitin in insulin-secreting cells

Articles

Mitochondrial free [Ca 2+ ] dynamics measured with a novel low-Ca 2+ affinity aequorin probe

Sergio de la Fuente, Rosalba I. Fonteriz, Pedro J. de la Cruz, Mayte Montero, Javier Alvarez

Biochem J (2012) 445 (3): 371–376.

https://doi.org/10.1042/BJ20120423

Published: 13 July 2012

...+ dynamics mitochondrion It has already been 20 years since the first measurements of [Ca 2+ ] M (mitochondrial [Ca 2+ ]) were made using targeted recombinant aequorin [ 1 ]. The original measurements were made using native aequorin and provided peak [Ca 2+ ] M values of 2–3 μM during histamine...

View articletitled, Mitochondrial free [Ca 2+ ] dynamics measured with a novel low-Ca 2+ affinity aequorin probe

Articles

Cysteine biosynthesis, in concert with a novel mechanism, contributes to sulfide detoxification in mitochondria of Arabidopsis thaliana

Hannah Birke, Florian H. Haas, Luit J. De Kok, Janneke Balk, Markus Wirtz, Rüdiger Hell

Biochem J (2012) 445 (2): 275–283.

https://doi.org/10.1042/BJ20120038

Published: 27 June 2012

... 2 5 2012 2 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 O -acetylserine(thiol)lyase cysteine cytochrome c oxidase (COX) electron transport chain mitochondrion sulfide toxicity Biosynthesis of cysteine in higher plants is catalysed by OAS...

View articletitled, Cysteine biosynthesis, in concert with a novel mechanism, contributes to sulfide detoxification in mitochondria of Arabidopsis thaliana

Includes: Supplementary data

Articles

Bax and Bcl-xL exert their regulation on different sites of the ceramide channel

Meenu N. Perera, Shang H. Lin, Yuri K. Peterson, Alicja Bielawska, Zdzislaw M. Szulc, Robert Bittman, Marco Colombini

Biochem J (2012) 445 (1): 81–91.

https://doi.org/10.1042/BJ20112103

Published: 15 June 2012

... Journal compilation © 2012 Biochemical Society 2012 ABT-263 ABT-737 apoptosis Bcl-2 family protein ceramide analogue ceramide channel 2-methoxyantimicin A 3 mitochondrion The sensitivity of isolated mitochondria to permeabilization by added ceramide or analogues varied from one...

View articletitled, Bax and Bcl-xL exert their regulation on different sites of the ceramide channel

Includes: Supplementary data

Articles

The post-transcriptional life of mammalian mitochondrial RNA

Joanna Rorbach, Michal Minczuk

Biochem J (2012) 444 (3): 357–373.

https://doi.org/10.1042/BJ20112208

Published: 29 May 2012

... ribosome is discussed. 1 To whom correspondence should be addressed (email [email protected] ). 21 12 2011 1 3 2012 6 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 mitochondrion ribosome biogenesis RNA degradation RNA...

View articletitled, The post-transcriptional life of mammalian mitochondrial RNA

Articles

Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition

Anne R. Diers, Katarzyna A. Broniowska, Ching-Fang Chang, Neil Hogg

Biochem J (2012) 444 (3): 561–571.

https://doi.org/10.1042/BJ20120294

Published: 29 May 2012

... extracellular flux technology mitochondrion reserve capacity Warburg effect Otto Warburg [ 1 ] first described the increased utilization of anaerobic metabolism in the presence of adequate oxygen by cancer cells compared with their normal counterparts: termed the ‘Warburg effect’. Since these initial...

View articletitled, Pyruvate fuels mitochondrial respiration and proliferation of breast cancer cells: effect of monocarboxylate transporter inhibition

Includes: Supplementary data

Articles

AMPK and GCN2–ATF4 signal the repression of mitochondria in colon cancer cells

Inmaculada Martínez-Reyes, María Sánchez-Aragó, José M. Cuezva

Biochem J (2012) 444 (2): 249–259.

https://doi.org/10.1042/BJ20111829

Published: 11 May 2012

... and AMP was carried out by standard enzymatic procedures. 14 10 2011 29 2 2012 21 3 2012 21 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 ATP synthase cancer cellular stress glycolysis mitochondrion translational control...

View articletitled, AMPK and GCN2–ATF4 signal the repression of mitochondria in colon cancer cells

Articles

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

Albert Giralt, Francesc Villarroya

Biochem J (2012) 444 (1): 1–10.

https://doi.org/10.1042/BJ20120030

Published: 26 April 2012

... [ 15 – 17 ] ( Figure 1 ). aging mitochondrion oxidative stress SIRT3 sirtuin thermogenesis Sirtuins constitute a family of proteins with NAD + -dependent protein deacetylase and/or ADP-ribosyltransferase activities. Seven members of the sirtuin family (SIRT1–SIRT7) have been...

View articletitled, SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

Articles

Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA

Shinya Matsumoto, Takeshi Uchiumi, Hiroyuki Tanamachi, Toshiro Saito, Mikako Yagi, Shinya Takazaki, Tomotake Kanki, Dongchon Kang

Biochem J (2012) 443 (2): 573–584.

https://doi.org/10.1042/BJ20111728

Published: 27 March 2012

... [email protected] ). 3 10 2011 5 1 2012 27 1 2012 27 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 mitochondrion messenger ribonucleoprotein particle (mRNP) oxidative phosphorylation (OXPHOS) translation Y-box-binding protein-1...

View articletitled, Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA

Includes: Supplementary data

Articles

Membrane integration of a mitochondrial signal-anchored protein does not require additional proteinaceous factors

Elisa Merklinger, Yana Gofman, Alexej Kedrov, Arnold J. M. Driessen, Nir Ben-Tal, Yechiel Shai, Doron Rapaport

Biochem J (2012) 442 (2): 381–389.

https://doi.org/10.1042/BJ20111363

Published: 13 February 2012

... of this membrane. 1 To whom correspondence should be addressed (email [email protected] ). ergosterol mitochondrion outer membrane signal-anchored protein (SA protein) Proteins residing in the MOM (mitochondrial outer membrane) facilitate various interactions between...

View articletitled, Membrane integration of a mitochondrial signal-anchored protein does not require additional proteinaceous factors

Includes: Supplementary data

Articles

Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells

Dominika Sliwa, Julien Dairou, Jean-Michel Camadro, Renata Santos

Biochem J (2012) 441 (3): 945–953.

https://doi.org/10.1042/BJ20111574

Published: 16 January 2012

... shuttle mitochondrion protein acetylation yeast FA (Friedreich's ataxia) is the most common autosomal recessive inherited ataxia. It is a slowly progressive neurodegenerative disease that affects the central and peripheral nervous system. Other organs can be affected in FA; 60% of patients...

View articletitled, Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells

Articles

Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic β-cells using ratiometric fluorescent proteins: confounding effects of pH with HyPer but not roGFP1

Leticia P. Roma, Jessica Duprez, Hilton K. Takahashi, Patrick Gilon, Andreas Wiederkehr, Jean-Christophe Jonas

Biochem J (2012) 441 (3): 971–978.

https://doi.org/10.1042/BJ20111770

Published: 16 January 2012

... (Visitech International), using a ×60 oil immersion objective. 4 10 2011 1 11 2011 3 11 2011 3 11 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 glucose hydrogen peroxide HyPer mitochondrion mt-AlpHi oxidative stress pancreatic β-cell...

View articletitled, Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic β-cells using ratiometric fluorescent proteins: confounding effects of pH with HyPer but not roGFP1

Articles

Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP: potential implications for ROS signalling

Khandaker Ahtesham Ahmed, Tomohiro Sawa, Hideshi Ihara, Shingo Kasamatsu, Jun Yoshitake, Md. Mizanur Rahaman, Tatsuya Okamoto, Shigemoto Fujii, Takaaki Akaike

Biochem J (2012) 441 (2): 719–730.

https://doi.org/10.1042/BJ20111130

Published: 21 December 2011

... 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 mitochondrion nitric oxide oxidative stress peroxynitrite reactive oxygen species (ROS) reactive oxygen species (ROS) signalling cGMP is a cyclic nucleotide formed from GTP by the catalytic action...

View articletitled, Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP: potential implications for ROS signalling

Includes: Supplementary data

Articles

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

Jisun Lee, Samantha Giordano, Jianhua Zhang

Biochem J (2012) 441 (2): 523–540.

https://doi.org/10.1042/BJ20111451

Published: 21 December 2011

... mitochondrion neurodegeneration nitrative stress oxidative stress redox signalling Autophagy (or self-eating) was first described by Christian de Duve in 1963 as a lysosome-mediated degradation process for non-essential or damaged cellular constituents [ 1 , 2 ]. Physiologically, it serves...

View articletitled, Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

Articles

Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n −3 polyunsaturated fatty acids

Ethan J. Anderson, Kathleen Thayne, Mitchel Harris, Kristen Carraway, Saame Raza Shaikh

Biochem J (2012) 441 (1): 359–366.

https://doi.org/10.1042/BJ20110626

Published: 14 December 2011

... correspondence should be addressed (email [email protected] ). 5 4 2011 19 8 2011 31 8 2011 31 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 aldehyde glutathione lipid peroxidation mitochondrion n −3 polyunsaturated fatty acid permeability...

View articletitled, Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n −3 polyunsaturated fatty acids

Includes: Supplementary data

Articles

LRPPRC mutation suppresses cytochrome oxidase activity by altering mitochondrial RNA transcript stability in a mouse model

Fenghao Xu, Jane B. L. Addis, Jessie M. Cameron, Brian H. Robinson

Biochem J (2012) 441 (1): 275–283.

https://doi.org/10.1042/BJ20110985

Published: 14 December 2011

... suggest that LRPPRC is involved in the maturation of COX, and is involved in stabilizing of mitochondrial mRNAs encoding COX transcripts. cytochrome oxidase (COX) gene trap leucine-rich pentatricopeptide repeat-containing (LRPPRC) mitochondrion pentatricopeptide repeat (PPR) respiratory chain...

View articletitled, LRPPRC mutation suppresses cytochrome oxidase activity by altering mitochondrial RNA transcript stability in a mouse model

Articles

Mutation in the Fe–S scaffold protein Isu bypasses frataxin deletion

Heeyong Yoon, Ramesh Golla, Emmanuel Lesuisse, Jayashree Pain, Jason E. Donald, Elise R. Lyver, Debkumar Pain, Andrew Dancis

Biochem J (2012) 441 (1): 473–480.

https://doi.org/10.1042/BJ20111637

Published: 14 December 2011

... The Authors Journal compilation © 2012 Biochemical Society 2012 frataxin haem iron iron–sulfur cluster (Fe–S cluster) mitochondrion Iron is an essential nutrient for virtually all organisms because many important proteins require iron as a constituent of haem and Fe–S cofactors. Iron...

View articletitled, Mutation in the Fe–S scaffold protein Isu bypasses frataxin deletion

Articles

Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p

Alejandro Martín-Montalvo, Isabel González-Mariscal, Sergio Padilla, Manuel Ballesteros, David L. Brautigan, Plácido Navas, Carlos Santos-Ocaña

Biochem J (2011) 440 (1): 107–114.

https://doi.org/10.1042/BJ20101422

Published: 27 October 2011

... ]. Yeasts were grown at 30°C with shaking (200 rev./min). coenzyme Q mitochondrion phosphorylation respiration yeast Coenzyme Q (CoQ or Q) is an essential isoprenylated benzoquinone component of mitochondria. CoQ resides in the phospholipid bilayer of mitochondrial membranes [ 1 ] where...

View articletitled, Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p

Includes: Supplementary data

Articles

Rim2, a pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria

Heeyong Yoon, Yan Zhang, Jayashree Pain, Elise R. Lyver, Emmanuel Lesuisse, Debkumar Pain, Andrew Dancis

Biochem J (2011) 440 (1): 137–146.

https://doi.org/10.1042/BJ20111036

Published: 27 October 2011

... with the unique Rim2 peptide (SIEKFGYQAEGTKSTSEKVKEWC) conjugated to KLH (keyhole-limpet haemocyanin) followed by affinity-purification of the immune serum (Covance). haem iron iron–sulfur mitochondrial carrier protein mitochondrion pyrimidine Iron in cells is used as a cofactor for many...

View articletitled, Rim2, a pyrimidine nucleotide exchanger, is needed for iron utilization in mitochondria

Articles

Interaction between the SH3 domain of Src family kinases and the proline-rich motif of HTLV-1 p13: a novel mechanism underlying delivery of Src family kinases to mitochondria

Elena Tibaldi, Andrea Venerando, Francesca Zonta, Carlo Bidoia, Elisa Magrin, Oriano Marin, Antonio Toninello, Luciana Bordin, Veronica Martini, Mario Angelo Pagano, Anna Maria Brunati

Biochem J (2011) 439 (3): 505–518.

https://doi.org/10.1042/BJ20101650

Published: 13 October 2011

...-cell leukaemia virus type 1 (HTLV-1) p13 mitochondrion Src family kinase (SFK) SH3 domain SFKs (Src family kinases) are non-receptor tyrosine kinases acting as molecular switches that are generally described as associated with the inner face of the plasma membrane, integrating diverse...

View articletitled, Interaction between the SH3 domain of Src family kinases and the proline-rich motif of HTLV-1 p13: a novel mechanism underlying delivery of Src family kinases to mitochondria

Includes: Supplementary data

Articles

A critical role for citrate metabolism in LPS signalling

Luke A. J. O'Neill

Biochem J (2011) 438 (3): e5–e6.

https://doi.org/10.1042/BJ20111386

Published: 26 August 2011

... lipopolysaccharide (LPS) metabolism mitochondrion Toll-like receptor 4 (TLR4) 1 email [email protected] 28 7 2011 2 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 As we delve deeper using newer technologies into the metabolic world of a cell activated...

View articletitled, A critical role for citrate metabolism in LPS signalling

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