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Keywords: mitochondrion
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Articles
Biochem J (2014) 464 (1): 13–22.
Published: 23 October 2014
.... endoplasmic reticulum (ER) fluorescence Ca 2+ imaging GCaMP mitochondrion multicolour imaging red fluorescent genetically encoded Ca 2+ indicator for optical imaging (R-GECO) As a ubiquitous intracellular messenger, Ca 2+ has essential physiological roles in a variety of cellular processes...
Includes: Supplementary data
Articles
Biochem J (2014) 464 (1): e5–e6.
Published: 23 October 2014
...@unife.it ). 22 9 2014 30 9 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 aequorin Ca 2+ measurement endoplasmic reticulum fluorescent Ca 2+ indicator GCaMP mitochondrion Since the identification of the intense Ca 2+ connection that occurs...
Articles
Biochem J (2014) 463 (3): e3–e5.
Published: 10 October 2014
... mitochondrion phenformin In 2000, two laboratories published independently in two different journals that metformin inhibited mitochondrial respiratory chain complex I [ 1 , 2 ]. Since then, more than ten different laboratories have reproduced this observation. However, although all of the laboratories...
Articles
Biochem J (2014) 463 (2): 309–317.
Published: 22 September 2014
... – 10 ]. cytosol glyoxylate cycle glyoxysome mitochondrion seedling The cytosolic location of AtACO3 and its importance in citrate metabolism support the operation of the classic glyoxylate cycle and not direct mitochondrial metabolism of citrate during lipid mobilization in seedlings...
Includes: Supplementary data
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Biochem J (2014) 461 (1): 137–146.
Published: 13 June 2014
... findings identified a key role of Drp1 in the induction of mitochondria-related necrosis under conditions of oxidative stress in vitro and in vivo , suggesting that Drp1 might be a useful target to combat necrosis in human disease. dynamin-related protein 1 (Drp1) mitochondrion necrosis...
Includes: Supplementary data
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Biochem J (2014) 460 (1): 91–101.
Published: 25 April 2014
... protein synthesis mitochondrion oxidative phosphorylation (OXPHOS) tRNA Gln Cloning of mgatA , mgatB and mgatC cDNAs were carried out by a reverse transcription reaction of mouse liver RNA (Invitrogen SuperScript® III Reverse Transcriptase kit) followed by PCR amplifications with the...
Articles
Biochem J (2014) 459 (2): 369–381.
Published: 28 March 2014
... nucleotides, NADH and Ca 2+ . In the present study, we show definitively that the E1 subunit is the site of action for these regulators, and identify the Ca 2+ -binding site. calcium binding citrate cycle energy metabolism E1 subunit mitochondrion α-oxoglutarate dehydrogenase (OGDH) The...
Includes: Supplementary data
Articles
Biochem J (2014) 459 (1): 71–81.
Published: 14 March 2014
... with the amino acid change M107I is able to bypass lack of the frataxin by stimulating cysteine desulfurase activity in mitochondria, although a kinetic defect in Fe–S cluster assembly persists. cysteine desulfurase eukaryote frataxin iron–sulfur Isu1 scaffold mitochondrion Frataxin...
Includes: Supplementary data
Articles
Biochem J (2014) 459 (1): 127–135.
Published: 14 March 2014
... cytochrome c oxidase (CcO) Drosophila melanogaster lifespan mitochondrion Decline in mitochondrial respiratory capacity, as manifested by attenuations of ADP-stimulated or state 3 respiration and the activities of ETC (electron-transport chain) oxidoreductases, is among the most consistent...
Includes: Supplementary data
Articles
Biochem J (2014) 459 (1): 149–160.
Published: 14 March 2014
... harbouring the MERRF A8344G mutation and overexpression of CA8 desensitizes mutant MERRF cybrids to apoptotic stress. Phosphorylated Akt is involved in the protection of cells by CA8 in MERRF cybrids. apoptosis autophagy carbonic anhydrase-related protein VIII (CA8) mitochondrion mtDNA point...
Articles
Biochem J (2014) 458 (3): e5–e7.
Published: 28 February 2014
... compilation © 2014 Biochemical Society 2014 2,3-bisphosphoglycerate phosphatase cancer glycolysis haemoglobin hypoxia mitochondrion oxygen sensing TIGAR [TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator] is an important survival factor for cancer cells [ 1 ]. The...
Articles
Biochem J (2014) 458 (2): 259–265.
Published: 14 February 2014
... and cardiolipin-bound mammalian cytochromes c implicate mobility of the 40–57 Ω loop in induction of peroxidase activity, but show that loss of axial Fe co-ordination is not essential. apoptosis cardiolipin cytochrome c mitochondrion omega loop peroxidase Cytochrome c plays an...
Includes: Supplementary data
Articles
Biochem J (2014) 458 (1): 33–40.
Published: 20 January 2014
... the 2–4 μM range. Moreover, in MICU1-knockdown cells MCU undergoes a Ca 2+ -dependent slow-developing inhibition that restores low MCU permeability. aequorin Ca 2+ uniporter Ca 2+ uniporter protein mitochondrial (MCU) Ca 2+ uptake protein 1 mitochondrial (MICU1) knockdown mitochondrion...
Includes: Supplementary data
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Biochem J (2014) 457 (2): 361–368.
Published: 20 December 2013
... and the cytoplasm. Loss of TRPML1 leads to production of reactive oxygen species, and to mitochondrial deterioration. iron lysosomal storage disease mitochondrion reactive oxygen species transient receptor potential (TRP) channel TRPML1 is a member of the mucolipin family of TRP...
Includes: Supplementary data
Articles
Biochem J (2013) 456 (3): 427–439.
Published: 22 November 2013
...-induced metabolic disruption in skeletal muscle. Despite being commonly represented as small segmented structures, mitochondria are highly dynamic organelles undergoing continuous fission and fusion. Indeed, the word mitochondrion itself reveals the typical state of the mitochondrion ( mitos means...
Includes: Supplementary data
Articles
Biochem J (2013) 456 (1): 139–146.
Published: 24 October 2013
... pMW172 plasmid as described previously [ 7 ]; the B. taurus protein did not contain the mitochondrion-targeting pre-sequence. Similarly, the mature 24 kDa protein coding sequence from Y. lipolytica was amplified from genomic DNA by PCR, and ligated into the pMW172 plasmid with the coding sequence for...
Includes: Supplementary data
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Biochem J (2013) 455 (1): 27–35.
Published: 13 September 2013
... mitochondrion The mitochondrion is a vitally important organelle that performs essential functions in many biological processes from ATP generation and Fe–S (iron–sulfur) cluster biogenesis to signalling and cell death (apoptosis) [ 1 – 3 ]. Mia40 is an evolutionarily conserved protein located in the...
Articles
Biochem J (2013) 454 (3): 447–457.
Published: 29 August 2013
...Jing Zou; Fei Yue; Xianhan Jiang; Wenjiao Li; Jinglin Yi; Leyuan Liu The mitochondrion-associated protein LRPPRC (leucine-rich pentatricopeptide repeat-containing) interacts with one of the microtubule-associated protein family members MAP1S (microtubule-associated protein 1 small form), originally...
Articles
Biochem J (2013) 454 (3): 371–386.
Published: 29 August 2013
...Manuel Gutiérrez-Aguilar; Christopher P. Baines The mitochondrion relies on compartmentalization of certain enzymes, ions and metabolites for the sake of efficient metabolism. In order to fulfil its activities, a myriad of carriers are properly expressed, targeted and folded in the inner...
Articles
Biochem J (2013) 452 (2): 173–181.
Published: 10 May 2013
...) GTPase of unknown function 1 (Guf1) mitochondrion The ribosome is a universally conserved ribonucleoprotein machine present in all living cells which uses aa-tRNA (aminoacyl-tRNA) substrates to translate genomic information encoded in an mRNA [ 1 – 5 ]. Translation can be roughly divided into...
Articles
Biochem J (2013) 452 (2): e1–e2.
Published: 10 May 2013
... fission and/or fusion mechanisms in a manner that could be a contributing factor in the loss of replicative lifespan seen in senescence. 5 4 2013 8 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 electron transport chain endothelium mitochondrion Nox4...
Articles
Biochem J (2013) 452 (2): 231–239.
Published: 10 May 2013
... whom correspondence should be addressed (email pidder.jansen-duerr@uibk.ac.at ). complex I electron transport chain mitochondrion Nox4 oxidative stress senescence NADPH oxidases are membrane-bound enzymes, which reduce molecular oxygen to the superoxide radical anion by electron...
Includes: Supplementary data
Articles
Biochem J (2013) 450 (2): 345–350.
Published: 15 February 2013
... synthetase aspartylation leukoencephalopathy missense mutation mitochondrion LBSL patients are typically compound heterozygous, although homozygous DARS2 mutations have been described recently in a Japanese family [ 13 ] and a German patient [ 14 ]. Relatives that are carriers of a DARS2...
Includes: Supplementary data
Articles
Biochem J (2013) 449 (2): 353–364.
Published: 14 December 2012
... haematopoietic cell types, including stem cells [ 15 , 16 , 21 ]. calcium flux GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) mitochondrion microtubule T-lymphocyte HEK-293 cells transiently transfected with Myc–GIMAP5 or FLAG–GIMAP5 expression constructs or the empty...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2013) 449 (1): 263–273.
Published: 07 December 2012
... , antoniogalina@yahoo.com.br or galina.antonio@gmail.com ). 6 3 2012 5 10 2012 8 10 2012 8 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 heterotrophic plant tissue mitochondrion nitric oxide succinate dehydrogenase NO (nitric oxide) is a...
Articles
Biochem J (2012) 448 (3): 297–306.
Published: 21 November 2012
... 2012 aminoacyl-tRNA synthetase mitochondrion Neurospora crassa oxidative phosphorylation (OXPHOS) complex respiratory chain Mitochondria are vital organelles that provide energy to the cells mainly through OXPHOS (oxidative phosphorylation). Indeed a myriad of human pathologies...
Includes: Supplementary data
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Biochem J (2012) 448 (2): 171–187.
Published: 07 November 2012
... intermediate. Subsequently, the Fe–S cluster intermediate is transferred to apoproteins, forming the holo or active proteins. cysteine desulfurase Fe–S cluster mitochondrion Nfs1p·Isd11p complex persulfide yeast © The Authors Journal compilation © 2012 Biochemical Society 2012 11 6...
Includes: Supplementary data
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Biochem J (2012) 447 (2): 281–289.
Published: 26 September 2012
... unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cell death energy metabolism mitochondrion Src tyrosine kinase reactive oxygen species (ROS) Mitochondrial serine/threonine phosphorylation has been investigated in...
Includes: Supplementary data
Articles
Biochem J (2012) 445 (3): 333–336.
Published: 13 July 2012
...-independent muscle contraction heart mitochondrion permeabilized myocyte respiration skeletal muscle With great interest, we have read the recent paper in the Biochemical Journal by Christopher Perry et al. [ 1 ] entitled ‘Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2012) 445 (3): 371–376.
Published: 13 July 2012
...+ dynamics mitochondrion It has already been 20 years since the first measurements of [Ca 2+ ] M (mitochondrial [Ca 2+ ]) were made using targeted recombinant aequorin [ 1 ]. The original measurements were made using native aequorin and provided peak [Ca 2+ ] M values of 2–3 μM during histamine...
Articles
Biochem J (2012) 445 (3): 349–359.
Published: 13 July 2012
... Gurgul-Convey.Ewa@mh-hannover.de ). 28 10 2011 8 5 2012 16 5 2012 16 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 ATP cytokine diabetes insulin-secreting cell mimitin mitochondrion Mimitin is a small 20 kDa mitochondrial protein...
Articles
Biochem J (2012) 445 (2): 275–283.
Published: 27 June 2012
... cysteine cytochrome c oxidase (COX) electron transport chain mitochondrion sulfide toxicity Biosynthesis of cysteine in higher plants is catalysed by OAS-TL [ O -acetylserine(thiol)lyase; EC 2.5.1.47). It transfers sulfide to the activated hydroxy group of OAS ( O -acetylserine), whereby...
Includes: Supplementary data
Articles
Biochem J (2012) 445 (1): 81–91.
Published: 15 June 2012
... © The Authors Journal compilation © 2012 Biochemical Society 2012 ABT-263 ABT-737 apoptosis Bcl-2 family protein ceramide analogue ceramide channel 2-methoxyantimicin A 3 mitochondrion The intrinsic pathway of apoptosis, a type of programmed cell death, is regulated at the...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (3): 357–373.
Published: 29 May 2012
... process and its role in mitochondria are provided in the sections below. mitochondrion ribosome biogenesis RNA degradation RNA polyadenylation RNA turnover According to the endosymbiotic theory, mitochondria originated from proteobacteria that were taken inside another cell (either by a...
Articles
Biochem J (2012) 444 (3): 561–571.
Published: 29 May 2012
...-hydroxycinnamic acid extracellular flux technology mitochondrion reserve capacity Warburg effect Otto Warburg [ 1 ] first described the increased utilization of anaerobic metabolism in the presence of adequate oxygen by cancer cells compared with their normal counterparts: termed the ‘Warburg effect...
Includes: Supplementary data
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Biochem J (2012) 444 (2): 249–259.
Published: 11 May 2012
... © The Authors Journal compilation © 2012 Biochemical Society 2012 ATP synthase cancer cellular stress glycolysis mitochondrion translational control Mitochondria play a central role in the homoeostasis of higher eukaryotic cells. The provision of metabolic energy by oxidative...
Articles
Biochem J (2012) 444 (1): 1–10.
Published: 26 April 2012
Articles
Biochem J (2012) 443 (2): 573–584.
Published: 27 March 2012
... addressed (email uchiumi@cclm.med.kyushu-u.ac.jp ). 3 10 2011 5 1 2012 27 1 2012 27 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 mitochondrion messenger ribonucleoprotein particle (mRNP) oxidative phosphorylation (OXPHOS) translation Y-box...
Includes: Supplementary data
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Biochem J (2012) 442 (2): 381–389.
Published: 13 February 2012
... membrane. 1 To whom correspondence should be addressed (email doron.rapaport@uni-tuebingen.de ). 27 7 2011 22 11 2011 5 12 2011 5 12 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 ergosterol mitochondrion outer membrane signal-anchored...
Includes: Supplementary data
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Biochem J (2012) 441 (3): 945–953.
Published: 16 January 2012
... functions. frataxin Friedreich's ataxia malate–aspartate NADH shuttle mitochondrion protein acetylation yeast FA (Friedreich's ataxia) is the most common autosomal recessive inherited ataxia. It is a slowly progressive neurodegenerative disease that affects the central and peripheral...
Articles
Biochem J (2012) 441 (3): 971–978.
Published: 16 January 2012
... glucose acutely decreases rather than increases mitochondrial thiol oxidation in rat β-cells. 4 10 2011 1 11 2011 3 11 2011 3 11 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 glucose hydrogen peroxide HyPer mitochondrion mt-AlpHi oxidative...
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Biochem J (2012) 441 (2): 523–540.
Published: 21 December 2011
... mitochondrion neurodegeneration nitrative stress oxidative stress redox signalling Autophagy (or self-eating) was first described by Christian de Duve in 1963 as a lysosome-mediated degradation process for non-essential or damaged cellular constituents [ 1 , 2 ]. Physiologically, it serves to...
Articles
Biochem J (2012) 441 (2): 719–730.
Published: 21 December 2011
... 6 2011 3 10 2011 4 10 2011 4 10 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 mitochondrion nitric oxide oxidative stress peroxynitrite reactive oxygen species (ROS) reactive oxygen species (ROS) signalling cGMP is a cyclic nucleotide...
Includes: Supplementary data
Articles
Biochem J (2012) 441 (1): 275–283.
Published: 14 December 2011
... compilation © 2012 Biochemical Society 2012 cytochrome oxidase (COX) gene trap leucine-rich pentatricopeptide repeat-containing (LRPPRC) mitochondrion pentatricopeptide repeat (PPR) respiratory chain Mutations in nuclear genes are widely associated with defects in respiratory chain...
Articles
Biochem J (2012) 441 (1): 473–480.
Published: 14 December 2011
...) mitochondrion 1 To whom correspondence should be addressed (email adancis@mail.med.upenn.edu ). 8 9 2011 21 9 2011 21 9 2011 The frataxin-deletion strain of Saccharomyces cerevisiae , 5Cyfh1 (MATα Δ yfh1::HIS3 ade2-1 leu2-3, 112 trp1-63 ura3-52 ) (strain no. 52-18), was...
Articles
Biochem J (2012) 441 (1): 359–366.
Published: 14 December 2011
... glutathione lipid peroxidation mitochondrion n −3 polyunsaturated fatty acid permeability transition pore © The Authors Journal compilation © 2012 Biochemical Society 2012 1 To whom correspondence should be addressed (email andersonet@ecu.edu ). 5 4 2011 19 8 2011 31 8...
Includes: Supplementary data
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Biochem J (2011) 440 (1): 107–114.
Published: 27 October 2011
... 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 coenzyme Q mitochondrion phosphorylation respiration yeast Coenzyme Q (CoQ or Q) is an essential isoprenylated benzoquinone component of mitochondria. CoQ resides in the phospholipid bilayer of mitochondrial...
Includes: Supplementary data
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Biochem J (2011) 440 (1): 137–146.
Published: 27 October 2011
... is a pyrimidine exchanger with an additional unique function in promoting mitochondrial iron utilization. haem iron iron–sulfur mitochondrial carrier protein mitochondrion pyrimidine Iron in cells is used as a cofactor for many essential enzymes [ 1 ]. For example, haem and Fe–S...
Articles
Biochem J (2011) 439 (3): 505–518.
Published: 13 October 2011
... human T-cell leukaemia virus type 1 (HTLV-1) p13 mitochondrion Src family kinase (SFK) SH3 domain SFKs (Src family kinases) are non-receptor tyrosine kinases acting as molecular switches that are generally described as associated with the inner face of the plasma membrane, integrating diverse...
Includes: Supplementary data
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Biochem J (2011) 438 (3): e5–e6.
Published: 26 August 2011
.... 1 email laoneill@tcd.ie 28 7 2011 2 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 citrate carrier lipopolysaccharide (LPS) metabolism mitochondrion Toll-like receptor 4 (TLR4) To most immunologists and inflammation biologists, the...