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Keywords: mitogen-activated protein kinase (MAPK)
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Articles
Ramin Samadani, Jun Zhang, Amanda Brophy, Taiji Oashi, U. Deva Priyakumar, E. Prabhu Raman, Franz J. St John, Kwan-Young Jung, Steven Fletcher, Edwin Pozharski, Alexander D. MacKerell, Jr, Paul Shapiro
Journal:
Biochemical Journal
Biochem J (2015) 467 (3): 425–438.
Published: 17 April 2015
... extracellular-signal-regulated kinases 1 and 2 (ERK1/2) in silico design melanoma mitogen-activated protein kinase (MAPK) The mitogen-activated protein kinase (MAPK) family members, which include the extracellular-signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases (JNKs), p38 MAPKs...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 463 (1): 41–52.
Published: 08 September 2014
... interference with mitochondrial complex I. mitogen-activated protein kinase (MAPK) neurotoxicity Parkinson’s disease (PD) primary neuron 5- S -cysteinyldopamine (CysDA) Previous observations have indicated that both CysDA and DHBT-1 may accumulate in isolated intact rat brain mitochondria where...
Articles
Natalia Alonso, Federico Monczor, Emiliana Echeverría, Carlos Davio, Carina Shayo, Natalia Fernández
Journal:
Biochemical Journal
Biochem J (2014) 459 (1): 117–126.
Published: 14 March 2014
... agonism G-protein-coupled receptor internalization (GPCR internalization) histamine H 2 receptor ligand (H 2 R ligand) mitogen-activated protein kinase (MAPK) pluridimensional efficacy seven-transmembrane receptor (7TMR) 7TMRs (seven-transmembrane receptors) represent the largest family...
Articles
Journal:
Biochemical Journal
Biochem J (2013) 450 (2): 351–363.
Published: 15 February 2013
... is properly cited. α 1 -adrenergic receptor cardiomyocyte endothelin mitogen-activated protein kinase (MAPK) p90 ribosomal S6 kinase (p90 RSK) transcriptomics The ERK1/2 (extracellular-signal-regulated kinase 1/2) cascade plays a major role in the global regulation of gene expression [ 1...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 446 (2): e5–e7.
Published: 14 August 2012
... © The Authors Journal compilation © 2012 Biochemical Society 2012 Arabidopsis mitogen-activated protein kinase (MAPK) MPK6 peptide array phosphorylation motif protein kinase Protein kinases are ubiquitous modifiers of proteins both in prokaryotic and eukaryotic cells, where...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 445 (1): 1–10.
Published: 15 June 2012
... of stem/progenitor cells in different tissues in physiology and disease. cancer cell specification cytokine signalling development mitogen-activated protein kinase (MAPK) self-renewal Embryonic development and maintenance of adult tissue homoeostasis are physiological processes where stem...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 443 (1): 95–102.
Published: 14 March 2012
...-OsMKK6. All primers used for the mutagenesis are shown in Supplementary Tables S2 and S3. © The Authors Journal compilation © 2012 Biochemical Society 2012 chilling stress constitutive activation kinase activity mitogen-activated protein kinase (MAPK) Oryza sativa L Low...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 441 (2): 571–578.
Published: 21 December 2011
... To whom correspondence should be addressed (email [email protected] ). 16 5 2011 8 9 2011 27 9 2011 27 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) mitogen...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 441 (2): 553–569.
Published: 21 December 2011
... [email protected] ). 14 2 2011 11 8 2011 11 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 cell signalling mitogen-activated protein kinase (MAPK) phosphorylation proliferation protein kinase 90 kDa ribosomal S6 kinase (RSK) The Ras...
Articles
Shaista Naqvi, Andrew Macdonald, Claire E. McCoy, Joanne Darragh, Alastair D. Reith, J. Simon C. Arthur
Journal:
Biochemical Journal
Biochem J (2012) 441 (1): 347–357.
Published: 14 December 2011
...-transcribed (iScript; BioRad Laboratories) and real-time PCR was carried out using SYBR Green-based detection. 18S rRNA levels were used as normalization controls and relative mRNA levels were calculated using the equation: cAMP-response-element-binding protein (CREB) mitogen-activated protein kinase...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 441 (1): 77–85.
Published: 14 December 2011
... correspondence should be addressed (email [email protected] ). 9 5 2011 7 9 2011 26 9 2011 26 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 computational biology cross-talk growth factor kinetic analysis mitogen-activated protein kinase (MAPK...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2011) 439 (3): 381–392.
Published: 13 October 2011
... Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. c-Jun N-terminal kinase (JNK) D domain mitogen-activated protein kinase (MAPK) mitogen-activated...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2011) 434 (1): 1–10.
Published: 27 January 2011
... (reviewed in [ 2 ]). Similarly, the specific interaction between BMP type I receptors and Smad1 (probably Smad5/8) is also conferred by the L3 loop of R-Smads and the L45 loop of the receptors [ 17 ]. cross-talk mitogen-activated protein kinase (MAPK) negative regulator Smad7 transforming growth...
Articles
Journal:
Biochemical Journal
Biochem J (2011) 433 (1): 11–18.
Published: 15 December 2010
... Biochemical Society 2011 adrenergic receptor β-arrestin G-protein-coupled receptor (GPCR) heteromerization mitogen-activated protein kinase (MAPK) signal specificity GPCRs (G-protein-coupled receptors), also called seven-transmembrane receptors or heptahelical receptors, are a large family...
Articles
Louay Mardini, Jadwiga Gasiorek, Anna Derjuga, Lucie Carrière, Matthias Schranzhofer, Barry H. Paw, Prem Ponka, Volker Blank
Journal:
Biochemical Journal
Biochem J (2010) 432 (1): 145–151.
Published: 25 October 2010
... erythropoiesis haemoglobin iron mitogen-activated protein kinase (MAPK) mitoferrin The mechanisms governing haemoglobin synthesis and the maturation of erythroid cells have been studied in great detail and serve as a paradigm for the regulation of gene expression and cellular differentiation [ 1...
Articles
Journal:
Biochemical Journal
Biochem J (2010) 430 (3): 439–451.
Published: 27 August 2010
... to apoptosis via activation of the p38 MAPK /p53 axis. © The Authors Journal compilation © 2010 Biochemical Society 2010 apoptosis glucose glutathione mitogen-activated protein kinase (MAPK) p53 reactive oxygen species (ROS) Oxidative stress is considered to be an important...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 430 (1): 161–169.
Published: 28 July 2010
... hypothiocyanous acid (HOSCN) mitogen-activated protein kinase (MAPK) myeloperoxidase p38 protein tyrosine phosphatase thiol MPO (myeloperoxidase) is a highly basic haem enzyme that is released extracellularly by activated neutrophils, monocytes and some macrophages. MPO catalyses the oxidation...
Articles
Journal:
Biochemical Journal
Biochem J (2010) 429 (3): 403–417.
Published: 14 July 2010
... regulation mitogen-activated protein kinase (MAPK) p38 phosphorylation signalling stress response Cells need to be constantly aware of changes in the extracellular milieu to respond accordingly, so they have developed sophisticated mechanisms to receive signals, transmit the information...
Articles
Judit Remenyi, Christopher J. Hunter, Christian Cole, Hideaki Ando, Soren Impey, Claire E. Monk, Kirsty J. Martin, Geoffrey J. Barton, Gyorgy Hutvagner, J. Simon C. Arthur
Journal:
Biochemical Journal
Biochem J (2010) 428 (2): 281–291.
Published: 13 May 2010
... to local ethical review and were carried out in accordance with U.K. Home Office regulations. brain-derived neurotrophic factor (BDNF) microRNA (miRNA) mitogen-activated protein kinase (MAPK) mitogen- and stress-activated kinase 1 (MSK1) mitogen- and stress-activated kinase 2 (MSK2) neuron...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 428 (1): 103–111.
Published: 28 April 2010
... 2010 18 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell cycle extracellular-signal-regulated kinase 3 (ERK3) mitogen-activated protein kinase (MAPK) mitosis protein phosphorylation ERK3 (extracellular-signal-regulated kinase 3) is an atypical...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 427 (3): 435–443.
Published: 14 April 2010
...) epoxomicin mitogen-activated protein kinase (MAPK) mixed lineage kinase 3 (MLK3) proteasome tumour necrosis factor α (TNFα) The activities and signalling pathways of many protein kinases are controlled through post-translational modifications. Reversible phosphorylation is the most common post...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 427 (2): 297–304.
Published: 29 March 2010
.... cell culture focal adhesion kinase (FAK) heparan sulfate hippocampal neuron mitogen-activated protein kinase (MAPK) poly- L -lysine Anti-tau antibody, anti-MAP2 (microtubule-associated protein 2) antibody, anti-p44/42 MAPK (ERK1/2) antibody and anti-synaptophysin antibody were purchased...
Articles
Robert Newton, Elizabeth M. King, Wei Gong, Christopher F. Rider, Karl J. Staples, Neil S. Holden, Martin W. Bergmann
Journal:
Biochemical Journal
Biochem J (2010) 427 (1): 113–124.
Published: 15 March 2010
... mitogen-activated protein kinase (MAPK) In inflammation, expression of cytokines, chemokines, adhesion molecules and other inflammatory proteins drives inflammatory cell recruitment [ 1 ]. Conversely, the profound anti-inflammatory effects of glucocorticoids (also known as corticosteroids...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2009) 417 (3): 705–715.
Published: 16 January 2009
... peptides using Hi-Trap columns (Amersham Biosciences) [ 25 ]. cross-talk extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) phosphorylation potassium channel protein kinase C (PKC) Regulation of transient outward K + currents in cardiac myocytes...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 417 (1): 331–342.
Published: 12 December 2008
... chemiluminescence) reaction for identification of the different proteins and their phosphorylated form were performed as described in Sambrook et al. [ 37 ] and by Yaakov et al. [ 38 ]. extracellular-signal-regulated kinase (ERK) c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) p38...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 413 (3): 429–436.
Published: 15 July 2008
[email protected] ). 14 3 2008 29 4 2008 13 5 2008 13 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 Argonaute (Ago) mitogen-activated protein kinase (MAPK) phosphorylation processing body RNA interference (RNAi) Non-coding RNAs of approx. 20...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 413 (2): 217–226.
Published: 26 June 2008
... cascade. Arabidopsis thaliana (thale cress) biotic and abiotic stresses mitogen-activated protein kinase (MAPK) phosphorylation cascade signalling As plants are sessile organisms unable to escape changing environmental conditions, they developed mechanisms to sense and adapt...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 413 (1): 37–49.
Published: 12 June 2008
... Society 2008 Aperts syndrome fibroblast growth factor receptor 2 (FGFR2) fibroblast growth factor receptor substrate 2 (FRS2) fluorescent lifetime imagining microscopy (FLIM) mitogen-activated protein kinase (MAPK) signal transduction systems biology temporal control tyrosine kinase...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 412 (2): e15–e16.
Published: 14 May 2008
... on the molecular mechanism of Bax activation and migration during ischaemia-induced apoptosis in cardiomyocytes. AMP-activated protein kinase (AMPK) apoptosis Bax heart ischaemia mitochondrion mitogen-activated protein kinase (MAPK) protein kinase Programmed cell death, or apoptosis, is an active...
Articles
Maria Ekerot, Marios P. Stavridis, Laurent Delavaine, Michael P. Mitchell, Christopher Staples, David M. Owens, Iain D. Keenan, Robin J. Dickinson, Kate G. Storey, Stephen M. Keyse
Journal:
Biochemical Journal
Biochem J (2008) 412 (2): 287–298.
Published: 14 May 2008
... (DUSP6) fibroblast growth factor (FGF) mitogen-activated protein kinase (MAPK) mitogen-activated protein kinase phosphatase-3 (MKP-3) phosphatase transcription DUSP (dual-specificity phosphatase) 6 or MKP [MAPK (mitogen-activated protein kinase) phosphatase]-3 is the prototypical member...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 409 (1): 179–185.
Published: 11 December 2007
... responses during immune responses to bacterial infections, stress stimuli and growth signals. mitogen-activated protein kinase (MAPK) signal transducer and activator of transcription (STAT) protein inhibitor of activated STAT1 (PIAS1) Ser 727 phosphorylation small ubiquitin-related modifier (SUMO...
Articles
Jun-ichi Saito, Shinnosuke Toriumi, Kenjiro Awano, Hidenori Ichijo, Keiichi Sasaki, Takayasu Kobayashi, Shinri Tamura
Journal:
Biochemical Journal
Biochem J (2007) 405 (3): 591–596.
Published: 13 July 2007
... in the brain ( Figure 1 C). © The Authors Journal compilation © 2007 Biochemical Society 2007 apoptosis apoptosis signal-regulating kinase 1 (ASK1) hydrogen peroxide (H 2 O 2 ) mitogen-activated protein kinase (MAPK) protein phosphatase 2C (PP2C) protein serine/threonine phosphatase 5 (PP5...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 405 (3): e5.
Published: 13 July 2007
...-activated protein kinase (MAPK) mobile phone reactive oxygen species ultra-high frequency radio wave (UHF radio wave) Over the last 10 to 15 years, there has been a large increase in the use of mobile phones, and more recently in wireless computer networks. These networks transmit information using...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 404 (2): 299–308.
Published: 14 May 2007
... substrate (Tropix) for 10 min at room temperature and immunoreactivity was detected using a Fuji Film Luminescent Image Analyzer (LAS-1000 CH, Japan). aggregation calcium mitogen-activated protein kinase (MAPK) protein kinase C Src family kinase Platelet activation is important...
Articles
Heather J. Lee, Hee-Chang Mun, Narelle C. Lewis, Michael F. Crouch, Emma L. Culverston, Rebecca S. Mason, Arthur D. Conigrave
Journal:
Biochemical Journal
Biochem J (2007) 404 (1): 141–149.
Published: 26 April 2007
... acid calcium-sensing receptor extracellular calcium extracellular-signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) The SureFire AlphaScreen-based phosphorylated ERK1/2 (pERK1/2) assay is based on a two-antibody system directed to the doubly phosphorylated epitope...
Articles
Claire E. Mccoy, Andrew Macdonald, Nick A. Morrice, David G. Campbell, Maria Deak, Rachel Toth, Joanne Mcilrath, J. Simon C. Arthur
Journal:
Biochemical Journal
Biochem J (2007) 402 (3): 491–501.
Published: 26 February 2007
...-Dye Ver3.1 chemistry on a capillary sequencer. 2 8 2006 10 11 2006 22 11 2006 22 11 2006 The Biochemical Society, London 2007 cAMP-response-element-binding protein (CREB) extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) p38...
Articles
Yalin Emre, Corinne Hurtaud, Tobias Nübel, François Criscuolo, Daniel Ricquier, Anne-Marie Cassard-Doulcier
Journal:
Biochemical Journal
Biochem J (2007) 402 (2): 271–278.
Published: 12 February 2007
... 10 2006 The Biochemical Society, London 2007 lipopolysaccharide mitochondria mitogen-activated protein kinase (MAPK) reactive oxygen species (ROS) signalling uncoupling protein 2 (UCP2) UCP2 (uncoupling protein 2) is a carrier protein located in the inner mitochondrial...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 401 (1): e1.
Published: 11 December 2006
... mitogen-activated protein kinase (MAPK) p90 ribosomal S6 kinase (RSK) protein kinase inhibitor small-molecule inhibitor There are four closely related RSK (p90 ribosomal S6 kinase) genes in the human genome (RSK1–4), which belong to the AGC family of protein kinases. RSKs phosphorylate a number...
Articles
Gopal P. Sapkota, Lorna Cummings, Felicity S. Newell, Christopher Armstrong, Jennifer Bain, Morten Frodin, Matthias Grauert, Matthias Hoffmann, Gisela Schnapp, Martin Steegmaier, Philip Cohen, Dario R. Alessi
Journal:
Biochemical Journal
Biochem J (2007) 401 (1): 29–38.
Published: 11 December 2006
..., London 2007 BI-D1870 kinase-specific inhibitor mitogen-activated protein kinase (MAPK) p90 ribosomal S6 kinase (RSK) phosphorylation Members of the AGC [PKA (cAMP-dependent protein kinase)/protein kinase G/PKC (protein kinase C)] subfamily of protein kinases, including isoforms of PKA...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2006) 396 (3): 517–527.
Published: 29 May 2006
.... adrenomedullin (ADM) hypoxia-inducible factor-1 (HIF-1) inflammation macrophages mitogen-activated protein kinase (MAPK) oxygen sensing The heterodimeric transcription factor HIF-1 (hypoxia-inducible factor-1) regulates the expression of genes involved in angiogenesis, oxygen transport, glucose...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 396 (3): 547–556.
Published: 29 May 2006
...-binding factor (E2F) mitogen-activated protein kinase (MAPK) promoter analysis E2F1 ( E2 promoter-binding factor 1) was initially identified as a cellular DNA-binding factor required for the E1A (adenovirus 5 early region 1A product)-mediated activation of the adenoviral E2 gene [ 1...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 394 (2): 459–464.
Published: 10 February 2006
..., London 2006 axon guidance HT-22 cell mitogen-activated protein kinase (MAPK) plexin semaphorin Rho GTPase Semaphorins are a family of soluble and membrane-associated proteins that were originally characterized in the nervous system and play a critical role in axon guidance. Outside...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 394 (1): 299–308.
Published: 27 January 2006
... sphingomyelinase colon cancer inflammatory bowel disease mitogen-activated protein kinase (MAPK) platelet-activating factor phospholipase C Human promyelocyte HL-60 cells grown in RPMI 1640 supplemented with 10% (v/v) FCS (foetal calf serum) and 1% penicillin/streptomycin were washed and incubated...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 394 (1): 365–373.
Published: 27 January 2006
.... The Biochemical Society, London 2006 extracellular-signal-regulated kinase 8 (ERK8) mass spectrometry mitogen-activated protein kinase (MAPK) oxidative stress protein phosphatase [γ- 32 P]ATP was obtained from Amersham Biosciences (Little Chalfont, Bucks, U.K.), Ro 318220 was from Calbiochem...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 393 (1): 69–77.
Published: 12 December 2005
...–cell adhesion epithelium ERK occludin mitogen-activated protein kinase (MAPK) zonula occludins-1 (ZO-1) The TJ (tight junction), located at the apical end of the lateral membrane of epithelial cells, forms a barrier to the diffusion of macromolecules such as allergens, toxins and pathogens...
Articles
Richard J. Orton, Oliver E. Sturm, Vladislav Vyshemirsky, Muffy Calder, David R. Gilbert, Walter Kolch
Journal:
Biochemical Journal
Biochem J (2005) 392 (2): 249–261.
Published: 22 November 2005
... 2005 computational modelling extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) receptor tyrosine kinase signalling network systems biology In molecular biology the MAPK (mitogen-activated protein kinase) pathway is considered to be a paradigm...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 392 (2): 389–397.
Published: 22 November 2005
... demonstrate that Pcp2 induces differentiation in PC12 cells, in part through Gβγ-mediated Ras and p38 MAPK activation and suggest the potential for similar signalling mechanisms in Purkinje cells. differentiation G-protein regulator mitogen-activated protein kinase (MAPK) neuron PC12 cell Purkinje...
Articles
Jaclyn Long, Peter Darroch, Kah Fei Wan, Kok Choi Kong, Nicholas Ktistakis, Nigel J. Pyne, Susan Pyne
Journal:
Biochemical Journal
Biochem J (2005) 391 (1): 25–32.
Published: 26 September 2005
... with the exception that it has a long C-terminal hydrophilic domain of approx. 400 amino acids [ 8 ]. apoptosis lipid phosphate phosphatase (LPP) lysophosphatidic acid mitogen-activated protein kinase (MAPK) phosphatidic acid sphingosine 1-phosphate (S1P) The Biochemical Society, London 2005...
Includes: Supplementary data
Articles
Rémy Nyga, Christian Pecquet, Noria Harir, Haihua Gu, Isabelle Dhennin-Duthille, Aline Régnier, Valérie Gouilleux-Gruart, Kaïss Lassoued, Fabrice Gouilleux
Journal:
Biochemical Journal
Biochem J (2005) 390 (1): 359–366.
Published: 09 August 2005
...-picardie.fr ). 6 9 2004 11 4 2005 18 4 2005 18 4 2005 The Biochemical Society, London 2005 Gab2 growth-factor-receptor-bound protein 2 (Grb2) mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K) proliferation signal transducer and activator...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 389 (3): 723–729.
Published: 26 July 2005
... incorporation (a measure of proteoglycan synthesis) by cartilage [ 11 ]. Surprisingly, the cell signalling mechanism by which IGF-I stimulates proteoglycan synthesis has not been reported. Akt articular cartilage chondrocyte insulin-like growth factor-I (IGF-I) mitogen-activated protein kinase (MAPK...
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