...Hagai Abeliovich Mitophagy, the autophagic breakdown of mitochondria, is observed in eukaryotic cells under various different physiological circumstances. These can be broadly categorized into two types: mitophagy related to quality control events and mitophagy induced during developmental...

..., and cancer. Mitochondrial homeostasis is controlled by a triad of mitochondrial biogenesis, dynamics (fusion and fission), and autophagy (mitophagy). Studies have underscored FoxO transcription factors as key mitochondrial regulators. Specifically, FoxOs regulate mitochondrial biogenesis by dampening NRF1...

... juvenile-onset Parkinsonism, probably through impairment of mitophagy. Inhibition of the de-ubiquitinating enzyme USP30 may counter this effect to enhance mitophagy. Using different tools and cellular approaches, we wanted to independently confirm this claimed role for USP30. Pharmacological...

... (mitophagy) contributes to mitochondrial quality control by selectively eliminating the dysfunctional mitochondria. Mitochondria motility, which is regulated by Miro1, is also associated with neuronal cell functions. However, the role played by Miro1 in the mitophagy mechanism, especially relative to AβO...

...Yujing Zhang; Huanfeng Bian; Yu Ma; Yuanyuan Xiao; Fang Xiao Hexavalent chromium [Cr(VI)] has aroused the main interest of environmental health researchers due to its high toxicity. Liver is the main target organ of Cr(VI), and the purpose of this study was to explore whether mitophagy contributes...

... in mitochondrial ROS production and nitrotyrosine formation was observed. These events were accompanied by disrupted mitophagy (accumulation of dysfunctional and damaged mitochondria, and of LC3II and p62), in an mTOR- and AMPK-independent manner, and despite the increased mitochondrial PINK1 (PTEN-inducible...

... ubiquitinated, promotes mitophagy, as SCF Fbxo7 substrates both in vitro and in vivo . Ubiquitin chain restriction analyses revealed that Fbxo7 modified Gsk3β using K63 linkages. Our results indicate that Fbxo7 negatively regulates Gsk3β activity, rather than its levels or localization. In addition, Fbxo7...

... response, leading to the biogenesis of mitochondria and improved organelle function. Exercise also promotes the degradation of poorly functioning mitochondria (i.e. mitophagy), thereby accelerating mitochondrial turnover, and preserving a pool of healthy organelles. In contrast, muscle disuse, as well...

... through autophagy-related pathways, and severely limits the ability of cells to remove depolarized mitochondria through PTEN-associated kinase 1 (PINK1)-mediated mitophagy. Recent research has demonstrated that chemical modulation of mitochondrial pathways related to acetyl-CoA metabolism regulates...

...) stressors [tunicamycin (TN) or thapsigargin (TG)]. nCDase −/− MEFs had higher autophagic flux and mitophagy than wild-type (WT) MEFs and inhibition of autophagy sensitized them to necroptosis. These data indicate that loss of nCDase protects cells from nutrient- deprivation-induced necroptosis via autophagy...

... on their impact on cardiovascular disease and neurodegeneration. 18 5 2015 9 6 2015 11 6 2015 © 2015 Authors; published by Portland Press Limited 2015 antioxidants autophagy KEAP1–NRF2 mitophagy p62 redox signalling The redox-dependent post-translational modifications...

... kinase 1] [ 5 , 6 ], another protein associated with early-onset Parkinson's disease. Ubiquitylation of several mitochondrial proteins including the mitofusins, Miro1 and TOMM70 (translocase of the outer mitochondrial membrane 70) by Parkin signals the turnover of damaged mitochondria (mitophagy...