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Keywords: mitophagy
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Biochem J (2023) 480 (20): 1639–1657.
Published: 18 October 2023
...Hagai Abeliovich Mitophagy, the autophagic breakdown of mitochondria, is observed in eukaryotic cells under various different physiological circumstances. These can be broadly categorized into two types: mitophagy related to quality control events and mitophagy induced during developmental...
Articles
Biochem J (2022) 479 (4): 525–536.
Published: 23 February 2022
..., and cancer. Mitochondrial homeostasis is controlled by a triad of mitochondrial biogenesis, dynamics (fusion and fission), and autophagy (mitophagy). Studies have underscored FoxO transcription factors as key mitochondrial regulators. Specifically, FoxOs regulate mitochondrial biogenesis by dampening NRF1...
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Biochem J (2021) 478 (23): 4099–4118.
Published: 06 December 2021
... juvenile-onset Parkinsonism, probably through impairment of mitophagy. Inhibition of the de-ubiquitinating enzyme USP30 may counter this effect to enhance mitophagy. Using different tools and cellular approaches, we wanted to independently confirm this claimed role for USP30. Pharmacological...
Includes: Supplementary data
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Biochem J (2020) 477 (23): 4581–4597.
Published: 08 December 2020
... (mitophagy) contributes to mitochondrial quality control by selectively eliminating the dysfunctional mitochondria. Mitochondria motility, which is regulated by Miro1, is also associated with neuronal cell functions. However, the role played by Miro1 in the mitophagy mechanism, especially relative to AβO...
Includes: Supplementary data
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Biochem J (2020) 477 (14): 2607–2619.
Published: 24 July 2020
...Yujing Zhang; Huanfeng Bian; Yu Ma; Yuanyuan Xiao; Fang Xiao Hexavalent chromium [Cr(VI)] has aroused the main interest of environmental health researchers due to its high toxicity. Liver is the main target organ of Cr(VI), and the purpose of this study was to explore whether mitophagy contributes...
Articles
Biochem J (2017) 474 (23): 3887–3902.
Published: 10 November 2017
... in mitochondrial ROS production and nitrotyrosine formation was observed. These events were accompanied by disrupted mitophagy (accumulation of dysfunctional and damaged mitochondria, and of LC3II and p62), in an mTOR- and AMPK-independent manner, and despite the increased mitochondrial PINK1 (PTEN-inducible...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (20): 3563–3580.
Published: 11 October 2016
... ubiquitinated, promotes mitophagy, as SCF Fbxo7 substrates both in vitro and in vivo . Ubiquitin chain restriction analyses revealed that Fbxo7 modified Gsk3β using K63 linkages. Our results indicate that Fbxo7 negatively regulates Gsk3β activity, rather than its levels or localization. In addition, Fbxo7...
Includes: Supplementary data
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Biochem J (2016) 473 (15): 2295–2314.
Published: 28 July 2016
... response, leading to the biogenesis of mitochondria and improved organelle function. Exercise also promotes the degradation of poorly functioning mitochondria (i.e. mitophagy), thereby accelerating mitochondrial turnover, and preserving a pool of healthy organelles. In contrast, muscle disuse, as well...
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Biochem J (2016) 473 (6): 743–755.
Published: 10 March 2016
...) stressors [tunicamycin (TN) or thapsigargin (TG)]. nCDase −/− MEFs had higher autophagic flux and mitophagy than wild-type (WT) MEFs and inhibition of autophagy sensitized them to necroptosis. These data indicate that loss of nCDase protects cells from nutrient- deprivation-induced necroptosis via autophagy...
Includes: Supplementary data
Articles
Biochem J (2015) 469 (3): 347–355.
Published: 23 July 2015
... – 72 ], although it is also highly conceivable that modification of autophagy proteins at cysteine residues may also play a role in modulating autophagy. antioxidants autophagy KEAP1–NRF2 mitophagy p62 redox signalling The redox-dependent post-translational modifications of proteins...
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Biochem J (2014) 460 (3): e1–e3.
Published: 29 May 2014
....200809125 19029340 6 Matsuda N. Sato S. Shiba K. Okatsu K. Saisho K. Gautier C. A. Sou Y. S. Saiki S. Kawajiri S. Sato F. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy J...