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Keywords: mitotic checkpoint
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Articles

Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)

Philippe Thebault, Dimitri Y. Chirgadze, Zhen Dou, Tom L. Blundell, Sabine Elowe, Victor M. Bolanos-Garcia
Journal: Biochemical Journal
Biochem J (2012) 448 (3): 321–328.
https://doi.org/10.1042/BJ20121448
Published: 21 November 2012
... region of human Mps1. The structure reveals an overall high similarity to the TPR motif of the mitotic checkpoint kinases Bub1 and BubR1, and a number of unique features that include the absence of the binding site for the kinetochore structural component KNL1 (kinetochore-null 1; blinkin...
View article titled, Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)
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Includes: Supplementary data
Articles

hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain

Larissa J. Vos, Jakub K. Famulski, Gordon K. T. Chan
Journal: Biochemical Journal
Biochem J (2011) 436 (1): 157–168.
https://doi.org/10.1042/BJ20110137
Published: 27 April 2011
..., along with its partners Rod (Roughdeal) and hZwilch, form a complex which recruits dynein–dynactin and Mad1–Mad2 complexes to the kinetochore and are essential components of the mitotic checkpoint. hZwint-1 localizes to the kinetochore in prophase, before hZw10 localization, and remains...
View article titled, hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain
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Includes: Supplementary data
Articles

The multiple facets of the Golgi reassembly stacking proteins

Fabian P. Vinke, Adam G. Grieve, Catherine Rabouille
Journal: Biochemical Journal
Biochem J (2011) 433 (3): 423–433.
https://doi.org/10.1042/BJ20101540
Published: 14 January 2011
... of the Golgi ribbon, a structure which is fragmented in mitosis owing to the phosphorylation of a number of serine and threonine residues situated in its C-terminus. Golgi ribbon unlinking is in turn shown to be part of a mitotic checkpoint. GRASP65 also seems to be the key target of signalling events leading...
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