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Keywords: mitoxantrone
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Articles
Aurélien Bidaud-Meynard, Daniela Arma, Said Taouji, Michel Laguerre, Jean Dessolin, Jean Rosenbaum, Eric Chevet, Violaine Moreau
Journal:
Biochemical Journal
Biochem J (2013) 450 (1): 55–62.
Published: 24 January 2013
... screening. A pilot compound library screen revealed that the topoisomerase II poison MTX (mitoxantrone) is an inhibitor of Rac1, and also inhibits RhoA and Cdc42 in vitro . We show that MTX prevents GTP binding to RhoA/Rac1/Cdc42 in vitro . Furthermore, MTX strongly inhibits RhoGTPase-mediated F-actin...
Includes: Supplementary data
