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Keywords: monoclonal antibody
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Biochem J (2012) 445 (1): 135–144.
Published: 15 June 2012
... and cytokine receptors. Recently it was shown that ADAM17 is highly expressed on the surface of many cancer cells, whereas normal cells express low levels of ADAM17, implying that ADAM17 is a potential immunotherapeutic target. We have generated a monoclonal antibody against human ADAM17, which recognized...
Includes: Supplementary data
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Biochem J (2002) 367 (3): 801–808.
Published: 01 November 2002
... and was facilitated by a cell-surface protein(s). Within 5min at 37°C, cell-bound Ib generated Na + /K + permeable channels that were blocked by Ia. However, Ib-induced channels or oligomers were not formed at 4°C. Two monoclonal antibodies raised against Ib that recognize unique, neutralizing epitopes within...
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Biochem J (2002) 362 (3): 585–595.
Published: 08 March 2002
... enzyme following cleavage mediated by an unidentified protease(s), referred to as ACE secretase, in a process known as ‘shedding'. The effects of monoclonal antibodies (mAbs) to eight different epitopes on the N-terminal domain of ACE on shedding was investigated using Chinese hamster ovary cells (CHO...
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Biochem J (2001) 355 (2): 289–296.
Published: 06 April 2001
... deletion of the C-terminal three residues (268-270) still retained full binding activity. Consistently, these alterations in LOX-1 impaired the recognition by a functionally blocking monoclonal antibody for LOX-1. These data demonstrated the distinct role of the lectin domain as the functional domain...
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