... in mycobacteria decreases the extent of MtrA methylation. Most importantly, we show that decreased MtrA methylation results in transcriptional activation of mtrA and sahH promoters. Collectively, we identify novel methylated proteins, expand the list of modifications in mycobacteria by adding arginine methylation...

... regulation histidine kinase mycobacteria protein phosphorylation Mycobacterium tuberculosis ( Mtb ) is a successful intracellular pathogen and continues to be one of the leading causes of mortality worldwide [ 1 , 2 ]. Despite extensive tuberculosis management programs, it still accounts...

..., we provide further evidence that mycobacteria recognition by DC-SIGN may be restricted to species of the M. tuberculosis complex. Fine analyses of the lipoarabinomannan molecules purified from these species show that the structure and amount of these molecules alone cannot account...

... intermediates and increases the turnover of polyprenol phosphate-Man. These findings are incorporated into a revised pathway for mycobacterial PIM biosynthesis. Key words: cell wall, lipoarabinomannan, mycobacteria, phos- phatidylinositol, phosphatidylinositol mannoside, polyprenol phosphate. INTRODUCTION...

..., London © 2003 Biochem. J. (2003) 374, 657 666 (Printed in Great Britain) 657 The metabolism of nitrosothiols in the mycobacteria: identification and characterization of S-nitrosomycothiol reductase Ryan N. VOGT*, Daniel J. STEENKAMP*1 , Renjian ZHENG and John S. BLANCHARD *Division of Chemical...

..., lipid transporter, mycobacteria, virulence. binding proteins, bind nucleotides [7,8]. The doxorubicin- resistance operon, first identified in Streptomyces peucetius [9], shares similarity with the eukaryotic P-glycoprotein. Two trans- lationally coupled open reading frames, drrA and drrB, encode an ABC...

... mycobacteria Abbreviations used: Ac, acylated; BCG, Bacille Calmette—Guérin; C 35 /C 50 -P-Man, polyprenol-monophosphorylmannose; FAB, fast atom bombardment; DIG, digoxigenin; GT1F, glycosyltransferase 1 family; hyg, hygromycin; LAM, lipoarabinomannan; LM, lipomannan; Man, mannose; NK, natural killer...

... that initiation of M. tuberculosis oriC involves intimate interactions between DnaA, adenine nucleotides and membrane phospholipids, and the latter helps to ensure that only the ATP form of the DnaA protein interacts continuously with oriC. ATP DNA filter-binding assays mycobacteria protein...

...Mariko NAITO; Tomohiko FUKUDA; Kiyotoshi SEKIGUCHI; Takeshi YAMADA We have recently shown that α antigen (α-Ag), the immunodominant antigen of mycobacteria, has a novel fibronectin (FN)-binding motif that is unique among mycobacteria [Naito, Ohara, Matsumoto and Yamada (1998) J. Biol. Chem. 273...