... ISYNA1 Ino1 lithium LC-MS myo -inositol Opi1 sugar scyllo -inositol The cyclitol inositol (cyclohexane-1,2,3,4,5,6-hexol) is essential to eukaryotic cells in the form of the myo -inositol isomer (inositol thereafter) and provides the backbone for the synthesis of signalling molecules...

..., but becomes slowly re-solubilized by extracellular dephosphorylation first to Ins P 3 isomers and subsequently to free myo -inositol. The precipitated metal–InsP 6 complex is endocytosed in a receptor-independent but intact-glycocalyx-dependent manner and appears in lysosomes, where it is immediately...

... genome and by recombinant expression and characterization it was shown to encode a catalytically active PIS, with a high specificity for myo -inositol. Immunofluorescence revealed that in T. brucei , PIS is found in both the endoplasmic reticulum and Golgi. We created a conditional double knockout...

... examined. Translation of globin mRNA by rabbit reticulocyte lysate decreased by 30—60% when osmolality was increased from 0.35 to 0.53osmol/kg of water by the addition of NaCl, KCl, CH 3 CO 2 Na or CH 3 CO 2 K. In contrast, equivalent additions of the compatible osmolytes betaine or myo -inositol caused...