... of the Biochemical Society 2023 epigenetics lysine methylation myogenesis Myogenic differentiation is tightly regulated by the coordinated activity of distinct transcription factors that bind at promoters and enhancers to dictate a precise pattern of gene expression [ 54 ]. To perform their specific...

... of the Biochemical Society 2021 GDF8 latency myogenesis procomplex tolloid transforming growth factors Growth differentiation factor 8 (GDF8), commonly known as myostatin, is a member of the larger transforming growth factor β (TGFβ) superfamily of signaling ligands and functions as a potent...

... factor-21 MyoD myogenesis p38 MAPK reactive oxygen species Results are expressed as means±S.E.M. Significance was determined by a two-tailed Student's t test. We determined FGF21 mRNA levels in the mouse-derived myogenic cell line C2C12 at distinct stages of differentiation...

...-mediated cell–cell adhesion also plays an important role in skeletal myogenesis. In the present study, we found that both genes were differentially expressed in C2C12 and Sol8 myoblasts during myogenic differentiation and that the expression of M-cadherin was preferentially enhanced in slow-twitch muscle...

...-induced muscle weakness in vivo , it has been suggested that TauT is essential for skeletal muscle function. However, the regulatory mechanisms of TauT expression remain to be elucidated. In the present study, we demonstrated that TauT was up-regulated during myogenesis in C2C12 cells. Treatment with bFGF...

... studies have implicated MARCKS in the stabilization of cytoskeletal structures during cell differentiation. The present study was performed to investigate the potential role of Ca 2+ -dependent proteinases (calpains) during myogenesis via proteolysis of MARCKS. It was first demonstrated that MARCKS...

... expression during myogenesis. Physical interaction between these two factors is required to synergistically activate gene transcription. p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) interacting with transcription factors is able to increase their activity on target gene promoters...

... markers, adipocyte lipid-binding protein and peroxisome-proliferator-activated receptor γ. Furthermore, we show that ERK activation is required only during RA treatment. PD98059 does not interfere with the commitment of ES cells into other lineages, such as neurogenesis, myogenesis and cardiomyogenesis...

... differentiation. 1 To whom correspondence should be addressed (e-mail [email protected] ). 31 7 2000 4 10 2000 18 10 2000 The Biochemical Society, London © 2000 2000 co-immunoprecipitation myogenesis proteinprotein interaction signal transduction Biochem. J. (2000) 352...

... to the disruption of a key structural element. 1 To whom correspondence should be addressed (e-mail [email protected] ). 18 2 2000 22 5 2000 7 6 2000 The Biochemical Society, London © 2000 2000 actin cytoskeleton glycine-rich repeat muscle myogenesis Biochem. J...