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Keywords: necrosis
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Articles
Biochem J (2016) 473 (6): 769–777.
Published: 10 March 2016
.... autophagy iron necrosis oxidative stress Ras Cell death plays an important role in the normal development and homoeostasis of living individuals, and is also implicated in abnormal activities of these processes in several diseases. Cells possess multiple cell death programmes including apoptosis...
Includes: Supplementary data
Articles
Biochem J (2014) 461 (1): 137–146.
Published: 13 June 2014
...Xing Guo; Hiromi Sesaki; Xin Qi Oxidative-stress-induced necrosis is considered to be one of the main pathological mediators in various neurological disorders, such as brain ischaemia. However, little is known about the mechanism by which cells modulate necrosis in response to oxidative stress. In...
Includes: Supplementary data
Articles
Biochem J (2012) 441 (3): 859–869.
Published: 16 January 2012
...-aminopyridine) or K v 4.3 small interfering RNA induces cell apoptosis and necrosis, which are completely rescued by the specific CaMKII (calcium/calmodulin-dependent protein kinase II) inhibitor KN-93, suggesting that K v 4.3 K + channels contribute to cell apoptosis and necrosis through CaMKII activation. In...
Includes: Supplementary data
Articles
Biochem J (2012) 441 (2): 609–621.
Published: 21 December 2011
... chemical entity (HSNO 2 ) with the potential to release NO, suppressing the pro-apoptotic, oxidative and nitrative properties of peroxynitrite. Physiological concentrations of H 2 S abrogated peroxynitrite-induced cell damage as demonstrated by the: (i) inhibition of apoptosis and necrosis caused by...
Includes: Supplementary data
Articles
Biochem J (2010) 425 (1): 137–148.
Published: 14 December 2009
... inhibited CyP-D over extramitochondrial CyP-A. In hippocampal neurons, mitochondrial targeting markedly enhanced the capacity of CsA to prevent cell necrosis brought about by oxygen and glucose deprivation, but largely abolished its capacity to inhibit glutamate-induced cell death. It is concluded that CyP...
Articles
Biochem J (2006) 394 (1): 325–334.
Published: 27 January 2006
.... 1 To whom correspondence should be addressed (email dgdorado@vhebron.net ). 20 5 2005 12 10 2005 20 10 2005 20 10 2005 The Biochemical Society, London 2006 cardiomyocytes CTP:phosphocholine cytidylyltransferase (CTP) ischaemia necrosis phosphatidylcholine...
Articles
Biochem J (2005) 387 (1): 47–55.
Published: 22 March 2005
... critical role in oxidative stress responses. One of the proteins regulated by NF-κB is the zinc-finger protein A20. In TNF (tumour necrosis factor)-α signalling, NF-κB induction of A20 leads to increased cell survival. In the present paper, we show that in response to oxidative stress, A20 actually...
Articles
Biochem J (2004) 383 (1): 101–109.
Published: 24 September 2004
... from an antiporter to a non-selective pore. The permeability transition has been widely considered as a mechanism in both apoptosis and necrosis. The present study examines the effects of cyclophilin-D on the permeability transition and lethal cell injury, using a neuronal (B50) cell line stably...
Articles
Biochem J (2004) 379 (3): 823–832.
Published: 01 May 2004
... cells. Moreover, both molecular and cellular read-outs indicated that staurosporine-induced cell death was necrosis rather than apoptosis in these cells. The study of the effects of Bcl2 down-regulation was extended to the global MCF7 protein expression profile, exploiting a proteomic approach. Two...
Articles
Biochem J (2003) 370 (2): 609–619.
Published: 01 March 2003
... production induced by tumour necrosis factor α (TNF-α) in L929 cells was associated with a decrease in the steady-state mRNA levels of the mitochondrial transcript ATPase 6-8. Simultaneously, the transcript levels of two nuclear-encoded glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and...
Articles
Biochem J (2003) 369 (2): 239–248.
Published: 15 January 2003
... addressed (e-mail marta.muzio@pharmacia.com ). 1 7 2002 16 10 2002 16 10 2002 16 10 2002 The Biochemical Society, London ©2003 2003 attenuated total reflection camptothecin necrosis Biochem. J. (2003) 369, 239 248 (Printed in Great Britain) 239 Monitoring of...
Articles
Biochem J (2001) 360 (3): 557–562.
Published: 10 December 2001
... an autoimmune response. Abbreviations used: Tg, thyroglobulin; TPO, thyroperoxidase; TSH, thyroid-stimulating hormone; mAb, monoclonal antibody; P40, 40kDa Tg peptide; FCS, fetal-calf serum. antigen processing endocytosis iodine necrosis oxidative stress The Biochemical Society...
Articles
Biochem J (2001) 359 (2): 335–343.
Published: 08 October 2001
... phenomenon preceded caspase activation, as well as changes of mitochondrial membrane potential. High sphingosine doses rapidly caused extensive lysosomal rupture and ensuing necrosis, without antecedent apoptosis or caspase activation. The sphingosine effect was prevented by pre-treatment with another, non...
Articles
Biochem J (2001) 358 (2): 481–487.
Published: 24 August 2001
...Toshihiko AKI; Yoichi MIZUKAMI; Yoshitomo OKA; Kazuhito YAMAGUCHI; Koichi UEMURA; Tatsuya FUJIMIYA; Ken-ichi YOSHIDA Using H9c2 cells derived from rat cardiomyocytes, we investigated the mechanism of cell death during hypoxia in the presence of serum and glucose. Hypoxic cell death is by necrosis...
Articles
Biochem J (2001) 356 (2): 549–555.
Published: 24 May 2001
... Society, London ©2001 2001 desferrioxamine dipyridyl iron Jurkat T-cell necrosis Biochem. J. (2001) 356, 549 555 (Printed in Great Britain) 549 Apoptosis induced by exposure to a low steady-state concentration of H2O2 is a consequence of lysosomal rupture Fernando ANTUNES*‹1, Enrique CADENAS...
Articles
Biochem J (2000) 349 (1): 255–260.
Published: 26 June 2000
...-43 can respond significantly to a biological process other than vesicular trafficking. 1 To whom correspondence should be addressed (e-mail heinrich@;rwth-aachen.de). 27 3 2000 25 4 2000 5 5 2000 The Biochemical Society, London © 2000 2000 annexin V necrosis...
Articles
Biochem J (1999) 344 (2): 443–449.
Published: 24 November 1999
...Margret C. M. VISSERS; Juliet M. PULLAR; Mark B. HAMPTON We have investigated the effect of hypochlorous acid (HOCl) on cultured human umbilical-vein endothelial cells and shown that, whereas higher concentrations cause rapid necrosis, smaller amounts of this oxidant induce apoptosis or growth...
Articles
Biochem J (1999) 341 (2): 233–249.
Published: 08 July 1999
.... 1 m.crompton@biochemistry.ucl.ac.uk The Biochemical Society, London © 1999 1999 apoptosis Ca 2+ cyclophilin necrosis oxidative stress Biochem. J. (1999) 341, 233 249 (Printed in Great Britain) 233 REVIEW ARTICLE The mitochondrial permeability transition pore and its role in cell...