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Keywords: negative feedback
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Biochem J (2012) 447 (1): 159–166.
Published: 12 September 2012
... and pharmacological disruption of the MAPK-activated kinase RSK (ribosomal S6 kinase) leads to elevated MAPK activity indicative of a RSK-dependent negative feedback loop. Using biochemical, pharmacological and quantitative MS approaches we show that RSK phosphorylates the Ras activator SOS1 (Son of Sevenless...
Includes: Supplementary data
Biochem J (2012) 446 (3): 509–516.
Published: 28 August 2012
...-apoptotic functions, for a considerably longer time frame than does IFNα2. We show that the diversification of α2/β responses progressively builds up at the receptor level as a result of accumulating USP18 (ubiquitin specific protease 18), itself an ISG, which exerts its negative feedback action by taking...
Includes: Supplementary data
Biochem J (2012) 444 (2): 343–355.
Published: 11 May 2012
... factor 3), Egr1 (early growth response 1) and Ptgs2 (prostaglandin-endoperoxide synthase 2) are rapi-dly and transiently up-regulated by endothelin-1 in cardiomyocytes. Atf3 regulates the expression of downstream genes and is implicated in negative feedback regulation of other immediate early genes...
Includes: Supplementary data