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Keywords: nephrogenic diabetes insipidus
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Articles
Chemical validation and optimization of pharmacoperones targeting vasopressin type 2 receptor mutant
Jo Ann Janovick, Timothy P. Spicer, Thomas D. Bannister, Emery Smith, Vadivel Ganapathy, Louis Scampavia
Journal:
Biochemical Journal
Biochem J (2018) 475 (18): 2941–2953.
Published: 25 September 2018
... is known to cause nephrogenic diabetes insipidus (NDI). Three compounds were particularly effective in rerouting the mutant receptor in a concentration-dependent manner, were neither agonists nor antagonists, and displayed low cellular toxicity. Compound 1 was most effective and can be used as a molecular...
