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Keywords: neurite outgrowth
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Articles
Biochem J (2016) 473 (17): 2591–2602.
Published: 30 August 2016
...-ribosylation factor). However, its specificity to Arf isoforms and physiological functions remain unclear. In the present study, we demonstrate that ACAP3 plays an important role in neurite outgrowth of mouse hippocampal neurons through its GAP activity specific to Arf6. In primary cultured mouse hippocampal...
Includes: Supplementary data
Articles
Biochem J (2014) 460 (3): 437–446.
Published: 29 May 2014
... with comparable activity as the function-triggering monoclonal antibody 557.B6 and induces neurite outgrowth and neuronal survival in cultured neurons, despite its monovalent function. Infusion of αL1 Fab into the lesioned spinal cord of mice enhanced functional recovery after thoracic spinal cord...
Includes: Supplementary data
Articles
Biochem J (2011) 440 (2): 273–282.
Published: 14 November 2011
... phosphorylation and enhanced the neurite outgrowth induced by NGF, whereas knock down of heparanase impaired this process. However, overexpression of latent pro-heparanase with a Y156A mutation still led to enhanced NGF-induced neurite outgrowth and increased p38 MAPK phosphorylation. Inhibition of p38 MAPK by...
Includes: Supplementary data
Articles
Biochem J (2009) 419 (2): 467–474.
Published: 27 March 2009
... was able to cleave amidated NPY (neuropeptide Y), probably contributing to the increased NPY levels reported in TTR-knockout mice. To assess the involvement of TTR proteolytic activity in axonal regeneration, neurite outgrowth of cells cultivated with wild-type TTR or TTR prot− , was measured. Cells...
Articles
Biochem J (2004) 383 (1): 149–158.
Published: 24 September 2004
... NGF have been cloned and an active recombinant NGF, sputa NGF, has been produced in Escherichia coli as a His-tagged fusion protein. Sputa NGF has been found to be non-toxic under both in vivo and in vitro conditions. The induction of neurite outgrowth by this NGF has been found to involve the high...
Articles
Biochem J (2004) 383 (1): 129–138.
Published: 24 September 2004
... expressing these HSPGs were cultured on the recombinant neurocan substrate. A significant increase in the rate of neurite outgrowth was observed on the wells coated with the C-terminal neurocan fragment, but not with the N-terminal one. Neurite outgrowth-promoting activity was inhibited by pretreatment of...
Articles
Biochem J (2003) 376 (3): 655–666.
Published: 15 December 2003
... previously showed that a secreted fungal 15 kDa protein, named p15, as well as its orthologue from Streptomyces coelicolor (named Scp15) induce neurite outgrowth in PC12 cells at nanomolar concentrations. We report here that both p15 and Scp15 are members of a newly identified group of fungal/bacterial sPLA...