... in growth and development, but also have well documented pathological roles as oncoproteins in a wide variety of cancers [ 1–3 ]. The N-myc gene was discovered in a neuroblastoma cell line as a copy number amplified DNA sequence with sequence similarity to c-myc [ 4 ]. It is an important driver for cancers...

... and function of neurons. The Trks share a high degree of homology and utilize overlapping signaling pathways, yet their signaling is associated with starkly different outcomes in certain cancers. For example, in neuroblastoma, TrkA expression and signaling correlates with a favorable prognosis, whereas TrkB...

... ) * These authors contributed equally to this work. 12 3 2019 22 5 2019 27 5 2019 28 5 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 aggregation Alzheimer disease amyloid-beta neuroblastoma peptides toxicity...

... that elevated mRNA levels of the two target enzymes DHPS and ODC correlate with poor prognosis in a large cohort of neuroblastoma (NB) tumors. The DHPS inhibitor GC7 ( N 1 -guanyl-1,7-diaminoheptane) and the ODC inhibitor α-difluoromethylornithine (DFMO) are target-specific and in combination induced...

...-binding protein 5) is a tumour suppressor gene (TSG) that maps to a region of consistent deletion on 1p36.31 in neuroblastomas (NBs) and other tumour types. CHD5 encodes a protein with chromatin remodelling, helicase and DNA-binding motifs that is preferentially expressed in neural and testicular tissues...

...Christina Schönherr; Kristina Ruuth; Yasuo Yamazaki; Therese Eriksson; James Christensen; Ruth H. Palmer; Bengt Hallberg Mutations in the kinase domain of ALK (anaplastic lymphoma kinase) have recently been shown to be important for the progression of the childhood tumour neuroblastoma...

... compilation © 2011 Biochemical Society 2011 AMP-activated protein kinase (AMPK) 3-bromo-pyruvate delocalized lipophilic cation neuroblastoma p38 mitogen-activated protein kinase (p38 MAPK ) p53 Extracellular lactate concentration was assessed as described previously [ 33 ]. Briefly, 10 μl...

... within the full-length ALK kinase domain, most commonly R1275Q and F1174L, which play a major role in neuroblastoma, were recently identified. To provide a structural framework for understanding these mutations and to guide structure-assisted drug discovery efforts, the X-ray crystal structure...

...-small cell lung cancer), together with the identification of activating point mutations in neuroblastoma, have highlighted ALK as a significant player and target for drug development in cancer. In the present review we address the role of ALK in development and disease and discuss implications...

...Helena Carén; Frida Abel; Per Kogner; Tommy Martinsson ALK (anaplastic lymphoma kinase) is oncogenic in several tumours and has recently been identified as a predisposition gene for familial NB (neuroblastoma) harbouring mutations in the TKD (tyrosine kinase domain). We have analysed a large set...

... (and deoxynucleoside) 5′-triphosphate. It is involved in complex cellular regulatory functions including the control of metastatic tumour dissemination. The mutation S120G has been identified in high-grade neuroblastomas. We have shown previously that this mutant has a folding defect: the urea-denatured protein could...

... (amyloid precursor protein) by various cell lines in vitro . Proteasome activity is altered during aging, a major risk factor for Alzheimer's disease. In the present study, a human neuroblastoma cell line expressing the C-terminal 100 residues of APP (SH-SY5Y-SPA4CT) was used to determine the effect...

...Helen A. RODWAY; Alan N. HUNT; Janice A. KOHLER; Anthony D. POSTLE; Karen A. LILLYCROP PPARγ (peroxisome proliferator-activated receptor γ) is a ligand-activated transcription factor that responds to 15dPGJ 2 (15-deoxy-Δ 12,14 -prostglandin J 2 ). 15dPGJ 2 , in vitro , halts neuroblastoma cell...

...Daniel NIELSEN; Hanna GYLLBERG; Pernilla ÖSTLUND; Tomas BERGMAN; Katarina BEDECS We have previously shown that ScN2a cells (scrapie-infected neuroblastoma N2a cells) express 2-fold- and 4-fold-increased levels of IR (insulin receptor) and IGF-1R (insulin-like growth factor-1 receptor) respectively...

... PACE4 gene expression in neural development, we analysed the effects of human achaete–scute homologue 1 (hASH-1) on PACE4 gene expression with various neuroblastoma cell lines. The expressions of PACE4 and hASH-1 are correlated inversely in these cell lines. The overexpression of hASH-1 or MASH-1 causes...

... expressed ‘exogenous’ wild-type and ligand-binding-defective mutant type I Ins(1,4,5) P 3 receptors in human neuroblastoma SH-SY5Y cells, in which muscarinic receptor activation elicits Ins(1,4,5) P 3 receptor down-regulation. We found (1) that exogenous wild-type Ins(1,4,5) P 3 receptors are efficiently...