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Keywords: neurotoxicity
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Articles
Biochem J (2019) 476 (8): 1285–1302.
Published: 26 April 2019
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 molecular interactions neurotoxicity neurotoxins nicotinic acetylcholine receptor venom Nicotinic acetylcholine receptors (nAChRs) belong to the large family of ligand-gated ion channels and consist...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (19): 3253–3267.
Published: 20 September 2017
... protein gene PRNP and accumulation of PrP Sc , an abnormal isomer of the normal host protein PrP C , in the brain of affected individuals. PrP Sc is the principal component of the transmissible neurotoxic prion agent. It is important to identify molecular pathways and cellular processes that regulate...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (14): 2119–2130.
Published: 12 July 2016
...Andrzej Maciejewski; Valeriy G. Ostapchenko; Flavio H. Beraldo; Vania F. Prado; Marco A.M. Prado; Wing-Yiu Choy Soluble oligomers of amyloid-beta peptide (AβO) transmit neurotoxic signals through the cellular prion protein (PrP C ) in Alzheimer's disease (AD). Secreted stress-inducible...
Articles
Biochem J (2014) 463 (1): 41–52.
Published: 08 September 2014
... be, in part, responsible for this selective neuronal loss, although the mechanisms by which they contribute to such neurotoxicity are not understood. Exposure of neurons in culture to CysDA caused cell injury, apparent 12–48 h post-exposure. A portion of the neuronal death induced by CysDA was preceded...
Articles
Biochem J (2014) 463 (1): 31–40.
Published: 08 September 2014
...-induced neurotoxicity during prion disease remains undefined. In the present study we investigated whether Drosophila transgenic for ovine PrP targeted to the plasma membrane, to the cytosol or for secretion, could produce transmissible toxicity following exposure to exogenous ovine prions. Although all...
Includes: Supplementary data
Articles
Biochem J (2014) 459 (1): 103–115.
Published: 14 March 2014
... endoproteolytic events known as α- and β-cleavage, yielding C-terminal fragments known as C1 and C2 respectively. It is unclear whether C-terminal fragments generated through α- and β-cleavage, especially C2, influence pathogenesis directly. Consequently, we compared the biophysical properties and neurotoxicity...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (1): 305–312.
Published: 12 December 2008
...Lucia Corich; Alejandro Aranda; Laura Carrassa; Cristina Bellarosa; J. Donald Ostrow; Claudio Tiribelli In vitro and in vivo studies have demonstrated that UCB (unconjugated bilirubin) is neurotoxic. Although previous studies suggested that both MRP1 (multidrug resistance-associated protein 1...
Articles
Biochem J (2003) 372 (1): 129–136.
Published: 15 May 2003
... 2003 The Biochemical Society, London ©2003 2003 apoptosis glycogen synthase kinase 3 lithium microtubule-associated protein neurodegeneration neurotoxicity prion spongiform encephalopathy Abbreviations used: GSK-3, glycogen synthase kinase 3; MAPK, mitogen-activated protein...
Articles
Biochem J (2001) 355 (3): 869–877.
Published: 24 April 2001
... of Aβ are produced. In an effort to determine how these peptides might contribute to the pathogenesis of the Flemish disease, comparative biophysical and neurotoxicity studies were performed on wild-type and Flemish Aβ(1–40), Aβ(5–40) and Aβ(11–40). The results revealed that the Flemish amino acid...