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Keywords: neurotoxicity
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Biochem J (2017) 474 (19): 3253–3267.
Published: 20 September 2017
... protein gene PRNP and accumulation of PrP Sc , an abnormal isomer of the normal host protein PrP C , in the brain of affected individuals. PrP Sc is the principal component of the transmissible neurotoxic prion agent. It is important to identify molecular pathways and cellular processes that regulate...
Includes: Supplementary data
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Biochem J (2016) 473 (14): 2119–2130.
Published: 12 July 2016
...Andrzej Maciejewski; Valeriy G. Ostapchenko; Flavio H. Beraldo; Vania F. Prado; Marco A.M. Prado; Wing-Yiu Choy Soluble oligomers of amyloid-beta peptide (AβO) transmit neurotoxic signals through the cellular prion protein (PrP C ) in Alzheimer's disease (AD). Secreted stress-inducible...
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Biochem J (2014) 463 (1): 31–40.
Published: 08 September 2014
...-induced neurotoxicity during prion disease remains undefined. In the present study we investigated whether Drosophila transgenic for ovine PrP targeted to the plasma membrane, to the cytosol or for secretion, could produce transmissible toxicity following exposure to exogenous ovine prions. Although all...
Includes: Supplementary data
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Biochem J (2014) 459 (1): 103–115.
Published: 14 March 2014
... endoproteolytic events known as α- and β-cleavage, yielding C-terminal fragments known as C1 and C2 respectively. It is unclear whether C-terminal fragments generated through α- and β-cleavage, especially C2, influence pathogenesis directly. Consequently, we compared the biophysical properties and neurotoxicity...
Includes: Supplementary data
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Biochem J (2003) 372 (1): 129–136.
Published: 15 May 2003
... peptide-induced cell death. These results are consistent with the view that the activation of GSK-3 is a crucial mediator of prion peptide-induced neurodegeneration. apoptosis glycogen synthase kinase 3 lithium microtubule-associated protein neurodegeneration neurotoxicity prion spongiform...
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