... such as RyR1, TRP-ML1 or TPCs. However, how the NAADP-binding protein finds the right channel to be activated is still mysterious and needs further experimental work. NAADP nicotinic acid–adenine dinucleotide phosphate NAADP-AM NAADP acetoxymethyl ester RyR1 ryanodine receptor type 1...

... 5 2013 2 5 2013 2 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 calcium endosome lysosome nicotinic acid–adenine dinucleotide phosphate (NAADP) two-pore segment channel 1 (TPCN1) trafficking NAADP (nicotinic acid–adenine dinucleotide...

... provides new molecular insight into the membrane insertion and oligomerization of TPCs. calcium signalling domain assembly nicotinic acid–adenine dinucleotide phosphate (NAADP) two-pore channel (TPC) voltage-gated ion channel 1 These authors contributed equally to this work. 2...

... Biochemical Society 2009 calcium stores glutamate hippocampal neuron lysosome nicotinic acid–adenine dinucleotide phosphate (NAADP) neurotransmitter Changes in the cytosolic Ca 2+ concentration regulate a multitude of cellular processes [ 1 ]. In the central nervous system, Ca 2...

... to increase cellular NAADP levels [ 9 , 14 , 20 , 23 – 27 ] establishes NAADP as a bona fide Ca 2+ -mobilizing messenger critical for the generation of agonist-specific Ca 2+ signals. calcium nicotinic acid–adenine dinucleotide phosphate (NAADP) non-selective cation channel patch-clamp ©...

... compilation © 2008 Biochemical Society 2008 ADP-ribosyl cyclase calcium nicotinic acid–adenine dinucleotide phosphate (NAADP) sea urchin second messenger sperm Currently, there are four generally accepted Ca 2+ -releasing second messengers: IP 3 (inositol 1,4,5-trisphosphate) [ 1 ], cADPR...

... ). 31 1 2008 8 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 ADP-ribosyl cyclase calcium nicotinic acid–adenine dinucleotide phosphate (NAADP) sea urchin second messenger sperm NAADP (nicotinic acid–adenine dinucleotide phosphate) is one...

... of their activation. The Biochemical Society, London 2006 calcium desensitization memory nicotinic acid–adenine dinucleotide phosphate (NAADP) sea urchin egg time sensing 1 To whom correspondence should be addressed (email [email protected] ). 30 1 2006 15 3 2006 21 3 2006...

... mammalian tissues, including brain, heart, liver, spleen and kidney [ 15 ]. calcium cADP-ribose (cADPR) inositol 1,4,5-trisphosphate (IP 3 ) nicotinic acid–adenine dinucleotide phosphate (NAADP) rat hepatocyte microsome ryanodine receptor (RyR) Compared with IP 3 and cADPR, NAADP exhibits...

... protein. 1 To whom correspondence should be addressed (email [email protected] ). 1 12 2004 17 12 2004 20 12 2004 20 12 2004 The Biochemical Society, London 2005 calcium nicotinic acid–adenine dinucleotide phosphate (NAADP) phospholipids sea urchin signal...

.... Experiments were carried out at least three times in duplicate and results are presented as means±S.D., unless otherwise stated. ADP-ribosyl cyclase CD38 cyclic ADP-ribose nicotinic acid–adenine dinucleotide phosphate (NAADP) sarcoplasmic reticulum skeletal muscle The formation of [ 32 P...

...Dev CHURAMANI; Elizabeth A. CARREY; George D. DICKINSON; Sandip PATEL Nicotinic acid–adenine dinucleotide phosphate (NAADP) is fast emerging as a new intracellular Ca 2+ -mobilizing messenger. In sea urchin egg homogenates, binding of NAADP to its receptor is not readily reversible; hence, prior...

... ). 22 8 2003 6 11 2003 10 11 2003 10 11 2003 The Biochemical Society, London ©2004 2004 calcium signalling dehydrogenase fertilization reduced nicotinic acid—adenine dinucleotide phosphate (reduced NAADP) nicotinic acid—adenine dinucleotide phosphate (NAADP) sea urchin...

...Eugen BRAILOIU; Sandip PATEL; Nae J. DUN Nicotinic acid–adenine dinucleotide phosphate (NAADP) is a recently described potent intracellular Ca 2+ -mobilizing messenger active in a wide range of diverse cell types. In the present study, we have investigated the interaction of NAADP with other Ca 2...

...Guy A. RUTTER The molecular mechanisms through which extracellular stimuli mobilize intracellular Ca 2+ stores are still incompletely understood. Recent work suggests that nicotinic acid–adenine dinucleotide phosphate (NAADP) can finally join the ranks of genuine Ca 2+ -mobilizing second messengers...