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Influence of the heme distal pocket on nitrite binding orientation and reactivity in Sperm Whale myoglobin

Wilford Tse, Nathan Whitmore, Myles R. Cheesman, Nicholas J. Watmough

Biochem J (2021) 478 (4): 927–942.

DOI: https://doi.org/10.1042/BCJ20200596

Published: 26 February 2021

...-fold increase in the rate of nitrite reduction by H93K relative to WT SWMb. heme magnetic circular dichroism spectroscopy myoglobin nitric oxide nitrite Heme containing nitrite reductases play a significant role in the transformation of nitrite to both nitric oxide and ammonia in animals...

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Lupeol-induced nitric oxide elicits apoptosis-like death within Escherichia coli in a DNA fragmentation-independent manner

Heesu Kim, Dong Gun Lee

Biochem J (2021) 478 (4): 855–869.

DOI: https://doi.org/10.1042/BCJ20200925

Published: 24 February 2021

...Heesu Kim; Dong Gun Lee Lupeol is known to be plentiful in fruits or plant barks and has an antimicrobial effect, however, its mode of action(s) has yet to be determined. To elucidate lupeol generates nitric oxide (NO), which is recognized for possessing an antimicrobial activity, intracellular...

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Articles

Exploiting S- nitrosylation for cancer therapy: facts and perspectives

Salvatore Rizza, Giuseppe Filomeni

Biochem J (2020) 477 (19): 3649–3672.

DOI: https://doi.org/10.1042/BCJ20200064

Published: 05 October 2020

...Salvatore Rizza; Giuseppe Filomeni S -nitrosylation, the post-translational modification of cysteines by nitric oxide, has been implicated in several cellular processes and tissue homeostasis. As a result, alterations in the mechanisms controlling the levels of S-nitrosylated proteins have been...

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Articles

Sugar beet hemoglobins: reactions with nitric oxide and nitrite reveal differential roles for nitrogen metabolism

Nélida Leiva Eriksson, Brandon J. Reeder, Michael T. Wilson, Leif Bülow

Biochem J (2019) 476 (14): 2111–2125.

DOI: https://doi.org/10.1042/BCJ20190154

Published: 31 July 2019

... 2019 8 7 2019 © 2019 The Author(s) 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . nitric oxide nitrite reductase no dioxygenase...

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Mechanism of nitrite-dependent NO synthesis by human sulfite oxidase

Daniel Bender, Alexander Tobias Kaczmarek, Dimitri Niks, Russ Hille, Guenter Schwarz

Biochem J (2019) 476 (12): 1805–1815.

DOI: https://doi.org/10.1042/BCJ20190143

Published: 28 June 2019

...Daniel Bender; Alexander Tobias Kaczmarek; Dimitri Niks; Russ Hille; Guenter Schwarz In addition to nitric oxide (NO) synthases, molybdenum-dependent enzymes have been reported to reduce nitrite to produce NO. Here, we report the stoichiometric reduction in nitrite to NO by human sulfite oxidase...

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Articles

Elevation of cytosolic Ca 2+ in response to energy deficiency in plants: the general mechanism of adaptation to low oxygen stress

Abir U. Igamberdiev, Robert D. Hill

Biochem J (2018) 475 (8): 1411–1425.

DOI: https://doi.org/10.1042/BCJ20180169

Published: 23 April 2018

... of glutamate decarboxylase, initiating the γ-aminobutyric acid shunt and triggering the formation of alanine, processes which play a role, in particular, in pH regulation. Ca 2+ activates the transcription of several genes, e.g. of plant hemoglobin (phytoglobin, Pgb) which scavenges nitric oxide and regulates...

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Articles

CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress

Louise V. Holyoake, Stuart Hunt, Guido Sanguinetti, Gregory M. Cook, Mark J. Howard, Michelle L. Rowe, Robert K. Poole, Mark Shepherd

Biochem J (2016) 473 (6): 693–701.

DOI: https://doi.org/10.1042/BJ20150536

Published: 10 March 2016

... thiol export, gene expression, metabolic perturbations, intracellular pH homoeostasis and tolerance to nitric oxide (NO). Loss of CydDC was found to decrease extracytoplasmic thiol levels, whereas overexpression diminished the cytoplasmic thiol content. Transcriptomic analysis revealed a dramatic up...

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Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock

Zhen Wang, Simon Lambden, Valerie Taylor, Elizabeth Sujkovic, Manasi Nandi, James Tomlinson, Alex Dyson, Neil McDonald, Stephen Caddick, Mervyn Singer, James Leiper

Biochem J (2014) 460 (2): 309–316.

DOI: https://doi.org/10.1042/BJ20131666

Published: 13 May 2014

... dimethylaminohydrolase 1), an enzyme that metabolizes endogenously produced nitric oxide synthase inhibitors, principally ADMA (asymmetric dimethylarginine). The present study employs a series of rodent models to evaluate the effectiveness a DDAH1-selective inhibitor (L-257). Short-term models involved the development...

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Nitric oxide inhibits succinate dehydrogenase-driven oxygen consumption in potato tuber mitochondria in an oxygen tension-independent manner

Vagner Simonin, Antonio Galina

Biochem J (2013) 449 (1): 263–273.

DOI: https://doi.org/10.1042/BJ20120396

Published: 07 December 2012

...Vagner Simonin; Antonio Galina NO (nitric oxide) is described as an inhibitor of plant and mammalian respiratory chains owing to its high affinity for COX (cytochrome c oxidase), which hinders the reduction of oxygen to water. In the present study we show that in plant mitochondria NO may interfere...

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Articles

Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity

Ryan Stapley, Benjamin Y. Owusu, Angela Brandon, Marianne Cusick, Cilina Rodriguez, Marisa B. Marques, Jeffrey D. Kerby, Scott R. Barnum, Jordan A. Weinberg, Jack R. Lancaster, Jr, Rakesh P. Patel

Biochem J (2012) 446 (3): 499–508.

DOI: https://doi.org/10.1042/BJ20120675

Published: 28 August 2012

.... In the present study we tested the hypothesis that storage of leucodepleted RBCs results in cells that inhibit NO (nitric oxide) signalling more so than younger cells. Using competition kinetic analyses and protocols that minimized contributions from haemolysis or microparticles, our data indicate...

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Resolving the contributions of the membrane-bound and periplasmic nitrate reductase systems to nitric oxide and nitrous oxide production in Salmonella enterica serovar Typhimurium

Gary Rowley, Daniela Hensen, Heather Felgate, Anke Arkenberg, Corinne Appia-Ayme, Karen Prior, Carl Harrington, Sarah J. Field, Julea N. Butt, Elizabeth Baggs, David J. Richardson

Biochem J (2012) 441 (2): 755–762.

DOI: https://doi.org/10.1042/BJ20110971

Published: 21 December 2011

...Gary Rowley; Daniela Hensen; Heather Felgate; Anke Arkenberg; Corinne Appia-Ayme; Karen Prior; Carl Harrington; Sarah J. Field; Julea N. Butt; Elizabeth Baggs; David J. Richardson The production of cytotoxic nitric oxide (NO) and conversion into the neuropharmacological agent and potent greenhouse...

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Articles

Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP: potential implications for ROS signalling

Khandaker Ahtesham Ahmed, Tomohiro Sawa, Hideshi Ihara, Shingo Kasamatsu, Jun Yoshitake, Md. Mizanur Rahaman, Tatsuya Okamoto, Shigemoto Fujii, Takaaki Akaike

Biochem J (2012) 441 (2): 719–730.

DOI: https://doi.org/10.1042/BJ20111130

Published: 21 December 2011

... ]. 1 To whom correspondence should be addressed (email takakaik@gpo.kumamoto-u.ac.jp ). mitochondrion nitric oxide oxidative stress peroxynitrite reactive oxygen species (ROS) reactive oxygen species (ROS) signalling cGMP, GTP, GDP, GMP and rotenone were obtained from Sigma–Aldrich...

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Observation of fast release of NO from ferrous d 1 haem allows formulation of a unified reaction mechanism for cytochrome cd 1 nitrite reductases

Serena Rinaldo, Katharine A. Sam, Nicoletta Castiglione, Valentina Stelitano, Alessandro Arcovito, Maurizio Brunori, James W. A. Allen, Stuart J. Ferguson, Francesca Cutruzzolà

Biochem J (2011) 435 (1): 217–225.

DOI: https://doi.org/10.1042/BJ20101615

Published: 15 March 2011

... involved and time course to previously published results [ 24 ] indicates that excess ascorbate does not alter the reaction mechanism. haemoprotein nitric oxide nitrite nitrite reductase Pseudomonas aeruginosa Paracoccus pantotrophus Denitrification is an anaerobic respiratory...

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Articles

Reduction of Nω-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC)

Jürke Kotthaus, Bettina Wahl, Antje Havemeyer, Joscha Kotthaus, Dennis Schade, Dieter Garbe-Schönberg, Ralf Mendel, Florian Bittner, Bernd Clement

Biochem J (2011) 433 (2): 383–391.

DOI: https://doi.org/10.1042/BJ20100960

Published: 22 December 2010

...Jürke Kotthaus; Bettina Wahl; Antje Havemeyer; Joscha Kotthaus; Dennis Schade; Dieter Garbe-Schönberg; Ralf Mendel; Florian Bittner; Bernd Clement NOSs (nitric oxide synthases) catalyse the oxidation of L -arginine to L -citrulline and nitric oxide via the intermediate NOHA ( N ω -hydroxy- L...

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Articles

Mesohaem substitution reveals how haem electronic properties can influence the kinetic and catalytic parameters of neuronal NO synthase

Jesús Tejero, Ashis Biswas, Mohammad Mahfuzul Haque, Zhi-Qiang Wang, Craig Hemann, Cornelius L. Varnado, Zachary Novince, Russ Hille, Douglas C. Goodwin, Dennis J. Stuehr

Biochem J (2011) 433 (1): 163–174.

DOI: https://doi.org/10.1042/BJ20101353

Published: 15 December 2010

... flavoprotein haemprotein mesohaem nitric oxide nitric oxide synthase (NOS) NO (nitric oxide) is a signalling molecule with a wide range of functions in biology [ 1 ]. In animals NO is synthesized from L -Arg ( L -arginine) by enzymes known as NOSs (NO synthases, EC 1.14.13.39). Three isoforms...

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Articles

Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron–sulfur cluster

Laura J. Smith, Melanie R. Stapleton, Gavin J. M. Fullstone, Jason C. Crack, Andrew J. Thomson, Nick E. Le Brun, Debbie M. Hunt, Evelyn Harvey, Salvatore Adinolfi, Roger S. Buxton, Jeffrey Green

Biochem J (2010) 432 (3): 417–427.

DOI: https://doi.org/10.1042/BJ20101440

Published: 25 November 2010

... but reacts rapidly with eight equivalents of nitric oxide to yield two dinuclear dinitrosyl-iron thiol complexes. The [4Fe-4S] form of WhiB1 did not bind whiB1 promoter DNA, but the reduced and oxidized apo-WhiB1, and nitric oxide-treated holo-WhiB1 did bind to DNA. Mycobacterium smegmatis RNA polymerase...

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Articles

Inhibition of the mitochondrial permeability transition by protein kinase A in rat liver mitochondria and hepatocytes

Peter Pediaditakis, Jae-Sung Kim, Lihua He, Xun Zhang, Lee M. Graves, John J. Lemasters

Biochem J (2010) 431 (3): 411–421.

DOI: https://doi.org/10.1042/BJ20091741

Published: 11 October 2010

... 2010 26 8 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cAMP cGMP glucagon ischaemia mitochondrial permeability transition nitric oxide protein kinase I/R (ischaemia/reperfusion) injury is a primary cause of graft dysfunction and failure after...

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Articles

Regulation of Nicotiana tabacum osmotic stress-activated protein kinase and its cellular partner GAPDH by nitric oxide in response to salinity

Izabela Wawer, Maria Bucholc, Jéremy Astier, Anna Anielska-Mazur, Jennifer Dahan, Anna Kulik, Aleksandra Wysłouch-Cieszynska, Monika Zaręba-Kozioł, Ewa Krzywinska, Michal Dadlez, Grażyna Dobrowolska, David Wendehenne

Biochem J (2010) 429 (1): 73–83.

DOI: https://doi.org/10.1042/BJ20100492

Published: 14 June 2010

...Izabela Wawer; Maria Bucholc; Jéremy Astier; Anna Anielska-Mazur; Jennifer Dahan; Anna Kulik; Aleksandra Wysłouch-Cieszynska; Monika Zaręba-Kozioł; Ewa Krzywinska; Michal Dadlez; Grażyna Dobrowolska; David Wendehenne Several studies focusing on elucidating the mechanism of NO (nitric oxide...

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Nitric oxide triggers mammary gland involution after weaning: remodelling is delayed but not impaired in mice lacking inducible nitric oxide synthase

Rosa Zaragozá, Ana Bosch, Concha García, Juan Sandoval, Eva Serna, Luís Torres, Elena R. García-Trevijano, Juan R. Viña

Biochem J (2010) 428 (3): 451–462.

DOI: https://doi.org/10.1042/BJ20091091

Published: 27 May 2010

..., NOS2 (inducible nitric oxide synthase)-KO (knockout) mice were used. No apparent differences were observed between NOS2 -KO and WT (wild-type) animals during pregnancy and lactation. However, upon cessation of lactation, a notable delay in involution was observed, compared with WT mice. NOS2 -KO mice...

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Articles

Role of nitric oxide-mediated glutathionylation in neuronal function: potential regulation of energy utilization

Li-Peng Yap, Jerome V. Garcia, Derick S. Han, Enrique Cadenas

Biochem J (2010) 428 (1): 85–93.

DOI: https://doi.org/10.1042/BJ20100164

Published: 28 April 2010

...Li-Peng Yap; Jerome V. Garcia; Derick S. Han; Enrique Cadenas Excessive generation of nitric oxide radical (NO • ) in neuroinflammation, excitotoxicity and during age-related neurodegenerative disorders entails the localized and concerted increase in nitric oxide synthase(s) expression in glial...

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Articles

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis

Stuart A. Ritchie, Christine F. Kohlhaas, Alasdair R. Boyd, Krishna C. Yalla, Kenneth Walsh, John M. C. Connell, Ian P. Salt

Biochem J (2010) 426 (1): 85–90.

DOI: https://doi.org/10.1042/BJ20091580

Published: 27 January 2010

...Stuart A. Ritchie; Christine F. Kohlhaas; Alasdair R. Boyd; Krishna C. Yalla; Kenneth Walsh; John M. C. Connell; Ian P. Salt Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser...

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Articles

Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction

Cilina Rodriguez, Dario A. Vitturi, Jin He, Marianne Vandromme, Angela Brandon, Anne Hutchings, Loring W. Rue, III, Jeffrey D. Kerby, Rakesh P. Patel

Biochem J (2009) 422 (3): 423–432.

DOI: https://doi.org/10.1042/BJ20090735

Published: 27 August 2009

... nitric oxide nitrite reductase activity resuscitation shock Safety concerns coupled with a lack of supply of donated RBCs (red blood cells) have led to a great deal of interest in the development of blood substitutes as alternative resuscitative agents. Such resuscitative agents would need...

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AMPKα1 regulates the antioxidant status of vascular endothelial cells

Sergio L. Colombo, Salvador Moncada

Biochem J (2009) 421 (2): 163–169.

DOI: https://doi.org/10.1042/BJ20090613

Published: 26 June 2009

.... Mitochondrial ROS (reactive oxygen species), generated as a result of the interaction between nitric oxide and mitochondrial cytochrome c oxidase, activate AMPKα1 in HUVECs (human umbilical-vein endothelial cells) at a low oxygen concentration (i.e. 3%). This activation is independent of changes in AMP...

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Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain

Catherine N. Hall, Robert G. Keynes, John Garthwaite

Biochem J (2009) 419 (2): 411–418.

DOI: https://doi.org/10.1042/BJ20082419

Published: 27 March 2009

...Catherine N. Hall; Robert G. Keynes; John Garthwaite In low nanomolar concentrations, NO (nitric oxide) functions as a transmitter in brain and other tissues, whereas near-micromolar NO concentrations are associated with toxicity and cell death. Control of the NO concentration, therefore...

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Articles

Reactivity of nitric oxide with the [4Fe–4S] cluster of dihydroxyacid dehydratase from Escherichia coli

Xuewu Duan, Juanjuan Yang, Binbin Ren, Guoqiang Tan, Huangen Ding

Biochem J (2009) 417 (3): 783–789.

DOI: https://doi.org/10.1042/BJ20081423

Published: 16 January 2009

...Xuewu Duan; Juanjuan Yang; Binbin Ren; Guoqiang Tan; Huangen Ding Although the NO (nitric oxide)-mediated modification of iron–sulfur proteins has been well-documented in bacteria and mammalian cells, specific reactivity of NO with iron–sulfur proteins still remains elusive. In the present study...

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High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo

Sudheer K. Mantena, Denty Paul Vaughn, Jr, Kelly K. Andringa, Heather B. Eccleston, Adrienne L. King, Gary A. Abrams, Jeannette E. Doeller, David W. Kraus, Victor M. Darley-Usmar, Shannon M. Bailey

Biochem J (2009) 417 (1): 183–193.

DOI: https://doi.org/10.1042/BJ20080868

Published: 12 December 2008

... respectively, for 8 or 16 weeks and liver hypoxia, mitochondrial bioenergetics, NO (nitric oxide)-dependent control of respiration, and 3-NT (3-nitrotyrosine), a marker of protein modification by RNS, were examined. Feeding a HFD for 16 weeks induced NASH-like pathology accompanied by elevated triacylglycerols...

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Articles

S-nitrosylation of syntaxin 1 at Cys 145 is a regulatory switch controlling Munc18-1 binding

Zoë J. Palmer, Rory R. Duncan, James R. Johnson, Lu-Yun Lian, Luciane V. Mello, David Booth, Jeff W. Barclay, Margaret E. Graham, Robert D. Burgoyne, Ian A. Prior, Alan Morgan

Biochem J (2008) 413 (3): 479–491.

DOI: https://doi.org/10.1042/BJ20080069

Published: 15 July 2008

... residue weighted molar ellipticity as follows [ 23 ]: membrane fusion neurotransmission nitric oxide Sec1/Munc18-like protein SNARE Exocytosis, the fusion of vesicles with the plasma membrane, can occur in a constitutive or regulated manner. In regulated exocytosis, fusion is generally...

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S-Nitrosation and thiol switching in the mitochondrion: a new paradigm for cardioprotection in ischaemic preconditioning

Bradford G. Hill, Victor M. Darley-Usmar

Biochem J (2008) 412 (2): e11–e13.

DOI: https://doi.org/10.1042/BJ20080716

Published: 14 May 2008

... between nitric oxide-induced protein thiol modifications and the cardioprotected phenotype. In a highly cited, seminal article published in the Biochemical Journal in 2006, Burwell and colleagues addressed this issue and provided direct evidence for S-nitrosation of complex I of the mitochondrial electron...

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Articles

Analysis of the contribution of the globin and reductase domains to the ligand-binding properties of bacterial haemoglobins

Judith Farrés, Susanna Burckhardt-Herold, Jan Scherrer, Alexander D. Frey, Pauli T. Kallio

Biochem J (2007) 407 (1): 15–22.

DOI: https://doi.org/10.1042/BJ20070668

Published: 12 September 2007

... the influence of each domain of flavoHbs on ligand binding, we have studied the kinetic ligand-binding properties of oxygen, carbon monoxide and nitric oxide to the chimaeric proteins, FHPg (truncated form of FHP comprising the globin domain alone) and VHb-Red (fusion protein between VHb and the C-terminal...

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Articles

The crystal structure of the pentahaem c -type cytochrome NrfB and characterization of its solution-state interaction with the pentahaem nitrite reductase NrfA

Thomas A. Clarke, Jeffrey A. Cole, David J. Richardson, Andrew M. Hemmings

Biochem J (2007) 406 (1): 19–30.

DOI: https://doi.org/10.1042/BJ20070321

Published: 26 July 2007

...Thomas A. Clarke; Jeffrey A. Cole; David J. Richardson; Andrew M. Hemmings NrfB is a small pentahaem electron-transfer protein widely involved in the respiratory reduction of nitrite or nitric oxide to ammonia, processes that provide energy for anaerobic metabolism in many enteric bacteria and also...

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Evidence for oxygen as the master regulator of the responsiveness of soluble guanylate cyclase and cytochrome c oxidase to nitric oxide

Aimee Landar, Victor M. Darley-Usmar

Biochem J (2007) 405 (2): e3.

DOI: https://doi.org/10.1042/BJ20070590

Published: 27 June 2007

...Aimee Landar; Victor M. Darley-Usmar Haem is used as a versatile receptor for redox active molecules; most notably NO (nitric oxide) and oxygen. Three haem-containing proteins, myoglobin, haemoglobin and cytochrome c oxidase, are now known to bind NO, and in all these cases competition with oxygen...

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Articles

Oxidative stress and cancer: have we moved forward?

Barry Halliwell

Biochem J (2007) 401 (1): 1–11.

DOI: https://doi.org/10.1042/BJ20061131

Published: 11 December 2006

... on p53, cell proliferation, invasiveness and metastasis. Chronic inflammation predisposes to malignancy, but the role of RS in this is likely to be complex because RS can sometimes act as anti-inflammatory agents. antioxidant cancer DNA repair nitric oxide reactive oxygen species However...

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STAT5 proteins are involved in down-regulation of iron regulatory protein 1 gene expression by nitric oxide

Rafal Radoslaw Starzynski, Ana Sofia Gonçalves, Françoise Muzeau, Zofia Tyrolczyk, Ewa Smuda, Jean-Claude Drapier, Carole Beaumont, Pawel Lipinski

Biochem J (2006) 400 (2): 367–375.

DOI: https://doi.org/10.1042/BJ20060623

Published: 14 November 2006

... be addressed (email P.Lipinski@ighz.pl ). 26 4 2006 11 7 2006 4 8 2006 4 8 2006 The Biochemical Society, London 2006 iron metabolism iron regulatory protein 1 (IRP1) nitric oxide promoter regulation signal transducer and activator of transcription (STAT) transcription...

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Direct evidence for S-nitrosation of mitochondrial complex I

Lindsay S. Burwell, Sergiy M. Nadtochiy, Andrew J. Tompkins, Sara Young, Paul S. Brookes

Biochem J (2006) 394 (3): 627–634.

DOI: https://doi.org/10.1042/BJ20051435

Published: 24 February 2006

...Lindsay S. Burwell; Sergiy M. Nadtochiy; Andrew J. Tompkins; Sara Young; Paul S. Brookes NO • (nitric oxide) is a pleiotropic signalling molecule, with many of its effects on cell function being elicited at the level of the mitochondrion. In addition to the well-characterized binding...

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Role of MKK3 and p38 MAPK in cytokine-induced death of insulin-producing cells

Natalia Makeeva, Jason W. Myers, Nils Welsh

Biochem J (2006) 393 (1): 129–139.

DOI: https://doi.org/10.1042/BJ20050814

Published: 12 December 2005

...Natalia Makeeva; Jason W. Myers; Nils Welsh The aim of the present investigation was to elucidate further the importance of p38 MAPK (mitogen-activated protein kinase) in nitric oxide- and cytokine-induced β-cell death. For this purpose, isolated human islets were treated with d-siRNA (diced small...

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Weaning induces NOS-2 expression through NF-κB modulation in the lactating mammary gland: importance of GSH

Rosa Zaragozá, Vicente J. Miralles, A. Diana Rus, Concha García, Rafael Carmena, Elena R. García-Trevijano, Teresa Barber, Federico V. Pallardó, Luís Torres, Juan R. Viña

Biochem J (2005) 391 (3): 581–588.

DOI: https://doi.org/10.1042/BJ20050507

Published: 25 October 2005

... immunoprecipitation assays, binding of NF-κB to the NOS-2 (inducible nitric oxide synthase) promoter at the early onset of events triggered during weaning. The three isoforms of NOS are constitutively present in the lactating mammary gland; however, while NOS-2 mRNA and protein levels and, consequently, NO production...

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Different phospholipase-C-coupled receptors differentially regulate capacitative and non-capacitative Ca 2+ entry in A7r5 cells

Zahid Moneer, Irene Pino, Emily J. A. Taylor, Lisa M. Broad, Yingjie Liu, Stephen C. Tovey, Leila Staali, Colin W. Taylor

Biochem J (2005) 389 (3): 821–829.

DOI: https://doi.org/10.1042/BJ20050145

Published: 26 July 2005

...) according to the manufacturer's instructions, and cDNA was synthesized in a final volume of 20 μl from the RNA (1–5 μg) using the Superscript II first-strand synthesis kit (Invitrogen) primed with oligo(dT) 12–18 . capacitative Ca 2+ entry 5-hydroxytryptamine (5-HT) nitric oxide vascular smooth...

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Interleukin-1β induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner

Rika Yasuhara, Yoichi Miyamoto, Takaaki Akaike, Teruo Akuta, Masanori Nakamura, Masamichi Takami, Naoko Morimura, Kayoko Yasu, Ryutaro Kamijo

Biochem J (2005) 389 (2): 315–323.

DOI: https://doi.org/10.1042/BJ20041996

Published: 05 July 2005

... cytometer (FACSCaliber, Becton Dickinson, San Jose, CA, U.S.A.). interleukin-1β NADPH oxidase nitric oxide nitric oxide synthase peroxynitrite superoxide Degradation of articular cartilage is a common pathogenic change seen in the degenerative joint diseases, such as RA (rheumatoid...

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Nitric oxide consumption through lipid peroxidation in brain cell suspensions and homogenates

Robert G. KEYNES, Charmaine H. GRIFFITHS, Catherine HALL, John GARTHWAITE

Biochem J (2005) 387 (3): 685–694.

DOI: https://doi.org/10.1042/BJ20041431

Published: 26 April 2005

...Robert G. KEYNES; Charmaine H. GRIFFITHS; Catherine HALL; John GARTHWAITE Mechanisms which inactivate NO (nitric oxide) are probably important in governing the physiological and pathological effects of this ubiquitous signalling molecule. Cells isolated from the cerebellum, a brain region rich...

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Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide

Alexander KOLLAU, Alexandra HOFER, Michael RUSSWURM, Doris KOESLING, Wing Ming KEUNG, Kurt SCHMIDT, Friedrich BRUNNER, Bernd MAYER

Biochem J (2005) 385 (3): 769–777.

DOI: https://doi.org/10.1042/BJ20041354

Published: 24 January 2005

... but not in tissue homogenates is explained. 1 To whom correspondence should be addressed (email mayer@kfunigraz.ac.at ). 9 8 2004 6 9 2004 17 9 2004 17 9 2004 The Biochemical Society, London 2005 aldehyde dehydrogenase glycerol dinitrate mitochondria nitric oxide...

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Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover

Stephen R. CLARK, Peter B. ANNING, Marcus J. COFFEY, Andrew G. ROBERTS, Lawrence J. MARNETT, Valerie B. O'DONNELL

Biochem J (2005) 385 (3): 815–821.

DOI: https://doi.org/10.1042/BJ20041353

Published: 24 January 2005

...Stephen R. CLARK; Peter B. ANNING; Marcus J. COFFEY; Andrew G. ROBERTS; Lawrence J. MARNETT; Valerie B. O'DONNELL PGHS-2 (prostaglandin H synthase-2) is induced in mammalian cells by pro-inflammatory cytokines in tandem with iNOS [high-output (‘inducible’) nitric oxide synthase], and is co...

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Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5′-AMP-activated protein kinase

Pilar CIDAD, Angeles ALMEIDA, Juan P. BOLAÑOS

Biochem J (2004) 384 (3): 629–636.

DOI: https://doi.org/10.1042/BJ20040886

Published: 07 December 2004

...Pilar CIDAD; Angeles ALMEIDA; Juan P. BOLAÑOS Recently, we have reported that the inhibition of mitochondrial respiration by nitric oxide (NO) leads to an up-regulation of glycolysis and affords cytoprotection against energy failure through the stimulation of AMPK (5′-AMP-activated protein kinase...

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Lysophosphatidylcholine and 7-oxocholesterol modulate Ca2+ signals and inhibit the phosphorylation of endothelial NO synthase and cytosolic phospholipase A2

Elisabeth MILLANVOYE-VAN BRUSSEL, Gökce TOPAL, Annie BRUNET, Thuc DO PHAM, Valérie DECKERT, Francine RENDU, Monique DAVID-DUFILHO

Biochem J (2004) 380 (2): 533–539.

DOI: https://doi.org/10.1042/bj20040069

Published: 01 June 2004

... lipid constitutents of oxidized LDLs. In particular, 7-oxocholesterol has been found in plasma from cardiac patients and atherosclerotic plaque. In the present study, we investigated the ability of 7-oxocholesterol and LPC to regulate the activation of eNOS (endothelial nitric oxide synthase) and cPLA 2...

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Dopamine in the ink defence system of Sepia officinalis: biosynthesis, vesicular compartmentation in mature ink gland cells, nitric oxide (NO)/cGMP-induced depletion and fate in secreted ink

Gabriella FIORE, Annarita POLI, Anna Di COSMO, Marco d'ISCHIA, Anna PALUMBO

Biochem J (2004) 378 (3): 785–791.

DOI: https://doi.org/10.1042/bj20031864

Published: 15 March 2004

... extracts, and the presence of the enzyme was confirmed by Western-blot analysis. Dopa and DA were found to be released from the ink glands by processes controlled through the NMDA-nitric oxide-cGMP (where NMDA stands for N -methyl- d -aspartate) signalling pathway, as apparent from incubation experiments...

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Peroxide-mediated chromatin remodelling of a nuclear factor kappaB site in the mouse inducible nitric oxide synthase promoter

Junping WEI, Hongtao GUO, Chengjiang GAO, Paul C. KUO

Biochem J (2004) 377 (3): 809–818.

DOI: https://doi.org/10.1042/bj20031235

Published: 01 February 2004

...Junping WEI; Hongtao GUO; Chengjiang GAO; Paul C. KUO Hepatocyte expression of iNOS (inducible nitric oxide synthase) and synthesis of nitric oxide convey protective antioxidant functions in models of sepsis, shock and reperfusion. However, the underlying redox-sensitive mechanisms that regulate...

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Accelerated ubiquitination and proteasome degradation of a genetic variant of inducible nitric oxide synthase

Wei-Zhong YING, Paul W. SANDERS

Biochem J (2003) 376 (3): 789–794.

DOI: https://doi.org/10.1042/bj20031058

Published: 15 December 2003

...Wei-Zhong YING; Paul W. SANDERS Biochemical and pharmacological studies have suggested that NOS2 (inducible nitric oxide synthase) has a functional role in the blood pressure response to increases in dietary salt intake. On a high-salt diet, the Dahl/Rapp salt-sensitive (S) strain of rat, a genetic...

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Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca2+- and phosphoinositide 3-kinase/Akt-dependent phosphorylation in aortic endothelial cells

Kennedy MAKONDO, Kazuhiro KIMURA, Naoki KITAMURA, Takanori KITAMURA, Daisuke YAMAJI, Bae Dong JUNG, Masayuki SAITO

Biochem J (2003) 374 (1): 63–69.

DOI: https://doi.org/10.1042/bj20030326

Published: 15 August 2003

...Kennedy MAKONDO; Kazuhiro KIMURA; Naoki KITAMURA; Takanori KITAMURA; Daisuke YAMAJI; Bae Dong JUNG; Masayuki SAITO Hepatocyte growth factor (HGF) causes endothelium-dependent vasodilation, but its relation to endothelial nitric oxide synthase (eNOS) activity remains to be elucidated. Treatment...

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Nitric oxide donors inhibit formation of the Apaf-1/caspase-9 apoptosome and activation of caspases

Birgit ZECH, Roman KÖHL, Andreas von KNETHEN, Bernhard BRÜNE

Biochem J (2003) 371 (3): 1055–1064.

DOI: https://doi.org/10.1042/bj20021720

Published: 01 May 2003

...Birgit ZECH; Roman KÖHL; Andreas von KNETHEN; Bernhard BRÜNE Caspases are critical for the initiation and execution of apoptosis. Nitric oxide (NO) or derived species can prevent programmed cell death in several cell types, reportedly through S-nitrosation and inactivation of active caspases...

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The metabolism of S-nitrosothiols in the trypanosomatids: the role of ovothiol A and trypanothione

Ryan N. VOGT, Daniel J. STEENKAMP

Biochem J (2003) 371 (1): 49–59.

DOI: https://doi.org/10.1042/bj20021649

Published: 01 April 2003

... catalytically to decompose these nitrosothiols, although non-productive mechanisms exist. The catalytic phase of the reaction was dependent on the production of thiyl radicals, since it was abolished in the presence of 5,5-dimethyl-1-pyrroline- N -oxide and the formation of nitric oxide could be detected...

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Effects of nitrogen monoxide and carbon monoxide on molecular and cellular iron metabolism: mirror-image effector molecules that target iron

Ralph N. WATTS, Prem PONKA, Des R. RICHARDSON

Biochem J (2003) 369 (3): 429–440.

DOI: https://doi.org/10.1042/bj20021302

Published: 01 February 2003

... involved in Fe metabolism. Both NO and CO avidly form complexes with a plethora of Fe-containing molecules. The generation of NO and CO is mediated by the nitric oxide synthase and haem oxygenase (HO) families of enzymes respectively. The effects of NO on Fe metabolism have been well characterized, whereas...

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