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Keywords: nitric oxide
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Biochem J (2021) 478 (4): 927–942.
Published: 26 February 2021
... with Portland Press and the Biochemical Society under a transformative agreement with JISC. heme magnetic circular dichroism spectroscopy myoglobin nitric oxide nitrite Heme containing nitrite reductases play a significant role in the transformation of nitrite to both nitric oxide and ammonia...
Includes: Supplementary data
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Biochem J (2020) 477 (19): 3649–3672.
Published: 05 October 2020
...Salvatore Rizza; Giuseppe Filomeni S -nitrosylation, the post-translational modification of cysteines by nitric oxide, has been implicated in several cellular processes and tissue homeostasis. As a result, alterations in the mechanisms controlling the levels of S-nitrosylated proteins have been...
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Biochem J (2019) 476 (12): 1805–1815.
Published: 28 June 2019
...Daniel Bender; Alexander Tobias Kaczmarek; Dimitri Niks; Russ Hille; Guenter Schwarz In addition to nitric oxide (NO) synthases, molybdenum-dependent enzymes have been reported to reduce nitrite to produce NO. Here, we report the stoichiometric reduction in nitrite to NO by human sulfite oxidase...
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Biochem J (2018) 475 (8): 1411–1425.
Published: 23 April 2018
... of glutamate decarboxylase, initiating the γ-aminobutyric acid shunt and triggering the formation of alanine, processes which play a role, in particular, in pH regulation. Ca 2+ activates the transcription of several genes, e.g. of plant hemoglobin (phytoglobin, Pgb) which scavenges nitric oxide and regulates...
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Biochem J (2014) 460 (2): 309–316.
Published: 13 May 2014
... dimethylaminohydrolase 1), an enzyme that metabolizes endogenously produced nitric oxide synthase inhibitors, principally ADMA (asymmetric dimethylarginine). The present study employs a series of rodent models to evaluate the effectiveness a DDAH1-selective inhibitor (L-257). Short-term models involved the development...
Includes: Supplementary data
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Biochem J (2012) 446 (3): 499–508.
Published: 28 August 2012
.... In the present study we tested the hypothesis that storage of leucodepleted RBCs results in cells that inhibit NO (nitric oxide) signalling more so than younger cells. Using competition kinetic analyses and protocols that minimized contributions from haemolysis or microparticles, our data indicate...
Includes: Supplementary data
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Biochem J (2011) 433 (2): 383–391.
Published: 22 December 2010
...Jürke Kotthaus; Bettina Wahl; Antje Havemeyer; Joscha Kotthaus; Dennis Schade; Dieter Garbe-Schönberg; Ralf Mendel; Florian Bittner; Bernd Clement NOSs (nitric oxide synthases) catalyse the oxidation of L -arginine to L -citrulline and nitric oxide via the intermediate NOHA ( N ω -hydroxy- L...
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Biochem J (2010) 431 (3): 411–421.
Published: 11 October 2010
... is blocked and necrosis develops. If ATP levels remain above 10–15%, then necrosis is prevented, and caspase-dependent apoptosis occurs instead [ 14 – 16 ]. Previously, we showed that hepatocytes subjected to I/R injury were protected from cell death by either NO (nitric oxide) or cGMP administered...
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Biochem J (2009) 422 (3): 423–432.
Published: 27 August 2009
... Society 2009 haemorrhage nitric oxide nitrite reductase activity resuscitation shock Safety concerns coupled with a lack of supply of donated RBCs (red blood cells) have led to a great deal of interest in the development of blood substitutes as alternative resuscitative agents...
Includes: Supplementary data
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Biochem J (2009) 421 (2): 163–169.
Published: 26 June 2009
.... Mitochondrial ROS (reactive oxygen species), generated as a result of the interaction between nitric oxide and mitochondrial cytochrome c oxidase, activate AMPKα1 in HUVECs (human umbilical-vein endothelial cells) at a low oxygen concentration (i.e. 3%). This activation is independent of changes in AMP...
Includes: Supplementary data
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Biochem J (2009) 419 (2): 411–418.
Published: 27 March 2009
...Catherine N. Hall; Robert G. Keynes; John Garthwaite In low nanomolar concentrations, NO (nitric oxide) functions as a transmitter in brain and other tissues, whereas near-micromolar NO concentrations are associated with toxicity and cell death. Control of the NO concentration, therefore...
Includes: Supplementary data
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Biochem J (2009) 417 (1): 183–193.
Published: 12 December 2008
... respectively, for 8 or 16 weeks and liver hypoxia, mitochondrial bioenergetics, NO (nitric oxide)-dependent control of respiration, and 3-NT (3-nitrotyrosine), a marker of protein modification by RNS, were examined. Feeding a HFD for 16 weeks induced NASH-like pathology accompanied by elevated triacylglycerols...
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Biochem J (2008) 413 (3): 479–491.
Published: 15 July 2008
..., that NO acts on more than one target to achieve these varied effects on exocytosis. membrane fusion neurotransmission nitric oxide Sec1/Munc18-like protein SNARE © The Authors Journal compilation © 2008 Biochemical Society 2008 8 1 2008 22 4 2008 2 5 2008 2 5 2008...
Includes: Supplementary data
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Biochem J (2008) 412 (2): e11–e13.
Published: 14 May 2008
... between nitric oxide-induced protein thiol modifications and the cardioprotected phenotype. In a highly cited, seminal article published in the Biochemical Journal in 2006, Burwell and colleagues addressed this issue and provided direct evidence for S-nitrosation of complex I of the mitochondrial electron...
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Biochem J (2007) 407 (1): 15–22.
Published: 12 September 2007
... the influence of each domain of flavoHbs on ligand binding, we have studied the kinetic ligand-binding properties of oxygen, carbon monoxide and nitric oxide to the chimaeric proteins, FHPg (truncated form of FHP comprising the globin domain alone) and VHb-Red (fusion protein between VHb and the C-terminal...
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Biochem J (2007) 401 (1): 1–11.
Published: 11 December 2006
... species can chlorinate cytosine and adenine (reviewed in [ 2 ]). Attack of RS on proteins and lipids might also aggravate DNA damage ( Figure 2 ). The Biochemical Society, London 2007 antioxidant cancer DNA repair nitric oxide reactive oxygen species In 1996, I co-authored...
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Biochem J (2006) 394 (3): 627–634.
Published: 24 February 2006
...Lindsay S. Burwell; Sergiy M. Nadtochiy; Andrew J. Tompkins; Sara Young; Paul S. Brookes NO • (nitric oxide) is a pleiotropic signalling molecule, with many of its effects on cell function being elicited at the level of the mitochondrion. In addition to the well-characterized binding...
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Biochem J (2006) 393 (1): 129–139.
Published: 12 December 2005
...Natalia Makeeva; Jason W. Myers; Nils Welsh The aim of the present investigation was to elucidate further the importance of p38 MAPK (mitogen-activated protein kinase) in nitric oxide- and cytokine-induced β-cell death. For this purpose, isolated human islets were treated with d-siRNA (diced small...
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Biochem J (2005) 391 (3): 581–588.
Published: 25 October 2005
... immunoprecipitation assays, binding of NF-κB to the NOS-2 (inducible nitric oxide synthase) promoter at the early onset of events triggered during weaning. The three isoforms of NOS are constitutively present in the lactating mammary gland; however, while NOS-2 mRNA and protein levels and, consequently, NO production...
Includes: Supplementary data
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Biochem J (2005) 389 (3): 821–829.
Published: 26 July 2005
... to the manufacturer's instructions, and cDNA was synthesized in a final volume of 20 μl from the RNA (1–5 μg) using the Superscript II first-strand synthesis kit (Invitrogen) primed with oligo(dT) 12–18 . capacitative Ca 2+ entry 5-hydroxytryptamine (5-HT) nitric oxide vascular smooth muscle vasopressin...
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Biochem J (2003) 371 (1): 49–59.
Published: 01 April 2003
... catalytically to decompose these nitrosothiols, although non-productive mechanisms exist. The catalytic phase of the reaction was dependent on the production of thiyl radicals, since it was abolished in the presence of 5,5-dimethyl-1-pyrroline- N -oxide and the formation of nitric oxide could be detected...