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Keywords: nitric oxide
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Articles
Biochem J (2021) 478 (4): 927–942.
Published: 26 February 2021
...-fold increase in the rate of nitrite reduction by H93K relative to WT SWMb. heme magnetic circular dichroism spectroscopy myoglobin nitric oxide nitrite Heme containing nitrite reductases play a significant role in the transformation of nitrite to both nitric oxide and ammonia in animals...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (4): 855–869.
Published: 24 February 2021
...Heesu Kim; Dong Gun Lee Lupeol is known to be plentiful in fruits or plant barks and has an antimicrobial effect, however, its mode of action(s) has yet to be determined. To elucidate lupeol generates nitric oxide (NO), which is recognized for possessing an antimicrobial activity, intracellular...
Articles
Biochem J (2020) 477 (19): 3649–3672.
Published: 05 October 2020
...Salvatore Rizza; Giuseppe Filomeni S -nitrosylation, the post-translational modification of cysteines by nitric oxide, has been implicated in several cellular processes and tissue homeostasis. As a result, alterations in the mechanisms controlling the levels of S-nitrosylated proteins have been...
Articles
Biochem J (2019) 476 (14): 2111–2125.
Published: 31 July 2019
... 2019 8 7 2019 © 2019 The Author(s) 2019 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . nitric oxide nitrite reductase no dioxygenase...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (12): 1805–1815.
Published: 28 June 2019
...Daniel Bender; Alexander Tobias Kaczmarek; Dimitri Niks; Russ Hille; Guenter Schwarz In addition to nitric oxide (NO) synthases, molybdenum-dependent enzymes have been reported to reduce nitrite to produce NO. Here, we report the stoichiometric reduction in nitrite to NO by human sulfite oxidase...
Articles
Biochem J (2018) 475 (8): 1411–1425.
Published: 23 April 2018
... of glutamate decarboxylase, initiating the γ-aminobutyric acid shunt and triggering the formation of alanine, processes which play a role, in particular, in pH regulation. Ca 2+ activates the transcription of several genes, e.g. of plant hemoglobin (phytoglobin, Pgb) which scavenges nitric oxide and regulates...
Articles
Biochem J (2016) 473 (6): 693–701.
Published: 10 March 2016
... thiol export, gene expression, metabolic perturbations, intracellular pH homoeostasis and tolerance to nitric oxide (NO). Loss of CydDC was found to decrease extracytoplasmic thiol levels, whereas overexpression diminished the cytoplasmic thiol content. Transcriptomic analysis revealed a dramatic up...
Includes: Supplementary data
Articles
Biochem J (2014) 460 (2): 309–316.
Published: 13 May 2014
... dimethylaminohydrolase 1), an enzyme that metabolizes endogenously produced nitric oxide synthase inhibitors, principally ADMA (asymmetric dimethylarginine). The present study employs a series of rodent models to evaluate the effectiveness a DDAH1-selective inhibitor (L-257). Short-term models involved the development...
Includes: Supplementary data
Articles
Biochem J (2013) 449 (1): 263–273.
Published: 07 December 2012
...Vagner Simonin; Antonio Galina NO (nitric oxide) is described as an inhibitor of plant and mammalian respiratory chains owing to its high affinity for COX (cytochrome c oxidase), which hinders the reduction of oxygen to water. In the present study we show that in plant mitochondria NO may interfere...
Articles
Biochem J (2012) 446 (3): 499–508.
Published: 28 August 2012
.... In the present study we tested the hypothesis that storage of leucodepleted RBCs results in cells that inhibit NO (nitric oxide) signalling more so than younger cells. Using competition kinetic analyses and protocols that minimized contributions from haemolysis or microparticles, our data indicate...
Includes: Supplementary data
Articles
Biochem J (2012) 441 (2): 755–762.
Published: 21 December 2011
...Gary Rowley; Daniela Hensen; Heather Felgate; Anke Arkenberg; Corinne Appia-Ayme; Karen Prior; Carl Harrington; Sarah J. Field; Julea N. Butt; Elizabeth Baggs; David J. Richardson The production of cytotoxic nitric oxide (NO) and conversion into the neuropharmacological agent and potent greenhouse...
Articles
Biochem J (2012) 441 (2): 719–730.
Published: 21 December 2011
... ]. 1 To whom correspondence should be addressed (email takakaik@gpo.kumamoto-u.ac.jp ). mitochondrion nitric oxide oxidative stress peroxynitrite reactive oxygen species (ROS) reactive oxygen species (ROS) signalling cGMP, GTP, GDP, GMP and rotenone were obtained from Sigma–Aldrich...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (1): 217–225.
Published: 15 March 2011
... involved and time course to previously published results [ 24 ] indicates that excess ascorbate does not alter the reaction mechanism. haemoprotein nitric oxide nitrite nitrite reductase Pseudomonas aeruginosa Paracoccus pantotrophus Denitrification is an anaerobic respiratory...
Includes: Supplementary data
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Biochem J (2011) 433 (2): 383–391.
Published: 22 December 2010
...Jürke Kotthaus; Bettina Wahl; Antje Havemeyer; Joscha Kotthaus; Dennis Schade; Dieter Garbe-Schönberg; Ralf Mendel; Florian Bittner; Bernd Clement NOSs (nitric oxide synthases) catalyse the oxidation of L -arginine to L -citrulline and nitric oxide via the intermediate NOHA ( N ω -hydroxy- L...
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Biochem J (2011) 433 (1): 163–174.
Published: 15 December 2010
... flavoprotein haemprotein mesohaem nitric oxide nitric oxide synthase (NOS) NO (nitric oxide) is a signalling molecule with a wide range of functions in biology [ 1 ]. In animals NO is synthesized from L -Arg ( L -arginine) by enzymes known as NOSs (NO synthases, EC 1.14.13.39). Three isoforms...
Articles
Biochem J (2010) 432 (3): 417–427.
Published: 25 November 2010
... but reacts rapidly with eight equivalents of nitric oxide to yield two dinuclear dinitrosyl-iron thiol complexes. The [4Fe-4S] form of WhiB1 did not bind whiB1 promoter DNA, but the reduced and oxidized apo-WhiB1, and nitric oxide-treated holo-WhiB1 did bind to DNA. Mycobacterium smegmatis RNA polymerase...
Articles
Biochem J (2010) 431 (3): 411–421.
Published: 11 October 2010
... 2010 26 8 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cAMP cGMP glucagon ischaemia mitochondrial permeability transition nitric oxide protein kinase I/R (ischaemia/reperfusion) injury is a primary cause of graft dysfunction and failure after...
Articles
Biochem J (2010) 429 (1): 73–83.
Published: 14 June 2010
...Izabela Wawer; Maria Bucholc; Jéremy Astier; Anna Anielska-Mazur; Jennifer Dahan; Anna Kulik; Aleksandra Wysłouch-Cieszynska; Monika Zaręba-Kozioł; Ewa Krzywinska; Michal Dadlez; Grażyna Dobrowolska; David Wendehenne Several studies focusing on elucidating the mechanism of NO (nitric oxide...
Includes: Supplementary data
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Biochem J (2010) 428 (3): 451–462.
Published: 27 May 2010
..., NOS2 (inducible nitric oxide synthase)-KO (knockout) mice were used. No apparent differences were observed between NOS2 -KO and WT (wild-type) animals during pregnancy and lactation. However, upon cessation of lactation, a notable delay in involution was observed, compared with WT mice. NOS2 -KO mice...
Articles
Biochem J (2010) 428 (1): 85–93.
Published: 28 April 2010
...Li-Peng Yap; Jerome V. Garcia; Derick S. Han; Enrique Cadenas Excessive generation of nitric oxide radical (NO • ) in neuroinflammation, excitotoxicity and during age-related neurodegenerative disorders entails the localized and concerted increase in nitric oxide synthase(s) expression in glial...
Articles
Biochem J (2010) 426 (1): 85–90.
Published: 27 January 2010
...Stuart A. Ritchie; Christine F. Kohlhaas; Alasdair R. Boyd; Krishna C. Yalla; Kenneth Walsh; John M. C. Connell; Ian P. Salt Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser...
Articles
Biochem J (2009) 422 (3): 423–432.
Published: 27 August 2009
... nitric oxide nitrite reductase activity resuscitation shock Safety concerns coupled with a lack of supply of donated RBCs (red blood cells) have led to a great deal of interest in the development of blood substitutes as alternative resuscitative agents. Such resuscitative agents would need...
Includes: Supplementary data
Articles
Biochem J (2009) 421 (2): 163–169.
Published: 26 June 2009
.... Mitochondrial ROS (reactive oxygen species), generated as a result of the interaction between nitric oxide and mitochondrial cytochrome c oxidase, activate AMPKα1 in HUVECs (human umbilical-vein endothelial cells) at a low oxygen concentration (i.e. 3%). This activation is independent of changes in AMP...
Includes: Supplementary data
Articles
Biochem J (2009) 419 (2): 411–418.
Published: 27 March 2009
...Catherine N. Hall; Robert G. Keynes; John Garthwaite In low nanomolar concentrations, NO (nitric oxide) functions as a transmitter in brain and other tissues, whereas near-micromolar NO concentrations are associated with toxicity and cell death. Control of the NO concentration, therefore...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (3): 783–789.
Published: 16 January 2009
...Xuewu Duan; Juanjuan Yang; Binbin Ren; Guoqiang Tan; Huangen Ding Although the NO (nitric oxide)-mediated modification of iron–sulfur proteins has been well-documented in bacteria and mammalian cells, specific reactivity of NO with iron–sulfur proteins still remains elusive. In the present study...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (1): 183–193.
Published: 12 December 2008
... respectively, for 8 or 16 weeks and liver hypoxia, mitochondrial bioenergetics, NO (nitric oxide)-dependent control of respiration, and 3-NT (3-nitrotyrosine), a marker of protein modification by RNS, were examined. Feeding a HFD for 16 weeks induced NASH-like pathology accompanied by elevated triacylglycerols...
Articles
Biochem J (2008) 413 (3): 479–491.
Published: 15 July 2008
... residue weighted molar ellipticity as follows [ 23 ]: membrane fusion neurotransmission nitric oxide Sec1/Munc18-like protein SNARE Exocytosis, the fusion of vesicles with the plasma membrane, can occur in a constitutive or regulated manner. In regulated exocytosis, fusion is generally...
Includes: Supplementary data
Articles
Biochem J (2008) 412 (2): e11–e13.
Published: 14 May 2008
... between nitric oxide-induced protein thiol modifications and the cardioprotected phenotype. In a highly cited, seminal article published in the Biochemical Journal in 2006, Burwell and colleagues addressed this issue and provided direct evidence for S-nitrosation of complex I of the mitochondrial electron...
Articles
Biochem J (2007) 407 (1): 15–22.
Published: 12 September 2007
... the influence of each domain of flavoHbs on ligand binding, we have studied the kinetic ligand-binding properties of oxygen, carbon monoxide and nitric oxide to the chimaeric proteins, FHPg (truncated form of FHP comprising the globin domain alone) and VHb-Red (fusion protein between VHb and the C-terminal...
Articles
Biochem J (2007) 406 (1): 19–30.
Published: 26 July 2007
...Thomas A. Clarke; Jeffrey A. Cole; David J. Richardson; Andrew M. Hemmings NrfB is a small pentahaem electron-transfer protein widely involved in the respiratory reduction of nitrite or nitric oxide to ammonia, processes that provide energy for anaerobic metabolism in many enteric bacteria and also...
Includes: Supplementary data
Articles
Biochem J (2007) 405 (2): e3.
Published: 27 June 2007
...Aimee Landar; Victor M. Darley-Usmar Haem is used as a versatile receptor for redox active molecules; most notably NO (nitric oxide) and oxygen. Three haem-containing proteins, myoglobin, haemoglobin and cytochrome c oxidase, are now known to bind NO, and in all these cases competition with oxygen...
Articles
Biochem J (2007) 401 (1): 1–11.
Published: 11 December 2006
... on p53, cell proliferation, invasiveness and metastasis. Chronic inflammation predisposes to malignancy, but the role of RS in this is likely to be complex because RS can sometimes act as anti-inflammatory agents. antioxidant cancer DNA repair nitric oxide reactive oxygen species However...
Articles
Biochem J (2006) 400 (2): 367–375.
Published: 14 November 2006
... be addressed (email P.Lipinski@ighz.pl ). 26 4 2006 11 7 2006 4 8 2006 4 8 2006 The Biochemical Society, London 2006 iron metabolism iron regulatory protein 1 (IRP1) nitric oxide promoter regulation signal transducer and activator of transcription (STAT) transcription...
Articles
Biochem J (2006) 394 (3): 627–634.
Published: 24 February 2006
...Lindsay S. Burwell; Sergiy M. Nadtochiy; Andrew J. Tompkins; Sara Young; Paul S. Brookes NO • (nitric oxide) is a pleiotropic signalling molecule, with many of its effects on cell function being elicited at the level of the mitochondrion. In addition to the well-characterized binding...
Articles
Biochem J (2006) 393 (1): 129–139.
Published: 12 December 2005
...Natalia Makeeva; Jason W. Myers; Nils Welsh The aim of the present investigation was to elucidate further the importance of p38 MAPK (mitogen-activated protein kinase) in nitric oxide- and cytokine-induced β-cell death. For this purpose, isolated human islets were treated with d-siRNA (diced small...
Articles
Biochem J (2005) 391 (3): 581–588.
Published: 25 October 2005
... immunoprecipitation assays, binding of NF-κB to the NOS-2 (inducible nitric oxide synthase) promoter at the early onset of events triggered during weaning. The three isoforms of NOS are constitutively present in the lactating mammary gland; however, while NOS-2 mRNA and protein levels and, consequently, NO production...
Includes: Supplementary data
Articles
Biochem J (2005) 389 (3): 821–829.
Published: 26 July 2005
...) according to the manufacturer's instructions, and cDNA was synthesized in a final volume of 20 μl from the RNA (1–5 μg) using the Superscript II first-strand synthesis kit (Invitrogen) primed with oligo(dT) 12–18 . capacitative Ca 2+ entry 5-hydroxytryptamine (5-HT) nitric oxide vascular smooth...
Includes: Supplementary data
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Biochem J (2005) 389 (2): 315–323.
Published: 05 July 2005
... cytometer (FACSCaliber, Becton Dickinson, San Jose, CA, U.S.A.). interleukin-1β NADPH oxidase nitric oxide nitric oxide synthase peroxynitrite superoxide Degradation of articular cartilage is a common pathogenic change seen in the degenerative joint diseases, such as RA (rheumatoid...
Articles
Biochem J (2005) 387 (3): 685–694.
Published: 26 April 2005
...Robert G. KEYNES; Charmaine H. GRIFFITHS; Catherine HALL; John GARTHWAITE Mechanisms which inactivate NO (nitric oxide) are probably important in governing the physiological and pathological effects of this ubiquitous signalling molecule. Cells isolated from the cerebellum, a brain region rich...
Articles
Biochem J (2005) 385 (3): 769–777.
Published: 24 January 2005
... but not in tissue homogenates is explained. 1 To whom correspondence should be addressed (email mayer@kfunigraz.ac.at ). 9 8 2004 6 9 2004 17 9 2004 17 9 2004 The Biochemical Society, London 2005 aldehyde dehydrogenase glycerol dinitrate mitochondria nitric oxide...
Articles
Biochem J (2005) 385 (3): 815–821.
Published: 24 January 2005
...Stephen R. CLARK; Peter B. ANNING; Marcus J. COFFEY; Andrew G. ROBERTS; Lawrence J. MARNETT; Valerie B. O'DONNELL PGHS-2 (prostaglandin H synthase-2) is induced in mammalian cells by pro-inflammatory cytokines in tandem with iNOS [high-output (‘inducible’) nitric oxide synthase], and is co...
Articles
Biochem J (2004) 384 (3): 629–636.
Published: 07 December 2004
...Pilar CIDAD; Angeles ALMEIDA; Juan P. BOLAÑOS Recently, we have reported that the inhibition of mitochondrial respiration by nitric oxide (NO) leads to an up-regulation of glycolysis and affords cytoprotection against energy failure through the stimulation of AMPK (5′-AMP-activated protein kinase...
Articles
Biochem J (2004) 380 (2): 533–539.
Published: 01 June 2004
... lipid constitutents of oxidized LDLs. In particular, 7-oxocholesterol has been found in plasma from cardiac patients and atherosclerotic plaque. In the present study, we investigated the ability of 7-oxocholesterol and LPC to regulate the activation of eNOS (endothelial nitric oxide synthase) and cPLA 2...
Articles
Biochem J (2004) 378 (3): 785–791.
Published: 15 March 2004
... extracts, and the presence of the enzyme was confirmed by Western-blot analysis. Dopa and DA were found to be released from the ink glands by processes controlled through the NMDA-nitric oxide-cGMP (where NMDA stands for N -methyl- d -aspartate) signalling pathway, as apparent from incubation experiments...
Articles
Biochem J (2004) 377 (3): 809–818.
Published: 01 February 2004
...Junping WEI; Hongtao GUO; Chengjiang GAO; Paul C. KUO Hepatocyte expression of iNOS (inducible nitric oxide synthase) and synthesis of nitric oxide convey protective antioxidant functions in models of sepsis, shock and reperfusion. However, the underlying redox-sensitive mechanisms that regulate...
Articles
Biochem J (2003) 376 (3): 789–794.
Published: 15 December 2003
...Wei-Zhong YING; Paul W. SANDERS Biochemical and pharmacological studies have suggested that NOS2 (inducible nitric oxide synthase) has a functional role in the blood pressure response to increases in dietary salt intake. On a high-salt diet, the Dahl/Rapp salt-sensitive (S) strain of rat, a genetic...
Articles
Biochem J (2003) 374 (1): 63–69.
Published: 15 August 2003
...Kennedy MAKONDO; Kazuhiro KIMURA; Naoki KITAMURA; Takanori KITAMURA; Daisuke YAMAJI; Bae Dong JUNG; Masayuki SAITO Hepatocyte growth factor (HGF) causes endothelium-dependent vasodilation, but its relation to endothelial nitric oxide synthase (eNOS) activity remains to be elucidated. Treatment...
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Biochem J (2003) 371 (3): 1055–1064.
Published: 01 May 2003
...Birgit ZECH; Roman KÖHL; Andreas von KNETHEN; Bernhard BRÜNE Caspases are critical for the initiation and execution of apoptosis. Nitric oxide (NO) or derived species can prevent programmed cell death in several cell types, reportedly through S-nitrosation and inactivation of active caspases...
Articles
Biochem J (2003) 371 (1): 49–59.
Published: 01 April 2003
... catalytically to decompose these nitrosothiols, although non-productive mechanisms exist. The catalytic phase of the reaction was dependent on the production of thiyl radicals, since it was abolished in the presence of 5,5-dimethyl-1-pyrroline- N -oxide and the formation of nitric oxide could be detected...
Articles
Biochem J (2003) 369 (3): 429–440.
Published: 01 February 2003
... involved in Fe metabolism. Both NO and CO avidly form complexes with a plethora of Fe-containing molecules. The generation of NO and CO is mediated by the nitric oxide synthase and haem oxygenase (HO) families of enzymes respectively. The effects of NO on Fe metabolism have been well characterized, whereas...