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Keywords: nitrogen-containing bisphosphonate drugs
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Biochem J (2012) 447 (3): 353–361.
Published: 05 October 2012
...James M. Nuttall; Ewald H. Hettema; Donald J. Watts NBP (nitrogen-containing bisphosphonate) drugs protect against excessive osteoclast-mediated bone resorption. After binding to bone mineral, they are taken up selectively by the osteoclasts and inhibit the essential enzyme FDPS (farnesyl...