... cells promote the utilization of less accurate processes. Homologous recombination serves to promote accuracy and stability during replication, providing a battlefield for cancer to gain instability. Non-homologous end-joining, a major DSB repair pathway in mammalian cells, usually operates with high...

... processes such as V(D)J recombination. If left unrepaired, DSBs can cause cell death. If misrepaired, DSBs may lead to chromosomal translocations and genomic instability. One of the major pathways for the repair of IR-induced DSBs in mammalian cells is NHEJ (non-homologous end-joining). The main proteins...

[email protected] ). 25 6 2002 12 8 2002 19 8 2002 19 8 2002 The Biochemical Society, London ©2002 2002 autophosphorylation site DNA double-strand break repair non-homologous end-joining Abbreviations used: DNA-PK, DNA-dependent protein kinase; DNA-PKcs, DNA-dependent...