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Keywords: nsp13
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Articles
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase
Open AccessJingkun Zeng, Florian Weissmann, Agustina P. Bertolin, Viktor Posse, Berta Canal, Rachel Ulferts, Mary Wu, Ruth Harvey, Saira Hussain, Jennifer C. Milligan, Chloe Roustan, Annabel Borg, Laura McCoy, Lucy S. Drury, Svend Kjaer, John McCauley, Michael Howell, Rupert Beale, John F.X. Diffley
Journal:
Biochemical Journal
Biochem J (2021) 478 (13): 2405–2423.
Published: 02 July 2021
... drugs represents a promising and potentially rapid opportunity to find novel antivirals against SARS-CoV-2. The virus encodes at least nine enzymatic activities that are potential drug targets. Here, we have expressed, purified and developed enzymatic assays for SARS-CoV-2 nsp13 helicase, a viral...
Includes: Supplementary data
