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Keywords: nuclear exportClose
Biochem J (2012) 441 (1): 209–217.
Published: 14 December 2011
...Iraia García-Santisteban; Sonia Bañuelos; Jose A. Rodríguez The mechanisms that regulate the nucleocytoplasmic localization of human deubiquitinases remain largely unknown. The nuclear export receptor CRM1 binds to specific amino acid motifs termed NESs (nuclear export sequences). By using in...
Includes: Supplementary data
Christine A. Biondi, Debipriya Das, Michael Howell, Ayesha Islam, Elizabeth K. Bikoff, Caroline S. Hill, Elizabeth J. Robertson
Biochem J (2007) 404 (2): 235–245.
Published: 14 May 2007
... localization signal) and an NES (nuclear export signal) located in its linker region. Cell culture experiments suggest that Smad4 nucleocytoplasmic shuttling plays an important role in TGF-β signalling. In the present study we have investigated the role of Smad4 shuttling in vivo using gene targeting to...
Biochem J (2005) 388 (2): 509–514.
Published: 24 May 2005
... The Biochemical Society, London 2005 fluorescence recovery after photobleaching (FRAP) nuclear export nuclear hormone receptor nuclear speckle nucleus vitamin D receptor B1 (VDRB1) The subcellular distribution of nuclear receptors such as steroid hormone receptor family members is a...
Biochem J (2002) 365 (1): 181–191.
Published: 01 July 2002
... import. CRM1 (more recently named ‘exportin-1') is a nuclear membrane protein that regulates protein export from the nucleus by binding to a specific nuclear export sequence. Leptomycin B is an inhibitor of CRM1/exportin-1, and reversed the ceramide-induced decrease in nuclear C/EBPβ at 24h. Taken...