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Articles

Priming IKKβ kinase for action

Steven C. Ley, Rudi Beyaert

Biochem J (2014) 463 (1): e1–e2.

https://doi.org/10.1042/BJ20140989

Published: 08 September 2014

... 8 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 inflammation inhibitor of NF-κB kinase β (IKKβ) nuclear factor κB (NF-κB) transforming growth factor β-activated kinase-1 (TAK1) phosphorylation ubiquitination The NF-κB (nuclear factor κB...

View article titled, Priming IKKβ kinase for action

Articles

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

Jiazhen Zhang, Kristopher Clark, Toby Lawrence, Mark W. Peggie, Philip Cohen

Biochem J (2014) 461 (3): 531–537.

https://doi.org/10.1042/BJ20140444

Published: 10 July 2014

... κB kinase (IKK) interleukin-1 (IL-1) linear ubiquitin chain assembly complex (LUBAC) nuclear factor κB (NF-κB) transforming growth factor β-activated kinase-1 (TAK1) The canonical IKK {IκB [inhibitor of NF-κB (nuclear factor κB)] kinase β} complex, consisting of the protein kinases IKKα...

View article titled, An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

Includes: Supplementary data

Articles

T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses

Sigrid S. Skånland, Kristine Moltu, Torunn Berge, Einar M. Aandahl, Kjetil Taskén

Biochem J (2014) 460 (3): 399–410.

https://doi.org/10.1042/BJ20140040

Published: 29 May 2014

... induce distinct signalling responses. These findings may offer means of specifically perturbing a signalling pathway activated by one co-receptor. co-stimulation immunology nuclear factor κB (NF-κB) phosphorylation signal transduction T-cell CD4 + T-cells initiate and direct...

View article titled, T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses

Includes: Supplementary data

Articles

The cytokine-induced conformational switch of nuclear factor κB p65 is mediated by p65 phosphorylation

Maja Milanovic, Michael Kracht, M. Lienhard Schmitz

Biochem J (2014) 457 (3): 401–413.

https://doi.org/10.1042/BJ20130780

Published: 10 January 2014

... phosphorylation of the NF-κB subunit p65 results in conformational changes of the protein. heat-shock protein p65 protein conformation nuclear factor κB (NF-κB) transcription The NF-κB (nuclear factor κB) DNA-binding subunits p65 (RelA), p50 (NFKB1), p52 (NFKB2), c-Rel and RelB form homo...

View article titled, The cytokine-induced conformational switch of nuclear factor κB p65 is mediated by p65 phosphorylation

Includes: Supplementary data

Articles

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

Sam Strickson, David G. Campbell, Christoph H. Emmerich, Axel Knebel, Lorna Plater, Maria Stella Ritorto, Natalia Shpiro, Philip Cohen

Biochem J (2013) 451 (3): 427–437.

https://doi.org/10.1042/BJ20121651

Published: 12 April 2013

...) nuclear factor κB (NF-κB) proteasome ubiquitin conjugating 13 (Ubc13) 29 10 2012 22 2 2013 27 2 2013 27 2 2013 Recently, mutations in MyD88 that cause the constitutive activation of the MyD88 signalling pathway have been identified as a major cause of the activated B-cell...

View article titled, The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

Includes: Supplementary data

Articles

Zc3h12c inhibits vascular inflammation by repressing NF-κB activation and pro-inflammatory gene expression in endothelial cells

Ling Liu, Zhou Zhou, Shengping Huang, Yanhong Guo, Yanbo Fan, Ji Zhang, Jifeng Zhang, Mingui Fu, Y. Eugene Chen

Biochem J (2013) 451 (1): 55–60.

https://doi.org/10.1042/BJ20130019

Published: 14 March 2013

... nuclear factor κB (NF-κB) vascular cell adhesion molecule-1 (VCAM-1) zinc finger CCCH-type-containing 12C (Zc3h12c) Endothelial activation is a critical process involved in many vascular diseases including atherosclerosis. Dysfunctional endothelial cells are strongly related to and promote...

View article titled, Zc3h12c inhibits vascular inflammation by repressing NF-κB activation and pro-inflammatory gene expression in endothelial cells

Articles

Nuclear factor κB down-regulates human UDP-glucuronosyltransferase 1A1: a novel mechanism involved in inflammation-associated hyperbilirubinaemia

Tzu-Yue Shiu, Tien-Yu Huang, Shih-Ming Huang, Yu-Lueng Shih, Heng-Cheng Chu, Wei-Kuo Chang, Tsai-Yuan Hsieh

Biochem J (2013) 449 (3): 761–770.

https://doi.org/10.1042/BJ20121055

Published: 09 January 2013

... compilation © 2013 Biochemical Society 2013 hyperbilirubinaemia inhibitor lipopolysaccharide (LPS) nuclear factor κB (NF-κB) promoter UDP-glucuronosyltransferase 1A1 (UGT1A1) UGT1A1 (UDP-glucuronosyltransferase 1A1) is a key enzyme, which is essential in the glucuronidation process...

View article titled, Nuclear factor κB down-regulates human UDP-glucuronosyltransferase 1A1: a novel mechanism involved in inflammation-associated hyperbilirubinaemia

Articles

TfR1 interacts with the IKK complex and is involved in IKK–NF-κB signalling

Niall S. Kenneth, Sharon Mudie, Sanne Naron, Sonia Rocha

Biochem J (2013) 449 (1): 275–284.

https://doi.org/10.1042/BJ20120625

Published: 07 December 2012

... ]; RelA, GCUGAUGUGCACCGACAAG [ 13 ]; TfR1_A, CCAAUACAGAGCAGACAUA; TfR1_B, ACUUGCUGUAGAUGAAGAA; TfR1_C, CUUCCAGACUAACAACAGA; and IKKγ, ACAGGAGGUGAUCGAUAAG [ 14 ]. inhibitor of nuclear factor κB kinase (IKK) iron nuclear factor κB (NF-κB) transferrin transferrin receptor 1 (TfR1) tumour necrosis...

View article titled, TfR1 interacts with the IKK complex and is involved in IKK–NF-κB signalling

Includes: Supplementary data

Articles

Myostatin is a novel tumoral factor that induces cancer cachexia

Sudarsanareddy Lokireddy, Isuru Wijerupage Wijesoma, Sabeera Bonala, Meng Wei, Siu Kwan Sze, Craig McFarlane, Ravi Kambadur, Mridula Sharma

Biochem J (2012) 446 (1): 23–36.

https://doi.org/10.1042/BJ20112024

Published: 27 July 2012

... request. activin receptor type II B autophagy–lysosome system myostatin nuclear factor κB (NF-κB) reactive oxygen species (ROS) skeletal muscle wasting tumoral factor ubiquitin–proteasome system Cachexia is associated with numerous chronic diseases, including cancer, renal failure...

View article titled, Myostatin is a novel tumoral factor that induces cancer cachexia

Includes: Supplementary data

Articles

β 2 -Glycoprotein I inhibits endothelial cell migration through the nuclear factor κB signalling pathway and endothelial nitric oxide synthase activation

Wen-Chin Chiu, Tzeon-Jye Chiou, An-Na Chiang

Biochem J (2012) 445 (1): 125–133.

https://doi.org/10.1042/BJ20111383

Published: 15 June 2012

... should be addressed (email [email protected] ). 28 7 2011 5 3 2012 10 4 2012 10 4 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 endothelial cell migration endothelial nitric oxide synthase (eNOS) β 2 -glycoprotein I (β 2 -GPI) nuclear factor...

View article titled, β 2 -Glycoprotein I inhibits endothelial cell migration through the nuclear factor κB signalling pathway and endothelial nitric oxide synthase activation

Includes: Supplementary data

Articles

Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase

Charles O. Brown, Kelley Salem, Brett A. Wagner, Soumen Bera, Neeraj Singh, Ajit Tiwari, Amit Choudhury, Garry R. Buettner, Apollina Goel

Biochem J (2012) 444 (3): 515–527.

https://doi.org/10.1042/BJ20112019

Published: 29 May 2012

.... dexamethasone interleukin-6 manganese superoxide dismutase (MnSOD) multiple myeloma nuclear factor κB (NF-κB) radiation therapy Cells were transduced with Ad-NF-κB Luc for 48 h and then treated with IL-6 (50 ng/ml), TNF-α (2.5 ng/ml), H 2 O 2 (100 μM) and/or IR. At 4 h post-irradiation, the cells...

View article titled, Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase

Includes: Supplementary data

Articles

Protease activity of MALT1: a mystery unravelled

Daniel Kirchhofer, Domagoj Vucic

Biochem J (2012) 444 (2): e3–e5.

https://doi.org/10.1042/BJ20120414

Published: 11 May 2012

... lymphoma mucosa-associated lymphoid tissue translocation gene 1 (MALT1) nuclear factor κB (NF-κB) protease substrate specificity 1 To whom correspondence should be addressed (email [email protected] ). 8 3 2012 22 3 2012 © The Authors Journal compilation © 2012...

View article titled, Protease activity of MALT1: a mystery unravelled

Articles

Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration

Ning Xiao, Hui Li, Jian Luo, Rui Wang, Haiquan Chen, Jiquan Chen, Ping Wang

Biochem J (2012) 441 (3): 979–987.

https://doi.org/10.1042/BJ20111358

Published: 16 January 2012

[email protected] ). 27 7 2011 22 9 2011 27 10 2011 27 10 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 migration nuclear factor κB (NF-κB) tumour necrosis factor (TNF)-receptor-associated factor 6 (TRAF6) ubiquitination ubiquitin-specific protease 4...

View article titled, Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration

Includes: Supplementary data

Articles

Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation

Neus Martinez-Micaelo, Noemi González-Abuín, Ximena Terra, Cristobal Richart, Anna Ardèvol, Monserrat Pinent, Mayte Blay

Biochem J (2012) 441 (2): 653–663.

https://doi.org/10.1042/BJ20110967

Published: 21 December 2011

... cyclo-oxygenase docosahexaenoic acid (DHA) nuclear factor κB (NF-κB) omega-3 fatty acid procyanidin prostaglandin The inflammatory response is a body defence mechanism that is triggered by an external aggression, such as trauma or infection by external pathogens, and it represents a complex...

View article titled, Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation

Articles

Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the nuclear factor κB (NF-κB) signalling pathway

Zhen-Bo Song, Yong-Li Bao, Yu Zhang, Xu-Guang Mi, Ping Wu, Yin Wu, Chun-Lei Yu, Ying Sun, Li-Hua Zheng, Yan-Xin Huang, Biao Liu, Yu-Xin Li

Biochem J (2011) 436 (2): 457–467.

https://doi.org/10.1042/BJ20101780

Published: 13 May 2011

... compilation © 2011 Biochemical Society 2011 breast cancer cell proliferation nuclear factor κB (NF-κB) signalling testes-specific protease 50 (TSP50) tumour formation TSP50 (testes-specific protease 50) is a testis-specific gene encoding a protein that is homologous to serine proteases...

View article titled, Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the nuclear factor κB (NF-κB) signalling pathway

Articles

Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

Charlotte J. Green, Katherine Macrae, Sarah Fogarty, D. Grahame Hardie, Kei Sakamoto, Harinder S. Hundal

Biochem J (2011) 435 (2): 463–474.

https://doi.org/10.1042/BJ20101517

Published: 29 March 2011

... nuclear factor κB (NF-κB) protein kinase B (PKB) There is mounting evidence that chronic activation of pro-inflammatory signalling in tissues such as skeletal muscle and adipose is a significant contributing factor in the development and progression of metabolic disorders such as insulin...

View article titled, Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

Includes: Supplementary data

Articles

p65 controls NF-κB activity by regulating cellular localization of IκBβ

Taras Valovka, Michael O. Hottiger

Biochem J (2011) 434 (2): 253–263.

https://doi.org/10.1042/BJ20101220

Published: 11 February 2011

... 8 2010 5 11 2010 16 12 2010 16 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 cellular localization gene expression inhibitory κB β (IκBβ) nuclear factor κB (NF-κB) tumour necrosis factor α (TNFα) NF-κB (nuclear factor κB) is a homo...

View article titled, p65 controls NF-κB activity by regulating cellular localization of IκBβ

Includes: Supplementary data

Articles

Phosphorylation-dependent association of the G4-1/G5PR regulatory subunit with IKKβ negatively modulates NF-κB activation through recruitment of protein phosphatase 5

Chao-Wei Chiang, Wei-Kuang Liu, Chi-Wu Chiang, Chen-Kung Chou

Biochem J (2011) 433 (1): 187–196.

https://doi.org/10.1042/BJ20100247

Published: 15 December 2010

... Society 2011 G4-1/G5PR inhibitor of nuclear factor κB kinase (IKK) nuclear factor κB (NF-κB) protein phosphatase 5 NF-κB (nuclear factor κB) is a ubiquitous and evolutionarily conserved transcription factor. In non-stimulated cells, NF-κB heterodimers are sequestered in the cytoplasm...

View article titled, Phosphorylation-dependent association of the G4-1/G5PR regulatory subunit with IKKβ negatively modulates NF-κB activation through recruitment of protein phosphatase 5

Articles

Survivin and IAP proteins in cell-death mechanisms

Dario C. Altieri

Biochem J (2010) 430 (2): 199–205.

https://doi.org/10.1042/BJ20100814

Published: 13 August 2010

... of tissues and organs throughout adult life [ 3 ]. Deregulation of apoptosis is a pathogenic factor of many human diseases, and aberrantly increased cell survival is a hallmark of virtually every human tumour [ 4 ]. cancer therapy inhibitor of apoptosis (IAP) mitochondrion nuclear factor κB (NF-κB...

View article titled, Survivin and IAP proteins in cell-death mechanisms

Articles

NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance

Suman Dasgupta, Sushmita Bhattacharya, Anindita Biswas, Subeer S. Majumdar, Satinath Mukhopadhyay, Sukanta Ray, Samir Bhattacharya

Biochem J (2010) 429 (3): 451–462.

https://doi.org/10.1042/BJ20100330

Published: 14 July 2010

... contemporary target for therapeutic intervention in Type 2 diabetes. adipogenesis fetuin-A insulin resistance nonesterified (‘free’) fatty acid nuclear factor κB (NF-κB) Type 2 diabetes 1 These authors contributed equally to this work. 2 To whom correspondence should be addressed...

View article titled, NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance

Includes: Supplementary data

Articles

Nitric oxide triggers mammary gland involution after weaning: remodelling is delayed but not impaired in mice lacking inducible nitric oxide synthase

Rosa Zaragozá, Ana Bosch, Concha García, Juan Sandoval, Eva Serna, Luís Torres, Elena R. García-Trevijano, Juan R. Viña

Biochem J (2010) 428 (3): 451–462.

https://doi.org/10.1042/BJ20091091

Published: 27 May 2010

... correspondence should be addressed to (email [email protected] ). 17 7 2009 8 3 2010 26 3 2010 26 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 apoptosis extracellular matrix (ECM) mammary gland nitric oxide nuclear factor κB (NF-κB) signal...

View article titled, Nitric oxide triggers mammary gland involution after weaning: remodelling is delayed but not impaired in mice lacking inducible nitric oxide synthase

Articles

Thr 435 phosphorylation regulates RelA (p65) NF-κB subunit transactivation

John M. O'Shea, Neil D. Perkins

Biochem J (2010) 426 (3): 345–354.

https://doi.org/10.1042/BJ20091630

Published: 24 February 2010

..., distribution and reproduction in any medium, provided the original work is properly cited. CXC ligand 2 (CXCL2)/macrophage inflammatory protein 2 (MIP2) histone acetylation histone deacetylase 1 (HDAC1) nuclear factor κB (NF-κB) RelA (p65) tumour necrosis factor α (TNFα) The RelA (p65) subunit...

View article titled, Thr 435 phosphorylation regulates RelA (p65) NF-κB subunit transactivation

Includes: Supplementary data

Articles

MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

Joanne Darragh, Olga Ananieva, Alan Courtney, Suzanne Elcombe, J. Simon C. Arthur

Biochem J (2010) 425 (3): 595–602.

https://doi.org/10.1042/BJ20091062

Published: 15 January 2010

...- and stress-activated kinase 1 (MSK1) nuclear factor κB (NF-κB) IL (interleukin)-1 is an inflammatory cytokine produced by the immune system that is critical in the host's response to infection. IL-1 activity is tightly regulated in vivo , both by control of IL-1 production and by levels...

View article titled, MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages

Articles

G-protein-coupled-receptor kinases mediate TNFα-induced NF-κB signalling via direct interaction with and phosphorylation of IκBα

Sonika Patial, Jiansong Luo, Katie J. Porter, Jeffrey L. Benovic, Narayanan Parameswaran

Biochem J (2010) 425 (1): 169–180.

https://doi.org/10.1042/BJ20090908

Published: 14 December 2009

... should be addressed (email [email protected] ). 18 6 2009 18 9 2009 2 10 2009 2 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 G-protein-coupled-receptor kinase (GRK) inflammation macrophage nuclear factor κB (NF-κB) tumour necrosis factor...

View article titled, G-protein-coupled-receptor kinases mediate TNFα-induced NF-κB signalling via direct interaction with and phosphorylation of IκBα

Includes: Supplementary data

Articles

IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

Hosea Handoyo, Margaret J. Stafford, Eamon McManus, Dionissios Baltzis, Mark Peggie, Philip Cohen

Biochem J (2009) 424 (1): 109–118.

https://doi.org/10.1042/BJ20091271

Published: 23 October 2009

... be addressed (email [email protected] ). innate immunity interleukin-1 (IL-1) interleukin1-receptor-associated kinase 1 (IRAK1) nuclear factor κB (NF-κB) tumour necrosis factor (TNF) tumour progression locus 2 (Tpl2) 17 8 2009 11 9 2009 15 9 2009 15 9 2009 ©...

View article titled, IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2

Includes: Supplementary data

Articles

A mechanism for the suppression of interleukin-1-induced nuclear factor κB activation by protein phosphatase 2Cη-2

Takeaki Henmi, Kazutaka Amano, Yuko Nagaura, Kunihiro Matsumoto, Seishi Echigo, Shinri Tamura, Takayasu Kobayashi

Biochem J (2009) 423 (1): 71–78.

https://doi.org/10.1042/BJ20090208

Published: 14 September 2009

... κB kinase β (IKKβ) interleukin-1 (IL-1) nuclear factor κB (NF-κB) protein phosphatase 2Cη-2 (PP2Cη-2) protein phosphatase magnesium- or manganese-dependent 1M (PPM1M) IL-1 (interleukin-1) is a pro-inflammatory cytokine that has a variety of effects during the process of inflammation...

View article titled, A mechanism for the suppression of interleukin-1-induced nuclear factor κB activation by protein phosphatase 2Cη-2

Articles

Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-κB modulates glucocorticoid receptor and NF-κB signalling in HEK-293 cells

Anna-Maria G. Psarra, Stefan Hermann, George Panayotou, Giannis Spyrou

Biochem J (2009) 422 (3): 521–531.

https://doi.org/10.1042/BJ20090107

Published: 27 August 2009

... be addressed (email [email protected] ). 2 Current address: Glucometrix, Potsdam, Germany 20 1 2009 25 6 2009 2 7 2009 2 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 glucocorticoid receptor (GR) mitochondria nuclear factor κB (NF-κB...

View article titled, Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-κB modulates glucocorticoid receptor and NF-κB signalling in HEK-293 cells

Articles

Generation and functional characterization of a BCL10-inhibitory peptide that represses NF-κB activation

Daniela Marasco, Romania Stilo, Annamaria Sandomenico, Simona Maria Monti, Barbara Tizzano, Antonia de Capua, Ettore Varricchio, Domenico Liguoro, Tiziana Zotti, Silvestro Formisano, Menotti Ruvo, Pasquale Vito

Biochem J (2009) 422 (3): 553–561.

https://doi.org/10.1042/BJ20090055

Published: 27 August 2009

... BCL10-inhibitory peptide caspase recruitment domain (CARD) caspase recruitment domain-containing membrane-associated guanylate kinase (CARMA) nuclear factor κB (NF-κB) Over the last few years, a number of adaptor molecules that contain the CARD (caspase recruitment domain) have been...

View article titled, Generation and functional characterization of a BCL10-inhibitory peptide that represses NF-κB activation

Articles

Two distinct signalling cascades target the NF-κB regulatory factor c-IAP1 for degradation

Rebecca A. Csomos, Casey W. Wright, Stefanie Galbán, Karolyn A. Oetjen, Colin S. Duckett

Biochem J (2009) 420 (1): 83–91.

https://doi.org/10.1042/BJ20082140

Published: 28 April 2009

... otherwise, plasmids used in the present study have been described previously [ 37 38 – 39 ]. CD30 inhibitor of apoptosis (IAP) lymphoma nuclear factor κB (NF-κB) second mitochondrial-derived activator of caspase (Smac)/direct inhibitor of apoptosis-binding protein with low pI (DIABLO) tumour...

View article titled, Two distinct signalling cascades target the NF-κB regulatory factor c-IAP1 for degradation

Includes: Supplementary data

Articles

Development of an insect-cell-based assay for detection of kinase inhibition using NF-κB-inducing kinase as a paradigm

Namir J. Hassan, Sheraz Gul, Fiona Flett, Edward Hollingsworth, Angela A. Dunne, Amanda J. Emmons, Jonathan P. Hutchinson, Martin J. Hibbs, Susan Dyos, Jeremy D. Kitson, Emma Hiley, Martin Rüdiger, David G. Tew, David J. Powell, Mary A. Morse

Biochem J (2009) 419 (1): 65–73.

https://doi.org/10.1042/BJ20081646

Published: 13 March 2009

... 12 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 baculovirus expression system cell-based assay nuclear factor κB-inducing kinase (NIK) inhibitor of nuclear factor κB kinase-1 (IKK1) nuclear factor κB (NF-κB) More recently, there has been increased...

View article titled, Development of an insect-cell-based assay for detection of kinase inhibition using NF-κB-inducing kinase as a paradigm

Articles

BCL11B enhances TCR/CD28-triggered NF-κB activation through up-regulation of Cot kinase gene expression in T-lymphocytes

Valeriu B. Cismasiu, Javier Duque, Elena Paskaleva, Danielle Califano, Sailaja Ghanta, Howard A. Young, Dorina Avram

Biochem J (2009) 417 (2): 457–466.

https://doi.org/10.1042/BJ20080925

Published: 23 December 2008

...) kinase C-terminal binding protein-interacting protein 2 (CTIP2) nuclear factor κB (NF-κB) T-cell receptor (TCR) signalling BCL11B, also known as CTIP2 [CtBP (C-terminal binding protein)-interacting protein 2], is a C 2 H 2 zinc-finger transcription factor with a critical role in T-cell...

View article titled, BCL11B enhances TCR/CD28-triggered NF-κB activation through up-regulation of Cot kinase gene expression in T-lymphocytes

Articles

Inhibitors of apoptosis catch ubiquitin

Krishnaraj Rajalingam, Ivan Dikic

Biochem J (2009) 417 (1): e1–e3.

https://doi.org/10.1042/BJ20082215

Published: 12 December 2008

... The Authors Journal compilation © 2009 Biochemical Society 2009 cellular inhibitor of apoptosis protein 1 (c-IAP1) cellular inhibitor of apoptosis protein 2 (c-IAP2) nuclear factor κB (NF-κB) ubiquitin ubiquitin-associated domain (UBA) X-linked inhibitor of apoptosis (XIAP) IAP (inhibitor...

View article titled, Inhibitors of apoptosis catch ubiquitin

Articles

β-Arrestin1 interacts with the G-protein subunits β1γ2 and promotes β1γ2-dependent Akt signalling for NF-κB activation

Ming Yang, Rong L. He, Jeffrey L. Benovic, Richard D. Ye

Biochem J (2009) 417 (1): 287–296.

https://doi.org/10.1042/BJ20081561

Published: 12 December 2008

... be addressed to either of these authors (email [email protected] or [email protected] ). 30 7 2008 26 8 2008 27 8 2008 27 8 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 Akt β-arrestin GTP-binding protein βγ subunit (G βγ ) nuclear factor κB (NF-κB...

View article titled, β-Arrestin1 interacts with the G-protein subunits β1γ2 and promotes β1γ2-dependent Akt signalling for NF-κB activation

Articles

Identification of lysine residues critical for the transcriptional activity and polyubiquitination of the NF-κB family member RelB

Julia Leidner, Lysann Palkowitsch, Uta Marienfeld, Dietmar Fischer, Ralf Marienfeld

Biochem J (2008) 416 (1): 117–127.

https://doi.org/10.1042/BJ20080432

Published: 28 October 2008

... ). 22 2 2008 7 7 2008 11 7 2008 11 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 co-factor gene expression nuclear factor κB (NF-κB) protein stability RelB ubiquitination The transcription factor NF-κB (nuclear factor κB) plays...

View article titled, Identification of lysine residues critical for the transcriptional activity and polyubiquitination of the NF-κB family member RelB

Includes: Supplementary data

Articles

The life of a cell: apoptosis regulation by the PI3K/PKB pathway

Vincent Duronio

Biochem J (2008) 415 (3): 333–344.

https://doi.org/10.1042/BJ20081056

Published: 15 October 2008

... © The Authors Journal compilation © 2008 Biochemical Society 2008 apoptosis Bcl-2 nuclear factor κB (NF-κB) phosphoinositide-dependent kinase 1 (PDK1) phosphoinositide 3-kinase (PI3K) protein kinase B (PKB) It is well known that investigations of the pathways that are regulated...

View article titled, The life of a cell: apoptosis regulation by the PI3K/PKB pathway

Articles

The cross-talk between NF-κB and HIF-1: further evidence for a significant liaison

Agnes Görlach, Steve Bonello

Biochem J (2008) 412 (3): e17–e19.

https://doi.org/10.1042/BJ20080920

Published: 28 May 2008

... hypoxia-inducible factor 1α (HIF-1α) nuclear factor κB (NF-κB) reactive oxygen species transcription factor tumour necrosis factor α (TNF-α) The family of HIFs (hypoxia-inducible factors) has been widely acknowledged to be critically involved in the cellular response to low oxygen tension...

View article titled, The cross-talk between NF-κB and HIF-1: further evidence for a significant liaison

Articles

Regulation of hypoxia-inducible factor-1α by NF-κB

Patrick van Uden, Niall S. Kenneth, Sonia Rocha

Biochem J (2008) 412 (3): 477–484.

https://doi.org/10.1042/BJ20080476

Published: 28 May 2008

.../2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. hypoxia hypoxia-inducible factor 1 (HIF-1) nuclear factor κB (NF-κB) tumour necrosis factor (TNF) HIF (hypoxia-inducible factor) plays key...

View article titled, Regulation of hypoxia-inducible factor-1α by NF-κB

Includes: Supplementary data

Articles

Interleukin-1β up-regulates RGS4 through the canonical IKK2/IκBα/NF-κB pathway in rabbit colonic smooth muscle

Wenhui Hu, Fang Li, Sunila Mahavadi, Karnam S. Murthy

Biochem J (2008) 412 (1): 35–43.

https://doi.org/10.1042/BJ20080042

Published: 25 April 2008

...-Tag antibody showed a transfection efficiency of 60–70%. interleukin-1β (IL-1β) intestinal smooth muscle nuclear factor κB (NF-κB) phospholipase C regulator of G-protein signaling 4 (RGS4) small interfering RNA In gastrointestinal smooth muscle, ACh (acetylcholine) induces...

View article titled, Interleukin-1β up-regulates RGS4 through the canonical IKK2/IκBα/NF-κB pathway in rabbit colonic smooth muscle

Articles

Heregulin β1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21 Cip1

Chengfeng Yang, Eric A. Klein, Richard K. Assoian, Marcelo G. Kazanietz

Biochem J (2008) 410 (1): 167–175.

https://doi.org/10.1042/BJ20070781

Published: 29 January 2008

[email protected] or [email protected] ). 11 6 2007 16 10 2007 18 10 2007 18 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 cyclin D1 extracellular-signal-regulated kinase 1/2 (ERK1/2) heregulin nuclear factor κB (NF-κB) p21 Cip1 Rac1...

View article titled, Heregulin β1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21 Cip1

Includes: Supplementary data

Articles

Involvement of phosphoinositide 3-kinase and Akt in the induction of muscle protein degradation by proteolysis-inducing factor

Steven T. Russell, Helen L. Eley, Stacey M. Wyke, Michael J. Tisdale

Biochem J (2008) 409 (3): 751–759.

https://doi.org/10.1042/BJ20070688

Published: 15 January 2008

... (protein kinase B) nuclear factor κB (NF-κB) proteasome expression protein degradation proteolysis-inducing factor (PIF) phosphoinositide 3-kinase The ubiquitin–proteasome proteolytic pathway has been shown to play a major role in muscle wasting in starvation, sepsis, metabolic acidosis, diabetes...

View article titled, Involvement of phosphoinositide 3-kinase and Akt in the induction of muscle protein degradation by proteolysis-inducing factor

Articles

Structure of the A20 OTU domain and mechanistic insights into deubiquitination

David Komander, David Barford

Biochem J (2008) 409 (1): 77–85.

https://doi.org/10.1042/BJ20071399

Published: 11 December 2007

... protocols, and purified with increasing DTT concentration (10 mM) in all buffers. All protein purifications were performed at 4 °C. A20 binding inhibitor of NF-κB (ABIN) cytokine signalling deubiquitinating enzyme inhibitor of κB kinase (IKK) Lys 63 -linked ubiquitin nuclear factor κB (NF-κB) TGF...

View article titled, Structure of the A20 OTU domain and mechanistic insights into deubiquitination

Articles

Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor κB-mediated transcription

Hiyaa S. Ghosh, James V. Spencer, Bobby Ng, Michael W. McBurney, Paul D. Robbins

Biochem J (2007) 408 (1): 105–111.

https://doi.org/10.1042/BJ20070817

Published: 29 October 2007

... (National Center for Biotechnology Information) GenBank® database for identification of the interacting proteins. deacetylase nuclear factor κB (NF-κB) Sirt1 transducin-like enhancer of split-1 (TLE1) transcription Sirt1, an NAD + -dependent deacetylase, is the human homologue...

View article titled, Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor κB-mediated transcription

Articles

Crucial roles of binding sites for NF-κB and C/EBPs in IκB-ζ-mediated transcriptional activation

Susumu Matsuo, Soh Yamazaki, Koichiro Takeshige, Tatsushi Muta

Biochem J (2007) 405 (3): 605–615.

https://doi.org/10.1042/BJ20061797

Published: 13 July 2007

..., and the luciferase activities were measured. The amount of transfected DNA was kept constant by using an empty vector. CCAAT/enhancer-binding protein (C/EBP) inflammation inhibitor of nuclear factor κB ζ (IκB-ζ) innate immunity nuclear factor κB (NF-κB) transcription Cells alter gene expression...

View article titled, Crucial roles of binding sites for NF-κB and C/EBPs in IκB-ζ-mediated transcriptional activation

Articles

Inhibition of human betaine–homocysteine methyltransferase expression by S -adenosylmethionine and methylthioadenosine

Xiaopeng Ou, Heping Yang, Komal Ramani, Ainhoa Iglesias Ara, Hui Chen, José M. Mato, Shelly C. Lu

Biochem J (2007) 401 (1): 87–96.

https://doi.org/10.1042/BJ20061119

Published: 11 December 2006

... 2006 10 8 2006 6 9 2006 6 10 2006 The Biochemical Society, London 2007 betaine–homocysteine methyltransferase (BHMT) endoplasmic reticulum stress HepG2 cell 5′-methylthioadenosine nuclear factor κB (NF-κB) S -adenosylmethionine BHMT (betaine–homocysteine...

View article titled, Inhibition of human betaine–homocysteine methyltransferase expression by S -adenosylmethionine and methylthioadenosine

Includes: Supplementary data

Articles

In vivo binding of NF-κB to the IκBβ promoter is insufficient for transcriptional activation

Bryan D. Griffin, Paul N. Moynagh

Biochem J (2006) 400 (1): 115–125.

https://doi.org/10.1042/BJ20060786

Published: 27 October 2006

.... chromatin immunoprecipitation (ChIP) cis -element inhibitory κB (IκB) nuclear factor κB (NF-κB) RNA polymerase II transcription The inducible expression of a wide range of immune and inflammatory response genes is controlled by the action of NF-κB (nuclear factor κB) [ 1 ]. NF-κB is a dimeric...

View article titled, In vivo binding of NF-κB to the IκBβ promoter is insufficient for transcriptional activation

Articles

Cell cycle-dependent expression of cIAP2 at G2/M phase contributes to survival during mitotic cell cycle arrest

Hyung-Seung Jin, Tae H. Lee

Biochem J (2006) 399 (2): 335–342.

https://doi.org/10.1042/BJ20060612

Published: 27 September 2006

... protein (cIAP) inhibitor of apoptosis protein (IAP) mitosis nuclear factor κB (NF-κB) Figure 2 G2/M-specific activity of the cIAP2 promoter is mediated by the region containing CDE-like and CHR elements ( A ) Increased cIAP2 promoter activity during G2/M phase. A series of cIAP2-promoter...

View article titled, Cell cycle-dependent expression of cIAP2 at G2/M phase contributes to survival during mitotic cell cycle arrest

Articles

Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor κB pathway

Varvara Nikolaidou-Neokosmidou, Vassilis I. Zannis, Dimitris Kardassis

Biochem J (2006) 398 (3): 439–450.

https://doi.org/10.1042/BJ20060169

Published: 29 August 2006

... hepatocyte nuclear factor 4 (HNF-4) nuclear factor κB (NF-κB) transcriptional inhibition tumour necrosis factor α (TNFα) All reagents for cell culture, including DMEM (Dulbecco's modified Eagle's medium), FBS (fetal bovine serum), trypsin/EDTA and PBS were purchased from Life Technologies...

View article titled, Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor κB pathway

Articles

Characterization of COMMD protein–protein interactions in NF-κB signalling

Prim de Bie, Bart van de Sluis, Ezra Burstein, Karen J. Duran, Ruud Berger, Colin S. Duckett, Cisca Wijmenga, Leo W. J. Klomp

Biochem J (2006) 398 (1): 63–71.

https://doi.org/10.1042/BJ20051664

Published: 27 July 2006

... 2005 20 2 2006 30 3 2006 30 3 2006 The Biochemical Society, London 2006 copper copper metabolism gene MURR1 domain protein 6 (COMMD6) mouse U2af1-rs1 region 1 (MURR1) nuclear factor κB (NF-κB) protein–protein interaction COMMD [copper metabolism gene MURR1 (mouse...

View article titled, Characterization of COMMD protein–protein interactions in NF-κB signalling

Articles

IκB is a sensitive target for oxidation by cell-permeable chloramines: inhibition of NF-κB activity by glycine chloramine through methionine oxidation

Robyn G. Midwinter, Fook-Choe Cheah, Jackob Moskovitz, Margret C. Vissers, Christine C. Winterbourn

Biochem J (2006) 396 (1): 71–78.

https://doi.org/10.1042/BJ20052026

Published: 26 April 2006

... ]. chloramine hypochlorous acid (HOCl) inhibitor of nuclear factor κB (IκB) methionine oxidation methionine sulphoxide reductase (Msr) nuclear factor κB (NF-κB) NF-κB (nuclear factor κB) is a major transcription factor that regulates expression of a large number of genes that code for cytokines...

View article titled, IκB is a sensitive target for oxidation by cell-permeable chloramines: inhibition of NF-κB activity by glycine chloramine through methionine oxidation

Articles

TNFα- and IKKβ-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKγ and NF-κB activation

Marianne Bonif, Marie-Alice Meuwis, Pierre Close, Valérie Benoit, Karen Heyninck, Jean-Paul Chapelle, Vincent Bours, Marie-Paule Merville, Jacques Piette, Rudi Beyaert, Alain Chariot

Biochem J (2006) 394 (3): 593–603.

https://doi.org/10.1042/BJ20051659

Published: 24 February 2006

... correspondence should be addressed, at Laboratory of Medical Chemistry, Pathology, +3 B23, CHU, Sart-Tilman, 4000 Liège, Belgium (email [email protected] ). 12 10 2005 6 12 2005 9 12 2005 9 12 2005 The Biochemical Society, London 2006 nuclear factor κB (NF-κB) p65...

View article titled, TNFα- and IKKβ-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKγ and NF-κB activation

Includes: Supplementary data

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