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1-31 of 31
Keywords: nuclear receptor
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Articles
Christian Bindesbøll, Susanna Tan, Debbie Bott, Tiffany Cho, Laura Tamblyn, Laura MacPherson, Line Grønning-Wang, Hilde Irene Nebb, Jason Matthews
Journal:
Biochemical Journal
Biochem J (2016) 473 (7): 899–910.
Published: 29 March 2016
... transcription factors and members of the nuclear receptor family [ 1 ]. LXRs function as oxysterol receptors and are important physiological regulators of lipid, cholesterol and glucose metabolism, but also modulate inflammatory pathways [ 2 ]. LXRα is mainly expressed in liver, adipose, intestine...
Includes: Supplementary data
Articles
Ryota Shizu, Taiki Abe, Satoshi Benoki, Miki Takahashi, Susumu Kodama, Masaaki Miayata, Atsushi Matsuzawa, Kouichi Yoshinari
Journal:
Biochemical Journal
Biochem J (2016) 473 (3): 257–266.
Published: 25 January 2016
...Ryota Shizu; Taiki Abe; Satoshi Benoki; Miki Takahashi; Susumu Kodama; Masaaki Miayata; Atsushi Matsuzawa; Kouichi Yoshinari Growth factor-mediated hepatocyte proliferation is crucial in liver regeneration and the recovery of liver function after injury. The nuclear receptor, pregnane X receptor...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 460 (3): 317–329.
Published: 29 May 2014
... be addressed (email [email protected] ). 3 3 2014 13 3 2014 19 3 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer nuclear export signal nuclear receptor protein–ligand interaction signalling virus–host interaction LD motifs...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 459 (1): 193–203.
Published: 14 March 2014
... was described previously [ 20 ]. dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) nuclear receptor phosphorylation pregnane X receptor (PXR) ubiquitination ubiquitin protein ligase E3 component n-recognin 5 (UBR5) The human liver detoxification system comprises transporters...
Includes: Supplementary data
Articles
Xin-rui Lv, Bin Zheng, Shu-ya Li, Ai-li Han, Chang Wang, Jian-hong Shi, Xin-hua Zhang, Yan Liu, Yong-hui Li, Jin-kun Wen
Journal:
Biochemical Journal
Biochem J (2013) 456 (1): 35–46.
Published: 24 October 2013
... the expression of active peptides in the cardiovascular system. Am80 promotes the interaction of RARα (retinoic acid receptor α) with KLF5 (Krüppel-like factor 5) and Sp1 (stimulating protein-1) prebound to the apelin promoter to enhance apelin gene transcription. apelin gene regulation nuclear receptor...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 452 (3): 519–529.
Published: 31 May 2013
... and RXR (retinoid X receptor) α. 1 To whom correspondence should be addressed (email [email protected] ). 31 10 2012 3 3 2013 7 3 2013 7 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 nuclear receptor retinoic acid receptor...
Articles
Tomoko Yamazaki, Jun-ichi Suehiro, Hideki Miyazaki, Takashi Minami, Tatsuhiki Kodama, Kohei Miyazono, Tetsuro Watabe
Journal:
Biochemical Journal
Biochem J (2013) 452 (2): 345–357.
Published: 10 May 2013
...Tomoko Yamazaki; Jun-ichi Suehiro; Hideki Miyazaki; Takashi Minami; Tatsuhiki Kodama; Kohei Miyazono; Tetsuro Watabe The COUP-TFII (chicken ovalbumin upstream promoter-transcription factor II) nuclear receptor, which is composed of a DNA-binding domain and a ligand-binding domain, exerts...
Includes: Supplementary data
Articles
Ismayil Tasdelen, Olivier van Beekum, Olena Gorbenko, Veerle Fleskens, Niels J. F. van den Broek, Arjen Koppen, Nicole Hamers, Ruud Berger, Paul J. Coffer, Arjan B. Brenkman, Eric Kalkhoven
Journal:
Biochemical Journal
Biochem J (2013) 451 (1): 45–53.
Published: 14 March 2013
..., including transcription factors. Phosphorylation of the nuclear receptor PPARγ (peroxisome-proliferator-activated receptor γ) at two conserved serine residue (Ser 112 and Ser 273 ) results in an altered transcriptional activity of this transcription factor. So far, only a very limited number of cellular...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 446 (1): e1–e3.
Published: 27 July 2012
... studies involving members of the nuclear receptor superfamily illustrate the chemical richness of molecules from marine species and helps to re-emphasize the translational possibilities of natural products in drug discovery. In this issue of the Biochemical Journal Wang et al. describe the identification...
Articles
Shanshan Wang, Zhao Wang, Shengchen Lin, Weili Zheng, Rui Wang, Shikai Jin, Jinan Chen, Lihua Jin, Yong Li
Journal:
Biochemical Journal
Biochem J (2012) 446 (1): 79–87.
Published: 27 July 2012
... with advantages over current RA drugs. The atomic co-ordinates and structure factors for RARα–luffariellolide have been deposited in the Protein Data Bank under code 4DQM. Similar to many other nuclear receptors, the ligand-dependent recruitment of co-activators by RARs is primarily determined...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 427 (3): 499–511.
Published: 14 April 2010
... should be addressed (email [email protected] ). 20 10 2009 8 2 2010 17 2 2010 17 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 amino-terminal enhancer of split (AES) androgen receptor (AR) androgen co-repressor nuclear receptor...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 405 (1): 31–39.
Published: 13 June 2007
... of the C-terminal NR (nuclear receptor)-boxes is required for the co-repressor activity, whereas the NR-box-like motif as well as additional elements in the C-terminal region are required for full repressive function. The C-terminal NR-box-like motif is necessary for interaction with LXRβ, whereas...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2007) 401 (3): 735–741.
Published: 12 January 2007
...Sawako Shindo; Satoshi Numazawa; Takemi Yoshida CAR (constitutive androstane receptor) is a nuclear receptor that regulates the transcription of target genes, including CYP (cytochrome P450) 2B and 3A. The transactivation by CAR is regulated by its subcellular localization; however, the mechanism...
Articles
Yutaka Maeda, Wendy W. Hwang-Verslues, Gang Wei, Takuya Fukazawa, Mary L. Durbin, Laurie B. Owen, Xuan Liu, Frances M. Sladek
Journal:
Biochemical Journal
Biochem J (2006) 400 (2): 303–313.
Published: 14 November 2006
... shown that p53 inhibits the transactivation function of HNF (hepatocyte nuclear factor) 4α1, a nuclear receptor known to be critical for early development and liver differentiation. In the present study we demonstrate that p53 also down-regulates expression of the human HNF4α gene via the proximal P1...
Articles
Hong Soon Kang, Ju Youn Beak, Yong-Sik Kim, Robert M. Petrovich, Jennifer B. Collins, Sherry F. Grissom, Anton M. Jetten
Journal:
Biochemical Journal
Biochem J (2006) 397 (1): 89–99.
Published: 14 June 2006
... microarray nucleic acid binding protein 1 (NABP1) nuclear receptor oligonucleotide/oligosaccharide binding-fold (OB-fold) RORγ (retinoid-related orphan receptor γ) thymopoiesis The ROR (retinoid-related orphan receptor) subfamily consists of three members, RORα, RORβ and RORγ (named NRF1–NRF3...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2005) 392 (1): 241–248.
Published: 08 November 2005
... receptor α) heterodimers in vitro , and inclusion of nuclear receptors in transfections boosted the transcriptional response. A construct containing both R1 and R2 was used to generate a stable luciferase reporter cell line that can be used as a tool to identify factors regulating Cyp26A1 expression...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 389 (1): 19–26.
Published: 21 June 2005
...Ming-Wei KUO; John POSTLETHWAIT; Wen-Chih LEE; Show-Wan LOU; Woon-Khiong CHAN; Bon-chu CHUNG Fushi tarazu factor 1 (Ftz-F1, NR5A) is a zinc-finger transcription factor that belongs to the nuclear receptor superfamily and regulates genes that are involved in sterol and steroid metabolism in gonads...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2005) 388 (2): 623–630.
Published: 24 May 2005
...Akiko UEDA; Kenji MATSUI; Yukio YAMAMOTO; Lars C. PEDERSEN; Tatsuya SUEYOSHI; Masahiko NEGISHI The mouse nuclear receptor CAR (constitutively active receptor) is a transcription factor that is activated by phenobarbital-type inducers such as TCPOBOP {1,4 bis[2-(3,5-dichloropyridyloxy)]benzene...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 388 (2): 407–418.
Published: 24 May 2005
... are direct repeats separated by 4 bp of the nuclear receptor consensus half-site AGGTCA, as well as an ER (everted repeat) separated by 7 bp (ER-7). Constitutive androstane receptor (CAR)–RXR (retinoic X receptor) heterodimers are known to bind to NR1, NR2 and NR3. Electrophoretic mobility-shift analysis...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 384 (3): 637–645.
Published: 07 December 2004
...Adam G. STAINES; Pavel SINDELAR; Michael W. H. COUGHTRIE; Brian BURCHELL Farnesol is an isoprenoid found in many aromatic plants and is also produced in humans, where it acts on numerous nuclear receptors and has received considerable attention due to its apparent anticancer properties. Although...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 384 (1): 79–85.
Published: 09 November 2004
...Caroline CHAUVET; Brigitte BOIS-JOYEUX; Edurne BERRA; Jacques POUYSSEGUR; Jean-Louis DANAN Retinoic acid-receptor-related orphan receptor (ROR) α is a nuclear receptor involved in many pathophysiological processes such as cerebellar ataxia, inflammation, atherosclerosis and angiogenesis...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 382 (3): 913–921.
Published: 07 September 2004
... 2004 17 6 2004 The Biochemical Society, London 2004 bile acid farnesoid X receptor (FXR) fasting nuclear receptor peroxisome-proliferator-activated receptor-γ co-activator-1α (PGC-1α) transcriptional co-activator To search for co-activators of FXR, we used a chimaeric...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 382 (1): 111–119.
Published: 10 August 2004
... not only determine its AD1 activity, but are also involved in its co-activator functions in some nuclear receptors. 1 To whom correspondence should be addressed (email [email protected] ). The Biochemical Society, London 2004 cAMP-responsive-element-binding-protein-binding...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 367 (3): 907–911.
Published: 01 November 2002
... Society, London ©2002 2002 nuclear receptor sumoylation transactivation Abbreviations used: AR, androgen receptor; FBS, foetal bovine serum; GR, glucocorticoid receptor; K277R, Lys 277 →Arg; LUC, luciferase; PR, progesterone receptor; SUMO-1, small ubiquitin-related modifier-1. Biochem...
Articles
Philippe THUILLIER, Alan R. BRASH, James P. KEHRER, Julie B. STIMMEL, Lisa M. LEESNITZER, Peiying YANG, Robert A. NEWMAN, Susan M. FISCHER
Journal:
Biochemical Journal
Biochem J (2002) 366 (3): 901–910.
Published: 15 September 2002
... ligands. Ligand-binding studies revealed that the LOX inhibitors bind directly to PPARs and demonstrate a novel mechanism for these inhibitors in altering PPAR-mediated gene expression. eicosanoid flavonoid nuclear receptor skin Abbreviations used: FLAP, five lipoxygenase-activated protein...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 365 (1): 223–228.
Published: 01 July 2002
... 2002 12 4 2002 The Biochemical Society, London ©2002 2002 glycolysis hypoxia insulin maturity-onset diabetes of the young metabolic zonation nuclear receptor Abbreviations used: DIG, digoxigenin; EMSA, electrophoretic mobility-shift assay; EPO, erythropoietin; GK...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 353 (2): 193–198.
Published: 08 January 2001
...Masaaki OKUNO; Emi ARIMOTO; Yukiko IKENOBU; Tsutomu NISHIHARA; Masayoshi IMAGAWA The peroxisome-proliferator-activated receptor γ (PPARγ) is a member of the steroid/thyroid nuclear receptor superfamily of ligand-activated transcription factors. PPARγ forms a heterodimer with the retinoid X receptor...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 353 (2): 231–238.
Published: 08 January 2001
... 25 10 2000 The Biochemical Society, London © 2001 2001 antagonist lipid metabolism nuclear receptor Biochem. J. (2001) 353, 231 238 (Printed in Great Britain) 231 Fatty-acyl-CoA thioesters inhibit recruitment of steroid receptor co-activator 1 to a and c isoforms of peroxisome...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 349 (3): 885–893.
Published: 25 July 2000
... cells from apoptosis. Co-transfection experiments in COS-7 cells showed that DAP3 had a stimulatory effect on the ligand-induced transcriptional activation by GR and also increased the steroid-sensitivity. Furthermore, DAP3 formed a complex with several other nuclear receptors and some basic helix–loop...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 348 (2): 439–446.
Published: 23 May 2000
...Wen-wen LIN; Hsin-Wei WANG; Cristina SUM; Dong LIU; Choy L. HEW; Bon-chu CHUNG Fushi-tarazu Factor-1 (FTZ-F1) is a family of nuclear receptors involved in various developmental processes. We have cloned a zebrafish FTZ-F1 gene, termed ff1 , which belongs to the fetoprotein transcription factor...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 340 (1): 161–169.
Published: 10 May 1999
... The Biochemical Society, London © 1999 1999 activation domain AF-2 C-terminal repression domain isoform nuclear receptor Biochem. J. (1999) 340, 161 169 (Printed in Great Britain) 161 The activity of the activation function 2 of the human hepatocyte nuclear factor 4 (HNF-4a) is differently modulated...