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Keywords: nuclear receptor
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Biochem J (2016) 473 (7): 899–910.
Published: 29 March 2016
... transcription factors and members of the nuclear receptor family [ 1 ]. LXRs function as oxysterol receptors and are important physiological regulators of lipid, cholesterol and glucose metabolism, but also modulate inflammatory pathways [ 2 ]. LXRα is mainly expressed in liver, adipose, intestine...
Includes: Supplementary data
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Biochem J (2016) 473 (3): 257–266.
Published: 25 January 2016
...Ryota Shizu; Taiki Abe; Satoshi Benoki; Miki Takahashi; Susumu Kodama; Masaaki Miayata; Atsushi Matsuzawa; Kouichi Yoshinari Growth factor-mediated hepatocyte proliferation is crucial in liver regeneration and the recovery of liver function after injury. The nuclear receptor, pregnane X receptor...
Includes: Supplementary data
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Biochem J (2014) 459 (1): 193–203.
Published: 14 March 2014
... was described previously [ 20 ]. dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) nuclear receptor phosphorylation pregnane X receptor (PXR) ubiquitination ubiquitin protein ligase E3 component n-recognin 5 (UBR5) The human liver detoxification system comprises transporters...
Includes: Supplementary data
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Biochem J (2013) 456 (1): 35–46.
Published: 24 October 2013
... the expression of active peptides in the cardiovascular system. Am80 promotes the interaction of RARα (retinoic acid receptor α) with KLF5 (Krüppel-like factor 5) and Sp1 (stimulating protein-1) prebound to the apelin promoter to enhance apelin gene transcription. apelin gene regulation nuclear receptor...
Includes: Supplementary data
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Biochem J (2013) 451 (1): 45–53.
Published: 14 March 2013
..., including transcription factors. Phosphorylation of the nuclear receptor PPARγ (peroxisome-proliferator-activated receptor γ) at two conserved serine residue (Ser 112 and Ser 273 ) results in an altered transcriptional activity of this transcription factor. So far, only a very limited number of cellular...
Includes: Supplementary data
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Biochem J (2012) 446 (1): e1–e3.
Published: 27 July 2012
... studies involving members of the nuclear receptor superfamily illustrate the chemical richness of molecules from marine species and helps to re-emphasize the translational possibilities of natural products in drug discovery. In this issue of the Biochemical Journal Wang et al. describe the identification...
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Biochem J (2007) 405 (1): 31–39.
Published: 13 June 2007
... of the C-terminal NR (nuclear receptor)-boxes is required for the co-repressor activity, whereas the NR-box-like motif as well as additional elements in the C-terminal region are required for full repressive function. The C-terminal NR-box-like motif is necessary for interaction with LXRβ, whereas...
Includes: Supplementary data
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Biochem J (2006) 400 (2): 303–313.
Published: 14 November 2006
... shown that p53 inhibits the transactivation function of HNF (hepatocyte nuclear factor) 4α1, a nuclear receptor known to be critical for early development and liver differentiation. In the present study we demonstrate that p53 also down-regulates expression of the human HNF4α gene via the proximal P1...
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Biochem J (2006) 397 (1): 89–99.
Published: 14 June 2006
... microarray nucleic acid binding protein 1 (NABP1) nuclear receptor oligonucleotide/oligosaccharide binding-fold (OB-fold) RORγ (retinoid-related orphan receptor γ) thymopoiesis The ROR (retinoid-related orphan receptor) subfamily consists of three members, RORα, RORβ and RORγ (named NRF1–NRF3...
Includes: Supplementary data
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Biochem J (2005) 392 (1): 241–248.
Published: 08 November 2005
... receptor α) heterodimers in vitro , and inclusion of nuclear receptors in transfections boosted the transcriptional response. A construct containing both R1 and R2 was used to generate a stable luciferase reporter cell line that can be used as a tool to identify factors regulating Cyp26A1 expression...
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Biochem J (2004) 384 (3): 637–645.
Published: 07 December 2004
...Adam G. STAINES; Pavel SINDELAR; Michael W. H. COUGHTRIE; Brian BURCHELL Farnesol is an isoprenoid found in many aromatic plants and is also produced in humans, where it acts on numerous nuclear receptors and has received considerable attention due to its apparent anticancer properties. Although...
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Biochem J (2004) 384 (1): 79–85.
Published: 09 November 2004
...Caroline CHAUVET; Brigitte BOIS-JOYEUX; Edurne BERRA; Jacques POUYSSEGUR; Jean-Louis DANAN Retinoic acid-receptor-related orphan receptor (ROR) α is a nuclear receptor involved in many pathophysiological processes such as cerebellar ataxia, inflammation, atherosclerosis and angiogenesis...
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Biochem J (2004) 382 (3): 913–921.
Published: 07 September 2004
... 2004 17 6 2004 The Biochemical Society, London 2004 bile acid farnesoid X receptor (FXR) fasting nuclear receptor peroxisome-proliferator-activated receptor-γ co-activator-1α (PGC-1α) transcriptional co-activator To search for co-activators of FXR, we used a chimaeric...
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Biochem J (2002) 367 (3): 907–911.
Published: 01 November 2002
... Society, London ©2002 2002 nuclear receptor sumoylation transactivation Abbreviations used: AR, androgen receptor; FBS, foetal bovine serum; GR, glucocorticoid receptor; K277R, Lys 277 →Arg; LUC, luciferase; PR, progesterone receptor; SUMO-1, small ubiquitin-related modifier-1. Biochem...
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Biochem J (2002) 365 (1): 223–228.
Published: 01 July 2002
... 2002 12 4 2002 The Biochemical Society, London ©2002 2002 glycolysis hypoxia insulin maturity-onset diabetes of the young metabolic zonation nuclear receptor Abbreviations used: DIG, digoxigenin; EMSA, electrophoretic mobility-shift assay; EPO, erythropoietin; GK...
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Biochem J (2000) 349 (3): 885–893.
Published: 25 July 2000
... cells from apoptosis. Co-transfection experiments in COS-7 cells showed that DAP3 had a stimulatory effect on the ligand-induced transcriptional activation by GR and also increased the steroid-sensitivity. Furthermore, DAP3 formed a complex with several other nuclear receptors and some basic helix–loop...
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Biochem J (2000) 348 (2): 439–446.
Published: 23 May 2000
...Wen-wen LIN; Hsin-Wei WANG; Cristina SUM; Dong LIU; Choy L. HEW; Bon-chu CHUNG Fushi-tarazu Factor-1 (FTZ-F1) is a family of nuclear receptors involved in various developmental processes. We have cloned a zebrafish FTZ-F1 gene, termed ff1 , which belongs to the fetoprotein transcription factor...
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