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Keywords: nutrient limitation
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Articles

Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins

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Kimberly Romero Rosales, Gurpreet Singh, Kevin Wu, Jie Chen, Matthew R. Janes, Michael B. Lilly, Eigen R. Peralta, Leah J. Siskind, Michael J. Bennett, David A. Fruman, Aimee L. Edinger
Journal: Biochemical Journal
Biochem J (2011) 439 (2): 299–311.
https://doi.org/10.1042/BJ20110853
Published: 28 September 2011
...Kimberly Romero Rosales; Gurpreet Singh; Kevin Wu; Jie Chen; Matthew R. Janes; Michael B. Lilly; Eigen R. Peralta; Leah J. Siskind; Michael J. Bennett; David A. Fruman; Aimee L. Edinger Cancer cells are hypersensitive to nutrient limitation because oncogenes constitutively drive glycolytic and TCA...
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Includes: Supplementary data
Articles

Targeting tumour cells at the entrance

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Stefan Bröer
Journal: Biochemical Journal
Biochem J (2011) 439 (2): e1–e2.
https://doi.org/10.1042/BJ20111484
Published: 28 September 2011
... Biochemical Society 2011 glutaminolysis leukaemia nutrient limitation sphingosine 1-phosphate transporter Warburg effect Tumour therapy has for many years relied on fairly non-specific drugs that are severely cytotoxic [ 1 ]. With the increased understanding of tumour cell biology [ 2...
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