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Keywords: obesity
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Biochem J (2021) 478 (13): 2539–2553.
Published: 09 July 2021
... Limited on behalf of the Biochemical Society 2021 insulin resistance mitochondria muscle metabolism obesity skeletal muscle Skeletal muscle plays a fundamental role in the maintenance of glucose homeostasis, and as a result, a reduction in skeletal muscle insulin responsiveness...
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Biochem J (2021) 478 (7): 1347–1358.
Published: 06 April 2021
... found this compound to function as an effective weight-loss agent at pharmacological doses in multiple models of obesity in mice. The drug was able to reduce the body weight when given orally in drinking water (1 mg/ml) in three different models of obesity: normal mice on high-fat diet, Slc6a14 -null...
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Adipose biology
Biochem J (2020) 477 (14): 2639–2653.
Published: 29 July 2020
...Robert M. Gutgesell; Evangelia E. Tsakiridis; Shanza Jamshed; Gregory R. Steinberg; Alison C. Holloway Obesity is a leading cause of morbidity, mortality and health care expenditure whose incidence is rapidly rising across the globe. Although the cause of the obesity epidemic is typically viewed...
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Adipose biology
Biochem J (2020) 477 (13): 2509–2541.
Published: 10 July 2020
...Yasuhiro Onogi; Ahmed Elagamy Mohamed Mahmoud Khalil; Siegfried Ussar Adipose tissue is a central regulator of metabolism and an important pharmacological target to treat the metabolic consequences of obesity, such as insulin resistance and dyslipidemia. Among the various cellular compartments...
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Adipose biology
Biochem J (2020) 477 (6): 1089–1107.
Published: 23 March 2020
...Nicole G. Barra; Brandyn D. Henriksbo; Fernando F. Anhê; Jonathan D. Schertzer Adipose tissue regulates metabolic homeostasis by participating in endocrine and immune responses in addition to storing and releasing lipids from adipocytes. Obesity skews adipose tissue adipokine responses and degrades...
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In Collection
Adipose biology
Biochem J (2020) 477 (3): 709–725.
Published: 14 February 2020
...Anna Roesler; Lawrence Kazak Obesity results from energy imbalance, when energy intake exceeds energy expenditure. Brown adipose tissue (BAT) drives non-shivering thermogenesis which represents a powerful mechanism of enhancing the energy expenditure side of the energy balance equation. The best...
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Biochem J (2018) 475 (22): 3535–3560.
Published: 20 November 2018
...Bruno P. Moreira; Mariana P. Monteiro; Mário Sousa; Pedro F. Oliveira; Marco G. Alves Obesity stands as one of the greatest healthcare challenges of the 21 st century. Obesity in reproductive-age men is ever more frequent and is reaching upsetting levels. At the same time, fertility has taken...
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Biochem J (2018) 475 (10): 1789–1791.
Published: 31 May 2018
... are at an increased risk of heart disease, stroke and type-2 diabetes. Obesity, especially build-up of visceral fat, is a recognized major risk factor for the development of metabolic syndrome. However, our understanding of the mechanistic links and biomarkers that associate visceral fat with the development...
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Biochem J (2017) 474 (17): 2981–2991.
Published: 17 August 2017
.... It was subsequently demonstrated to be a cell surface molecule involved in many physiological processes, such as vesicle trafficking. Here, we investigated the roles of PrP C in the response to insulin and obesity development. Two independent PrP C knockout (KO) and one PrP C overexpressing (TG20) mouse models were...
Includes: Supplementary data
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Biochem J (2016) 473 (22): 4063–4082.
Published: 10 November 2016
...Ricardo Lage; Johan Fernø; Rubén Nogueiras; Carlos Diéguez; Miguel López Obesity and its related disorders are among the most pervasive diseases in contemporary societies, and there is an urgent need for new therapies and preventive approaches. Given (i) our poor social capacity to correct...
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Biochem J (2016) 473 (14): 2187–2203.
Published: 12 July 2016
...Annalaura Mastrangelo; María I. Panadero; Laura M. Pérez; Beatriz G. Gálvez; Antonia García; Coral Barbas; Francisco J. Rupérez Obesity affects the functional capability of adipose-derived stem cells (ASCs) and their effective use in regenerative medicine through mechanisms that are still poorly...
Includes: Supplementary data
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Biochem J (2016) 473 (9): 1215–1224.
Published: 26 April 2016
...Jie Li; Dong Wei; Mark A. McCrory; Alexander J. Szalai; Gangyi Yang; Ling Li; Fanghong Li; Allan Z. Zhao Defective central leptin signalling and impaired leptin entry into the CNS (central nervous system) represent two important aspects of leptin resistance in obesity. In the present study, we...
Includes: Supplementary data
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Biochem J (2016) 473 (1): 43–54.
Published: 09 December 2015
...Henna Zahid; Layeque Miah; Andy M. Lau; Lea Brochard; Debolina Hati; Tam T.T. Bui; Alex F. Drake; Jayesh Gor; Stephen J. Perkins; Lindsay C. McDermott Zinc α2 glycoprotein (ZAG) is an adipokine with a class I MHC protein fold and is associated with obesity and diabetes. Although its intrinsic...
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Biochem J (2015) 466 (2): 291–298.
Published: 20 February 2015
..., such as in the case of ob/ob (no leptin production due to leptin gene mutation) and db/db (null mutation of leptin receptor) mice, leads to severe obesity, elevated blood circulating insulin levels, hyperglycaemia and infertility [ 3 , 4 ]. Leptin is primarily produced in and secreted from white adipocytes, whose...
Includes: Supplementary data
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Biochem J (2013) 453 (2): 167–178.
Published: 28 June 2013
...Tim J. Schulz; Yu-Hua Tseng Obesity represents a major risk factor for the development of several of our most common medical conditions, including Type 2 diabetes, dyslipidaemia, non-alcoholic fatty liver, cardiovascular disease and even some cancers. Although increased fat mass is the main feature...
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Biochem J (2013) 452 (2): 271–280.
Published: 10 May 2013
...Stephan Schultz; Anja Saalbach; John T. Heiker; Rene Meier; Tristan Zellmann; Jan C. Simon; Annette G. Beck-Sickinger The excessive accumulation of adipose tissue in obesity is associated with multiple inflammatory dermatological diseases. Chemerin, a chemoattractant adipokine, dependent...
Includes: Supplementary data
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Biochem J (2010) 431 (2): e1–e3.
Published: 28 September 2010
... in the treatment of diseases such as cancer where S6K1 is overexpressed, but most importantly in metabolic disease such as insulin resistance and obesity. Work in the laboratory of B. V. is supported by the Medical Research Council [grant number G0700755] and Cancer Research UK [grant number C23338/A10200...
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Biochem J (2010) 430 (2): e1–e4.
Published: 13 August 2010
...Marie-Soleil Gauthier; Neil B. Ruderman In recent years, it has become widely accepted that obesity is characterized by a chronic low-grade inflammation of adipose tissue that predisposes affected individuals to insulin resistance, Type 2 diabetes and other disorders associated with the metabolic...
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Biochem J (2010) 430 (1): 141–149.
Published: 28 July 2010
...Nuria Barbarroja; Rosario López-Pedrera; Maria Dolores Mayas; Eduardo García-Fuentes; Lourdes Garrido-Sánchez; M. Macías-González; Rajaa El Bekay; Antonio Vidal-Puig; Francisco J. Tinahones A paradoxical but common finding in the obesity clinic is the identification of individuals who can...
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Biochem J (2010) 428 (3): 305–324.
Published: 27 May 2010
... cause human obesity, or protect against it, the melanocortin system is by far the most significant. The present review is a discussion of the current understanding of the roles and mechanism of action of POMC, melanocortin receptors and AgRP (agouti-related peptide) in obesity and Type 2 diabetes...
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Biochem J (2010) 427 (1): 1–17.
Published: 15 March 2010
... diabetes metabolic syndrome metabolism obesity Wnt signalling The name Wnt is derived from a combination of two homologous genes; W g (the Drosophila wingless gene) and I nt [the murine homologue MMTV (mouse mammary tumour virus) integration site 1 gene]. Wnts represent a large morphogenic...
Includes: Multimedia, Supplementary data
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Biochem J (2010) 425 (1): 71–85.
Published: 14 December 2009
...Fangnian Wang; Hongsheng Liu; Wanda P. Blanton; Anna Belkina; Nathan K. Lebrasseur; Gerald V. Denis Certain human subpopulations are metabolically healthy but obese, or metabolically obese but normal weight; such mutations uncouple obesity from glucose intolerance, revealing pathways implicated...
Includes: Supplementary data
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Biochem J (2009) 423 (2): 243–252.
Published: 25 September 2009
..., hyperinsulinaemia, glucose intolerance, hepatic steatosis and obesity. Previous studies have shown that PDHK4 deficiency lowers blood glucose by limiting the supply of three carbon gluconeogenic substrates to the liver. There is concern, however, that the increase in glucose oxidation caused by less inhibition...
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Biochem J (2008) 414 (3): 313–325.
Published: 27 August 2008
... conserved process essential for survival. Today, in the presence of nutrient excess and sedentary lifestyles, the regulation of this pathway is viewed as an important therapeutic target for disease prevention, as elevated circulating fatty acids in obesity contribute to many aspects of the metabolic...
Includes: Multimedia, Supplementary data
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Biochem J (2008) 409 (3): 623–633.
Published: 15 January 2008
... complexes [ 45 – 47 ]. In both db / db diabetic mice and ob / ob obese mice, the ratio of HMW to total adiponectin is markedly decreased compared with their lean controls, although the serum levels of total adiponectin are comparable among these mice [ 39 , 48 ]. In line with these data from...
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Biochem J (2008) 409 (2): 449–459.
Published: 21 December 2007
... for a further 30 min. 14-3-3 Akt substrate of 160 kDa (AS160) AMP-activated protein kinase (AMPK) metformin obesity protein kinase B (PKB) TBC1D1 Rabs are GTP-activated proteins that regulate the flow of vesicle traffic between organelles by interacting with effectors of vesicle formation...
Includes: Supplementary data
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Biochem J (2007) 407 (1): 129–140.
Published: 12 September 2007
... for designing safer uncouplers for obesity therapy. 1 To whom correspondence should be addressed (email martin.brand@mrc-dunn.cam.ac.uk ). 8 5 2007 29 6 2007 4 7 2007 4 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 Weight gain, leading...
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Biochem J (2007) 402 (2): 387–395.
Published: 12 February 2007
...Shao-Chun Lu; Shwu-Fen Chang; Hui-Ling Chen; Yuan-Yi Chou; Ya-Hsin Lan; Chia-Ying Chuang; Wei-Hsuan Yu; Chia-Lin Chen Although resistin was first suggested as a possible link between obesity and diabetes, we have demonstrated previously that expression of resistin is induced by LPS...
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Biochem J (2006) 393 (1): 7–20.
Published: 12 December 2005
..., among others. 1 email gfruhbeck@unav.es 26 9 2005 7 10 2005 7 10 2005 The Biochemical Society, London 2006 adipocyte cytokine Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT pathway) leptin receptor obesity signalling cascade...
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Biochem J (2005) 388 (3): 895–903.
Published: 07 June 2005
...Alan R. RENDINA; Dong CHENG C75, a synthetic inhibitor of FAS (fatty acid synthase), has both anti-tumour and anti-obesity properties. In this study we provide a detailed kinetic characterization of the mechanism of in vitro inhibition of rat liver FAS. At room temperature, C75 is a competitive...
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Biochem J (2004) 379 (2): 229–233.
Published: 15 April 2004
...-mail dcohen@aecom.yu.edu ). 22 1 2004 19 2 2004 25 2 2004 25 2 2004 The Biochemical Society, London ©2004 2004 bile salts cholesterol leptin liver obesity Abbreviations used: apo, apolipoprotein; Cyp7A1, cholesterol 7α-hydroxylase; FXR, farnesoid X receptor; HMG...
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Biochem J (2003) 376 (1): e7–e8.
Published: 15 November 2003
... of appetite. As a consequence, malfunction of this signalling system leads to the development of obesity. It has been shown previously that melanocortin signalling can be modulated by the type 1 transmembrane protein attractin, apparently acting as a co-receptor for the inhibitory ligand agouti. Work reported...
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