... to signaling by ErbB2 in SKOV-3 cells. It has been previously identified as an oncogene and is located on chromosomal arm 17q 0.76 Mb centromeric to ErbB2. It is expressed in serous ovarian cancer cell lines as a 40 kDa protein. In SKOV-3 cells, it was phosphorylated and was inhibited by Lapatinib...

...Iru Paudel; Sean M. Hernandez; Gilda M. Portalatin; Tara P. Chambers; Jeremy W. Chambers The occurrence of chemotherapy-resistant tumors makes ovarian cancer (OC) the most lethal gynecological malignancy. While many factors may contribute to chemoresistance, the mechanisms responsible...

... cancer cells has not been thoroughly elucidated. Our results from the present study indicate that Puma plays a critical role in the apoptosis of chemo-resistant ovarian cancer cells treated with BetA (betulinic acid). The reduction of Puma expression inhibits Bax activation and apoptosis. However, p53...

...Ming-Cheng Chang; Chi-An Chen; Pao-Jen Chen; Ying-Cheng Chiang; Yu-Li Chen; Tsui-Lien Mao; Han-Wei Lin; Wen-Hsien Lin Chiang; Wen-Fang Cheng Ovarian cancer has one of the highest mortalities in malignancies in women, but little is known of its tumour progression properties and there is still...

...-mediated gene transcription. Although Wnt pathway mutations are rare in epithelial ovarian cancer (with the exception of the endometrioid histotype), accumulating evidence supports a role for Wnt signalling in ovarian tumorigenesis in the absence of genetic mutations. The present review summarizes evidence...

... PCR, RT (reverse transcription)–PCR, cytotoxicity assays, proliferative assays, apoptotic assays by Hoechst staining, detection of active caspases 3 and 7 by flow cytometric analysis, and immunoprecipitation and immunoblotting were performed. Cancer tissues in paclitaxel-resistant ovarian cancer...

...Alessandro Prinetti; Danilo Millimaggi; Sandra D'Ascenzo; Matilda Clarkson; Arianna Bettiga; Vanna Chigorno; Sandro Sonnino; Antonio Pavan; Vincenza Dolo PTX (Paclitaxel®) is an antimitotic agent used in the treatment of a number of major solid tumours, particularly in breast and ovarian cancer...

... proliferation urokinase ovarian cancer Biochem. J. (1999) 341, 765 769 (Printed in Great Britain) 765 Autocrine regulation of growth stimulation in human epithelial ovarian carcinoma by serine-proteinase-catalysed release of the urinary-type-plasminogen-activator N-terminal fragment David A. FISHMAN...