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Keywords: overoxidation
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Journal:
Biochemical Journal
Biochem J (2012) 441 (1): 113–118.
Published: 14 December 2011
... formation between Cys 87 and Cys 208 , a critical step of the catalysis. The structural explanation for the restricting role of the YF motif on the active site dynamics is provided in detail. Prx4 has a high reactivity with H 2 O 2 , but is susceptible to overoxidation and consequent inactivation by H 2 O 2...
Includes: Supplementary data
