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Keywords: oxidative phosphorylation
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Articles

Biochemical basis and therapeutic potential of mitochondrial uncoupling in cardiometabolic syndrome

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Bernardo Gindri dos Santos, Niki F. Brisnovali, Leigh Goedeke
Journal: Biochemical Journal
Biochem J (2024) 481 (23): 1831–1854.
https://doi.org/10.1042/BCJ20240005
Published: 04 December 2024
...Bernardo Gindri dos Santos; Niki F. Brisnovali; Leigh Goedeke Mild uncoupling of oxidative phosphorylation is an intrinsic property of all mitochondria, allowing for adjustments in cellular energy metabolism to maintain metabolic homeostasis. Small molecule uncouplers have been extensively studied...
View articletitled, Biochemical basis and therapeutic potential of mitochondrial uncoupling in cardiometabolic syndrome
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Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis

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Maria E. Solesio, Lihan Xie, Brendan McIntyre, Mathew Ellenberger, Erna Mitaishvili, Siddharth Bhadra-Lobo, Lisa F. Bettcher, Jason N. Bazil, Daniel Raftery, Ursula Jakob, Evgeny V. Pavlov
Journal: Biochemical Journal
Biochem J (2021) 478 (8): 1631–1646.
https://doi.org/10.1042/BCJ20200975
Published: 30 April 2021
... expression of the polyP hydrolyzing enzyme (scPPX). We found that these cells have significantly reduced rates of oxidative phosphorylation (OXPHOS), while their rates of glycolysis were elevated. Consistent with this, metabolomics assays confirmed increased levels of metabolites involved in glycolysis...
View articletitled, Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis
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Includes: Supplementary data
Articles

Blackout in the powerhouse: clinical phenotypes associated with defects in the assembly of OXPHOS complexes and the mitoribosome

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Daniella H. Hock, David R. L. Robinson, David A. Stroud
Journal: Biochemical Journal
Biochem J (2020) 477 (21): 4085–4132.
https://doi.org/10.1042/BCJ20190767
Published: 05 November 2020
...Daniella H. Hock; David R. L. Robinson; David A. Stroud Mitochondria produce the bulk of the energy used by almost all eukaryotic cells through oxidative phosphorylation (OXPHOS) which occurs on the four complexes of the respiratory chain and the F 1 –F 0 ATPase. Mitochondrial diseases...
View articletitled, Blackout in the powerhouse: clinical phenotypes associated with defects in the assembly of OXPHOS complexes and the mitoribosome
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Articles

Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5′ AMP-activated protein kinase signalling in malignant cells

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James A. Austin, Rosalind E. Jenkins, Gemma M. Austin, Mark A. Glenn, Karen Dunn, Laura Scott, Claire M. Lucas, Richard E. Clark
Journal: Biochemical Journal
Biochem J (2019) 476 (15): 2255–2269.
https://doi.org/10.1042/BCJ20190121
Published: 15 August 2019
..., we show that high CIP2A levels significantly bias cellular energy production towards oxidative phosphorylation (OXPHOS) rather than glycolysis. Mass spectrometric analysis of CIP2A interactors and isobaric tagging for relative and absolute protein quantitation (ITRAQ) experiments identified many...
View articletitled, Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5′ AMP-activated protein kinase signalling in malignant cells
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Includes: Supplementary data
Articles

The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits

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Jana Cesnekova, Marie Rodinova, Hana Hansikova, Josef Houstek, Jiri Zeman, Lukas Stiburek
Journal: Biochemical Journal
Biochem J (2016) 473 (6): 797–804.
https://doi.org/10.1042/BJ20151029
Published: 10 March 2016
... oxidative phosphorylation YME1L Mitochondria are essential cellular organelles containing their own DNA (mtDNA) of non-nuclear origin. They take part in a variety of fundamental cellular processes, including haem biosynthesis, programmed cell death (apoptosis), iron–sulfur complex assembly...
View articletitled, The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits
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Palmitate-induced impairment of glucose-stimulated insulin secretion precedes mitochondrial dysfunction in mouse pancreatic islets

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Jonathan Barlow, Verena Hirschberg Jensen, Martin Jastroch, Charles Affourtit
Journal: Biochemical Journal
Biochem J (2016) 473 (4): 487–496.
https://doi.org/10.1042/BJ20151080
Published: 09 February 2016
... collected on ice. Supernatants were centrifuged at 10000  g to pellet any detached cells and were then assayed for insulin by ELISA. Secreted insulin was normalized to cell density determined from DAPI fluorescence [ 15 ]. glucolipotoxicity mitochondria obesity oxidative phosphorylation...
View articletitled, Palmitate-induced impairment of glucose-stimulated insulin secretion precedes mitochondrial dysfunction in mouse pancreatic islets
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Articles

Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of F o -a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation

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Kateřina Hejzlarová, Vilma Kaplanová, Hana Nůsková, Nikola Kovářová, Pavel Ješina, Zdeněk Drahota, Tomáš Mráček, Sara Seneca, Josef Houštěk
Journal: Biochemical Journal
Biochem J (2015) 466 (3): 601–611.
https://doi.org/10.1042/BJ20141462
Published: 06 March 2015
... and unable to synthesize ATP. Unless otherwise indicated, chemicals of the highest purity were obtained from Sigma–Aldrich. ATP synthase cytochrome c oxidase mitochondrial diseases mtDNA MT-ATP6 mutation oxidative phosphorylation threshold effect Mitochondrial diseases due...
View articletitled, Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of F o -a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation
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Articles

Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells

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Jonathan Barlow, Charles Affourtit
Journal: Biochemical Journal
Biochem J (2013) 456 (3): 417–426.
https://doi.org/10.1042/BJ20131002
Published: 22 November 2013
...-sensitivity of mitochondrial respiration and lowers coupling efficiency of glucose-stimulated oxidative phosphorylation. These mitochondrial defects coincide with an increased level of ROS (reactive oxygen species), impaired GSIS (glucose-stimulated insulin secretion) and decreased cell viability. Palmitate...
View articletitled, Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells
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Articles

Attenuation of the hypoxia-induced protein kinase Cδ interaction with the ‘d’ subunit of F 1 F o -ATP synthase in neonatal cardiac myocytes: implications for energy preservation and survival

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Tiffany T. Nguyen, Mourad Ogbi, Qilin Yu, John A. Johnson
Journal: Biochemical Journal
Biochem J (2010) 429 (2): 335–345.
https://doi.org/10.1042/BJ20091927
Published: 28 June 2010
... o -ATP synthase-mode activity as well. However, to date, the precise roles of the F 1 F o complex in cardiac IR injury and PC are not fully understood. cardiac injury F 1 F o -ATP synthase hypoxia mitochondrion oxidative phosphorylation protein kinase C (PKC) Each peptide included...
View articletitled, Attenuation of the hypoxia-induced protein kinase Cδ interaction with the ‘d’ subunit of F 1 F o -ATP synthase in neonatal cardiac myocytes: implications for energy preservation and survival
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Articles

Decreased cytochrome c mediates an age-related decline of oxidative phosphorylation in rat kidney mitochondria

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John F. O'Toole, Hiral V. Patel, Colin J. Naples, Hisashi Fujioka, Charles L. Hoppel
Journal: Biochemical Journal
Biochem J (2010) 427 (1): 105–112.
https://doi.org/10.1042/BJ20091373
Published: 15 March 2010
... 344 rats. OXPHOS (oxidative phosphorylation) of intact mitochondria and cytochrome c oxidase activity in permeabilized mitochondria were determined with polarographic assays. The activities of the ETC (electron transport chain) complexes and the cytochrome content in solubilized mitochondria were...
View articletitled, Decreased cytochrome c mediates an age-related decline of oxidative phosphorylation in rat kidney mitochondria
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Includes: Supplementary data
Articles

Selective inhibition of β-F1-ATPase mRNA translation in human tumours

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Imke M. Willers, Antonio Isidoro, Álvaro D. Ortega, Pedro L. Fernández, José M. Cuezva
Journal: Biochemical Journal
Biochem J (2010) 426 (3): 319–326.
https://doi.org/10.1042/BJ20091570
Published: 24 February 2010
... Journal compilation © 2010 Biochemical Society 2010 cancer H + -ATP synthase mitochondrion oxidative phosphorylation regulation of gene expression translation Mitochondria play a central role in the physiology of eukaryotic cells. The biogenesis of mitochondria is a complex genetic...
View articletitled, Selective inhibition of β-F1-ATPase mRNA translation in human tumours
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Includes: Supplementary data
Articles

Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart

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Bernard Korzeniewski, Véronique Deschodt-Arsac, Guillaume Calmettes, Gilles Gouspillou, Jean-Michel Franconi, Philippe Diolez
Journal: Biochemical Journal
Biochem J (2009) 423 (3): 421–428.
https://doi.org/10.1042/BJ20090395
Published: 12 October 2009
...Bernard Korzeniewski; Véronique Deschodt-Arsac; Guillaume Calmettes; Gilles Gouspillou; Jean-Michel Franconi; Philippe Diolez Mitochondrial respiration/oxidative phosphorylation is the main source of energy, in the form of ATP, in the heart under physiological conditions. Different respiratory...
View articletitled, Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart
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Articles

Modular regulation analysis of integrative effects of hypoxia on the energetics of contracting skeletal muscle in vivo

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Christophe Beuste, Sylvain Miraux, Véronique J. Deschodt-Arsac, Eric Thiaudiere, Jean-Michel Franconi, Philippe Diolez, Laurent M. Arsac
Journal: Biochemical Journal
Biochem J (2009) 420 (1): 67–72.
https://doi.org/10.1042/BJ20082385
Published: 28 April 2009
... oxidative phosphorylation 31 P-MR (magnetic resonance) spectroscopy skeletal muscle As an effective oxygen sink, mitochondria house the ultimate step of the fate of the oxygen pathway from air through the cardiovascular and pulmonary systems. Oxygen is used for substrate oxidation by mitochondria...
View articletitled, Modular regulation analysis of integrative effects of hypoxia on the energetics of contracting skeletal muscle in vivo
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Articles

Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death in Trypanosoma cruzi

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Florencia Irigoín, Natalia M. Inada, Mariana P. Fernandes, Lucía Piacenza, Fernanda R. Gadelha, Anibal E. Vercesi, Rafael Radi
Journal: Biochemical Journal
Biochem J (2009) 418 (3): 595–604.
https://doi.org/10.1042/BJ20081981
Published: 25 February 2009
... © 2009 Biochemical Society 2009 apoptosis membrane attack complex (MAC) oxidative phosphorylation reactive oxygen species (ROS) Trypanosoma cruzi trypanosomatid Trypanosoma cruzi is a protozoan parasite of the order Kinetoplastida that causes Chagas' disease, an infection...
View articletitled, Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death in Trypanosoma cruzi
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Includes: Supplementary data
Articles

Physiological heart activation by adrenaline involves parallel activation of ATP usage and supply

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Bernard Korzeniewski, Véronique Deschodt-Arsac, Guillaume Calmettes, Jean-Michel Franconi, Philippe Diolez
Journal: Biochemical Journal
Biochem J (2008) 413 (2): 343–347.
https://doi.org/10.1042/BJ20080162
Published: 26 June 2008
... of the regulation of oxidative phosphorylation in heart postulated previously in a theoretical way. 1 To whom correspondence should be addressed (email [email protected] ). 21 1 2008 26 3 2008 31 3 2008 31 3 2008 © The Authors Journal compilation © 2008 Biochemical...
View articletitled, Physiological heart activation by adrenaline involves parallel activation of ATP usage and supply
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Articles

Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion

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Charles Affourtit, Martin D. Brand
Journal: Biochemical Journal
Biochem J (2008) 409 (1): 199–204.
https://doi.org/10.1042/BJ20070954
Published: 11 December 2007
... secretion mitochondrial uncoupling oxidative phosphorylation pancreatic β-cell Type 2 diabetes uncoupling protein-2 (UCP2) Type 2 diabetes is rapidly becoming a global pandemic. Although the development of this metabolic disorder is understood incompletely, it is evident that pancreatic β-cell...
View articletitled, Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion
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Articles

Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1

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Gregg L. Semenza
Journal: Biochemical Journal
Biochem J (2007) 405 (1): 1–9.
https://doi.org/10.1042/BJ20070389
Published: 13 June 2007
... different regulatory mechanism, suggesting that selection for O 2 -dependent homoeostatic regulation of mitochondrial respiration is ancient and likely to be shared by all eukaryotic organisms. The goal of oxidative phosphorylation is the transfer of electrons through a series of acceptor cytochromes...
View articletitled, Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
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Articles

Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines

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Taku Amo, Martin D. Brand
Journal: Biochemical Journal
Biochem J (2007) 404 (2): 345–351.
https://doi.org/10.1042/BJ20061609
Published: 14 May 2007
...Taku Amo; Martin D. Brand We introduce a general test of the bioenergetic importance of mtDNA (mitochondrial DNA) variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mtDNA. We have applied this test...
View articletitled, Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
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Articles

Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins

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Marina A. Schwab, Sven W. Sauer, Jürgen G. Okun, Leo G. J. Nijtmans, Richard J. T. Rodenburg, Lambert P. van den Heuvel, Stefan Dröse, Ulrich Brandt, Georg F. Hoffmann, Henk Ter Laak, Stefan Kölker, Jan A. M. Smeitink
Journal: Biochemical Journal
Biochem J (2006) 398 (1): 107–112.
https://doi.org/10.1042/BJ20060221
Published: 27 July 2006
... results, oxidative phosphorylation was severely compromised in both patients. Furthermore, expression of respiratory chain complexes I–IV and the amount of mitochondrial DNA were strongly decreased, and ultrastructural mitochondrial abnormalities were found, highlighting severe mitochondrial dysfunction...
View articletitled, Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins
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Control by cytochrome c oxidase of the cellular oxidative phosphorylation system depends on the mitochondrial energy state

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Claudia Piccoli, Rosella Scrima, Domenico Boffoli, Nazzareno Capitanio
Journal: Biochemical Journal
Biochem J (2006) 396 (3): 573–583.
https://doi.org/10.1042/BJ20060077
Published: 29 May 2006
... coefficient and the threshold value of cytochrome oxidase are modified with respect to the uncoupled condition. The results obtained are consistent with a model based on changes in the assembly state of the oxidative phosphorylation enzyme complexes and possible implications in the understanding of exercise...
View articletitled, Control by cytochrome c oxidase of the cellular oxidative phosphorylation system depends on the mitochondrial energy state
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Articles

Maturation of the unusual single-cysteine (XXXCH) mitochondrial c -type cytochromes found in trypanosomatids must occur through a novel biogenesis pathway

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James W. A. ALLEN, Michael L. GINGER, Stuart J. FERGUSON
Journal: Biochemical Journal
Biochem J (2004) 383 (3): 537–542.
https://doi.org/10.1042/BJ20040832
Published: 26 October 2004
... mitochondrial respiratory chain oxidative phosphorylation trypanosome Intriguingly, there is a small group of organisms within the phylum Euglenozoa that does not conform to the usual pattern of c -type cytochromes with a CXXCH haem-binding motif. The cytochromes c and c 1 from the mitochondria...
View articletitled, Maturation of the unusual single-cysteine (XXXCH) mitochondrial c -type cytochromes found in trypanosomatids must occur through a novel biogenesis pathway
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Includes: Supplementary data
Articles

Factors determining the oxygen consumption rate (V.o2) on-kinetics in skeletal muscles

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Bernard KORZENIEWSKI, Jerzy A. ZOLADZ
Journal: Biochemical Journal
Biochem J (2004) 379 (3): 703–710.
https://doi.org/10.1042/bj20031740
Published: 01 May 2004
...Bernard KORZENIEWSKI; Jerzy A. ZOLADZ Using a computer model of oxidative phosphorylation developed previously [Korzeniewski and Mazat (1996) Biochem. J. 319 , 143–148; Korzeniewski and Zoladz (2001) Biophys. Chem. 92 , 17–34], we analyse the effect of several factors on the oxygen-uptake kinetics...
View articletitled, Factors determining the oxygen consumption rate (V.o2) on-kinetics in skeletal muscles
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Regulation of oxidative phosphorylation in different muscles and various experimental conditions

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Bernard KORZENIEWSKI
Journal: Biochemical Journal
Biochem J (2003) 375 (3): 799–804.
https://doi.org/10.1042/bj20030882
Published: 01 November 2003
...Bernard KORZENIEWSKI It has been shown previously that direct stimulation of oxidative-phosphorylation complexes in parallel with the stimulation of ATP usage is able to explain the stability of intermediate metabolite (ATP/ADP, phosphocreatine/creatine, NADH/NAD + , protonmotive force...
View articletitled, Regulation of oxidative phosphorylation in different muscles and various experimental conditions
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Mitochondrial threshold effects

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Rodrigue ROSSIGNOL, Benjamin FAUSTIN, Christophe ROCHER, Monique MALGAT, Jean-Pierre MAZAT, Thierry LETELLIER
Journal: Biochemical Journal
Biochem J (2003) 370 (3): 751–762.
https://doi.org/10.1042/bj20021594
Published: 15 March 2003
... 1.10.2.2) IV (EC 1.9.3.1) V (EC 3.6.1.34) 38 0 10 10 14 7 4 1 3 2 FMN, [Fe S] centres, ubiquinones FAD, [Fe S] centres, cytochrome b560 Cytochromes b and c1, Rieske protein [Cua] centre, [Cub-haem a3] centre None Pyruvate H+ Q Figure 1 Oxidative phosphorylation network and composition of mito- chondrial...
View articletitled, Mitochondrial threshold effects
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Assembly of the ribonucleoprotein complex containing the mRNA of the β-subunit of the mitochondrial H+-ATP synthase requires the participation of two distal cis-acting elements and a complex set of cellular trans-acting proteins

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Javier RICART, José M. IZQUIERDO, Carlo M. Di LIEGRO, José M. CUEZVA
Journal: Biochemical Journal
Biochem J (2002) 365 (2): 417–428.
https://doi.org/10.1042/bj20011726
Published: 15 July 2002
... RNA cross-talking required for the association of the mRNA with the translational machinery. Key words: mRNA localization, oxidative phosphorylation, translation. not all, of the components of the translational machinery [15,16]. Paradigms of these granules are those containing the b-actin mRNA...
View articletitled, Assembly of the ribonucleoprotein complex containing the mRNA of the β-subunit of the mitochondrial H+-ATP synthase requires the participation of two distal cis-acting elements and a complex set of cellular trans-acting proteins
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Articles

Cardiolipin prevents rate-dependent uncoupling and provides osmotic stability in yeast mitochondria

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Vasilij KOSHKIN, Miriam L. GREENBERG
Journal: Biochemical Journal
Biochem J (2002) 364 (1): 317–322.
https://doi.org/10.1042/bj3640317
Published: 08 May 2002
..., and the isogenic wild type. The results indicated that the importance of cardiolipin for energetic coupling strongly depends on the rate of oxidative phosphorylation, which was set by using NADH (maximal rate limited by coupling mechanism) or ethanol (moderate rate limited by electron supply) as a respiratory...
View articletitled, Cardiolipin prevents rate-dependent uncoupling and provides osmotic stability in yeast mitochondria
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Effect of ‘binary mitochondrial heteroplasmy’ on respiration and ATP synthesis: implications for mitochondrial diseases

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Bernard KORZENIEWSKI, Monique MALGAT, Thierry LETELLIER, Jean-Pierre MAZAT
Journal: Biochemical Journal
Biochem J (2001) 357 (3): 835–842.
https://doi.org/10.1042/bj3570835
Published: 25 July 2001
...Bernard KORZENIEWSKI; Monique MALGAT; Thierry LETELLIER; Jean-Pierre MAZAT Respiratory-chain-complex subunits in mitochondria are encoded by nuclear or mitochondrial DNA. This property might have profound implications for the phenotypic expression of mutations affecting oxidative phosphorylation...
View articletitled, Effect of ‘binary mitochondrial heteroplasmy’ on respiration and ATP synthesis: implications for mitochondrial diseases
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Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69

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Xing Xian YU, David A. LEWIN, Alan ZHONG, Jennifer BRUSH, Peter W. SCHOW, Steven W. SHERWOOD, Guohua PAN, Sean H. ADAMS
Journal: Biochemical Journal
Biochem J (2001) 353 (2): 369–375.
https://doi.org/10.1042/bj3530369
Published: 08 January 2001
... be addressed (e-mail [email protected] ). 2 7 2000 3 10 2000 7 11 2000 The Biochemical Society, London © 2001 2001 metabolic rate oxidative phosphorylation reactive oxygen species respiration thermogenesis Biochem. J. (2001) 353, 369 375 (Printed in Great Britain) 369...
View articletitled, Overexpression of the human 2-oxoglutarate carrier lowers mitochondrial membrane potential in HEK-293 cells: contrast with the unique cold-induced mitochondrial carrier CGI-69
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Activity of the human cytochrome c1 promoter is modulated by E2F

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Katarina LUCIAKOVA, Peter BARATH, Ronggui LI, Ahmed ZAID, B. Dean NELSON
Journal: Biochemical Journal
Biochem J (2000) 351 (1): 251–256.
https://doi.org/10.1042/bj3510251
Published: 26 September 2000
... specific suppressor domains, inhibits cytochrome c 1 promoter activity when co-transfected into HeLa cells, indicating that the E2F proteins modulate the cytochrome c 1 promoter in mammalian cells. However, E2F is not a general regulator of oxidative phosphorylation genes since three additional nuclear...
View articletitled, Activity of the human cytochrome c1 promoter is modulated by E2F
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Internal-ribosome-entry-site functional activity of the 3′-untranslated region of the mRNA for the β subunit of mitochondrial H+-ATP synthase

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José M. IZQUIERDO, José M. CUEZVA
Journal: Biochemical Journal
Biochem J (2000) 346 (3): 849–855.
https://doi.org/10.1042/bj3460849
Published: 07 March 2000
...José M. IZQUIERDO; José M. CUEZVA Translation in vitro of the mammalian nucleus-encoded mRNA for the β subunit of mitochondrial H + -ATP synthase (β-mRNA) of oxidative phosphorylation is promoted by a 150 nt translational enhancer sequence in the 3ʹ-untranslated region (3ʹ UTR). Titration...
View articletitled, Internal-ribosome-entry-site functional activity of the 3′-untranslated region of the mRNA for the β subunit of mitochondrial H+-ATP synthase
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