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Keywords: oxidative stress
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Articles
Maria Eduarda S. F. do Espírito Santo, Bárbara F. Frascino, Larissa M. M. Mattos, Daniele C. Pires, Simone S. C. de Oliveira, Lucas B. Menezes, Bernardo F. Braz, Ricardo E. Santeli, André L. S. Santos, Adolfo Horn, Jr, Christiane Fernandes, Marcos D. Pereira
Journal:
Biochemical Journal
Biochem J (2024) 481 (23): 1771–1786.
Published: 28 November 2024
...-iS) is a physiological phenomenon that leads to the formation of advanced glycation end-products, triggering detrimental effects such as oxidative stress, inflammation, and damage to intracellular structures, tissues, and organs. This process is particularly relevant because it has been associated with various human...
Includes: Supplementary data
Articles
Lokesh K. Saini, Manisha Sharma, Barkha Ravi, Soma Ghosh, Sonam Pahuja, Nidhi Singh, Girdhar K. Pandey
Journal:
Biochemical Journal
Biochem J (2023) 480 (9): 555–571.
Published: 28 April 2023
... growth. Also, AtPUB2 -OE seedlings showed sensitive phenotype in the presence of exogenous cytokinin. We found that AtPUB2 expression is induced under oxidative stress. Subcellular localization analysis shows that AtPUB2 is predominantly localized in the nucleus. We performed the phenotypic analysis...
Articles
Journal:
Biochemical Journal
Biochem J (2023) 480 (3): 197–217.
Published: 07 February 2023
.... In the presence of acetate, glutathione-dependent oxidative stress occurs, reduced thiol groups bind to proteins, and glutathione is exported out of the cells, these changes probably being triggered by an increase in glutathione-S-transferases. Overall, our results suggest that the role of cellular redox status...
Includes: Supplementary data
Articles
Manisha Banerjee, Namrata Waghamare, Prakash Kalwani, Deepak T. Hurali, Rachna Agarwal, Anand Ballal
Journal:
Biochemical Journal
Biochem J (2023) 480 (1): 87–104.
Published: 13 January 2023
... cysteine was mutated to serine, was capable of forming intermolecular disulfide bond and exist as a dimer when treated with H 2 O 2 . Overproduction of Alr2205 in E. coli protected cells from heavy metals, but not oxidative stress. To delve into its physiological role, Alr2205/Alr2205C41S was overexpressed...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (20): 3741–3756.
Published: 21 October 2021
... and CNC homolog 1 (BACH1). BACH1 is a ubiquitous master regulator of the cellular response to oxidative stress. Here, we show that BACH1 may have a dual effect on CFTR expression by direct occupancy of CREs at physiological oxygen (∼8%), while indirectly modulating expression under conditions of oxidative...
Includes: Supplementary data
Articles
Marina Kolbanovskiy, Abraham Aharonoff, Ana Helena Sales, Nicholas E. Geacintov, Vladimir Shafirovich
Journal:
Biochemical Journal
Biochem J (2021) 478 (12): 2359–2370.
Published: 23 June 2021
... translocation distance of NEIL1 is ∼80 base pairs. This estimate suggests that facilitated diffusion enhances the probability that NEIL1 can locate its substrate embedded in an excess of unmodified plasmid DNA nucleotides by a factor of ∼10. base excision repair DNA damage DNA glycosylase oxidative stress...
Includes: Supplementary data
Articles
Hayato Irokawa, Satoshi Numasaki, Shin Kato, Kenta Iwai, Atsushi Inose-Maruyama, Takumi Ohdate, Gi-Wook Hwang, Takashi Toyama, Toshihiko Watanabe, Shusuke Kuge
Journal:
Biochemical Journal
Biochem J (2021) 478 (7): 1453–1470.
Published: 16 April 2021
... M2 (PKM2), a rate-limiting enzyme in glycolysis, is critical for the metabolic shift from glycolysis to the pentose phosphate pathway under oxidative stress in cancer cell growth. The PKM2 tetramer is required for optimal pyruvate kinase (PK) activity, whereas the inhibition of inter-subunit...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (4): 749–764.
Published: 24 February 2021
..., in particular through alterations in electron transport chain function, reactive oxygen species (ROS) production and oxidative stress (OS), mitochondrial dynamics and mitophagy. Finally, we describe the impact of cocaine on brain energy metabolism in the developing brain following prenatal exposure...
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (24): 4689–4710.
Published: 18 December 2020
...Teresa Gonzalez; Franck Peiretti; Catherine Defoort; Patrick Borel; Roland Govers Fluorophore 2′,7′-dichlorofluorescin (DCF) is the most frequently used probe for measuring oxidative stress in cells, but many aspects of DCF remain to be revealed. Here, DCF was used to study the Fenton reaction...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (21): 4281–4294.
Published: 13 November 2020
...: A. Russell Tupling ( [email protected] ) 27 4 2020 15 10 2020 28 10 2020 28 10 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 heat shock proteins myocardium oxidative stress sarcoplasmic reticulum skeletal...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (19): 3709–3727.
Published: 05 October 2020
... oxidative stress to form S -mycothiolated monomer or inter-molecular disulfide-containing dimer, resulting in its dissociation from the target DNA promoter. Transcriptomics uncovered the strong up-regulation of many multidrug efflux pump genes and organic peroxide stress-involving genes in oasR mutant...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (17): 3123–3130.
Published: 04 September 2020
... in cardiomyocytes that includes fetal reprogramming of gene expression where adult genes are repressed and fetal genes turned on, endoplasmic reticulum stress and oxidative stress. In this short review and analysis, we examine these different phenomenon from the viewpoint of the glutathione cycle and the role...
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (16): 3033–3054.
Published: 26 August 2020
... of the organelle. The protein import into mitochondria is mediated by diverse import pathways and is continuously under watch by quality control systems. However, it is often challenged by both internal and external factors, such as oxidative stress or energy shortage. The impaired protein import and biogenesis...
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (15): 2859–2871.
Published: 12 August 2020
...-oxoadenine DNA polymerase mutagenesis oxidative DNA damage oxidative stress translesion synthesis Correspondence: Seongmin Lee ( [email protected] ) 4 6 2020 15 7 2020 17 7 2020 20 7 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf...
Articles
A nonpeptidyl molecule modulates apoptosis-like cell death by inhibiting P. falciparum metacaspase-2
Vandana, Sudha Shankar, Kona Madhavinadha Prasad, Mohammad Kashif, Inderjeet Kalia, Rajkishor Rai, Agam P. Singh, Kailash C. Pandey
Journal:
Biochemical Journal
Biochem J (2020) 477 (7): 1323–1344.
Published: 17 April 2020
... cathepsins-B, D and L, and caspase-3 and -7 were not inhibited by SS-5. SS-5 blocked the development of P. falciparum in vitro (IC50 1 µM) and caused prominent morphological distortions. Incubation with SS-5 led to persistent parasite oxidative stress accompanied by depolarization of mitochondrial potential...
Includes: Supplementary data
Articles
Alessandro G. Salerno, Thiago Rentz, Gabriel G. Dorighello, Ana Carolina Marques, Estela Lorza-Gil, Amarylis C. B. A. Wanschel, Audrey de Moraes, Anibal E. Vercesi, Helena C. F. Oliveira
Journal:
Biochemical Journal
Biochem J (2019) 476 (24): 3769–3789.
Published: 20 December 2019
... oxidative stress and increase atherosclerosis development. Thus, we compared peritoneal macrophages and liver mitochondria from three C57BL/6J mice lines: Ldlr and Nnt double mutant, single Nnt mutant and wild-type. We found increased oxidants production in both mitochondria and macrophages according...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2019) 476 (24): 3705–3719.
Published: 17 December 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 ATP7B Cisplatin copper oxidative stress TMEM16A Squamous cell carcinoma of the head and neck (SCCHN) is the sixth leading cause of cancer worldwide. These cancers are strongly associated with a risk to tobacco exposure...
Articles
LHC-like proteins involved in stress responses and biogenesis/repair of the photosynthetic apparatus
In Collection
Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019
,
Photosynthesis
Journal:
Biochemical Journal
Biochem J (2019) 476 (3): 581–593.
Published: 14 February 2019
... ]. Correspondence: Jean-David Rochaix ( [email protected] ) 13 12 2018 18 1 2019 21 1 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 LHC-like protein non-photochemical quenching oxidative stress photosynthesis...
Articles
Andrew G. Turner, Karrera Y. Djoko, Cheryl-lynn Y. Ong, Timothy C. Barnett, Mark J. Walker, Alastair G. McEwan
Journal:
Biochemical Journal
Biochem J (2019) 476 (3): 595–611.
Published: 14 February 2019
...Andrew G. Turner; Karrera Y. Djoko; Cheryl-lynn Y. Ong; Timothy C. Barnett; Mark J. Walker; Alastair G. McEwan Bacterial pathogens encounter a variety of adverse physiological conditions during infection, including metal starvation, metal overload and oxidative stress. Here, we demonstrate...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2018) 475 (24): 3979–3995.
Published: 19 December 2018
... functions have so far been limited to only two proteins, regulator of oxidative stress response RosR and quinone oxidoreductase regulator QosR. Here, we report that the ncgl2617 gene ( cosR ) of C. glutamicum encoding an MarR-type transcriptional regulator plays an important role in oxidative stress...
Includes: Supplementary data
Articles
Lionel Tarrago, Sandrine Grosse, Marina I. Siponen, David Lemaire, Béatrice Alonso, Guylaine Miotello, Jean Armengaud, Pascal Arnoux, David Pignol, Monique Sabaty
Journal:
Biochemical Journal
Biochem J (2018) 475 (23): 3779–3795.
Published: 06 December 2018
... and chicken lysozyme (Sigma–Aldrich), 32 300 M −1 cm −1 . Protein solutions were stored at −20°C until further use. enzyme kinetics methionine sulfoxide reductase molybdoenzyme oxidative stress protein oxidation proteomics Aerobic life exposes organisms to reactive oxygen species (ROS...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2018) 475 (19): 3105–3121.
Published: 12 October 2018
... was up-regulated in response to salinity, drought, and oxidative stress. Full-length cDNA encoding OsCSD3 was cloned and expressed in Escherichia coli and analyzed for spectral characteristics. UV (ultraviolet)–visible spectroscopic analysis showed evidences of d–d transitions, while circular dichroism...
Includes: Supplementary data
Articles
Structure-guided identification of function: role of Capsicum annuum vicilin during oxidative stress
Journal:
Biochemical Journal
Biochem J (2018) 475 (19): 3057–3071.
Published: 10 October 2018
... pathway, and revelation of superoxide dismutase activity suggest that Vic_CAPAN has an important role during oxidative stress. As salicylic acid changes the redox state of cell, it may act as a downstream signal for various pathways involved in plant biotic and abiotic stress rescue. Correspondence...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2018) 475 (10): 1789–1791.
Published: 31 May 2018
... and the response to oxidative stress, whereas plasmalogens, a poorly studied class of phospholipids, are known contributors to insulin resistance and hypertension. Both classes of metabolites are intriguing candidate biomarkers that warrant further investigation. Correspondence: Alessandro Rufini ( ar230...
Articles
The inositol-requiring enzyme 1 (IRE1α) RNAse inhibitor, 4µ8C, is also a potent cellular antioxidant
Journal:
Biochemical Journal
Biochem J (2018) 475 (5): 923–929.
Published: 09 March 2018
... 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 ER stress IRE1 oxidative stress unfolded protein response The endoplasmic reticulum (ER) is the site for the synthesis and processing of secretory and membrane proteins...
Articles
Ana Perea, José Ignacio Manzano, Yasuhisa Kimura, Kazumitsu Ueda, Santiago Castanys, Francisco Gamarro
Journal:
Biochemical Journal
Biochem J (2018) 475 (1): 87–97.
Published: 02 January 2018
...Ana Perea; José Ignacio Manzano; Yasuhisa Kimura; Kazumitsu Ueda; Santiago Castanys; Francisco Gamarro The Leishmania LABCG2 transporter has a key role in the redox metabolism of these protozoan parasites. Recently, the involvement of LABCG2 in virulence, autophagy and oxidative stress has been...
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (23): 3887–3902.
Published: 10 November 2017
... an Olympus FV1000 laser scanning confocal microscope with a 60× objective (zoom = 1.5x−2.5x) and analyzed with ImageJ. autophagy mitophagy oxidative stress stress transfection agent Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved catabolic pathway found...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (17): 3027–3043.
Published: 22 August 2017
.... Periplanetasin-2 induced oxidative stress by generation of reactive oxygen species (ROS) and lipid peroxidation. Periplanetasin-2 also caused apoptosis by exposure of phosphatidylserine and fragmentation of DNA, exerted in a concentration-dependent manner. Hence, we investigated the mitochondrial apoptotic...
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (16): 2713–2731.
Published: 02 August 2017
... of the ΔG ≠ values is an indication that a common mechanism in the above disorders may be taking place. We attribute this common mechanism to the (same) role of the oxidative stress and specifically of singlet oxygen, ( 1 Δ g ), to the above-mentioned processes: excitation of ground state oxygen...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (15): 2563–2572.
Published: 18 July 2017
... be a previously unrecognized mechanism by which ascorbate mitigates oxidative damage to heme-dependent enzymes and redox proteins in nature. © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 antioxidants cytochrome electron transfer oxidative stress...
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (7): 1195–1203.
Published: 20 March 2017
...Yasemin Sunucu Karafakıoğlu; Mehmet Fatih Bozkurt; Ömer Hazman; A. Fatih Fıdan The aim of the present study was to investigate the effects of safranal on cisplatin-induced nephrotoxicity and oxidative stress in rats. Adult male Sprague–Dawley rats were randomly divided into five groups. The control...
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (6): 877–883.
Published: 07 March 2017
... of muscle function? Free Radic. Biol. Med. 44 , 132 – 141 doi: 10.1016/j.freeradbiomed.2007.06.003 2 Naviaux , R.K. ( 2012 ) Oxidative shielding or oxidative stress? J. Pharmacol. Exp. Ther. 342 , 608 – 618 doi: 10.1124/jpet.112.192120 3 Anderson , L.E. and Duggan...
Articles
Philip Newsholme, Vinicius Fernandes Cruzat, Kevin Noel Keane, Rodrigo Carlessi, Paulo Ivo Homem de Bittencourt, Jr
Journal:
Biochemical Journal
Biochem J (2016) 473 (24): 4527–4550.
Published: 09 December 2016
...Philip Newsholme; Vinicius Fernandes Cruzat; Kevin Noel Keane; Rodrigo Carlessi; Paulo Ivo Homem de Bittencourt, Jr Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative...
Articles
Adam Neal, Austin Rountree, Kelly Kernan, Brian Van Yserloo, Huiliang Zhang, Benjamin J. Reed, William Osborne, Wang Wang, Ian R. Sweet
Journal:
Biochemical Journal
Biochem J (2016) 473 (23): 4443–4456.
Published: 25 November 2016
... O 2 and will have great utility for islet studies involving mechanisms of H 2 O 2 -mediated signaling and oxidative stress. Protein samples were prepared from islet samples using a lysis buffer (Cell Signaling) containing protease inhibitors (Sigma). After SDS–PAGE, proteins were transferred...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (23): 4373–4384.
Published: 25 November 2016
... polymerization. In the present study, we investigated the influence of oxidative stress of fibrinogen induced by H 2 O 2 on the polymerization state of fibrin. UV absorbance spectroscopy, circular dichroism, ζ-potential, dynamic light scattering and steady shear viscosity were all employed to study the influence...
Articles
Dong Keun Rhee, Jung Chae Lim, Steven C. Hockman, Faiyaz Ahmad, Dong Ho Woo, Youn Wook Chung, Shiwei Liu, Allison L. Hockman, Vincent C. Manganiello
Journal:
Biochemical Journal
Biochem J (2016) 473 (22): 4205–4225.
Published: 10 November 2016
...Dong Keun Rhee; Jung Chae Lim; Steven C. Hockman; Faiyaz Ahmad; Dong Ho Woo; Youn Wook Chung; Shiwei Liu; Allison L. Hockman; Vincent C. Manganiello Oxidative stress plays a pivotal role in pathogenesis of cardiovascular diseases and diabetes; however, the roles of protein kinase A (PKA) and human...
Includes: Supplementary data
Articles
Gary G.A. Silkstone, Rebecca S. Silkstone, Michael T. Wilson, Michelle Simons, Leif Bülow, Kristian Kallberg, Khuanpiroon Ratanasopa, Luca Ronda, Andrea Mozzarelli, Brandon J. Reeder, Chris E. Cooper
Journal:
Biochemical Journal
Biochem J (2016) 473 (19): 3371–3383.
Published: 27 September 2016
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . hemoglobin oxidative stress reactive oxygen species Hemoglobin (Hb)-based oxygen carriers (HBOC, colloquially termed ‘blood substitutes’) have the potential to be transfused in place of packed red...
Articles
Seiji Torii, Ryosuke Shintoku, Chisato Kubota, Makoto Yaegashi, Ryoko Torii, Masaya Sasaki, Toshinobu Suzuki, Masanobu Mori, Yuhei Yoshimoto, Toshiyuki Takeuchi, Keiichi Yamada
Journal:
Biochemical Journal
Biochem J (2016) 473 (6): 769–777.
Published: 10 March 2016
.... autophagy iron necrosis oxidative stress Ras Cell death plays an important role in the normal development and homoeostasis of living individuals, and is also implicated in abnormal activities of these processes in several diseases. Cells possess multiple cell death programmes including apoptosis...
Includes: Supplementary data
Articles
Yasuhiko Kizuka, Miyako Nakano, Shinobu Kitazume, Takashi Saito, Takaomi C. Saido, Naoyuki Taniguchi
Journal:
Biochemical Journal
Biochem J (2016) 473 (1): 21–30.
Published: 09 December 2015
...-plaque formation in the brain by accelerating lysosomal degradation of BACE1. Therefore, we hypothesized that bisecting GlcNAc would stabilize BACE1 protein on oxidative stress. In the present study, we first show that Aβ deposition in the mouse brain induces oxidative stress, together with an increase...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 471 (2): 267–279.
Published: 02 October 2015
... of these reagents could prevent EGF-dependent PRDX6 induction ( Figure 4 B). Along the same line, enhanced oxidative stress caused by glucose oxidase or H 2 O 2 had no effect on PRDX6 protein levels in human melanoma cells or NHEM cells ( Figures 4 C and 4 D). Figure 4 ROS-independent and PI3K-dependent...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 470 (3): 281–291.
Published: 04 September 2015
...Ami Oguro; Shoko Oida; Susumu Imaoka sEH (soluble epoxide hydrolase), which is encoded by the EPHX2 gene, regulates the actions of bioactive lipids, EETs (epoxyeicosatrienoic acids). Previously, we found that high-glucose-induced oxidative stress suppressed sEH levels in a hepatocarcinoma cell line...
Articles
Meiru Si, Yixiang Xu, Tietao Wang, Mingxiu Long, Wei Ding, Can Chen, Xinmeng Guan, Yingbao Liu, Yao Wang, Xihui Shen, Shuang-Jiang Liu
Journal:
Biochemical Journal
Biochem J (2015) 469 (1): 45–57.
Published: 19 June 2015
... MPx represents a new type of GPx that uses both mycoredoxin and Trx systems for oxidative stress response. © 2015 Authors; published by Portland Press Limited 2015 Mycothiol peroxidase, a new type of GSH peroxidase distributed in GSH-lacking high-(G+C)-content Gram-positive actinobacteria...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 465 (3): 371–382.
Published: 22 January 2015
...P. Patrick Dotson, II; Alexander A. Karakashian; Mariana N. Nikolova-Karakashian Neutral sphingomyelinase-2 (nSMase-2) is the major sphingomyelinase activated in response to pro-inflammatory cytokines and during oxidative stress. It is a membrane-bound 655 amino acid protein containing 22 cysteine...
Includes: Supplementary data
Articles
Zsuzsa Kovacs, Teresa Schacht, Ann-Kathrin Herrmann, Philipp Albrecht, Konstantinos Lefkimmiatis, Axel Methner
Journal:
Biochemical Journal
Biochem J (2014) 462 (1): 125–132.
Published: 24 July 2014
... cytoprotective constitutive activity via G α13 , but has no effect on ligand-mediated activation of G s and G q regardless of its inhibitory activity on protein kinase A. G-protein-coupled receptor 39 (GPR39) oxidative stress protein kinase A inhibitor β (PKIB) zinc In the present study, we...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 461 (1): 137–146.
Published: 13 June 2014
...Xing Guo; Hiromi Sesaki; Xin Qi Oxidative-stress-induced necrosis is considered to be one of the main pathological mediators in various neurological disorders, such as brain ischaemia. However, little is known about the mechanism by which cells modulate necrosis in response to oxidative stress...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 460 (3): 425–435.
Published: 29 May 2014
... peroxide (H 2 O 2 ). Cellular oxidative stress also increased significantly upon PAG inhibition or CSE knockdown. Further experiments using an activity-null Y60A mutant, a hyperactive E339A mutant and a control E349A mutant demonstrated that modulation of CSE catalytic activity altered its antioxidative...
Articles
Journal:
Biochemical Journal
Biochem J (2013) 456 (1): 139–146.
Published: 24 October 2013
... that arise from decreased respiratory capacity and increased oxidative stress [ 1 ]. Complex I is a complicated membrane-bound enzyme that catalyses NADH oxidation and quinone reduction, coupled with proton translocation across an energy-transducing membrane [ 2 ]. It is composed of a membrane-intrinsic...
Includes: Supplementary data
Articles
Alberto Bartolomé, Ana López-Herradón, Sergio Portal-Núñez, Ana García-Aguilar, Pedro Esbrit, Manuel Benito, Carlos Guillén
Journal:
Biochemical Journal
Biochem J (2013) 455 (3): 329–337.
Published: 10 October 2013
... and triggered autophagy by a mechanism dependent on reactive oxygen species overproduction in osteoblastic MC3T3-E1 cells. MC3T3-E1 cell survival was impaired by HG and worsened by chemical or genetic inhibition of autophagy. These findings were mimicked by H 2 O 2 -induced oxidative stress in these cells...
Includes: Supplementary data
Articles
Iman van den Bout, David R. Jones, Zahid H. Shah, Jonathan R. Halstead, Willem-Jan Keune, Shabaz Mohammed, Clive S. D’Santos, Nullin Divecha
Journal:
Biochemical Journal
Biochem J (2013) 455 (3): 347–358.
Published: 10 October 2013
... and in the nucleus. Three isoforms of PIP5K1 (phosphatidylinositol 4-phosphate 5-kinase), A, B and C, are responsible for the regulation of the major pools of cellular PtdIns(4,5) P 2 . PIP5K1B is negatively regulated in response to oxidative stress although it remains unclear which pathways regulate its activity...
Includes: Supplementary data
Articles
Florian Kern, Ruslan I. Stanika, Bettina Sarg, Martin Offterdinger, Daniel Hess, Gerald J. Obermair, Herbert Lindner, Christine E. Bandtlow, Ludger Hengst, Rüdiger Schweigreiter
Journal:
Biochemical Journal
Biochem J (2013) 455 (2): 217–227.
Published: 27 September 2013
... family. We characterized the Nogo-A–Apg-1 interaction by affinity precipitation, co-immunoprecipitation and proximity ligation assay, using primary hippocampal neurons derived from Nogo -deficient mice. Under conditions of hypoxic and oxidative stress we found that Nogo-A and Apg-1 were tightly co...
Includes: Supplementary data
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