...Nicolas Venteclef; Pascal Ferré Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Accumulation of cholesterol and its intermediates, such as oxysterols, lead to activation of the nuclear receptors LXRs (liver X receptors). LXR is an important...

...Mike H. Ngo; Terry R. Colbourne; Neale D. Ridgway Cholesterol and its numerous oxygenated derivatives (oxysterols) profoundly affect the biophysical properties of membranes, and positively and negatively regulate sterol homoeostasis through interaction with effector proteins. As the bulk...

...Karsten Gehrig; Thomas A. Lagace; Neale D. Ridgway In addition to suppressing cholesterol synthesis and uptake, oxysterols also activate glycerophospholipid and SM (sphingomyelin) synthesis, possibly to buffer cells from excess sterol accumulation. In the present study, we investigated the effects...

... of rapamycin (mTORC1) hepatic steatosis hepatitis B virus (HBV) oxysterol statin steatohepatitis In conclusion, the study by Kim et al. [ 2 ] has shed new light on the mechanism by which a prevalent human pathogen, HBV, causes lipid accumulation in the liver. LXRα represents a vital link between...

... investigated the regulation of sPLA 2 gene expression in rat aortic SMCs by oxysterols. We found that oxysterol ligands that bind to the LXR (liver X receptor), including 25-HC (25-hydroxycholesterol) and 22( R )-HC, cause the accumulation of sPLA 2 mRNA and an increased enzyme activity. Transient transfection...

... 2001 19 2 2002 26 3 2002 The Biochemical Society, London ©2002 2002 apolipoprotein A-I bile nuclear hormone receptor oxysterol retinoic acid Abbreviations used: AP, apical; apoA-I, apolipoprotein A-I; apoE, apolipoprotein E; ABC, ATP-binding cassette; BHK, baby...

... at significant and potentially biologically active concentrations. Oxysterols, similar to those formed during low-density lipo- protein (LDL) oxidation (see below), are present [3,4] and are also in the foam cells [5]. Two of the predominant species are 7-ketocholesterol (7K) and 7b-hydroxycholesterol (7bOH...